HRP20231570T1 - Peptid za uporabu u imunoterapiji protiv nesitnostaničnog raka pluća i sitnostaničnog raka pluća - Google Patents
Peptid za uporabu u imunoterapiji protiv nesitnostaničnog raka pluća i sitnostaničnog raka pluća Download PDFInfo
- Publication number
- HRP20231570T1 HRP20231570T1 HRP20231570TT HRP20231570T HRP20231570T1 HR P20231570 T1 HRP20231570 T1 HR P20231570T1 HR P20231570T T HRP20231570T T HR P20231570TT HR P20231570 T HRP20231570 T HR P20231570T HR P20231570 T1 HRP20231570 T1 HR P20231570T1
- Authority
- HR
- Croatia
- Prior art keywords
- small cell
- lung cancer
- cell lung
- peptide
- cancer
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 6
- 206010028980 Neoplasm Diseases 0.000 title claims 5
- 208000002154 non-small cell lung carcinoma Diseases 0.000 title claims 5
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 title claims 5
- 238000009169 immunotherapy Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 4
- 108091008874 T cell receptors Proteins 0.000 claims 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464484—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/464486—MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
Claims (4)
1. Peptid koji se sastoji od aminokiselinske sekvence SEQ ID No. 1 (KVLEHVVRV), ili njegove farmaceutski prihvatljive soli, za uporabu u liječenju raka, pri čemu je navedeni rak izabran od nesitnostaničnog raka pluća i sitnostaničnog raka pluća.
2. T-stanični receptor, poželjno rekombinantni, topljivi ili T-stanični receptor vezan za membranu koji je reaktivan sa HLA ligandom, pri čemu se navedeni ligand sastoji od peptida prema patentnom zahtjevu 1, za uporabu u liječenju nesitnostaničnog raka pluća ili sitnostaničnog raka pluća.
3. Antitijelo, posebno topljivo ili antitijelo vezano za membranu, koje specifično prepoznaje peptid prema patentnom zahtjevu 1 kada je vezan za MHC molekulu za uporabu u liječenju nesitnostaničnog raka pluća ili sitnostaničnog raka pluća.
4. Farmaceutski pripravak koji sadrži najmanje jedan aktivni sastojak izabran iz grupe koja se sastoji od peptida prema patentnom zahtjevu 1, ili antitijela prema patentnom zahtjevu 3 ili T- staničnog receptora prema patentnom zahtjevu 2, i farmaceutski prihvatljivog nosača, i izborno dodatnih farmaceutski prihvatljivih ekscipijenasa i/ili stabilizatora za uporabu u liječenju raka, pri čemu je navedeni rak izabran od liječenju nesitnostaničnog raka pluća ili sitnostaničnog raka pluća.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662308944P | 2016-03-16 | 2016-03-16 | |
GBGB1604458.8A GB201604458D0 (en) | 2016-03-16 | 2016-03-16 | Peptides and combination of peptides for use in immunotherapy against cancers |
PCT/EP2017/056049 WO2017157972A1 (en) | 2016-03-16 | 2017-03-15 | Peptides and combination of peptides for use in immunotherapy against non-small cell lung cancer and other cancers |
EP17710904.8A EP3430027B1 (en) | 2016-03-16 | 2017-03-15 | Peptide for use in immunotherapy against non-small cell lung cancer and small cell lung cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20231570T1 true HRP20231570T1 (hr) | 2024-03-15 |
Family
ID=55952389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20231570TT HRP20231570T1 (hr) | 2016-03-16 | 2017-03-15 | Peptid za uporabu u imunoterapiji protiv nesitnostaničnog raka pluća i sitnostaničnog raka pluća |
