HUE032069T2

HUE032069T2 - Perfume systems

Info

Publication number: HUE032069T2
Application number: HUE11728511A
Authority: HU
Inventors: Johan Smets; Hugo Robert Germain Denutte; An Pintens; Aken Koen Van; Freek Annie Camiel Vrielynck
Original assignee: Procter & Gamble
Priority date: 2010-06-22
Filing date: 2011-06-22
Publication date: 2017-10-30
Also published as: WO2011163337A1; JP2015163704A; JP5744192B2; CN104546520A; ES2666195T3; EP2585569A1; EP2585569B1; CA2799582A1; US20110308555A1; JP2013530285A; BR112012032706A2; CN102947432A; CN102947432B; PL2585569T3; CA2879555C; CN104546520B; ES2604704T3; CA2879555A1; JP5997313B2; EP3085759B1

Abstract

The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

Description

FIELD OF INVENTION

[0001] The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products.

BACKGROUND OF THE INVENTION

[0002] Consumer products may comprise one or more perfumes and/or perfume delivery systems that can provide a desired scent to such product and/or a situs that is contacted with such a product and/or mask an undesirable odor. While current perfumes and perfume delivery systems provide desirable odors, consumers continue to seek products that have scents that may be longer lasting and that are tailored to their individual desires (see for example USPA 2007/0275866 A1 and US Patent Application US 2008/0305977) - unfortunately the pool of perfume raw materials and perfume delivery systems that is available is still too limited to completely meet the perfume community’s needs. Thus, perfumers need an ever larger pool of perfume raw materials and perfume delivery systems.

[0003] Applicants believe that the perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume community’s options, as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles. In certain aspects, such perfume raw materials and/or perfume delivery systems comprising such perfume raw materials provide variations on character and/or odor profiles that are better than expected as measured by parameters such as headspace analysis which can be used to determine perfume delivery system perfume leakage and/or perfume delivery efficiency; ClogP; boiling point and/or odordetection threshold.

SUMMARY OF THE INVENTION

[0004] The present application relates to perfume raw materials, perfume systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume systems and consumer products.

DETAILED DESCRIPTION OF THE INVENTION

Definitions [0005] As used herein "consumer product" means baby care, beauty care, fabric & home care, family care, feminine care, health care, snack and/or beverage products or devices generally intended to be used or consumed in the form in which it is sold. Such products include but are not limited to diapers, bibs, wipes; products for and/or methods relating to treating hair (human, dog, and/or cat), including, bleaching, coloring, dyeing, conditioning, shampooing, styling; deodorants and antiperspirants; personal cleansing; cosmetics; skin care including application of creams, lotions, and other topically applied products for consumer use including fine fragrances; and shaving products, products for and/or methods relating to treating fabrics, hard surfaces and any other surfaces in the area of fabric and home care, including: air care including air fresheners and scent delivery systems, car care, dishwashing, fabric conditioning (including softening and/or freshing), laundry detergency, laundry and rinse additive and/or care, hard surface cleaning and/or treatment including floor and toilet bowl cleaners, and other cleaning for consumer or institutional use; products and/or methods relating to bath tissue, facial tissue, paper handkerchiefs, and/or papertowels; tampons, feminine napkins; products and/or methods relating to oral care including toothpastes, tooth gels, tooth rinses, denture adhesives, tooth whitening; over-the-counter health care including cough and cold remedies, pain relievers, RX pharmaceuticals, pet health and nutrition; processed food products intended primarily for consumption between customary meals or as a meal accompaniment (non-limiting examples include potato chips, tortilla chips, popcorn, pretzels, corn chips, cereal bars, vegetable chips or crisps, snack mixes, party mixes, multigrain chips, snack crackers, cheese snacks, pork rinds, corn snacks, pellet snacks, extruded snacks and bagel chips); and coffee.

[0006] As used herein, the term "cleaning and/or treatment composition" is a subset of consumer products that includes, unless otherwise indicated, beauty care, fabric & home care products. Such products include, but are not limited to, products for treating hair (human, dog, and/or cat), including, bleaching, coloring, dyeing, conditioning, shampooing, styling; deodorants and antiperspirants; personal cleansing; cosmetics; skin care including application of creams, lotions, and other topically applied products for consumer use including fine fragrances; and shaving products, products for treating fabrics, hard surfaces and any other surfaces in the area of fabric and home care, including: air care including air fresheners and scent delivery systems, car care, dishwashing, fabric conditioning (including softening and/or freshing), laundry detergency, laundry and rinse additive and/or care, hard surface cleaning and/or treatment including floor and toilet bowl cleaners, granular or powder-form all-purpose or "heavy-duty" washing agents, especially cleaning detergents; liquid, gel or paste-form all-purpose washing agents, especially the so-called heavy-duty liquid types; liquid fine-fabric detergents; hand dishwashing agents or light duty dishwashing agents, especially those of the high-foaming type; machine dishwashing agents, including the various tablet, granular, liquid and rinse-aid types for household and institutional use; liquid cleaning and disinfecting agents, including antibacterial hand-wash types, cleaning bars, mouthwashes, denture cleaners, dentifrice, car or carpet shampoos, bathroom cleaners including toilet bowl cleaners; hair shampoos and hair-rinses; shower gels , fine fragrances and foam baths and metal cleaners; as well as cleaning auxiliaries such as bleach additives and "stain-stick" or pre-treat types, substrate-laden products such as dryer added sheets, dry and wetted wipes and pads, nonwoven substrates, and sponges; as well as sprays and mists all for consumer or/and institutional use; and/or methods relating to oral care including toothpastes, tooth gels, tooth rinses, denture adhesives, tooth whitening.

[0007] As used herein, the term "fabric and/or hard surface cleaning and/or treatment composition" is a subset of cleaning and treatment compositions that includes, unless otherwise indicated, granular or powder-form all-purpose or "heavy-duty" washing agents, especially cleaning detergents; liquid, gel or paste-form all-purpose washing agents, especially the so-called heavy-duty liquid types; liquid fine-fabric detergents; hand dishwashing agents or light duty dishwashing agents, especially those of the high-foaming type; machine dishwashing agents, including the various tablet, granular, liquid and rinse-aid types for household and institutional use; liquid cleaning and disinfecting agents, including antibacterial hand-wash types, cleaning bars, car or carpet shampoos, bathroom cleaners including toilet bowl cleaners; and metal cleaners, fabric conditioning products including softening and/or freshing that may be in liquid, solid and/or dryer sheet form ; as well as cleaning auxiliaries such as bleach additives and "stain-stick" or pre-treat types, substrateladen products such as dryer added sheets, dry and wetted wipes and pads, nonwoven substrates, and sponges; as well as sprays and mists. All of such products which were applicable may be in standard, concentrated or even highly concentrated form even to the extent that such products may in certain aspect be non-aqueous.

[0008] As used herein, articles such as "a" and "an" when used in a claim, are understood to mean one or more of what is claimed or described.

[0009] As used herein, the terms "include", "includes" and "including" are meant to be non-limiting.

[0010] As used herein, the term "solid" includes granular, powder, bar and tablet product forms.

[0011] As used herein, the term "fluid" includes liquid, gel, paste and gas product forms.

[0012] As used herein, the term "situs" includes paper products, fabrics, garments, hard surfaces, hair and skin.

[0013] Unless otherwise noted, all component or composition levels are in reference to the active portion of that component or composition, and are exclusive of impurities, for example, residual solvents or by-products, which may be present in commercially available sources of such components or compositions.

[0014] All percentages and ratios are calculated by weight unless otherwise indicated. All percentages and ratios are calculated based on the total composition unless otherwise indicated.

[0015] It should be understood that every maximum numerical limitation given throughout this specification includes every lower numerical limitation, as if such lower numerical limitations were expressly written herein. Every minimum numerical limitation given throughout this specification will include every higher numerical limitation, as if such higher numerical limitations were expressly written herein. Every numerical range given throughout this specification will include every narrower numerical range that falls within such broader numerical range, as if such narrower numerical ranges were all expressly written herein.

Perfume Raw Materials (herein after "PRMs") [0016] PRMs include the PRMs listed in table 1 below and stereoisomers thereof. Only PRMs of formula 2 are with

(continued)

[0017] The PRMs disclosed in Table 1 above may provide one or more of the following benefits at a level that Applicants believe is unexpected in view of PRMs in general: neat product odor; wet fabric odor when applied to a fabric; dry fabric odor when applied to a fabric; reduced leakage from an encapsulate, including an encapsulate such as a perfume microcapsule; increased head space versus neat oil in certain perfume delivery technologies; odor when used in a matrix perfume delivery that is applied to a package; neat product odor when applied to a cleaning and/or treatment composition; fine fragrance composition odor when used in a fine fragrance; dry hair odor when a composition comprising such a PRM is applied to hair; PRM bloom from a solution comprising such a PRM and new PRM character when applied to a situs. Confirmation of such benefits can be obtained by applying standard test methodologies.

[0018] The PRMs and stereoisomers of such PRMs (also known as molecules in the examples of the present specification) disclosed in Table 1 above can be made in accordance with the respective teachings found, for example in the examples of the present specification.

[0019] In one aspect, a PRM having the structure of Table 1 PRM 2, 5, 7, 8, 10, 13, 14, 15, 16, 17, 18, 19, 21,25, 26, 30, 32, 33, 40, 41,42, 43 and 65 are disclosed.

[0020] In one aspect, the PRMs disclosed in Table 1 and stereoisomers thereof are suitable for use, as defined by the present specification, in consumer products at levels, based on total consumer product weight of from about 0.0001% to about 25%, from about 0.0005% to about 10%, from about 0.001% to about 5%, from about 0.005% to about 2.5%, or even from 0.01% to about 1%. Such PRMs and stereoisomers thereof may be used in combination in the aforemen tioned consumer product. In one aspect, a consumer product that may comprise one or more PRMs selected from Table 1 PRMs 2, 5, 7, 8, 10, 13, 14, 15, 16, 17, 18, 19, 21,22, 25, 26, 29, 30, 31, 32, 33, 34, 35, 39, 40, 41, 42, 43, 51, 55, 56, 57, 58, 59, 60, 65, 71, 74, 78, 79 and 82 and stereoisomers of such PRMs is disclosed.

[0021] In one aspect, the PRMs disclosed in Table 1 and stereoisomers thereof are suitable for use, as defined by the present specification, in cleaning and/or treatment composition at levels, based on total cleaning and treatment products weight of from about 0.0001% to about 25%, from about 0.0005% to about 10%, from about 0.001% to about 5%, from about 0.005% to about 2.5%, or even from 0.01% to about 1%. Such PRMs and stereoisomers thereof may be used in combination in the aforementioned cleaning and/ treatment compositions. In one aspect, a cleaning and/or treatment composition that may comprise one or more PRMs selected from Table 1 PRMs 2, 5, 7, 8, 10, 13, 14, 15, 16, 17, 18, 19, 20, 21,22, 25, 26, 27, 29, 30, 31, 32, 33, 34, 35, 39, 40, 41,42, 43, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 64, 65, 67, 68, 69, 70, 71, 72, 74, 75, 76, 77, 78, 79, 81,82 and 83 and stereoisomers of such PRMs is disclosed.

[0022] In one aspect, the PRMs disclosed in Table 1 and stereoisomers thereof are suitable for use, as defined by the present specification, in fabric and/or hard surface cleaning and/or treatment compositions at levels, based on total fabric and/or hard surface cleaning and/or treatment composition weight of from about 0.00001% to about 25%, from 0.00005% to about 10%, from 0.0001% to about 5%, from 0.0005% to about 1.0%, or even from 0.001% to about 0.5%. Such PRMs and stereoisomers thereof may be used in combination in the aforementioned fabric and/or hard surface cleaning and/ortreatment compositions. In one aspect, a fabric and/or hard surface cleaning and/ortreatment composition that may comprise one or more PRMs selected from Table 1 PRMs 2, 5, 7, 8, 10, 13, 14, 15, 16, 17, 18, 19, 20, 21,22, 23, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 39, 40, 41,42, 43, 51,52, 53, 54, 55, 56, 57, 58, 59, 60, 64, 65, 66, 67, 68, 69, 70, 71,72, 74, 75, 76, 77, 78, 79, 81,82 and 83 and stereoisomers of such PRMs is disclosed.

[0023] In one aspect, a detergent that may comprise the same level of the PRMs as disclosed for the aforementioned fabric and hard surface cleaning and/ortreatment compositions is disclosed. In one aspect, a detergent that may comprise one or more PRMs selected from Table 1 PRMs 2, 4, 5, 7, 8, 10, 13, 14, 15, 16, 17, 18, 19, 20, 21,22, 23, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 39, 40, 41,42, 43, 51,52, 53, 54, 55, 56, 57, 58, 59, 60, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 81, 82 and 83 and stereoisomers of such PRMs is disclosed.

[0024] In one aspect, the PRMs disclosed in Table 1 and stereoisomers thereof are suitable for use, in highly compacted consumer products, including highly compacted fabric and hard surface cleaning and/or treatment compositions, for example highly compacted detergents that may be solids or fluids, at levels, based on total composition weight, of from about 0.00001% to about 25%, from 0.00005% to about 10%, from 0.0001% to about 5%, from 0.0005% to about 1.0%, or even from 0.001 % to about 0.5%. Such PRMs and stereoisomers thereof may be used in combination in the aforementioned highly compacted detergent compositions. Such highly compact detergents typically comprise a higher than normal percentage of active ingredients. In one aspect, a highly compacted detergent that may comprise one or more PRMs selected from Table 1 PRMs and stereoisomers of such PRMs is disclosed. In another aspect, highly compacted a detergent that may comprise one or more PRMs selected from Table 1 PRMs 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21,22, 23, 24, 25, 26, 27, 28, 29, 30, 31,32, 33, 34, 35, 36, 37, 38, 39, 40, 41,42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71,72, 73, 74, 75, 76, 77, 78, 79, 80, 81,82, 83, 84, 85, 86 and 87 and stereoisomers of such PRMs is disclosed.

