HUE054912T2 - Pirazolil-amino-benzimidazol-származékok mint JAK inhibitorok - Google Patents

Pirazolil-amino-benzimidazol-származékok mint JAK inhibitorok

Info

Publication number
HUE054912T2
HUE054912T2 HUE17740885A HUE17740885A HUE054912T2 HU E054912 T2 HUE054912 T2 HU E054912T2 HU E17740885 A HUE17740885 A HU E17740885A HU E17740885 A HUE17740885 A HU E17740885A HU E054912 T2 HUE054912 T2 HU E054912T2
Authority
HU
Hungary
Prior art keywords
pyrazolylaminobenzimidazole
derivatives
jak inhibitors
jak
inhibitors
Prior art date
Application number
HUE17740885A
Other languages
English (en)
Inventor
Jolie Anne Bastian
Joshua Ryan Clayton
David Andrew Coates
Daniel Jon Sall
Timothy Andrew Woods
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HUE054912T2 publication Critical patent/HUE054912T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HUE17740885A 2016-07-14 2017-07-10 Pirazolil-amino-benzimidazol-származékok mint JAK inhibitorok HUE054912T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662362208P 2016-07-14 2016-07-14

Publications (1)

Publication Number Publication Date
HUE054912T2 true HUE054912T2 (hu) 2021-10-28

Family

ID=59366549

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE17740885A HUE054912T2 (hu) 2016-07-14 2017-07-10 Pirazolil-amino-benzimidazol-származékok mint JAK inhibitorok

Country Status (22)

Country Link
US (2) US10323019B2 (hu)
EP (1) EP3484875B1 (hu)
JP (1) JP6712331B2 (hu)
KR (1) KR102225840B1 (hu)
CN (1) CN109476643B (hu)
AU (1) AU2017296026B2 (hu)
BR (1) BR112018075086B1 (hu)
CA (1) CA3030697C (hu)
CY (1) CY1124308T1 (hu)
DK (1) DK3484875T3 (hu)
EA (1) EA038129B1 (hu)
ES (1) ES2877198T3 (hu)
HR (1) HRP20210965T1 (hu)
HU (1) HUE054912T2 (hu)
LT (1) LT3484875T (hu)
MX (1) MX2019000542A (hu)
NZ (1) NZ748942A (hu)
PL (1) PL3484875T3 (hu)
PT (1) PT3484875T (hu)
RS (1) RS61991B1 (hu)
SI (1) SI3484875T1 (hu)
WO (1) WO2018013486A1 (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230141115A (ko) 2022-03-31 2023-10-10 한림대학교 산학협력단 신규한 2-아릴-1H-벤조[d]이미다졸 유도체, 이의 제조 방법 및 이의 항암제로서의 용도
KR102582097B1 (ko) 2022-12-28 2023-09-25 (주)메디언스 야누스키나아제 표적 억제제 및 이의 용도

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010524911A (ja) * 2007-04-18 2010-07-22 アストラゼネカ アクチボラグ 5−アミノピラゾール−3−イル−3H−イミダゾ[4,5−b]ピリジン誘導体と癌の治療のためのその使用
US8445676B2 (en) * 2008-10-08 2013-05-21 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
WO2010068806A1 (en) * 2008-12-10 2010-06-17 Cgi Pharmaceuticals, Inc. Amide derivatives as btk inhibitors in the treatment of allergic, autoimmune and inflammatory disorders as well as cancer
CN102712640A (zh) * 2010-01-12 2012-10-03 弗·哈夫曼-拉罗切有限公司 三环杂环化合物、其组合物和应用方法
AR083933A1 (es) * 2010-11-19 2013-04-10 Incyte Corp Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak
WO2013040863A1 (en) * 2011-09-22 2013-03-28 Merck Sharp & Dohme Corp. Cycloalkylnitrile pyrazole carboxamides as janus kinase inhibitors
GB201401086D0 (en) 2014-01-23 2014-03-12 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
WO2016065138A1 (en) * 2014-10-22 2016-04-28 Dana-Farber Cancer Institute, Inc. Thiazolyl-containing compounds for treating proliferative diseases
AR105400A1 (es) * 2015-08-04 2017-09-27 Lilly Co Eli Inhibidores de jak1

Also Published As

Publication number Publication date
SI3484875T1 (sl) 2021-08-31
MX2019000542A (es) 2019-07-04
EP3484875B1 (en) 2021-04-07
CN109476643B (zh) 2021-06-08
JP6712331B2 (ja) 2020-06-17
WO2018013486A1 (en) 2018-01-18
EP3484875A1 (en) 2019-05-22
PT3484875T (pt) 2021-07-05
CA3030697A1 (en) 2018-01-18
KR102225840B1 (ko) 2021-03-11
US10344018B2 (en) 2019-07-09
BR112018075086A2 (pt) 2019-03-12
DK3484875T3 (da) 2021-06-28
ES2877198T3 (es) 2021-11-16
RS61991B1 (sr) 2021-07-30
JP2019525908A (ja) 2019-09-12
EA201892698A1 (ru) 2019-06-28
NZ748942A (en) 2020-08-28
HRP20210965T1 (hr) 2021-09-17
KR20190015561A (ko) 2019-02-13
AU2017296026A1 (en) 2018-12-20
CN109476643A (zh) 2019-03-15
AU2017296026B2 (en) 2019-11-21
CY1124308T1 (el) 2022-07-22
US20190177300A1 (en) 2019-06-13
US10323019B2 (en) 2019-06-18
CA3030697C (en) 2021-02-23
LT3484875T (lt) 2021-07-26
PL3484875T3 (pl) 2021-11-02
US20180325873A1 (en) 2018-11-15
BR112018075086B1 (pt) 2024-02-27
EA038129B1 (ru) 2021-07-09

Similar Documents

Publication Publication Date Title
IL250709A0 (en) Aminopyrimidines and their use to inhibit jak
HK1255045A1 (zh) 取代的氧代吡啶衍生物
SG11201706729SA (en) Derivatives of sobetirome
PL3218378T3 (pl) Pochodne 6-amino-7-bicyklo-7-deazapuryny jako inhibitory kinaz białkowych
HUE064003T2 (hu) JAK-gátló
IL253381A0 (en) History of h9-pyrrolo-dipyridine
EP3290418A4 (en) Jak inhibitors
IL263050B (en) History of Subtirum
HK1246667A1 (zh) 作為jak抑制劑的2-(吡唑並吡啶-3-基)嘧啶衍生物
HK1245258A1 (zh) 新的二氟酮酰胺衍生物
HK1257565A1 (zh) 作為htra1抑制劑的新型三氟甲基丙酰胺衍生物
HK1257567A1 (zh) 作為htra1抑制劑的新型二氟酮酰胺衍生物
IL251005B (en) Pyrido-oxazinone derivatives
HK1252767A1 (zh) 作為eaat3抑制劑的吡唑-吡啶衍生物
HUE054912T2 (hu) Pirazolil-amino-benzimidazol-származékok mint JAK inhibitorok