Country Status (31)
Country | Link |
---|---|
US (4) | US20170296641A1 (hr) |
EP (2) | EP3430027B1 (hr) |
JP (2) | JP2019515650A (hr) |
KR (2) | KR20230004914A (hr) |
CN (1) | CN108779149A (hr) |
AU (3) | AU2017235364B2 (hr) |
BR (1) | BR112018017022A2 (hr) |
CA (1) | CA3016410A1 (hr) |
CL (2) | CL2018002591A1 (hr) |
CO (1) | CO2018010009A2 (hr) |
CR (1) | CR20180491A (hr) |
DK (1) | DK3430027T3 (hr) |
EA (1) | EA201891701A1 (hr) |
ES (1) | ES2965011T3 (hr) |
FI (1) | FI3430027T3 (hr) |
GB (1) | GB201604458D0 (hr) |
HR (1) | HRP20231570T1 (hr) |
HU (1) | HUE064592T2 (hr) |
IL (1) | IL261785A (hr) |
LT (1) | LT3430027T (hr) |
MA (2) | MA43719B1 (hr) |
MD (1) | MD3430027T2 (hr) |
MX (1) | MX2018011215A (hr) |
PE (1) | PE20181824A1 (hr) |
PH (1) | PH12018501865A1 (hr) |
PL (1) | PL3430027T3 (hr) |
PT (1) | PT3430027T (hr) |
RS (1) | RS64907B1 (hr) |
SG (2) | SG10202006119TA (hr) |
SI (1) | SI3430027T1 (hr) |
WO (1) | WO2017157972A1 (hr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4357454A2 (en) * | 2016-03-16 | 2024-04-24 | Immatics Biotechnologies GmbH | Transfected t-cells and t-cell receptors for use in immunotherapy against cancers |
GB201609193D0 (en) | 2016-05-25 | 2016-07-06 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers |
JP7075125B2 (ja) | 2016-05-25 | 2022-05-25 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ |
EP3539562A1 (en) | 2018-03-12 | 2019-09-18 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Immunotherapeutic peptides |
DE102018108612A1 (de) | 2018-03-21 | 2019-09-26 | Immatics US, Inc. | Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen |
JP2022515473A (ja) * | 2018-12-28 | 2022-02-18 | エフ.ホフマン-ラ ロシュ アーゲー | 免疫応答が増幅された患者における治療的使用のためのペプチド-mhc-i-抗体融合タンパク質 |
JP2022534716A (ja) | 2019-05-27 | 2022-08-03 | イマティクス ユーエス,アイエヌシー. | ウイルスベクターおよびその養子細胞療法における使用 |
US20200384028A1 (en) | 2019-06-06 | 2020-12-10 | Immatics Biotechnologies Gmbh | Sorting with counter selection using sequence similar peptides |
DE102019121007A1 (de) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Antigenbindende Proteine, die spezifisch an MAGE-A binden |
DE102021100038A1 (de) | 2020-12-31 | 2022-06-30 | Immatics US, Inc. | Modifizierte cd8-polypeptide, zusammensetzungen und verfahren zu deren verwendung |
EP4271481A2 (en) | 2020-12-31 | 2023-11-08 | Immatics US, Inc. | Cd8 polypeptides, compositions, and methods of using thereof |
CN113087801B (zh) * | 2021-04-07 | 2022-07-05 | 深圳市核子基因科技有限公司 | 一种用核酸和抗体联合检测肺癌的试剂盒 |
CA3217739A1 (en) | 2021-05-05 | 2022-11-10 | Sebastian Bunk | Bma031 antigen binding polypeptides |
CN114230636B (zh) * | 2021-11-12 | 2023-04-25 | 四川大学 | 一类多肽及其应用以及含该类多肽的药物 |
US20240066127A1 (en) | 2022-04-28 | 2024-02-29 | Immatics US, Inc. | Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof |
WO2023212691A1 (en) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | DOMINANT NEGATIVE TGFβ RECEPTOR POLYPEPTIDES, CD8 POLYPEPTIDES, CELLS, COMPOSITIONS, AND METHODS OF USING THEREOF |
WO2023212697A1 (en) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
WO2023215825A1 (en) | 2022-05-05 | 2023-11-09 | Immatics US, Inc. | Methods for improving t cell efficacy |
CN115785207A (zh) * | 2022-06-10 | 2023-03-14 | 河北博海生物工程开发有限公司 | 肺癌特异性分子靶标02及其用途 |