Perfume Delivery Systems [0025] Certain perfume delivery systems, methods of making certain perfume delivery systems and the uses of such perfume delivery systems are disclosed in USPA 2007/0275866 A1. Such perfume delivery systems include: I. Polymer Assisted Delivery (PAD): This perfume delivery technology uses polymeric materials to deliver perfume materials. Classical coacervation, water soluble or partly soluble to insoluble charged or neutral polymers, liquid crystals, hot melts, hydrogels, perfumed plastics, microcapsules, nano- and micro-latexes, polymeric film formers, and polymeric absorbents, polymeric adsorbents, etc. are some examples. PAD includes but is not limited to: a.) Matrix Systems: The fragrance is dissolved or dispersed in a polymer matrix or particle. Perfumes, for example, may be 1) dispersed into the polymer prior to formulating into the product or 2) added separately from the polymer during or after formulation of the product. Diffusion of perfume from the polymer is a common trigger that allows or increases the rate of perfume release from a polymeric matrix system that is deposited or applied to the desired surface (situs), although many othertriggers are know that may control perfume release. Absorption and/or adsorption into or onto polymeric particles, films, solutions, and the like are aspects of this technology. Nano- or micro-particles composed of organic materials (e.g., latexes) are examples. Suitable particles include a wide range of materials including, but not limited to polyacetal, polyacrylate, polyacrylic, polyacrylonitrile, polyamide, polyaryletherketone, polybutadiene, polybutylene, polybutylene terephthalate, polychloroprene, poly ethylene, polyethylene terephthalate, polycyclohexylene dimethylene terephthalate, polycarbonate, polychlo- roprene, polyhydroxyalkanoate, polyketone, polyester, polyethylene, polyetherimide, polyethersulfone, polyeth-ylenechlorinates, polyimide, polyisoprene, polylactic acid, polymethylpentene, polyphenylene oxide, polyphenylene sulfide, polyphthalamide, polypropylene, polystyrene, polysulfone, polyvinyl acetate, polyvinyl chloride, as well as polymers or copolymers based on acrylonitrile-butadiene, cellulose acetate, ethylene-vinyl acetate, ethylene vinyl alcohol, styrene-butadiene, vinyl acetate-ethylene, and mixtures thereof. "Standard" systems refer to those that are "pre-loaded" with the intent of keeping the pre-loaded perfume associated with the polymer until the moment or moments of perfume release. Such polymers may also suppress the neat product odor and provide a bloom and/or longevity benefit depending on the rate of perfume release. One challenge with such systems is to achieve the ideal balance between 1 ) in-product stability (keeping perfume inside carrier until you need it) and 2) timely release (during use or from dry situs). Achieving such stability is particularly important during in-product storage and product aging. This challenge is particularly apparent for aqueous-based, surfactant-containing products, such as heavy duty liquid laundry detergents. Many "Standard" matrix systems available effectively become "Equilibrium" systems when formulated into aqueous-based products. One may select an "Equilibrium" system or a Reservoir system, which has acceptable in-product diffusion stability and available triggers for release (e.g., friction). "Equilibrium" systems are those in which the perfume and polymer may be added separately to the product, and the equilibrium interaction between perfume and polymer leads to a benefit at one or more consumer touch points (versus a free perfume control that has no polymer-assisted delivery technology). The polymer may also be pre-loaded with perfume; however, part or all of the perfume may diffuse during in-product storage reaching an equilibrium that includes having desired perfume raw materials (PRMs) associated with the polymer. The polymer then carries the perfume to the surface, and release is typically via perfume diffusion. The use of such equilibrium system polymers has the potential to decrease the neat product odor intensity of the neat product (usually more so in the case of pre-loaded standard system). Deposition of such polymers may serve to "flatten" the release profile and provide increased longevity. As indicated above, such longevity would be achieved by suppressing the initial intensity and may enable the formulator to use more high impact or low odor detection threshold (ODT) or low Kovats Index (Kl) PRMs to achieve FMOT benefits without initial intensity that is too strong or distorted. It is important that perfume release occurs within the time frame of the application to impact the desired consumer touch point or touch points. Suitable micro-particles and micro-latexes as well as methods of making same may be found in USPA 2005/0003980 A1. Matrix systems also include hot melt adhesives and perfume plastics. In addition, hydropho-bically modified polysaccharides may be formulated into the perfumed product to increase perfume deposition and/or modify perfume release. All such matrix systems, including for example polysaccarides and nanolatexes may be combined with other PDTs, including other PAD systems such as PAD reservoir systems in the form of a perfume microcapsule (PMC). Polymer Assisted Delivery (PAD) matrix systems may include those described in the following references: US Patent Applications 2004/0110648 A1; 2004/0092414 A1; 2004/0091445 A1 and 2004/0087476 A1 ; and US Patents 6,531,444; 6,024,943; 6,042,792; 6,051,540; 4,540,721 and 4,973,422. Silicones are also examples of polymers that may be used as PDT, and can provide perfume benefits in a manner similar to the polymer-assisted delivery "matrix system". Such a PDT is referred to as silicone-assisted delivery (SAD). One may pre-load silicones with perfume, or use them as an equilibrium system as described for PAD. Suitable silicones as well as making same may be found in WO 2005/102261; USPA 20050124530A1 ; USPA 20050143282A1 ; and WO 2003/015736. Functionalized silicones may also be used as described in USPA 2006/003913 A1. Examples of silicones include polydimethylsiloxane and polyalkyldimethylsiloxanes. Other examples include those with amine functionality, which may be used to provide benefits associated with amine-assisted delivery (AAD) and/or polymer-assisted delivery (PAD) and/or amine-reaction products (ARP). Other such examples may be found in USP 4,911,852; USPA 2004/0058845 A1 ; USPA 2004/0092425 A1 and USPA 2005/0003980 A1. b.) Reservoir Systems: Reservoir systems are also known as a core-shell type technology, or one in which the fragrance is surrounded by a perfume release controlling membrane, which may serve as a protective shell. The material inside the microcapsule is referred to as the core, internal phase, or fill, whereas the wall is sometimes called a shell, coating, or membrane. Microparticles or pressure sensitive capsules or microcapsules are examples of this technology. Microcapsules of the current invention are formed by a variety of procedures that include, but are not limited to, coating, extrusion, spray-drying, interfacial, in-situ and matrix polymerization. The possible shell materials vary widely in their stability toward water. Among the most stable are polyoxymeth-yleneurea (PMU)-based materials, which may hold certain PRMs for even long periods of time in aqueous solution (or product). Such systems include but are not limited to urea-formaldehyde and/or melamine-formaldehyde. Stable shell materials include polyacrylate-based materials obtained as reaction product of an oil soluble or dispersible amine with a multifunctional acrylate or methacrylate monomer or oligomer, an oil soluble acid and an initiator, in presence of an emulsifier which can be anionic, non-ionic, cationic orzwitterionic comprising a water soluble or water dispersible acrylic acid alkyl acid copolymer, an alkali or alkali salt. Gelatin-based microcapsules may be prepared so that they dissolve quickly or slowly in water, depending for example on the degree of cross-linking. Many other capsule wall materials are available and vary in the degree of perfume diffusion stability observed. Without wishing to be bound by theory, the rate of release of perfume from a capsule, for example, once deposited on a surface is typically in reverse order of in-product perfume diffusion stability. As such, urea-formaldehyde and melamine-formaldehyde microcapsules for example, typically require a release mechanism other than, or in addition to, diffusion for release, such as mechanical force (e.g., friction, pressure, shear stress) that serves to break the capsule and increase the rate of perfume (fragrance) release. Other triggers include melting, dissolution, hydrolysis or other chemical reaction, electromagnetic radiation, and the like. The use of pre-loaded microcapsules requires the proper ratio of in-product stability and in-use and/or on-surface (on-situs) release, as well as proper selection of PRMs. Microcapsules that are based on urea-formaldehyde and/or melamine-formaldehyde are relatively stable, especially in near neutral aqueous-based solutions. These materials may require a friction trigger which may not be applicable to all product applications. Other microcapsule materials (e.g., gelatin) may be unstable in aqueous-based products and may even provide reduced benefit (versus free perfume control) when in-product aged. Scratch and sniff technologies are yet another example of PAD. Perfume microcapsules (PMC) may include those described in the following references: US Patent Applications: 2003/0125222 A1 ; 2003/215417 A1 ; 2003/216488 A1 ; 2003/158344 A1 ; 2003/165692 A1 ; 2004/071742 A1; 2004/071746 A1; 2004/072719 A1; 2004/072720 A1; 2006/0039934 A1; 2003/203829 A1; 2003/195133 A1 ; 2004/087477 A1 ; 2004/0106536 A1 ; and US Patents 6,645,479 B1 ; 6,200,949 B1 ; 4,882,220; 4,917,920; 4,514,461; 6,106,875 and 4,234,627, 3,594,328 and US RE 32713, PCT Patent Application: WO 2009/134234 A1, WO 2006/127454 A2, WO 2010/079466 A2, WO 2010/079467 A2, WO 2010/079468 A2, WO 2010/084480 A2. |L Molecule-Assisted Delivery (MAD): Non-polymer materials or molecules may also serve to improve the delivery of perfume. Without wishing to be bound by theory, perfume may non-covalently interact with organic materials, resulting in altered deposition and/or release. Non-limiting examples of such organic materials include but are not limited to hydrophobic materials such as organic oils, waxes, mineral oils, petrolatum, fatty acids or esters, sugars, surfactants, liposomes and even other perfume raw material (perfume oils), as well as natural oils, including body and/or other soils. Perfume fixatives are yet another example. In one aspect, non-polymeric materials or molecules have a CLogP greater than about 2. Molecule-Assisted Delivery (MAD) may also include those described in USP 7,119,060 and USP 5,506,201. III. Fiber-Assisted Delivery (FAD): The choice or use of a situs itself may serve to improve the delivery of perfume. In fact, the situs itself may be a perfume delivery technology. For example, different fabric types such as cotton or polyester will have different properties with respect to ability to attract and/or retain and/or release perfume. The amount of perfume deposited on or in fibers may be altered by the choice of fiber, and also by the history or treatment of the fiber, as well as by any fiber coatings or treatments. Fibers may be woven and non-woven as well as natural or synthetic. Natural fibers include those produced by plants, animals, and geological processes, and include but are not limited to cellulose materials such as cotton, linen, hemp jute, flax, ramie, and sisal, and fibers used to manufacture paperand cloth. Fiber-Assisted Delivery may consist of the use ofwood fiber, such as thermomechanical pulp and bleached or unbleached kraft or sulfite pulps. Animal fibers consist largely of particular proteins, such as silk, sinew, catgut and hair (including wool). Polymer fibers based on synthetic chemicals include but are not limited to polyamide nylon, PET or PBT polyester, phenol-formaldehyde (PF), polyvinyl alcohol fiber (PVOH), polyvinyl chloride fiber (PVC), polyolefins (PP and PE), and acrylic polymers. All such fibers may be pre-loaded with a perfume, and then added to a product that may or may not contain free perfume and/or one or more perfume delivery technologies. In one aspect, the fibers may be added to a product prior to being loaded with a perfume, and then loaded with a perfume by adding a perfume that may diffuse into the fiber, to the product. Without wishing to be bound by theory, the perfume may absorb onto or be adsorbed into the fiber, for example, during product storage, and then be released at one or more moments of truth or consumer touch points. IV. Amine Assisted Delivery (AAD): The amine-assisted delivery technology approach utilizes materials that contain an amine group to increase perfume deposition or modify perfume release during product use. There is no requirement in this approach to pre-complex or pre-react the perfume raw material(s) and amine prior to addition to the product. In one aspect, amine-containing AAD materials suitable for use herein may be non-aromatic; for example, polyalkylimine, such as polyethyleneimine (PEI), or polyvinylamine (PVAm), or aromatic, for example, anthranilates. Such materials may also be polymeric or non-polymeric. In one aspect, such materials contain at least one primary amine. This technology will allow increased longevity and controlled release also of low ODT perfume notes (e.g., aldehydes, ketones, enones) via amine functionality, and delivery of other PRMs, without being bound by theory, via polymer-assisted delivery for polymeric amines. Without technology, volatile top notes can be lost too quickly, leaving a higher ratio of middle and base notes to top notes. The use of a polymeric amine allows higher levels of top notes and other PRMS to be used to obtain freshness longevity without causing neat product odor to be more intense than desired, or allows top notes and other PRMs to be used more efficiently. In one aspect, AAD systems are effective at delivering PRMs at pH greater than about neutral. Without wishing to be bound by theory, conditions in which more of the amines of the AAD system are deprotonated may result in an increased affinity of the depro-tonated amines for PRMs such as aldehydes and ketones, including unsaturated ketones and enones such as damascone. In another aspect, polymeric amines are effective at delivering PRMs at pH less than about neutral. Without wishing to be bound by theory, conditions in which more of the amines of the AAD system are protonated may result in a decreased affinity of the protonated amines for PRMs such as aldehydes and ketones, and a strong affinity of the polymer framework for a broad range of PRMs. In such an aspect, polymer-assisted delivery may be delivering more of the perfume benefit; such systems are a subspecies of AAD and may be referred to as Amine-Polymer-Assisted Delivery or APAD. In some cases when the APAD is employed in a composition that has a pH of less than seven, such APAD systems may also be considered Polymer-Assisted Delivery (PAD). In yet another aspect, AAD and PAD systems may interact with other materials, such as anionic surfactants or polymers to form coacervate and/or coacervates-like systems. In another aspect, a material that contains a heteroatom other than nitrogen, for example sulfur, phosphorus or selenium, may be used as an alternative to amine compounds. In yet another aspect, the aforementioned alternative compounds can be used in combination with amine compounds. In yet another aspect, a single molecule may comprise an amine moiety and one or more of the alternative heteroatom moieties, for example, thiols, phosphines and selenols. Suitable AAD systems as well as methods of making same may be found in US Patent Applications 2005/0003980 A1; 2003/0199422 A1; 2003/0036489 A1; 2004/0220074 A1 and USP 6,103,678. V. Cyclodextrin Delivery System (CD): This technology approach uses a cyclic oligosaccharide or cyclodextrin to improve the delivery of perfume. Typically a perfume and cyclodextrin (CD) complex is formed. Such complexes may be preformed, formed in-situ, or formed on or in the situs. Without wishing to be bound by theory, loss of water may serve to shift the equilibrium toward the CD-Perfume complex, especially if other adjunct ingredients (e.g., surfactant) are not present at high concentration to compete with the perfume for the cyclodextrin cavity. A bloom benefit may be achieved if water exposure or an increase in moisture content occurs at a later time point. In addition, cyclodextrin allows the perfume formulator increased flexibility in selection of PRMs. Cyclodextrin may be pre-loaded with perfume or added separately from perfume to obtain the desired perfume stability, deposition or release benefit. Suitable CDs as well as methods of making same may be found in USPA 2005/0003980 A1 and 2006/0263313 A1 and US Patents 5,552,378; 3,812,011 ; 4,317,881 ; 4,418,144 and 4,378,923. VI. Starch Encapsulated Accord (SEA): The use of a starch encapsulated accord (SEA) technology allows one to modify the properties of the perfume, for example, by converting a liquid perfume into a solid by adding ingredients such as starch. The benefit includes increased perfume retention during product storage, especially under non-aqueous conditions. Upon exposure to moisture, a perfume bloom may be triggered. Benefits at other moments of truth may also be achieved because the starch allows the product formulator to select PRMs or PRM concentrations that normally cannot be used without the presence of SEA. Another technology example includes the use of other organic and inorganic materials, such as silica to convert perfume from liquid to solid. Suitable SEAs as well as methods of making same may be found in USPA 2005/0003980 A1 and USP 6,458,754 B1. VII. Inorganic Carrier Delivery System (ZIC): This technology relates to the use of porous zeolites or other inorganic materials to deliver perfumes. Perfume-loaded zeolite may be used with or without adjunct ingredients used for example to coat the perfume-loaded zeolite (PLZ) to change its perfume release properties during product storage or during use or from the dry situs. Suitable zeolite and inorganic carriers as well as methods of making same may be found in USPA 2005/0003980 A1 and US Patents 5,858,959; 6,245,732 B1; 6,048,830 and 4,539,135. Silica is another form of ZIC. Another example of a suitable inorganic carrier includes inorganic tubules, where the perfume or other active material is contained within the lumen of the nano- or micro-tubules. In one aspect, the perfume-loaded inorganic tubule (or Perfume-Loaded Tubule or PLT) is a mineral nano- or micro-tubule, such as halloysite or mixtures of halloysite with other inorganic materials, including other clays. The PLT technology may also comprise additional ingredients on the inside and/or outside of the tubule for the purpose of improving in-product diffusion stability, deposition on the desired situs or for controlling the release rate of the loaded perfume. Monomeric and/or polymeric materials, including starch encapsulation, may be used to coat, plug, cap, or otherwise encapsulate the PLT. Suitable PLT systems as well as methods of making same may be found in USP 5,651,976. VIII. Pro-Perfume (PP): This technology refers to perfume technologies that result from the reaction of perfume materials with other substrates or chemicals to form materials that have a covalent bond between one or more PRMs and one or more carriers. The PRM is converted into a new material called a pro-PRM (i.e., pro-perfume), which then may release the original PRM upon exposure to a trigger such as water or light. Pro-perfumes may provide enhanced perfume delivery properties such as increased perfume deposition, longevity, stability, retention, and the like. Pro-perfumes include those that are monomeric (non-polymeric) or polymeric, and may be pre-formed or may be formed in-situ under equilibrium conditions, such as those that may be present during in-product storage or on the wet or dry situs. Nonlimiting examples of pro-perfumes include Michael adducts (e.g., beta-amino ketones), aromatic or non-aromatic imines (Schiff bases), oxazolidines, beta-keto esters, and orthoesters. Another aspect includes compounds comprising one or more beta-oxy or beta-thio carbonyl moieties capable of releasing a PRM, for example, an alpha, beta-unsaturated ketone, aldehyde or carboxylic ester. The typical trigger for perfume release is exposure to water; although other triggers may include enzymes, heat, light, pH change, autoxidation, a shift of equilibrium, change in concentration or ionic strength and others. For aqueous-based products, light-triggered properfumes are particularly suited. Such photo-pro-perfumes (PPPs) include but are not limited to those that release coumarin derivatives and perfumes and/or pro-perfumes upon being triggered. The released pro-perfume may release one or more PRMs by means of any of the above mentioned triggers. In one aspect, the photo-pro-perfume releases a nitrogen-based pro-perfume when exposed to a light and/or moisture trigger. In another aspect, the nitrogen-based pro-perfume, released from the photo-pro-perfume, releases one or more PRMs selected, for example, from aldehydes, ketones (including enones) and alcohols. In still another aspect, the PPP releases a dihydroxy coumarin derivative. The light-triggered pro-perfume may also be an ester that releases a coumarin derivative and a perfume alcohol. In one aspect the pro-perfume is a dimethoxybenzoin derivative as described in USPA 2006/0020459 A1. In another aspect the pro-perfume is a 3’, 5’-dimethoxybenzoin (DMB) derivative that releases an alcohol upon exposure to electromagnetic radiation. In yet another aspect, the pro-perfume releases one or more low ODT PRMs, including tertiary alcohols such as linalool, tetrahydrolinalool, or dihydromyrcenol. Suitable properfumes and methods of making same can be found in US Patents 7,018,978 B2; 6,987,084 B2; 6,956,013 B2; 6,861,402 B1 ; 6,544,945 B1; 6,093,691; 6,277,796 B1; 6,165,953; 6,316,397 B1; 6,437,150 B1; 6,479,682 B1; 6,096,918; 6,218,355 B1; 6,133,228; 6,147,037; 7,109,153 B2; 7,071,151 B2; 6,987,084 B2; 6,610,646 B2 and 5,958,870, as well as can be found in USPA 2005/0003980 A1 and USPA 2006/0223726 A1. a.) Amine Reaction Product (ARP): For purposes of the present application, ARP is a subclass or species of PP. One may also use "reactive" polymeric amines in which the amine functionality is pre-reacted with one or more PRMs to form an amine reaction product (ARP). Typically the reactive amines are primary and/or secondary amines, and may be part of a polymer or a monomer (non-polymer). Such ARPs may also be mixed with additional PRMs to provide benefits of polymer-assisted delivery and/or amine-assisted delivery. Nonlimiting examples of polymeric amines include polymers based on polyalkylimines, such as polyethyleneimine (PEI), or polyvinylamine (PVAm). Nonlimiting examples of monomeric (non-polymeric) amines include hydroxyl amines, such as 2-aminoethanol and its alkyl substituted derivatives, and aromatic amines such as anthranilates. The ARPs may be premixed with perfume or added separately in leave-on or rinse-off applications. In another aspect, a material that contains a heteroatom other than nitrogen, for example oxygen, sulfur, phosphorus or selenium, may be used as an alternative to amine compounds. In yet another aspect, the aforementioned alternative compounds can be used in combination with amine compounds. In yet another aspect, a single molecule may comprise an amine moiety and one or more of the alternative heteroatom moieties, for example, thiols, phosphines and selenols. The benefit may include improved delivery of perfume as well as controlled perfume release. Suitable ARPs as well as methods of making same can be found in USPA 2005/0003980 A1 and USP 6,413,920 B1.

