HUE050796T2 - (R)-4-(5-(ciklopropiletinil)izoxazol-3-il)-N-hidroxi-2-metil-2-(metilszulfonil)butánamid kristályos formája baktériumellenes szerként - Google Patents
(R)-4-(5-(ciklopropiletinil)izoxazol-3-il)-N-hidroxi-2-metil-2-(metilszulfonil)butánamid kristályos formája baktériumellenes szerkéntInfo
- Publication number
- HUE050796T2 HUE050796T2 HUE17739696A HUE17739696A HUE050796T2 HU E050796 T2 HUE050796 T2 HU E050796T2 HU E17739696 A HUE17739696 A HU E17739696A HU E17739696 A HUE17739696 A HU E17739696A HU E050796 T2 HUE050796 T2 HU E050796T2
- Authority
- HU
- Hungary
- Prior art keywords
- cyclopropylethynyl
- butanamide
- isoxazol
- methylsulfonyl
- hydroxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2016085694 | 2016-06-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE050796T2 true HUE050796T2 (hu) | 2021-01-28 |
Family
ID=59337734
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE17739696A HUE050796T2 (hu) | 2016-06-14 | 2017-06-12 | (R)-4-(5-(ciklopropiletinil)izoxazol-3-il)-N-hidroxi-2-metil-2-(metilszulfonil)butánamid kristályos formája baktériumellenes szerként |
Country Status (28)
Country | Link |
---|---|
US (1) | US10071973B2 (hu) |
EP (1) | EP3468957B1 (hu) |
JP (1) | JP6941630B2 (hu) |
KR (1) | KR20190018637A (hu) |
CN (1) | CN109311828A (hu) |
AU (1) | AU2017283768B2 (hu) |
BR (1) | BR112018074983A2 (hu) |
CA (1) | CA3026356A1 (hu) |
CL (1) | CL2018003559A1 (hu) |
CY (1) | CY1123368T1 (hu) |
DK (1) | DK3468957T3 (hu) |
EA (1) | EA036243B1 (hu) |
ES (1) | ES2820502T3 (hu) |
HR (1) | HRP20201524T1 (hu) |
HU (1) | HUE050796T2 (hu) |
IL (1) | IL263299A (hu) |
MA (1) | MA45250B1 (hu) |
MD (1) | MD3468957T2 (hu) |
MX (1) | MX2018015634A (hu) |
PH (1) | PH12018502523A1 (hu) |
PL (1) | PL3468957T3 (hu) |
PT (1) | PT3468957T (hu) |
SG (1) | SG11201810656WA (hu) |
SI (1) | SI3468957T1 (hu) |
TW (1) | TWI746572B (hu) |
UA (1) | UA123790C2 (hu) |
WO (1) | WO2017216705A1 (hu) |
ZA (1) | ZA201807680B (hu) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107375211B (zh) * | 2017-08-24 | 2021-02-26 | 正大制药(青岛)有限公司 | 一种甲苯磺酸妥舒沙星小儿用舌下喷雾剂及其制备方法 |
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2017
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- 2017-06-12 PT PT177396967T patent/PT3468957T/pt unknown
- 2017-06-12 EA EA201990012A patent/EA036243B1/ru not_active IP Right Cessation
- 2017-06-12 HU HUE17739696A patent/HUE050796T2/hu unknown
- 2017-06-12 CA CA3026356A patent/CA3026356A1/en not_active Abandoned
- 2017-06-12 AU AU2017283768A patent/AU2017283768B2/en not_active Ceased
- 2017-06-12 SI SI201730409T patent/SI3468957T1/sl unknown
- 2017-06-12 UA UAA201811400A patent/UA123790C2/uk unknown
- 2017-06-12 MX MX2018015634A patent/MX2018015634A/es unknown
- 2017-06-12 EP EP17739696.7A patent/EP3468957B1/en active Active
- 2017-06-12 ES ES17739696T patent/ES2820502T3/es active Active
- 2017-06-12 CN CN201780036712.0A patent/CN109311828A/zh active Pending
- 2017-06-12 MD MDE20190477T patent/MD3468957T2/ro not_active IP Right Cessation
- 2017-06-12 PL PL17739696T patent/PL3468957T3/pl unknown
- 2017-06-12 MA MA45250A patent/MA45250B1/fr unknown
- 2017-06-12 US US15/620,373 patent/US10071973B2/en not_active Expired - Fee Related
- 2017-06-12 DK DK17739696.7T patent/DK3468957T3/da active
- 2017-06-12 BR BR112018074983-4A patent/BR112018074983A2/pt not_active IP Right Cessation
- 2017-06-12 JP JP2018565302A patent/JP6941630B2/ja active Active
- 2017-06-13 TW TW106119562A patent/TWI746572B/zh not_active IP Right Cessation
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2018
- 2018-11-15 ZA ZA2018/07680A patent/ZA201807680B/en unknown
- 2018-11-26 IL IL263299A patent/IL263299A/en unknown
- 2018-11-29 PH PH12018502523A patent/PH12018502523A1/en unknown
- 2018-12-11 CL CL2018003559A patent/CL2018003559A1/es unknown
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2020
- 2020-09-21 CY CY20201100888T patent/CY1123368T1/el unknown
- 2020-09-23 HR HRP20201524TT patent/HRP20201524T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
MD3468957T2 (ro) | 2020-11-30 |
BR112018074983A2 (pt) | 2019-03-12 |
IL263299A (en) | 2018-12-31 |
MA45250B1 (fr) | 2020-09-30 |
EA036243B1 (ru) | 2020-10-16 |
JP6941630B2 (ja) | 2021-09-29 |
HRP20201524T1 (hr) | 2021-03-05 |
PH12018502523A1 (en) | 2019-10-14 |
US20170355684A1 (en) | 2017-12-14 |
AU2017283768A1 (en) | 2018-12-06 |
ES2820502T3 (es) | 2021-04-21 |
US10071973B2 (en) | 2018-09-11 |
CL2018003559A1 (es) | 2019-01-18 |
TW201803858A (zh) | 2018-02-01 |
CA3026356A1 (en) | 2017-12-21 |
PL3468957T3 (pl) | 2021-01-25 |
DK3468957T3 (da) | 2020-09-14 |
EA201990012A1 (ru) | 2019-05-31 |
EP3468957A1 (en) | 2019-04-17 |
KR20190018637A (ko) | 2019-02-25 |
AU2017283768B2 (en) | 2019-05-23 |
CY1123368T1 (el) | 2021-12-31 |
CN109311828A (zh) | 2019-02-05 |
JP2019522645A (ja) | 2019-08-15 |
WO2017216705A1 (en) | 2017-12-21 |
ZA201807680B (en) | 2019-08-28 |
MX2018015634A (es) | 2019-03-06 |
SI3468957T1 (sl) | 2020-11-30 |
EP3468957B1 (en) | 2020-08-26 |
TWI746572B (zh) | 2021-11-21 |
PT3468957T (pt) | 2020-09-24 |
UA123790C2 (uk) | 2021-06-02 |
SG11201810656WA (en) | 2018-12-28 |
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