CN115785208A (zh) * | 2022-06-10 | 2023-03-14 | 河北博海生物工程开发有限公司 | 肺癌特异性分子靶标01及其用途 |
WO2024077601A1 (en) * | 2022-10-14 | 2024-04-18 | Guangdong Tcrcure Biopharma Technology Co., Ltd. | Peptide vaccines against glioma and uses thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2273701A (en) * | 1999-12-13 | 2001-06-18 | Epimmune, Inc. | Hla class i a2 tumor associated antigen peptides and vaccine compositions |
AU2002227498A1 (en) * | 2000-07-31 | 2002-02-13 | Kyogo Itoh | Tumor antigen |
CA2598889A1 (en) * | 2005-02-24 | 2006-08-31 | Cemines, Inc. | Compositions and methods for classifying biological samples |
CA2694805C (en) * | 2007-07-27 | 2014-09-09 | Immatics Biotechnologies Gmbh | Immunogenic epitopes of tumour-associated antigens |
NO2119726T3 (hr) * | 2008-05-14 | 2015-05-23 | ||
US20130011496A1 (en) * | 2009-11-25 | 2013-01-10 | Ludwig Institute For Cancer Research Ltd. | Cancer testis antigens as biomarkers in non-small cell lung cancer |
GB201004551D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
CN101870725B (zh) * | 2010-06-29 | 2012-06-27 | 郑州大学 | Mage-4抗肿瘤ctl表位肽及其应用 |
CA2847332A1 (en) * | 2011-08-31 | 2013-03-07 | Mie University | Vaccine preparation for cancer treatment |
TWI777194B (zh) * | 2013-08-05 | 2022-09-11 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(一) |
GB201319446D0 (en) * | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
WO2015172843A1 (en) * | 2014-05-16 | 2015-11-19 | Biontech Diagnostics Gmbh | Methods and kits for the diagnosis of cancer |
CN105219714A (zh) * | 2015-10-20 | 2016-01-06 | 上海隆耀生物科技有限公司 | 一种用于激活肺癌特异性免疫反应的试剂盒 |
-
2016
- 2016-03-16 GB GBGB1604458.8A patent/GB201604458D0/en not_active Ceased
-
2017
- 2017-03-15 BR BR112018017022A patent/BR112018017022A2/pt unknown
- 2017-03-15 SI SI201731451T patent/SI3430027T1/sl unknown
- 2017-03-15 KR KR1020227043762A patent/KR20230004914A/ko not_active Application Discontinuation
- 2017-03-15 ES ES17710904T patent/ES2965011T3/es active Active
- 2017-03-15 HU HUE17710904A patent/HUE064592T2/hu unknown
- 2017-03-15 LT LTEPPCT/EP2017/056049T patent/LT3430027T/lt unknown
- 2017-03-15 SG SG10202006119TA patent/SG10202006119TA/en unknown
- 2017-03-15 MA MA43719A patent/MA43719B1/fr unknown
- 2017-03-15 CN CN201780017499.9A patent/CN108779149A/zh active Pending
- 2017-03-15 HR HRP20231570TT patent/HRP20231570T1/hr unknown
- 2017-03-15 PE PE2018001795A patent/PE20181824A1/es unknown
- 2017-03-15 MA MA43327A patent/MA43327A1/fr unknown
- 2017-03-15 EA EA201891701A patent/EA201891701A1/ru unknown
- 2017-03-15 KR KR1020187026097A patent/KR20180121530A/ko not_active Application Discontinuation
- 2017-03-15 MD MDE20190100T patent/MD3430027T2/ro unknown
- 2017-03-15 EP EP17710904.8A patent/EP3430027B1/en active Active
- 2017-03-15 WO PCT/EP2017/056049 patent/WO2017157972A1/en active Application Filing
- 2017-03-15 CA CA3016410A patent/CA3016410A1/en active Pending
- 2017-03-15 PL PL17710904.8T patent/PL3430027T3/pl unknown
- 2017-03-15 AU AU2017235364A patent/AU2017235364B2/en not_active Expired - Fee Related
- 2017-03-15 DK DK17710904.8T patent/DK3430027T3/da active
- 2017-03-15 CR CR20180491A patent/CR20180491A/es unknown
- 2017-03-15 EP EP22201204.9A patent/EP4180450A1/en active Pending