[0026] In one aspect, the PRMs disclosed in Table 1 and stereoisomers thereof are suitable for use in perfume delivery systems at levels, based on total perfume delivery system weight, of from 0.001% to about 50%, from 0.005% to 30%, from 0.01% to about 10%, from 0.025% to about 5%, or even from 0.025% to about 1%.

[0027] In one aspect, the perfume delivery systems disclosed herein are suitablefor use in consumer products, cleaning and treatment compositions and fabric and hard surface cleaning and/or treatment compositions, detergents, and highly compacted consumer products, including highly compacted fabric and hard surface cleaning and/or treatment compositions, for example highly compacted detergents that may be solids or fluids, at levels, based on total consumer product weight, from about 0.001% to about 20%, from about 0.01% to about 10%, from about 0.05% to about 5%, from about 0.1% to about 0.5%.

[0028] In one aspect, the amount of Table 1 PRMs, based on the total microcapsules and/or nanocapsules (Polymer Assisted Delivery (PAD) Reservoir System) weight, may be from about 0.1% to about 99%, from 25% to about 95%, from 30 to about 90%, from 45% to about 90%, from 65% to about 90%. I n one aspect, m icrocapsules and/or nanocapsules that may comprise one or more PRMs selected from Table 1 PRMs 1,2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21,22, 23, 24, 25, 26, 27, 28, 29, 30, 31,32, 33, 34, 35, 36, 37, 38, 39, 40, 41,42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61,62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,82, 83, 84, 85, 86 and 87; stereoisomers of Table 1 PRMs 1,2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21,22, 23, 24, 25, 26, 27, 28, 29, 30, 31,32, 33, 34, 35, 36, 37, 38, 39, 40, 41,42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61,62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81,82, 83, 84, 85, 86 and 87; and mixtures thereof. PRMs 1,2, 5, 6, 8, 16, 20, 21, 24, 27, 28, 32, 33, 36, 40, 41,52, 56, 58, 62, 82, 83, 86 are ketones. PRMs 9, 10, 18, 44, 45, 47, 53, 54, 59, 64, 78, 85 are aldehydes. PRMs 4, 11, 12, 15, 17, 22, 29, 34, 35, 37, 42, 43, 46, 48, 49, 50, 63, 67, 68, 71,72, 73, 81, 87 are alcohols. PRMs 19, 30, 38, 60, 65, 66, 80 are esters. PRMs 3, 23, 26, 31, 39, 51, 55, 57, 61, 74, 84 are nitriles. PRMs 69, 70, 75, 76, 77 and 79 are ethers. PRM 7 is an imine. PRMs 13, 14 are methanamines. PRM 25 is a dioxolane.

[0029] In one aspect, the amount of total perfume based on total weight of starch encapsulates and starch agglomerates (Starch Encapsulated Accord (SEA)) ranges from 0.1% to about 99%, from 25% to about 95%, from 30 to about 90%, from 45% to about 90%, from 65% to about 90%. In one aspect, the PRMs disclosed in Table 1 and stereoisomers thereof are suitable for use in such starch encapsulates and starch agglomerates. Such PRMs and stereoisomers thereof may be used in combination in such starch encapsulates and starch agglomerates.

[0030] In one aspect, the amount of total perfume based on total weight of [cyclodextrin - perfume] complexes (Cyclodextrin (CD)) ranges from 0.1% to about 99%, from 2.5% to about 75%, from 5% to about 60%, from 5% to about 50%, from 5% to about 25%. In one aspect, the PRMs disclosed in Table 1 and stereoisomers thereof are suitable for use in such [cyclodextrin - perfume] complexes. Such PRMs and stereoisomers thereof may be used in combination in such [cyclodextrin - perfume] complexes.

[0031] In one aspect, the amount of total perfume based on total weight of Polymer Assisted Delivery (PAD) Matrix Systems (including Silicones) ranges from 0.1% to about 99%, from 2.5% to about 75%, from 5% to about 60%, from 5% to about 50%, from 5% to about 25%. In one aspect, the amount of total perfume based on total weight of a hot melt perfume delivery system/perfume loaded plastic Matrix System and ranges from 1% to about 99%, from 2.5% to about 75%, from 5% to about 60%, from 5% to about 50%, from 10 % to about 50%. In one aspect, the PRMs disclosed in Table 1 and stereoisomers thereof are suitable for use in such Polymer Assisted Delivery (PAD) Matrix Systems, including hot melt perfume delivery system/perfume loaded plastic Matrix Systems. Such PRMs and stereoisomers thereof may be used in combination in such Polymer Assisted Delivery (PAD) Matrix Systems (including hot melt perfume delivery system/perfume loaded plastic Matrix Systems).

