HUE037936T2 - Mono- és di-pegil IL-10 elõállítása és alkalmazása - Google Patents

Mono- és di-pegil IL-10 elõállítása és alkalmazása

Info

Publication number
HUE037936T2
HUE037936T2 HUE09774794A HUE09774794A HUE037936T2 HU E037936 T2 HUE037936 T2 HU E037936T2 HU E09774794 A HUE09774794 A HU E09774794A HU E09774794 A HUE09774794 A HU E09774794A HU E037936 T2 HUE037936 T2 HU E037936T2
Authority
HU
Hungary
Prior art keywords
peg
mono
production
Prior art date
Application number
HUE09774794A
Other languages
English (en)
Inventor
Steven Blaisdell
Collette Cutler
Brittany Paporello
Alexandre Ambrogelly
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of HUE037936T2 publication Critical patent/HUE037936T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
HUE09774794A 2008-12-17 2009-12-15 Mono- és di-pegil IL-10 elõállítása és alkalmazása HUE037936T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13842108P 2008-12-17 2008-12-17
US24518209P 2009-09-23 2009-09-23

Publications (1)

Publication Number Publication Date
HUE037936T2 true HUE037936T2 (hu) 2018-09-28

Family

ID=42224354

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE09774794A HUE037936T2 (hu) 2008-12-17 2009-12-15 Mono- és di-pegil IL-10 elõállítása és alkalmazása

Country Status (15)

Country Link
US (4) US8691205B2 (hu)
EP (2) EP2379115B1 (hu)
JP (5) JP5888980B2 (hu)
CN (2) CN102256625B (hu)
AU (1) AU2009333325B2 (hu)
CA (1) CA2745443C (hu)
DK (1) DK2379115T3 (hu)
ES (2) ES2655364T3 (hu)
HK (2) HK1190736A1 (hu)
HU (1) HUE037936T2 (hu)
NO (1) NO2379115T3 (hu)
PL (1) PL2379115T3 (hu)
PT (1) PT2379115T (hu)
RU (1) RU2549702C2 (hu)
WO (1) WO2010077853A2 (hu)

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EP3068425B1 (en) 2013-11-11 2021-01-27 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
CN106573072A (zh) 2014-06-02 2017-04-19 阿尔莫生物科技股份有限公司 降低血清胆固醇的方法
WO2016060996A2 (en) 2014-10-14 2016-04-21 Armo Biosciences, Inc. Interleukin-15 compositions and uses thereof
MX2017004983A (es) 2014-10-22 2017-11-13 Armo Biosciences Inc Metodos para usar interleucina 10 para tratar enfermedades y trastornos.
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WO2016126615A1 (en) 2015-02-03 2016-08-11 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
KR20180020141A (ko) 2015-05-28 2018-02-27 아르모 바이오사이언시스 인코포레이티드 암 치료에 사용되는 peg화된 인터류킨-10
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JP2020508436A (ja) 2016-12-07 2020-03-19 プロジェニティ， インコーポレイテッド 胃腸管の検出方法、装置およびシステム
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WO2019094268A1 (en) 2017-11-10 2019-05-16 Armo Biosciences, Inc. Compositions and methods of use of interleukin-10 in combination with immune checkpoint pathway inhibitors
EP3810189A1 (en) 2018-06-19 2021-04-28 Armo Biosciences, Inc. Compositions and methods of use of il-10 agents in conjunction with chimeric antigen receptor cell therapy
CN116726362A (zh) 2018-11-19 2023-09-12 比奥拉治疗股份有限公司 用生物治疗剂治疗疾病的方法和装置
CN112955546B (zh) * 2018-11-26 2024-04-16 江苏恒瑞医药股份有限公司 一种人白细胞介素10变体及其衍生物
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Also Published As

Publication number Publication date
JP5888980B2 (ja) 2016-03-22
EP2379115B1 (en) 2017-10-25
US8691205B2 (en) 2014-04-08
ES2957546T3 (es) 2024-01-22
WO2010077853A3 (en) 2010-09-02
US9566345B2 (en) 2017-02-14
HK1258403A1 (zh) 2019-11-08
CA2745443C (en) 2017-02-21
JP2015221817A (ja) 2015-12-10
JP6905024B2 (ja) 2021-07-21
RU2011129638A (ru) 2013-01-27
EP2379115A2 (en) 2011-10-26
CN102256625B (zh) 2013-11-20
US20160193352A1 (en) 2016-07-07
AU2009333325A1 (en) 2010-07-08
JP6349371B2 (ja) 2018-06-27
JP6791906B2 (ja) 2020-11-25
PT2379115T (pt) 2018-01-03
CA2745443A1 (en) 2010-07-08
JP2018168160A (ja) 2018-11-01
AU2009333325B2 (en) 2014-07-10
DK2379115T3 (da) 2018-01-29
EP3348281A1 (en) 2018-07-18
US20110250163A1 (en) 2011-10-13
NO2379115T3 (hu) 2018-03-24
ES2655364T3 (es) 2018-02-19
WO2010077853A2 (en) 2010-07-08
JP2020019808A (ja) 2020-02-06
US20170202923A1 (en) 2017-07-20
US9259478B2 (en) 2016-02-16
JP2012512250A (ja) 2012-05-31
RU2549702C2 (ru) 2015-04-27
JP2017052780A (ja) 2017-03-16
CN103601800B (zh) 2015-10-21
EP3348281B1 (en) 2023-07-05
HK1190736A1 (zh) 2014-07-11
PL2379115T3 (pl) 2018-03-30
US20150086505A1 (en) 2015-03-26
CN103601800A (zh) 2014-02-26
US10639353B2 (en) 2020-05-05
CN102256625A (zh) 2011-11-23

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