- 2017-03-15 RS RS20231154A patent/RS64907B1/sr unknown
- 2017-03-15 FI FIEP17710904.8T patent/FI3430027T3/fi active
- 2017-03-15 SG SG11201806905UA patent/SG11201806905UA/en unknown
- 2017-03-15 PT PT177109048T patent/PT3430027T/pt unknown
- 2017-03-15 JP JP2018547374A patent/JP2019515650A/ja active Pending
- 2017-03-15 MX MX2018011215A patent/MX2018011215A/es unknown
- 2017-03-16 US US15/460,396 patent/US20170296641A1/en not_active Abandoned
-
2018
- 2018-09-03 PH PH12018501865A patent/PH12018501865A1/en unknown
- 2018-09-11 CL CL2018002591A patent/CL2018002591A1/es unknown
- 2018-09-15 IL IL261785A patent/IL261785A/en unknown
- 2018-09-21 CO CONC2018/0010009A patent/CO2018010009A2/es unknown
-
2019
- 2019-11-12 US US16/681,472 patent/US20200085930A1/en active Pending
-
2022
- 2022-04-06 AU AU2022202307A patent/AU2022202307B2/en active Active
- 2022-12-15 AU AU2022287621A patent/AU2022287621A1/en active Pending
-
2023
- 2023-01-12 JP JP2023003167A patent/JP2023055722A/ja active Pending
- 2023-05-10 CL CL2023001346A patent/CL2023001346A1/es unknown
- 2023-10-19 US US18/490,581 patent/US20240123044A1/en active Pending
- 2023-12-08 US US18/533,733 patent/US20240100137A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20231570T1 (hr) | Peptid za uporabu u imunoterapiji protiv nesitnostaničnog raka pluća i sitnostaničnog raka pluća | |
PH12020550929A1 (en) | Bicyclic peptide ligands specific for epha2 | |
PH12020552179A1 (en) | Bicyclic peptide ligands specific for nectin-4 | |
JP2018503668A5 (hr) | ||
HRP20191009T1 (hr) | Personalizirana imunoterapija protiv nekoliko neuronalnih i moždanih tumora | |
NZ731185A (en) | Bicyclic peptide ligands specific for mt1-mmp | |
JP2016527286A5 (hr) | ||
JP2018510215A5 (hr) | ||
SI3079715T1 (en) | A mixture of peptides | |
MX360208B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
MX363136B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
MX360211B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
EP3412304A3 (en) | Hla-a24 agonist epitopes of muc1-c oncoprotein and compositions and methods of use | |
JP2018521983A5 (hr) | ||
CL2019003410A1 (es) | Péptido asociado a tumor (tumap) aislado; ácido nucleico; vector de expresión; célula huésped recombinante que comprende el péptido; método para producir el péptido; uso para preparar un medicamento útil para tratar el cáncer; kit farmacéutico. (divisional solicitud 201702407). | |
HRP20211852T1 (hr) | Nova imunoterapija protiv nekoliko tumora, poput raka pluća, uključujući nsclc | |
JP2016520075A5 (hr) | ||
MX2021006991A (es) | Ligandos peptidicos biciclicos especificos para metaloproteasa tipo 1 de membrana (mt1-mmp). | |
MX2023001319A (es) | Polipeptidos condicionalmente activos. | |
CL2020003293A1 (es) | Péptido que consiste en la secuencia de aminoácidos de seq id no: 42; anticuerpo que reconoce dicho péptido; receptor de linfocito t; célula hospedadora; linfocito t activado; composición farmacéutica; uso; y kit (divisional de la solicitud no. 201802969) | |
JP2016523558A5 (hr) | ||
RU2012127358A (ru) | Олигопептиды imp-3 и содержащие их вакцины | |
HRP20181021T1 (hr) | Formulacija za bispecifične aktivatore limfocita t (bites) | |
IN2014DN09963A (hr) | ||
RU2012136464A (ru) | Модифицированные пептиды melk и содержащие их вакцины |