[0032] In one aspect, the amount of total perfume based on total weight of Amine Assisted Delivery (AAD) (including Aminosilicones) ranges from 1 % to about 99%, from 2.5% to about 75%, from 5% to about 60%, from 5% to about 50%, from 5% to about 25%. In one aspect, the PRMs disclosed in Table 1 and stereoisomers thereof are suitable for use in such Amine Assisted Delivery (AAD) systems. Such PRMs and stereoisomers thereof may be used in combination in such Amine Assisted Delivery (AAD) systems. In one aspect, an Amine Assisted Delivery (AAD) system that may comprise one or more PRMs selected from Table 1 PRMs 1,2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 20, 21,22, 23, 24, 25, 26, 27, 28, 29, 31,32, 33, 34, 35, 36, 37, 39, 40, 41,42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 81, 82, 83, 84, 85, 86 and 87; stereoisomers of Table 1 PRMs 1,2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18,20,21,22, 23,24,25, 26, 27, 28, 29, 31,32, 33, 34, 35, 36, 37, 39, 40, 41,42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61,62, 63, 64, 65, 67, 68, 69, 70, 71,72, 73, 74, 75, 76, 77, 78, 79, 81,82, 83, 84, 85, 86 and 87; and mixtures thereof is disclosed. PRMs 1,2, 5, 6, 8,16, 20, 21,24, 27, 28, 32, 33, 36, 40, 41,52, 56, 58, 62, 82, 83, 86 are ketones. PRMs 9, 10, 18, 44, 45,47, 53, 54,59, 64, 78,85 are aldehydes. PRMs 4, 11,12, 15, 17,22,29, 34,35, 37, 42,43,46, 48, 49, 50, 63, 67, 68, 71,72, 73, 81,87 are alcohols. PRMs 3, 23, 26, 31,39, 51,55, 57, 61,74, 84 are nitriles. PRMs 69, 70, 75, 76, 77 and 79 are ethers. PRMs 60 and 65 are esters. PRM 7 is an imine. PRMs 13, 14 are methanamines. PRM 25 is a dioxolane.

[0033] In one aspect, a Pro-Perfume (PP) Amine Reaction Product (ARP) system that may comprise one or more PRMs selected from Table 1 PRMs 1,2, 5, 6, 8, 9, 10, 16, 18, 20, 21,24, 27, 28, 32, 33, 36, 40, 41,44, 45, 47, 52, 53, 54, 56, 58, 59, 62, 64, 78, 82, 83, 85, 86 is disclosed. PRMs 1, 2, 5, 6, 8, 16, 20, 21,24, 27, 28, 32, 33, 36, 40, 41,52, 56, 58, 62, 82, 83, 86 are ketones. PRM’s 9, 10, 18, 44, 45, 47, 53, 54, 59, 64, 78, 85 are aldehydes. In one aspect, the amount of total perfume based on total weight of Pro-Perfume (PP) Amine Reaction Product (ARP) system ranges from 0.1% to about 99%, from about 1% to about 99%, from 5% to about 90%, from 10% to about 75%, from 20% to about 75%, from 25% to about 60%.

[0034] The perfume delivery technologies also known as perfume delivery systems that are disclosed in the present specification may be used in any combination in any type of consumer product, cleaning and/or treatment composition, fabric and hard surface cleaning and/or treatment composition, detergent, and highly compact detergent.

Perfumes [0035] The PRMs disclosed in Table 1 may be used to formulate perfumes. Such perfumes are combinations of PRMs that may comprise a combination of Table 1 PRMs, or one or Table 1 PRMs and one or more additional PRMs. When used in a perfume, the Table 1 PRMs may used, based on total perfume weight, at levels of from about 0.01% to about 50%, from about 0.1% to about 15%, from about 0.1% to about 10% or even from about 0.5% to about 10%. Such perfumes may be used in multiple applications including being applied neat to a situs or used in a consumer product, cleaning and/or treatment composition, fabric and hard surface cleaning and/or treatment composition, detergent, and/or a highly compact detergent.

Adjunct Materials [0036] For the purposes of the present invention, the non-limiting list of adjuncts illustrated hereinafter are suitable for use in the instant compositions and may be desirably incorporated in certain embodiments of the invention, for example to assist or enhance performance, for treatment of the substrate to be cleaned, or to modify the aesthetics of the composition as is the case with perfumes, colorants, dyes or the like. It is understood that such adjuncts are in addition to the components that are supplied via Applicants’ perfumes and/or perfume systems. The precise nature of these additional components, and levels of incorporation thereof, will depend on the physical form of the composition and the nature of the operation for which it is to be used. Suitable adjunct materials include, but are not limited to, surfactants, builders, chelating agents, dye transfer inhibiting agents, dispersants, enzymes, and enzyme stabilizers, catalytic materials, bleach activators, polymeric dispersing agents, clay soil removal/anti-redeposition agents, brighteners, suds suppressors, dyes, additional perfume and perfume delivery systems, structure elasticizing agents, fabric softeners, carriers, hydrotropes, processing aids and/or pigments. In addition to the disclosure below, suitable examples of such other adjuncts and levels of use are found in U.S. Patent Nos. 5,576,282, 6,306,812 B1 and 6,326,348 B1.

[0037] Each adjunct ingredient is not essential to Applicants’ compositions. Thus, certain embodiments of Applicants’ compositions do not contain one or more of the following adjuncts materials: bleach activators, surfactants, builders, chelating agents, dye transfer inhibiting agents, dispersants, enzymes, and enzyme stabilizers, catalytic metal complexes, polymeric dispersing agents, clay and soil removal/anti-redeposition agents, brighteners, suds suppressors, dyes, additional perfumes and perfume delivery systems, structure elasticizing agents, fabric softeners, carriers, hydrotropes, processing aids and/or pigments. However, when one or more adjuncts are present, such one or more adjuncts may be present as detailed below:

Surfactants - The compositions according to the present invention can comprise a surfactant or surfactant system wherein the surfactant can be selected from nonionic and/or anionic and/or cationic surfactants and/or ampholytic and/or zwitterionic and/or semi-polar nonionic surfactants. The surfactant is typically present at a level of from about 0.1 %, from about 1 %, or even from about 5% by weight of the cleaning compositions to about 99.9%, to about 80%, to about 35%, or even to about 30% by weight of the cleaning compositions.

[0038] Builders - The compositions of the present invention can comprise one or more detergent builders or builder systems. When present, the compositions will typically comprise at least about 1% builder, or from about 5% or 10% to about 80%, 50%, or even 30% by weight, of said builder. Builders include, but are not limited to, the alkali metal, ammonium and alkanolammonium salts of polyphosphates, alkali metal silicates, alkaline earth and alkali metal carbonates, aluminosilicate builders polycarboxylate compounds, ether hydroxypolycarboxylates, copolymers of maleic anhydride with ethylene or vinyl methyl ether, 1,3,5-trihydroxybenzene-2,4,6-trisulphonic acid, and carboxymethyl-oxysuccinic acid, the various alkali metal, ammonium and substituted ammonium salts of polyacetic acids such as ethylenediamine tetraacetic acid and nitrilotriacetic acid, as well as polycarboxylates such as mellitic acid, succinic acid, oxydisuccinic acid, polymaleic acid, benzene 1,3,5-tricarboxylic acid, carboxymethyloxysuccinic acid, and soluble salts thereof.

[0039] Chelating Agents - The compositions herein may also optionally contain one or more copper, iron and/or manganese chelating agents. If utilized, chelating agents will generally comprise from about 0.1% by weight of the compositions herein to about 15%, or even from about 3.0% to about 15% by weight of the compositions herein.

[0040] Dye Transfer Inhibiting Agents - The compositions of the present invention may also include one or more dye transfer inhibiting agents. Suitable polymeric dye transfer inhibiting agents include, but are not limited to, polyvinylpyrrolidone polymers, polyamine N-oxide polymers, copolymers of N-vinylpyrrolidone and N-vinylimidazole, polyvinyloxa-zolidones and polyvinylimidazoles or mixtures thereof. When present in the compositions herein, the dye transfer inhibiting agents are present at levels from about 0.0001%, from about 0.01%, from about 0.05% by weight of the cleaning compositions to about 10%, about 2%, or even about 1% by weight of the cleaning compositions.

[0041] Dispersants - The compositions of the present invention can also contain dispersants. Suitable water-soluble organic materials are the homo- or co-polymeric acids or their salts, in which the polycarboxylic acid may comprise at least two carboxyl radicals separated from each other by not more than two carbon atoms.

[0042] Enzymes-The compositions can comprise one or more detergent enzymes which provide cleaning performance and/or fabric care benefits. Examples of suitable enzymes include, but are not limited to, hemicellulases, peroxidases, proteases, cellulases, xylanases, lipases, phospholipases, esterases, cutinases, pectinases, keratanases, reductases, oxidases, phenoloxidases, lipoxygenases, ligninases, pullulanases, tannases, pentosanases, malanases, ß-glucanases, arabinosidases, hyaluronidase, chondroitinase, laccase, and amylases, or mixtures thereof. A typical combination is a cocktail of conventional applicable enzymes like protease, lipase, cutinase and/or cellulase in conjunction with amylase.

[0043] Enzyme Stabilizers - Enzymes for use in compositions, for example, detergents can be stabilized by various techniques. The enzymes employed herein can be stabilized by the presence of water-soluble sources of calcium and/or magnesium ions in the finished compositions that provide such ions to the enzymes.

[0044] Catalytic Metal Complexes - Applicants’ compositions may include catalytic metal complexes. One type of metal-containing bleach catalyst is a catalyst system comprising a transition metal cation of defined bleach catalytic activity, such as copper, iron, titanium, ruthenium, tungsten, molybdenum, or manganese cations, an auxiliary metal cation having little or no bleach catalytic activity, such as zinc or aluminum cations, and a sequestrate having defined stability constants for the catalytic and auxiliary metal cations, particularly ethylenediaminetetraacetic acid, ethylenedi-aminetetra (methyl-enephosphonic acid) and water-soluble salts thereof. Such catalysts are disclosed in U.S. patent 4,430,243.

[0045] If desired, the compositions herein can be catalyzed by means of a manganese compound. Such compounds and levels of use are well known in the art and include, for example, the manganese-based catalysts disclosed in U.S. patent 5,576,282.

[0046] Cobalt bleach catalysts useful herein are known, and are described, for example, in U.S. patents 5,597,936 and 5,595,967. Such cobalt catalysts are readily prepared by known procedures, such as taught for example in U.S. patents 5,597,936, and 5,595,967.

[0047] Compositions herein may also suitably include a transition metal complex of a macropolycyclic rigid ligand -abbreviated as "MRL". As a practical matter, and not by way of limitation, the compositions and cleaning processes herein can be adjusted to provide on the order of at least one part per hundred million of the benefit agent MRL species in the aqueous washing medium, and may provide from about 0.005 ppm to about 25 ppm, from about 0.05 ppm to about 10 ppm, or even from about 0.1 ppm to about 5 ppm, of the MRL in the wash liquor.

[0048] Suitable transition-metals in the instant transition-metal bleach catalyst include manganese, iron and chromium. Suitable MRL’s herein are a special type of ultra-rigid ligand that is cross-bridged such as 5,12-diethyl-1,5,8,12-tetraazabi-cyclo[6.6.2]hexa-decane.

[0049] Suitable transition metal MRLs are readily prepared by known procedures, such as taught for example in WO 00/32601, and U.S. patent 6,225,464.

Method of Use [0050] Certain of the consumer products disclosed herein can be used to clean or treat a situs inter alia a surface or fabric. Typically at least a portion of the situs is contacted with an embodiment of Applicants’ composition, in neat form or diluted in a liquor, for example, a wash liquor and then the situs may be optionally washed and/or rinsed. In one aspect, a situs is optionally washed and/or rinsed, contacted with a particle according to the present invention or composition comprising said particle and then optionally washed and/or rinsed. For purposes of the present invention, washing includes but is not limited to, scrubbing, and mechanical agitation. The fabric may comprise most any fabric capable of being laundered or treated in normal consumer use conditions. Liquors that may comprise the disclosed compositions may have a pH of from about 3 to about 11.5. Such compositions are typically employed at concentrations of from about 500 ppm to about 15,000 ppm in solution. When the wash solvent is water, the water temperature typically ranges from about 5 °C to about 90 °C and, when the situs comprises a fabric, the water to fabric ratio is typically from about 1:1 to about 30:1.

TEST METHODS

[0051] It is understood that the test methods that are disclosed in the Test Methods Section of the present application should be used to determine the respective values of the parameters of Applicants’ invention as such invention is described and claimed herein.

(PCIogP

[0052] The "calculated logP" (ClogP) is determined by the fragment approach of Hansch and Leo (cf., A. Leo, in Comprehensive Medicinal Chemistry, Vol. 4, C. Hansch, P.G. Sammens, J.B. Taylor, and C.A. Ramsden, Eds. P. 295,

Pergamon Press, 1990, incorporated herein by reference). ClogP values may be calculated by using the "CLOGP" program available from Daylight Chemical Information Systems Inc. of Irvine, California U.S.A.. (2) Boiling Point [0053] Boiling point is measured by ASTM method D2887-04a, "Standard Test Method for Boiling Range Distribution of Petroleum Fractions by Gas Chromatography," ASTM International. (3) Headspace Ratio [0054] (a) Obtain a fragrance free consumer product formulation (shampoo or leave-on conditioner). (b) Obtain fragrance microcapsules whose water content has been adjusted to achieve a perfume content of 25wt% in the aqueous slurry. (c) Prepare Sample A by adding 2.0 grams of the fragrance microcapsule aqueous slurry to 95 grams of the fragrance free consumer product formulation. Then add 3.0 grams of deionized water to balance the formulation to 100 grams. Age this formulation for 1 week at 40 degrees Centigrade. (d) Prepare Sample B by adding 0.50 grams of the neat fragrance to 95 grams of fragrance free consumer product formulation. Then add 4.5 grams of deionized water to balance the formulation to 100 grams. Age this formulation for 1 week at 40 degrees Centigrade.

[0055] The Headspace Ratio for determining perfume leakage from a perfume delivery system is defined as the headspace concentration of Sample A divided by the headspace concentration of Sample

^sample A's the headspace concentration of a consumer product formulation Sample A, and Hß is the headspace concentration of a consumer product formulation Sample B.

[0056] The Headspace Ratio for determining perfume delivery efficiency from a perfume delivery system is defined as the headspace concentration of Sample B divided by the headspace concentration of Sample A,

where is the headspace concentration of a consumer product formulation Sample A, and Hsampte_B is the headspace concentration of a consumer product formulation Sample B.

[0057] Solid-Phase Micro-Extraction (SPME)-Gas Chromatography/Mass Spectrometry is used to measure the level of perfume raw materials in the headspace of products. 1.0 grams of the 1 week at 40 degrees Centigrade aged sample (shampoo or conditioner) are placed into a clean 20 ml headspace vial and allowed to equilibrate for at least 2 hours at room temperature.

[0058] The samples are then analyzed using the MPS2-SMPE-GC-MS analysis system (GC-02001-0153, MSD-02001-0154, MPS2-02001 -0155).

Apparatus: [0059] 1.20 ml headspace vial 2. Timer. 3. Gas Chromatograph (GC): Agilent model 6890 with a CIS-4 injector (Gerstel, Mülheim, Germany) and MPS-2 Autosampler and TDU. For SPME analysis, we used the split/splitless injector (not the CIS-4 injector). 4. GC column: J&W DB-5 MS, 30 M x 0.25 mm ID, 1.0 Dm film thickness obtained from J&W Scientific of Folsom, California, USA. 5. Carrier gas, helium, 1.5 ml/min. flow rate. 6. The injector liner is a special SPME liner (0.75 mm ID) from Supelco. 7. The Detector is a model 5973 Mass Selective Detector obtained from Agilent Technologies, Inc., Wilmington, DE, USA having a source temperature of about 230 °C, and a MS Quad temperature of about 150 °C.

Analysis procedure: [0060] 1. Transfer sample to proper sample tray and proceed with SPME-GC-MS analysis. 2. Start sequence of sample loading and analysis. In this step, the sample is allowed to equilibrate for at least two hours on the auto sampler tray, then sampled directly from the tray. The SPME fiber assembly is DVB/CAR/PDMS (50/30 urn, 24 ga, 1 cm length). Sampling time is 5 minutes. 3. Injector temperature is at 260C. 4. Then GC-MS analysis run is started. Desportion time is 5 minutes. 5. The following temperature program is used: i) an initial temperature of about 50 °C which is held for 3 minutes, ii) increase the initial temperature at a rate of about 6 °C/min until a temperature of about 250 °C is reached, then 25 °C/min to 275 °C, hold at about 275 °C for 4.67 minute. 6. Perfume compounds are identified using the MS spectral libraries of John Wiley & Sons and the National Institute of Standards and Technology (NIST), purchased and licensed through Hewlett Packard. 7. Chromatographic peaks for specific ions are integrated using the Chemstation software obtained from Agilent Technologies, Inc., Wilmington, DE, USA.. 8. The ratio for each PRM is calculated by dividing the peak area for the perfume raw material in Sample A by the peak area in Sample B. 9. Each ratio is then weighted by that perfume raw material’s weight composition in the perfume. 10. The Headspace Ratio is calculated as the sum of the individual perfume raw material ratios obtained in step 9. (4) Perfume leakage can also be evaluated via% liquid-liquid extraction and gas chromatographic-mass spectrometric analysis [0061] When determining the % perfume leakage from Perfume Microcapsules in liquid detergent, a fresh sample of liquid detergent with equal level of free perfume (without Perfume Microcapsules) must also be analysed in parallel for reference. 1 .Preparation of an internal standard solution [0062]

Stock solution of tonalid : Weigh 70 mg tonalid and add 20 ml hexane p.a.

Internal Standard Solution solution: Dilute 200 μΙ of stock solution in 20 ml hexane p.a.

Mix to homogenize 2.Perfume extraction from liquid detergent without perfume microcapsules (reference) [0063]

Weigh 2 g of liquid detergent product into an extraction vessel Add 2 ml of Internal Standard Solution and close vessel

Extract perfume by gently turning the extraction vessel upside-down for 20 times (manually) [0064]

Add spoon tip of Sodium Sulphate

After separation of layers, immediately transfer hexane-layer into Gas Chromatograph auto sampler-vial and cap vial

Inject splitless (1,5μΙ) into Gas Chromatograph injection-port

Run Gas Chromatographic-Mass Spectrometric analysis 3. Perfume extraction from liquid detergent with perfume microcapsules [0065]

Weigh 2 g of liquid detergent product into an extraction vessel

Add 2 ml of Internal Standard Solution and close vessel

Extract perfume by gently turning the extraction vessel upside-down for 20 times (manually) [0066]

Add spoon tip of Sodium Sulphate

Inject splitless (1,5μΙ) into Gas Chromatograph injection-port

Run Gas Chromatographic-Mass Spectrometric analysis 4. Calculation [0067]

The perfume leakage from capsules per individual Perfume Raw Material: % perfume leakage = ((Area Perfume Raw Material caps x Area Internal Standard Solution ref x Weight ref) / (Area Internal Standard Solution caps x Area Perfume Raw Material ref x Weight caps)) x 100 (5) Odor Detection Threshold (OPT) is determined using a gas chromatograph. The gas chromatograph is calibrated to determine the exact volume of material injected by the syringe, the precise split ratio, and the hydrocarbon response using a hydrocarbon standard of known concentration and chain length distribution. The air flow rate is accurately measured and, assuming the duration of human inhalation to last 12 seconds, the sampled volume is calculated. Since the precise concentration at the detector at any point in time is known, the mass per volume inhaled is known, and hence the concentration of material. For example, to determinewhether a material has a threshold below 50 parts per bullion, solutions are delivered to the snifF port at the calculated concentration. A panelist sniffs the GC effluent and identifies the retention time when odor is noticed. The average among 6 panelists determines the threshold of noticeability. The necessary amount of analyte is injected into the column to achieve a 50 parts per billion concentration at the detector. Typical gas chromatograph parameters for determining odor detection thresholds are listed below: GC: 5890 Series II with FID detector, 7673 Autosampler

Column: J&W Scientific DB-1

Length: 30 meters, 0.25millmeter inside diameter, 1 micrometer film thickness Method: split injection: 17/1 split ratio

Autosampler: 1.13 microliters per injection

Column flow: 1.10 milliLiters per minute

Air Flow : 345 milliLiters per minute

Inlet Temperature : 245 degrees Centigrade

Detector Temperature: 285 degrees Centigrade

Initial Temperature = 50 degrees Centigrade, 5 degrees Centigrade per minute ramp rate, final temperature = 280 degrees Centigrade, Final time = 6 minutes Leading assumptions: 12 seconds per sniff, GC air adds to sample dilution

EXAMPLES

[0068] While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Synthesis of Table 1 Molecule Number 3, 23, 26, 31, 39, 51, 61, 74 & 84: [0069]

Table 1

(continued)

[0070] A representative procedure is given for the synthesis of Table 1 Molecule 84.

[0071] A solution of n-butyllithium (2.2M in cyclohexane -1 eq.) is added drop wise to an ice cold solution of diisopropylamine (1 eq.) in dry THF (0.5 M). After stirring for 10 minutes at this temperature, /-butyronitrile (1 eq.) is added to the mixture. (1R,SS)-2-(chloromethyl)-6,6-dimethylbicyclo[3.1.1]hept-2-ene (1 eq.) is added after another mixing of 10 minutes at 0 °C. Reaction conversion is followed by GC-MS and seen as complete after 30 minutes stirring at 0 °C. The reaction is quenched by addition of a saturated NH4CI aqueous solution and extracted with Et20. The combined organic layers are dried over MgS04 and concentrated under reduced pressure. The resulting oil is purified using a quick filtration over silica by elution with a petroleum ether- Et20 mixture (9-1). Concentration of the eluent under reduced pressure resulted in the compound as a colorless oil (84% yield).

Synthesis of Table 1 Molecule Number 1, 2, 5, 6, 8,16, 20, 21,24, 27, 28, 32, 33, 36, 40, 41, 52, 56, 58, 62, 82 & 86: [0072]

Table 2

(continued)

[0073] A representative procedure is given for the synthesis of Table 1 Molecule 40.

[0074] A n-butyllithium solution (1.2 equiv.) is added drop wise to a solution of the nitrile (1 eq.) in dry THF (0.5M) at -20 °C. After stirring for 15 minutes at -10 / -20 °C, full conversion is observed by GC-MS. The reaction is quenched with a H2S04 solution (2M - 2 eq.) and stirred at ambient temperature till full hydrolysis of the in situ formed imine is observed. The mixture is then extracted with Et20 and washed with a saturated NaHCOs aqueous solution. The combined organic phases are dried over MgS04 and concentrated under reduced pressure. The resulting oil is purified using a quick filtration over silica gel by eluting with a petroleum ether - Et20 mixture (9-1). Concentration of the eluent under reduced pressure resulted in the compound as a colorless oil (94% yield).

Synthesis of Table 1 Molecule Number 83: [0075]

Stepl. '

Step 2 Step 3. p

Step 1.

[0076] To a solution of the phosphonium bromide [50889-29-7] (1.2 eq.) in dry THF (0.3 M) is added KHMDS (Potas-siumhexamethyldisilazane - 2.4 eq.) at ambient temperature. After stirring for 30 minutes at the same temperature, a solution of acetone (1 eq.) in dry THF (0.3 M) is added drop wise. The mixture is stirred for 3 hours, quenched with water (0.3 M) and extracted with Et20. The resulting water layer is acidified with a HCI aqueous solution (10%) till pH 2 is obtained. This mixture is extracted with Et20 and the extracts are dried over MgS04 and concentrated under reduced pressure. The resulting oil is purified using a quick filtration over silica gel by eluting with a petroleum ether - Et20 mixture (1-1). Concentration under reduced pressure resulted in the compound as a slightly yellow oil.

Step 2.

[0077] To a solution of the acid formed in step 1 (1 eq.) in dry CH2CI2 (0.5 M) is added 1 ,T-carbonyldiimidazole (1 eq.) at ambient temperature. The mixture is stirred for 15 minutes and Ν,Ο-Dimethylhydroxylamine hydrochloride (1 eq.) is added. Stirring is continued at the same temperature for 1 hour and the mixture is quenched with an aqueous HCI solution (1 M - 1.1 eq.). The aqueous layer is extracted with Et20, washed with NaHC03 and dried over MgS04 Concentration under reduced pressure resulted in the compound as a colorless oil.

Step 3.

[0078] The Weinreb amide formed in step 2 is solved in dry THF (0.5 M) and cooled to -15 °C. A solution of cyclopro-pylmagnesium bromide (prepared from cyclopropyl bromide and magnesium turnings in THF - 2 eq.) is added drop wise to the mixture. Complete reaction conversion is observed with GC-MS after 30 minutes stirring at 0 °C. This reaction mixture is quenched with a saturated aqueous NH4CI solution, extracted with Et20; dried over MgS04 and concentrated under reduced pressure. The resulting oil is purified using a quick filtration over silica gel by eluting with a petroleum ether - Et20 mixture (9-1). Concentration under reduced pressure resulted in the compound as a colorless oil.

Synthesis of Table 1 Molecule Number 55 & 57: [0079]

Table 3

[0080] A representative procedure is given for the synthesis of Table 1 Molecule 55.

[0081] To a solution of diisopropylamine (1 eq.) in dry THF (0.5 M) is added drop wise a solution of n-butyllithium (1 eq.) at 0 °C. Bicyclo[2.2.1]hept-5-ene-2-carbonitrile (1 eq. - commercial available [95-11-4]) is added to the solution after 10 minutes of stirring at the same temperature. A supplementary stirring for 10 minutes is followed by the drop wise addition of iodomethane (1 eq.). Reaction completion is observed after 10 minutes stirring at 0 °C. The mixture is quenched with an aqueous solution of NH4CI, extracted with Et20, dried over MgS04 and concentrated under reduced pressure. The resulting oil is purified using a quick filtration over silica gel byeluting with a petroleum ether - Et20 mixture (9-1). Concentration under reduced pressure resulted in the compound as a colorless oil (96% yield).

Synthesis of Table 1 Molecule Number 11, 15,17, 22, 29, 34, 35, 37, 42, 43, 46, 48, 49, 50, 63, 67, 68, 71, 72, 73 , 81 & 87: [0082]

Table 4

(continued)

[0083] A representative procedure is given for the synthesis of Table 1 Molecule 81.

[0084] To a solution of compound 78 (1 eq.) in dry THF (0.5 M) is added portion wise lithium-aluminiumhydride (0.5 eq.) at 0 °C. Reaction completion is observed by GC-MS after 15 minutes of stirring at ambient temperature. The mixture is cooled to 0 °C and consequently is added: water (same amount of mL as mg hydride used), 15% NaOH solution (same amount of mL as mg hydride used) & water (2 times amount of mL as mg hydride used). This quenching is followed by stirring for 1 hour at ambient temperature. The resulting mixture is filtered over celite and the filter is washed with Et20. Concentration of the filtrate under reduced pressure resulted in the compound as a colorless oil (95% yield).

Synthesis of Table 1 Molecule Number 4 & 12: [0085]

[0086] A representative procedure is given for the synthesis of Table 1 Molecule 116.

[0087] To a solution of the ketone (1 eq.) in dry THF (0.5 M) is added a solution of méthylmagnésium bromide (1.5 eq. - 3M) at -20 °C. The reaction mixture is allowed to warm to ambient temperature and stirring is continued for 2 hours. The reaction is quenched with the addition of a saturated aqueous NH4CI solution and extracted with Et20. The combined organic layers are dried over MgS04 and concentrated under reduced pressure. The resulting oil is purified by column chromatography using the eluens petroleum ether- MTBE (95-5). Concentration of the required fractions resulted in the compound as a colorless oil.

Synthesis of a nitrile used in the synthesis of Table 1 Molecule 45: [0088]

Synthesized starting from 100 mmol nitrile [2947-60-6], [0089] To a solution of diisopropylamine (2.2 eq. - 28.1 mL) in dry THF (0.5 M) is added drop wise a solution of n-butyllithium (2.2 eq. - 100 mL 2.2 M) at 0 °C. 2-m-Tolylacetonitrile (1 eq. - 13 mL) is added to the solution after 10 minutes of stirring at the same temperature. A supplementary stirring for 10 minutes is followed by the drop wise addition of iodomethane (2.5 eq. - 15.6 mL). Reaction completion is observed after 10 minutes stirring at 0 °C. The mixture is quenched with an aqueous solution of NH4CI, extracted with Et20, dried over MgS04 and concentrated under reduced pressure. The resulting oil is purified using a quick filtration over silica gel byeluting with a petroleum ether - Et20 mixture (9-1). Concentration under reduced pressure resulted in the compound as a colorless oil.

Synthesis of Table 1 Molecule Number 9, 10, 18, 44, 45, 47, 53, 54, 59, 64, 78 & 85: [0090]

Table 5

(continued)

[0091] A representative procedure is given for the synthesis of Table 1 Molecule 85.

[0092] To a solution of compound 84 (1 eq.) in dry CH2CI2 (0.5 M) at -60 °C is added drop wise a diisobutylalumini-umhydride (1.3 eq.) solution (1.1 M cyclohexane). The resulting mixture is allowed to warm to ambient temperature for 2 hours. Reaction completion is observed by GC-MS. The mixture is cooled to 0 °C and a saturated aqueous sodium potassium tartrate solution is added carefully. This quenching is followed by stirring for 2 hours at ambient temperature. The resulting mixture is extracted with CH2CI2, dried over MgS04 and reduced under reduced pressure to yield the pure aldehyde (97% yield).

Synthesis of Table 1 Molecule Number 69, 70, 75, 76, 77 & 79: [0093]

Table 6

[0094] A representative procedure is given for the synthesis of Table 1 Molecule 79.

[0095] To a solution of compound 72 (1 eq.) in dry THF (0.5 M) is added sodium hydride (1.1 eq.) and iodomethane (1.5 eq.) at 0 °C. The resulting mixture is allowed to stir at ambient temperature over night. The reaction is quenched with an aqueous saturated solution of ammonium chloride and subsequently extracted with Et20. The combined organic phases are dried over MgS04 and reduced under reduced pressure. The resulting oil is purified using a quick filtration over silica gel by eluting with a petroleum ether - Et20 mixture (9-1). Concentration under reduced pressure resulted in the compound as a colorless oil (96% yield).

Synthesis of Table 1 Molecule Number 19, 30 & 38: [0096]

Table 7

[0097] A representative procedure is given for the synthesis of Table 1 Molecule 38.

[0098] To a solvent-free mixture of the alcohol 37 (1 eq.) and acetic anhydride (2 eq.) at ambient temperature is added lithium trifluoromethanesulfonate (0.2 eq.). The resulting mixture is stirred for2 hours at 50 °C. Full conversion is observed with GC-MS. The reaction is quenched by the addition of EtzO and washed with a NaHC03 aqueous solution. The organic phase is dried over MgS04 and reduced under reduced pressure. The resulting oil is purified using a quick filtration over silica gel by eluting with a petroleum ether - Et2Q mixture (9-1). Concentration under reduced pressure resulted in the compound as a colorless oil (86% yield).

Synthesis of Table 1 Molecule Number 60, 65 & 66: [0099]

Table 8

[0100] A representative procedure is given for the synthesis of Table 1 Molecule 66.

[0101] To a solvent-free mixture of the alcohol (±)-lavandulol (1 eq.) and dimethylcarbonate (5 eq.) at ambient temperature is added the catalyst Zr(acac)4 (5 mol%). The resulting mixture is stirred over night at 80 °C. Full conversion is observed with GC-MS. The reaction is quenched by the addition of an aqueous ammonium chloride solution and extracted with Et20. The organic phase is dried over MgS04 and reduced under reduced pressure. The resulting oil is purified using a quick filtration over silica gel by eluting with a petroleum ether - Et20 mixture (9-1). Concentration under reduced pressure resulted in the compound as a colorless oil (98% yield).

Synthesis of Table 1 Molecule Number 7,13 & 14: [0102]

Table 9

[0103] The synthesis procedure for compound Table 1 Molecule 7.

[0104] A s-butyllithium solution (1.2 equiv.) is added drop wise to a solution of the nitrile (1 eq.) in dry THF (0.5M) at -20 °C. After stirring for 15 minutes at-10/-20 °C, full conversion is observed by GC-MS. The reaction is quenched with a H2S04 solution (2M - 2 eq.) and extracted with Et20. The aqueous layer is neutralized to pH 8 with a NaOH solution and subsequently extracted with Et20. The combined organic phases are dried over MgS04 and concentrated under reduced pressure to yield the compound as a colorless oil.

[0105] A representative procedure for compound 13 and 14 is given for the synthesis of Table 1 Molecule 14.

[0106] A s-butyllithium solution (1.2 equiv.) is added drop wise to a solution of the nitrile (1 eq.) in dry THF (0.5M) at -20 °C. After stirring for 15 minutes at-10/-20 °C, full conversion is observed by GC-MS. The reaction is quenched with iodomethane (1.5 eq.) and stirred for 30 minutes at ambient temperature. Tha reaction is quenched by the addition of water and subsequently extracted with Et20. The combined organic phases are dried over MgS04 and concentrated under reduced pressure to yield the compound as a colorless oil.

Synthesis of Table 1 Molecule 25: [0107]

[0108] To a solution of the ketone (synthesis described in ketone synthesis table) (1 eq.) in toluene (0.5 M) is added ethyleneglycol (1.1 eq.) and para-toluenesulfonic acid (1 mol%). The resulting mixture is refluxed under Dean-Stark conditions for 3 hours. The reaction is extracted with an aqueous NaHCOs solution, dried over MgS04 and reduced under reduced pressure to yield the compound as a colorless oil (92% yield).

Synthesis of Table 1 Molecule 80: [0109]

[0110] A solvent-free mixture of pivaloyl chloride (1 eq.) and prenyl alcohol (1 eq.) is stirred for 10 minutes at ambient temperature. To the mixture is added Et20 and water. The product is extracted with Et20 and the resulting organic layer washed with an aqueous NaHC03 solution. The organic phase is dried over MgS04 and reduced under reduced pressure. The resulting oil is purified using a quick filtration over silica gel by eluting with a petroleum ether - Et20 mixture (9-1). Concentration under reduced pressure resulted in the compound as a colorless oil (75% yield).

Example 2 Preformed Amine Reaction Product [0111] The following ingredients are weighted off in a glass vial: 50% of the perfume material comprising one or more Table 1 PRMs 50% of Lupasol WF (CAS# 09002-98-6) from BASF, is put at 60°C in warm water bath for 1 hour before use. Mixing of the two ingredients is done by using the Ultra-Turrax T25 Basic equipment (from IKA) during 5 minutes. When the mixing is finished the sample is put in a warm water bath at 60°Cfor ± 12 hours. A homogenous, viscous material is obtained.

[0112] In the same way as described above different ratios between the components can be used:

Weight %

Example 3: 84wt% Core / 16wt% Wall Melamine Formaldehyde (MF) Capsule (PAD Reservoir System [0113] 25 grams of butyl acrylate-acrylic acid copolymer emulsifier (Colloid C351,25% solids, pka 4.5-4.7, (Kemira Chemicals, Inc. Kennesaw, Georgia U.S.A.) is dissolved and mixed in 200 grams deionized water. The pH of the solution is adjusted to pH of 4.0 with sodium hydroxide solution. 8 grams of partially methylated methylol melamine resin (Cymel 385, 80% solids, (Cytec Industries West Paterson , New Jersey, U.S.A.)) is added to the emulsifier solution. 200 grams of perfume oil comprising one or more Table 1 PRMs is added to the previous mixture under mechanical agitation and the temperature is raised to 50 °C. After mixing at higher speed until a stable emulsion is obtained, the second solution and 4 grams of sodium sulfate salt are added to the emulsion. This second solution contains 10 grams of butyl acrylate-acrylic acid copolymer emulsifier (Colloid C351,25% solids, pka 4.5-4.7, Kemira), 120 grams of distilled water, sodium hydroxide solution to adjust pH to 4.8, 25 grams of partially methylated methylol melamine resin (Cymel 385, 80% solids, Cytec). This mixture is heated to 70 °C and maintained overnight with continuous stirring to complete the encapsulation process. 23 grams of acetoacetamide (Sigma-Aldrich, Saint Louis, Missouri, U.S.A.) is added to the suspension. An average capsule size of 30um is obtained as analyzed by a Model 780 Accusizer.

Example 4: Process of Making a Polymer Assisted Delivery (PAD) Matrix System [0114] A mixture comprising 50% of a perfume composition comprising one or more Table 1 PRMs, 40% of carboxyl-terminated Hycar @1300X18 (CAS#0068891-50-9) from Noveon, (put at 60°C in warm water bath for 1 hour before mixing) and 10% of Lupasol® WF(CAS# 09002-98-6) from BASF (put at 60°C in warm water bath for 1 hour before mixing). Mixing is achieved by mixing forfive minutes using a Ultra-TurraxT25 Basic equipment (from IKA). After mixing, the mixture is put in a warm water bath at 60°C for ± 12 hours. A homogenous, viscous and sticky material is obtained.

[0115] In the same way as described above different ratios between the components can be used:

Example 5: Product Formulation [0116] Non-limiting examples of product formulations containing PRMs disclosed in the present specification perfume and amines summarized in the following table.

(continued)

Example 6 Dry Laundry Formulations [0117]

(continued)

Example 7 Liquid Laundry Formulations (HDLs) [0118]

(continued)

Example 8 Shampoo Formulation [0119]

(continued)

Example 9 Fine Fragrance Formulation [0120]

[0121] Only those examples are within the scope of the claims, wherein the PRM comprises 3,3-dimethyl-5-((1R,5S)-6,6-dimethylbicyclo[3.1,1]hept-2-en-2-yl)pentan-2-one.

[0122] The dimensions and values disclosed herein are not to be understood as being strictly limited to the exact numerical values recited. Instead, unless otherwise specified, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, a dimension disclosed as "40 mm" is intended to mean "about 40 mm".

[0123] The citation of any document is notto be construed as an admission that it is prior art with respect to the present invention. To the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in a document, the meaning or definition assigned to that term in this document shall govern.

[0124] While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims 1. A consumer product comprising: a. ) based on total consumer product weight, from 0.0001% to 25% of a perfume raw material being 3,3-dimethyl-5-((1 R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)pentan-2-one, ; and/or b. ) a perfume delivery system comprising from 0.001% to 50% of 3,3-dimethyl-5-((1R,5S)-6,6-dimethylbicyc-lo[3.1,1]hept-2-en-2-yl)pentan-2-one, ; said perfume delivery system being a polymer assisted delivery system, a molecule-assisted delivery system, a fiber-assisted delivery system, an amine assisted delivery system, a cyclodextrin delivery system, a starch encapsulated accord, an inorganic carrier delivery system, or a properfume; and c. ) an adjunct ingredient. 2. A consumer product according to Claim 1 comprising a perfume raw material being 3,3-dimethyl-5-((1R,SS)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)pentan-2-one. 3. A consumer product according to Claim 1, said consumer product being a cleaning and/or treatment composition, said composition comprising, based on total composition weight, from 0.0001% to 25% of a perfume raw material being 3,3-dimethyl-5-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)pentan-2-one. 4. A consumer product according to Claim 1, said consumer product being a fabric and/or hard surface cleaning and/or treatment composition, said composition comprising, based on total composition weight, from 0.00001% to 25% of a perfume raw material being 3,3-dimethyl-5-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)pentan-2-one. 5. A consumer product according to Claim 1, said consumer product being a detergent, said detergent comprising, based on total detergent weight, from 0.00001% to 25% of a perfume raw material being 3,3-dimethyl-5-((1 R,5S)-6,6-dimethylbicyclo[3.1,1]hept-2-en-2-yl)pentan-2-one. 6. A consumer product according to Claim 1, said consumer product being a highly compacted consumer product, said highly compacted consumer product comprising, based on total highly compacted consumer product weight, from 0.00001% to 25% of a perfume raw material being, 3,3-dimethyl-5-((1 R,5S)-6,6-dimethylbicyclo[3.1,1]hept-2-en-2-yl)pentan-2-one. 7. A consumer product according to Claim 1, said perfume delivery system being a nanocapsule or a microcapsule comprising, based on total nanocapsule or microcapsule weight, from 0.1% to 99% of a perfume raw material being, 3.3- dimethyl-5-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)pentan-2-one. 8. A consumer product according to Claim 1, said perfume delivery system being a starch encapsulated accord. 9. A consumer product according to Claim 1, said perfume delivery system being a cyclodextrin delivery system comprising, based on total cyclodextrin delivery system weight, from 0.1% to 99% of a perfume raw material being, 3.3- dimethyl-5-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)pentan-2-one. 10. A consumer product according to Claim 1, said perfume delivery system being a polymer assisted delivery matrix system comprising, based on total polymer assisted delivery matrix system weight, from 0.1% to 99% of a perfume raw material being, 3,3-dimethyl-5-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)pentan-2-one. 11. A consumer product according to Claim 1, said perfume delivery system being a amine assisted delivery system, said amine assisted delivery system comprising, based on total amine assisted delivery system weight, from 1% to 99% of a perfume raw material being 3,3-dimethyl-5-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)pentan-2-one. 12. A consumer product according to Claim 1, said perfume delivery system being a pro-perfume amine reaction product, said pro-perfume amine reaction product comprising, based on total pro-perfume amine reaction product weight, from 0.1% to 99% of a perfume raw material being, 3,3-dimethyl-5-((1 R,5S)-6,6-dimethylbicyclo[3.1,1]hept-2-en-2-yl)pentan-2-one. 13. A consumer product according to any of Claims 1 to 12 comprising, based on total consumer product weight, from 0.001 % to 20% of said perfume delivery system. 14. A method of cleaning or treating a situs comprising optionally washing and/or rinsing said situs, contacting said situs with the consumer product of any of Claims 1 to 13, and optionally washing and/or rinsing said situs.

Patentansprüche 1. Endprodukt, umfassend: a. ) basierend auf dem Gesamtgewicht des Endprodukts, von 0,0001 % bis 25 % ein Duftstoffrohmaterial, welches 3,3-Dimethyl-5-((1 R,5S)-6,6-dimethylbicyclo[3.1.1]-hept-2-en-2-yl)pentan-2-on ist, b. ) ein Duftstoffabgabesystem, umfassend von 0,001 % bis 50 % 3,3-Dime-thyl-5-((1 R,5S)-6,6-dimethylbicy-clo[3.1.1]hept-2-en-2-yl)pentan-2-on; wobei das DuftstofFabgabesystem ein polymergestütztes Abgabesystem, ein molekülgestütztes Abgabesystem, ein fasergestütztes Abgabesystem, ein amingestütztes Abgabesystem, ein Cyclodextrin-Abgabesystem, eine in Stärke eingekapselte Mischung, ein Abgabesystem mit einem anorganischen Träger oder ein Pro-Duftstoff ist. c. ) einen Zusatzbestandteil. 2. Endprodukt nach Anspruch 1, umfassend ein DuftstofFrohmaterial, welches 3,3-Dimethyl-5-((1R,5S)-6,6-dimethyl- bicyclo[3.1,1]hept-2-en-2-yl)pentan-2-on ist. 3. Endprodukt nach Anspruch 1, wobei das Endprodukt eine Reinigungs- und/ oder Behandlungszusammensetzung ist, wobei die Zusammensetzung, basierend auf dem Gesamtgewicht der Zusammensetzung, von 0,0001 % bis 25 % ein Duftstoffrohmaterial umfasst, welches 3,3-Dimethyl-5-((1 R,5S)-6,6-dimethylbicyc-lo[3.1,1]hept-2-en-2-yl)pentan-2-on ist. 4. Endprodukt nach Anspruch 1, wobei das Endprodukt eine Zusammensetzung zur

Reinigung und/oder Behandlung von Stoffen und/oder harten Oberflächen ist, wobei die Zusammensetzung, basierend auf dem

Gesamtgewicht der Zusammensetzung, von 0,00001 % bis 25 % ein Duftstoffrohmaterial umfasst, welches 3,3-Dimethyl-5-((1R,5S)-6,6-dimethylbicyclo-[3.1,1]hept-2-en-2-yl)pentan-2-on ist. 5. Endprodukt nach Anspruch 1, wobei das Endprodukt ein Waschmittel ist, wobei das Waschmittel, basierend auf dem Gesamtgewicht des Waschmittels, von 0,00001 % bis 25 % ein Duftstoffrohmaterial umfasst, welches 3,3-Dimethyl-5-((1R,5S)-6,6-dimethylbicyclo[3.1,1]hept-2-en-2-yl)pentan-2-on ist. 6. Endprodukt nach Anspruch 1, wobei das Endprodukt ein hochverdichtetes Endprodukt ist, wobei das hochverdichtete Endprodukt, basierend auf dem Gesamtgewicht des hochverdichteten Endprodukts, von 0,00001 % bis 25 % ein Duftstoffrohmaterial umfasst, welches 3,3-Dimethyl-5-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)pentan-2-on ist. 7. Endprodukt nach Anspruch 1, wobei das Duftstoffabgabesystem eine Nanokapsel oder eine Mikrokapsel ist, die, basierend auf dem Gesamtgewicht der Nanokapsel oder Mikrokapsel, von 0,1 % bis 99 % ein Duftstoffrohmaterial umfasst, welches 3,3-Dimethyl-5-((1R,5S)-6,6-dimethylbicyclo[3.1,1]hept-2-en-2-yl)pentan-2-on ist. 8. Endprodukt nach Anspruch 1, wobei das Duftstoffabgabesystem eine in Stärke eingekapselte Mischung ist. 9. Endprodukt nach Anspruch 1, wobei das Duftstoffabgabesystem ein Cyclodextrin-Abgabesystem ist, das, basierend auf dem Gesamtgewicht des Cyclodextrin-Abgabesystems, von 0,1 % bis 99 % ein Duftstoffrohmaterial umfasst, welches 3,3-Dimethyl-5-((1 R,5S)-6,6-dimethylbicyclo[3.1,1]hept-2-en-2-yl)pentan-2-on ist. 10. Endprodukt nach Anspruch 1, wobei das Duftstoffabgabesystem ein Matrixsystem zur polymergestützten Abgabe ist, das, basierend auf dem Gesamtgewicht des Matrixsystems zur polymergestützten Abgabe, von 0,1 % bis 99 % ein Duftstoffrohmaterial umfasst, welches 3,3-Dimethyl-5-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)pen-tan-2-on ist. 11. Endprodukt nach Anspruch 1, wobei das Duftstoffabgabesystem ein amingestütztes Abgabesystem ist, wobei das amingestützte Abgabesystem, basierend auf dem Gesamtgewicht des amingestützten Abgabesystems, von 1 % bis 99 % ein Duftstoffrohmaterial umfasst, welches 3,3-Dimethyl-5-((1 R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)pentan-2-on ist. 12. Endprodukt nach Anspruch 1, wobei das Duftstoffabgabesystem ein Pro-Duftstoff-Amin-Reaktionsprodukt ist, wobei das Pro-Duftstoff-Amin-Reaktionsprodukt, basierend auf dem Gesamtgewicht des Pro-Duftstoff-Amin-Reaktions-produkts, von 0,1 % bis 99 % ein Duftstoffrohmaterial umfasst, welches 3,3-Dimethyl-5-((1R,5S)-6,6-dimethylbicy-clo[3.1.1]hept-2-en-2-yl)pentan-2-on ist. 13. Endprodukt nach einem der Ansprüche 1 bis 12, umfassend, basierend auf dem Gesamtgewicht des Endprodukts, von 0,001 % bis 20 % das Duftstoffabgabesystem. 14. Verfahren zum Reinigen oder Behandeln einer Stelle, umfassend wahlweise Waschen und/oder Spülen der Stelle, Inkontaktbringen der Stelle mit dem Endprodukt nach einem der Ansprüche 1 bis 13 und wahlweise Waschen und/ oder Spülen der Stelle.

Revendications 1. Produit de consommation comprenant : a. ) sur la base du poids total de produit de consommation, de 0,0001 % à 25 % d’une matière première de parfum étant de la 3,3-diméthyl-5-((1R,5S)-6,6-diméthylbicyclo[3.1.1]hept-2-én-2-yl)pentan-2-one, b. ) un système de libération de parfum comprenant de 0,001 % à 50 % de 3,3-diméthyl-5-((1R,5S)-6,6-dimé-thylbicyclo[3.1.1]hept-2-én-2-yl)pentan-2-one ; ledit système de libération de parfum étant un système de libération assistée par polymère, un système de libération assistée par molécule, un système de libération assistée par fibre, un système de libération assistée par une amine, un système de libération parcyclodextrine, un accord encapsulé dans de l’amidon, un système de libération par véhicule inorganique, ou un proparfum. c. ) un ingrédient additif. 2. Produit de consommation selon la revendication 1, comprenant une matière première de parfum étant de la 3,3-diméthyl-5-((1R,5S)-6,6-diméthylbicyclo[3.1.1]hept-2-én-2-yl)pentan-2-one. 3. Produit de consommation selon la revendication 1, ledit produitde consommation étant une composition de nettoyage et/ou de traitement, ladite composition comprenant, sur la base du poids total de la composition, de 0,0001 % à 25 % d’une matière première de parfum étant de la 3,3-diméthyl-5-((1R,5S)-6,6-diméthylbicyclo[3.1.1]hept-2-én-2-yl)pentan-2-one. 4. Produitde consommation selon la revendication 1, ledit produitde consommation étant une composition de nettoyage et/ou de traitement des tissus et/ou des surfaces dures, ladite composition comprenant, sur la base du poids total de la composition, de 0,00001 % à 25 % d’une matière première de parfum étant de la 3,3-diméthyl-5-((1R,5S)-6,6-diméthylbicyclo[3.1.1]hept-2-én-2-yl)pentan-2-one. 5. Produitde consommation selon la revendication 1, ledit produit de consommation étant un détergent, ledit détergent comprenant, sur la base du poids total du détergent, de 0,00001 % à 25 % d’une matière première de parfum étant de la 3,3-diméthyl-5-((1 R,5S)-6,6-diméthylbicyclo[3.1,1]hept-2-én-2-yl)pentan-2-one. 6. Produitde consommation selon la revendication 1, ledit produit de consommation étant un produitde consommation fortement compacté, ledit produit de consommation fortement compacté comprenant, sur la base du poids total du produit de consommation fortement compacté, de 0,00001 % à 25 % d’une matière première de parfum étant de la 3,3-diméthyl-5-((1R,5S)-6,6-diméthylbicyclo[3.1,1]hept-2-én-2-yl)pentan-2-one. 7. Produit de consommation selon la revendication 1, ledit système de libération de parfum étant une nanocapsule ou une microcapsule comprenant, sur la base du poids total de nanocapsule ou de microcapsule, de 0,1 % à 99 % d’une matière première de parfum étant de la 3,3-diméthyl-5-((1 R,5S)-6,6-diméthylbicyclo[3.1,1]hept-2-én-2-yl)pen-tan-2-one. 8. Produit de consommation selon la revendication 1, ledit système de libération de parfum étant un accord encapsulé dans de l’amidon. 9. Produit de consommation selon la revendication 1, ledit système de libération de parfum étant un système de libération par cyclodextrine comprenant, sur la base du poids total du système de libération par cyclodextrine, de 0,1 % à 99 % d’une matière première de parfum étant de la 3,3-diméthyl-5-((1 R,5S)-6,6-diméthylbicyclo[3.1.1]hept-2-én-2-yl)pentan-2-one. 10. Produitde consommation selon la revendication 1, ledit système de libération de parfum étant un système de matrice de libération assistée par polymère comprenant, sur la base du poids total du système de matrice de libération assistée par polymère, de 0,1 % à 99 % d’une matière première de parfum étant de la 3,3-diméthyl-5-((1 R,5S)-6,6-diméthylbicyclo[3.1,1]hept-2-én-2-yl)pentan-2-one. 11. Produit de consommation selon la revendication 1, ledit système de libération de parfum étant un système de libération assistée par une amine, ledit système de libération assistée par une amine comprenant, sur la base du poids total du système de libération assistée par une amine, de 1 % à 99 % d’une matière première de parfum étant de la 3,3-diméthyl-5-((1R,5S)-6,6-diméthylbicyclo[3.1,1]hept-2-én-2-yl)pentan-2-one. 12. Produitde consommation selon la revendication 1, ledit système de libération de parfum étant un produitde réaction d’amine à proparfum, ledit produitde réaction d’amine à proparfum comprenant, sur la base du poids total du produit de réaction d’amine à proparfum, de 0,1 % à 99 % d’une matière première de parfum étant de la 3,3-diméthyl-5-((1 R,5S)-6,6-diméthylbicyclo[3.1,1]hept-2-én-2-yl)pentan-2-one. 13. Produit de consommation selon l’une quelconque des revendications 1 à 12, comprenant, sur la base du poids total du produit de consommation, de 0,001 % à 20 % dudit système de libération de parfum. 14. Procédé de nettoyage ou de traitement d’un site comprenant le lavage et/ou le rinçage éventuel(s) dudit site, la mise en contact dudit site avec le produit de consommation selon l’une quelconque des revendications 1 à 13, et le lavage et/ou le rinçage éventuel(s) dudit site.

REFERENCES CITED IN THE DESCRIPTION

This list of references cited by the applicant is for the reader’s convenience only. It does not form part of the European patent document. Even though great care has been taken in compiling the references, errors or omissions cannot be excluded and the EPO disclaims all liability in this regard.

Patent documents cited in the description • US 20070275866 A1 [0002] [0025] • US 20080305977 A[0002] • US 20050003980 A1 [0025] • US 20040110648A1 [0025] • US 20040092414A1 [0025] • US 20040091445A1[0025] • US 20040087476 A1 [0025] • US 6531444 B [0025] • US 6024943 A [0025] • US 6042792 A [0025] • US 6051540 A [0025] • US 4540721 A [0025] • US 4973422 A [0025] • WO 2005102261 A [0025] • US 20050124530A1 [0025] • US 20050143282A1 [0025] • WO 2003015736 A [0025] • US 2006003913 A1 [0025] • US 4911852 A [0025] • US 20040058845 A1 [0025] • US 20040092425 A1[0025] • US 20030125222 A1 [0025] • US 2003215417 A1 [0025] • U S 2003216488 A1 [0025] • US 2003158344 A1 [0025] • US 2003165692 A1 [0025] • U S 2004071742 A1 [0025] • U S 2004071746 A1 [0025] • U S 2004072719 A1 [0025] • US 2004072720 A1 [0025] • US 20060039934 A1 [0025] • US 2003203829 A1 [0025] • US 2003195133 A1 [0025] • US 2004087477 A1 [0025] • U S 20040106536 A1 [0025] • US 6645479 B1 [0025] • US 6200949 B1 [0025] • US 4882220 B1 [0025] • US 4917920 B1 [0025] • US 4514461 B1 [0025] • US 6106875 B1 [0025] • US 4234627 A [0025] • US 3594328 A [0025] • US RE32713 E [0025] • WO 2009134234 A1 [0025] • WO 2006127454 A2 [0025] • WO 2010079466 A2 [0025] • WO 2010079467 A2 [0025] • WO 2010079468 A2 [0025] • WO 2010084480 A2 [0025] • US 7119060 B [0025] • US 5506201 A [0025] • U S 20030199422 A1 [0025] • US 20030036489A1 [0025] • US 20040220074 A1 [0025] • US 6103678 A [0025] • US 20060263313 A1 [0025] • US 5552378 A [0025] • US 3812011 A [0025] • US 4317881 A [0025] • US 4418144 A [0025] • US 4378923 A [0025] • US 6458754 B1 [0025] • US 5858959 A [0025] • US 6245732 B1 [0025] • US 6048830 B1 [0025] • US 4539135 B1 [0025] • US 5651976 A [0025] • US 20060020459 A1 [0025] • US 7018978 B2 [0025] • US 6987084 B2 [0025] • US 6956013 B2 [0025] • US 6861402 B1 [0025] • US 6544945 B1 [0025] • US 6093691 B1 [0025] • US 6277796 B1 [0025] • US 6165953 B1 [0025] • US 6316397 B1 [0025] • US 6437150 B1 [0025] • US 6479682 B1 [0025] • US 6096918 B1 [0025] • US 6218355 B1 [0025] • US 6133228 B1 [0025] • US 6147037 B1 [0025] • US 7109153 B2 [0025] • US 7071151 B2 [0025] • US 6610646 B2 [0025] • US 5958870 B2 [0025] • US 20060223726 A1 [0025] • US 6413920 B1 [0025] • US 5576282 A [0036] [0045] • US 6306812 B1 [0036] • US 6326348 B1 [0036] • US 4430243 A [0044] • US 5597936 A [0046] • US 5595967 A [0046] • WO 0032601 A [0049] • US 6225464 B [0049] • US 5574179 A [0116]

Non-patent literature cited in the description • A. LEO. Comprehensive Medicinal Chemistry. Pergamon Press, 1990, vol. 4, 295 [0052]

Claims

SZABADALMI IGÉNYPONTOK 1. kogyasztesi cikk, amely a kővetkezőket tartalmazza: a.) a fogyasztóm c&k teljes tömege alapján 0.0001 -25% íNstalepanyagot, ahol az íllateiapanyag a 3.3- ílmielil-5--Ç| 1R, öSkBA -OirnetilSiölkfé |3et 1| hept-2-én -2-1 spontán -2-on vagyaiét, :p,) ágy 5llá!ááp§--aáagoiáyi0PsaeAv amely 0,001 ~Sü%-ÄNgrtaimaz §ß* pr-pyl 5 5S}-0,6 diívskGcitvo |3 1 *\ áept-2 én-ó ifn^tó;v3-er >egusieíet :Äöl AZ emlfleá iataoyagmoagolé rendszeregy polimer áltál szabályozott adia^ßtenöaaar, #gy moiekuíáÉW: ^ ágy szál által szetv%ozottadagoi0reoctezer, agy amin által szabályozott adagolóieodszer, egy iGkWeÄbeb álapuló ádágáloráálsZáL ágy kemémyltókapsaufábá zMi iátekkoti, egy szervetlen hordozóé atepufp adegolórf ndppryagy «HW liaMar iyag. c.) srjysegébanyagol G, Az 1 Igénypont szedeti fogyasztást oil, amelyben m Slátalápanyág e %& dlmetb'S'Cn R, óSyb.S'dsmeklbroíklo [3 1 1] hept-2-árt>Z-il}peníánG-onoeiy||fáLPATIENT LETTERS 1. An online article that contains the following: a.) Based on the total weight of my consumer &amp; c < / RTI > 1R, ÖSkBA -OirnetilSilf | 3et 1 | hept-2 on -2-1 spontaneous -2-on,: p,) bed 5 oncontinue § - oiOpsaPaAaV which is 0.001 ~ S%% -Nagtaimaz §ß * pr-pyl 5 5S} -0,6 diívskGcitvo | 3 1 * ad-2 I nd i nd v3-ert l e rt: Does the mammalian α-α-thienate of the mammalian αoyoyagmagolea system regulated by? an iGkWeÄbeb dummy calorie bedwallow chamomile cape, an inorganic carrier atepufp adjuvrrndpjrp Hd liaMar iyag. c.) srjysegébanyagol G, 1 Claims for consumption of oil, in which m adolescence e% & dlmetb'S'Cn R, ÓSyb.S'dsmeklbroíklo [3 1 1] hept-2-hurt> Z-il} peníánG-onoeiy ||

3. Az. 1 fénypont szenek fogyasztás! cikk, ahol az említett fogyasztás! cikk íiztftó- Mfyify kiáélöitáezitmány, és aha; az ételiét! készítmény a taps tömege alapján 0,0001A25% llátáSápányá|ót3Iiiifóiz,:lmely illatalapanyag a: ZjZ^gimeflLO-'CCIB, iSb^.b-^lmetlblelkio ;0ορΐ'2~#ρ#Μ|ρβη1#η>2·Λ on vagyaiét. 4 Az: 1, Iginypott száábti fögyásztiál sikk, ahol az említett fogyasztási cikk textiltisztító készítmény és/vagy burteiahléziító készítmény éerVagy kezelckészitmény; és ahol az érellett készítmény a teljes Pmágé aláppn 0,00001-2001 ilitalppanyagot tartalmaz, amely iátalapanyeg a 3,3-blmetiO'-gÍR, óSbó^Miméttíblcíklö ρ,ί,Ι] hipb2-én-2nl)pentáiv2-on vágyóiéi o. Az 1. Igénypont szerinti fogyasztást cikk, ahol az említett fogyasztási cikk sigsószbi es az említett 1 naletspanyagot tartalmaz. amely «aiaiapanyag a 3,3--01^00)--5- e; i R, $SV>$,6-simetHblclkk?}3. 1 5; h£Oi-2-éf!-2-ii}pentán-2-on vegyülök i:. Al ix Igényem szennfc fogyasztási cikk, ahol az erratet* fogfif^âg pkk .riaQymêjitÂi^ ^^t^m^Îtaft.^gyàSÂiàsi cikk, és ahoi m említett nagymértekben osszetombdtatt fogyasztás» este a teljes Iomega alapján 0,00001-¾¾¾ iligfâiapbnyâgot tartalmaz, amely »tálapanyag a .3.,3* dmiedko-íflR, 58)416-ürnrnmUcMo 13, Uj heph2ten--2di>peniam2-on vegyidet T Az 1. ^íyp^:;^ei'1^p8S^Sí Ä, álig! m említett iaianyag-iidágöiá fteteizéf' o|ÿ hiaikápizuli vagy eg y msk rokapszula. amely a gabbkapszote «|f a míkrokspszula telles tömege alapján 0.1-99% 5Ílafálápany«gol:Íá?|álmáz> amely ilíatalapanyap a 9JMipeyl-5*(iï% SS>-8,6~ dsmetíibícíkío [3 * >| hepi--2--em2-ti)pentáiv2-on vegyidet 6 Az 1 Igénypont szentel fogyasztás; etek, ahol az említett ilipianyag-Adagoló rendszer egy keniényOókapszgláfea zári iaiakkerd. fl Az i igénypont szerinti fogyasztási cikk, ahol az említett ilistenytg-adagoló rendszer egy Cíklodetenoan alapuló abagoiórendszer, amely a |ff$^ex?rinen aiepu«o adagoiorendazer teljes iömep alapién 6.1-99¾¾ IIÉlálapanyagot tartalmaz, amely illataiapanyag a 3íJ*i>met«i-S“UiR* MJtíBSe* óapt^-én-Z-^pentárna-on vegyiket iö. Az 1. tgénypom szenot* fogyasztási c«kk< idol az említett iáfatiyá|* édagolP remizze* egy polimer által szabályozott adagoló miirtefendszep amely á ppilniBr Élfai szabályozod aaagoio métnxfendszer teljes tömege alapján 0.1-99% lliatalapanyagot tartalmaz. amely illata lapanyag a X3-dsmotA-S -ó1R. 58)-5,6-dimotllbicikto |3 1 I] hepi-2 en-2-ii)pentàn-2--ûn vegyidet, fi, M 1 - iginypbn! Szerinti fogpeztésí öikk, ahol az említed il«ataáp§* aoagolô módszer egy am«n áhai szabályozod ndagoiö-!endszer. amely az amin Ékel szabályozott adagoló rendszer teljes tömege alapján 1-99% ;liataxpan>agoi tartalma*, amely l3 11 \ nept -2 - éfi.-2-H)|Pfitén?Í« «gpet 12. ;m% - Ipbypoft sggpl f||ya$|psi cikk, ahol az amStatt ásianyaa-adaoöiö pnd^ef^^^róSl^W^i^it;litta0vö iatolőanyeg. amely az amin* makcétémièkkém ièîire^vô tffsteiêsnyag teljes tömege alapján 0,1-99% llátaiipnyagol tadáímaz ameiy sMáíápoyag a 3.3dáimetik5~ii1 R, 6Sh6.6' dimeybiakk> (3,U j hept<2-en>2^ípc^(áív-2-on vegyél3. Consumption of 1 point light! Article where said consumption! Article, Mfyify, and aha; your food! composition based on the weight of the applause 0.0001A25% of the total weight of the product: a perfume material of: ZjZ ^ gimeflLO-'CCIB, iSb ^ .b- ^ lmetlblelkio; 0ορΐ'2 ~ # ρ> Μ | ρβη1 # η> 2 · Λ on desires. 4 A: 1, a tumbled mouthpiece, wherein said consumer article is a fabric cleansing composition and / or a lacquer coating composition; and wherein the composition comprises 0.00001-2001 ilital substance of total Pmag, which is the base of 3,3-blmetiO'-GYL, bóó ^imimimimöρρρρρρρίίί, Ι] hipb2-en-2nl) pentavalent-2. Consumption according to claim 1, wherein said consumer article comprises ssp. which is a "base material of 3.3 - 01 ^ 00) - 5- e; i R, $ SV> $, 6-simethHblclkk?} 3. 1 5; h-O-2-ynyl-2-yl} pentan-2-one compound:. Al ix I need sennfc consumer goods, where I find the article in my article, and the large amount of consumption mentioned here is 0.00001 to ¾¾¾ iligfahnyp in terms of total Iomega , which is a "tray material of .3., 3 * dmiedko-1flR, 58) 416-yrnrnmUcMo 13, UH heph2ten - 2di> peniam2 on a chemical T The 1 st st1:; , dear! m iaia ö ÿ ÿ iz iz iz iz iz sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk sk which is the Gabbapskin «| by the weight of a wood chipspole telles 0.1-99% 5Flower" gol: Yao | dream> which is the base of the 9JMipeyl-5 * (iï% SS> -8,6 ~ dsmetíibícíkío [3 *> | hepi - 2 --em2-ti) pentazine2 is a chemical 6 The 1 is dedicated to consumption; et al., wherein said ilipeal metering system is a penis olfactory capsule actuator. The consumer article according to claim 1, wherein said ilistenytg delivery system is an adhesion system based on Clichetetenan, which comprises a total weight of 6.1 to 99µ¾ II of base material of the adreniorendazer of the ff $ ^ ex? «IS» UiR * MJtILs * is a chimeric compound. The first tomato pomegranate * consumption c k k <idol iz ag iz iz iz iz iz iz iz iz iz iz iz egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy egy which fragrance sheet material is X3-dsmotA-S-1R. 58) -5,6-Dimethylbicyclo [3] I] hepi-2-en-2-yl) pentane-2-ene, fi, M 1 - iginypbn! According to the present invention, the aforementioned method is a method for treating a disease. which is 1-99% based on the total weight of amine Ékel-controlled dosing system, liataxpan> -i *, which is l3 11 nept -2 - dd-2-H) | Pfiten? pet gpet 12.; m% - Ipbypoft sggpl f || ya $ | psi article, where amStat is an acyl derivative. which, based on the total weight of the amine * macchemic chemistry, is from about 0.1% to about 99% of the total amount of the active ingredient (s), (3, U hept <2-en> 2 ^ ipc ^). (buy at Aiv-2

13. Λζ 1-Ί2. igénypont szi|lfogyasztási cikk., amelynek a teljes tömege alapján 0.001 -2ö%· át teszi ki az eaiÜM iátaay^pgagiiöreagafir.13. Λζ 1-Ί2. An article of consumption according to claim 1, wherein the total weight of 0.001 to 2% is equal to?

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