HRP20230655T1 - Metode liječenja artritisa - Google Patents
Metode liječenja artritisa Download PDFInfo
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- HRP20230655T1 HRP20230655T1 HRP20230655TT HRP20230655T HRP20230655T1 HR P20230655 T1 HRP20230655 T1 HR P20230655T1 HR P20230655T T HRP20230655T T HR P20230655TT HR P20230655 T HRP20230655 T HR P20230655T HR P20230655 T1 HRP20230655 T1 HR P20230655T1
- Authority
- HR
- Croatia
- Prior art keywords
- sustained
- use according
- release preparation
- release
- phospholipid
- Prior art date
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- 206010003246 arthritis Diseases 0.000 title claims 3
- 239000003405 delayed action preparation Substances 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 7
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 150000003904 phospholipids Chemical class 0.000 claims 5
- 229940123907 Disease modifying antirheumatic drug Drugs 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 239000002988 disease modifying antirheumatic drug Substances 0.000 claims 4
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 4
- 239000002502 liposome Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 150000003431 steroids Chemical class 0.000 claims 4
- 239000007900 aqueous suspension Substances 0.000 claims 3
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 3
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 238000013268 sustained release Methods 0.000 claims 3
- 239000012730 sustained-release form Substances 0.000 claims 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
- DSNRWDQKZIEDDB-SQYFZQSCSA-N 1,2-dioleoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC DSNRWDQKZIEDDB-SQYFZQSCSA-N 0.000 claims 2
- SNKAWJBJQDLSFF-NVKMUCNASA-N 1,2-dioleoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC SNKAWJBJQDLSFF-NVKMUCNASA-N 0.000 claims 2
- 108010008165 Etanercept Proteins 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 229960000403 etanercept Drugs 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 229960000905 indomethacin Drugs 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 229960003957 dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960002344 dexamethasone sodium phosphate Drugs 0.000 claims 1
- PLCQGRYPOISRTQ-FCJDYXGNSA-L dexamethasone sodium phosphate Chemical compound [Na+].[Na+].C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)COP([O-])([O-])=O)(O)[C@@]1(C)C[C@@H]2O PLCQGRYPOISRTQ-FCJDYXGNSA-L 0.000 claims 1
- 229940048921 humira Drugs 0.000 claims 1
- 229960004260 indomethacin sodium Drugs 0.000 claims 1
- BKBBTCORRZMASO-ZOWNYOTGSA-M methotrexate monosodium Chemical group [Na+].C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C([O-])=O)C=C1 BKBBTCORRZMASO-ZOWNYOTGSA-M 0.000 claims 1
- 229960003058 methotrexate sodium Drugs 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- JMHRGKDWGWORNU-UHFFFAOYSA-M sodium;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate Chemical compound [Na+].CC1=C(CC([O-])=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 JMHRGKDWGWORNU-UHFFFAOYSA-M 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Claims (16)
1. Pripravak s produljenim otpuštanjem za uporabu u liječenju artritisa, koji sadrži:
liposome; i
jedno ili više terapijskih sredstava,
naznačen time što liposomi sadrže mješavinu prvog fosfolipida i drugog fosfolipida i kolesterola, prvi fosfolipid je DOPC i drugi fosfolipid DOPG,
pri čemu je molarni postotak DOPC:DOPG:kolesterola liposoma oko 56.25 do 72.5: 7.5 do 18.75 : 20 do 25,
pri čemu su liposomi u vodenoj suspenziji, i
pri čemu terapeutsko sredstvo nije kovalentno vezano na fosfolipid, i pripravak s produljenim otpuštanjem se intraartikularno ubrizgava u zglob subjekta kojem je potrebno liječenje artritisa.
2. Pripravak s produljenim otpuštanjem za uporabu prema zahtjevu 1, naznačen time što je pripravak s produljenim otpuštanjem pripravljen rekonstitucijom lipidnog kolača koji je liofiliziran s vodenom otopinom koja sadrži navedeno jedno ili više terapijskih sredstava da se formira vodena suspenzija.
3. Pripravak s produljenim otpuštanjem za uporabu prema zahtjevu 1, naznačen time što je pripravak za produljeno otpuštanje pripremljen rekonstitucijom liofilizirane kombinacije navedenog jednog ili više terapijskih sredstava i lipidnog kolača s vodenom otopinom da se dobije vodena suspenzija.
4. Pripravak s produljenim otpuštanjem za uporabu prema bilo kojem od zahtjeva 1 do 3, naznačen time što terapeutsko sredstvo sadrži otopinu steroida topljivu u vodi koja sadrži učinkovitu količinu steroida topljivog u vodi ili njegove farmaceutski prihvatljive soli.
5. Pripravak s produljenim otpuštanjem za uporabu prema zahtjevu 4, naznačen time što je steroid topljiv u vodi deksametazon natrijev fosfat.
6. Pripravak s produljenim otpuštanjem za uporabu prema zahtjevu 4, naznačen time što otopina steroida topljivog u vodi ima snagu koja je ekvivalentna dozi od oko 2 mg do oko 8 mg doze deksametazona.
7. Pripravak s produljenim otpuštanjem za uporabu prema bilo kojem od zahtjeva 1 do 3, naznačen time što terapeutsko sredstvo sadrži nesteroidni protuupalni lijek ili njegovu farmaceutski prihvatljivu sol.
8. Pripravak s produljenim otpuštanjem za uporabu prema zahtjevu 7, naznačen time što je nesteroidni protuupalni lijek indometacin.
9. Pripravak s produljenim otpuštanjem za uporabu prema zahtjevu 8, naznačen time što farmaceutski prihvatljiva sol indometacina je indometacin natrij.
10. Pripravak s produljenim otpuštanjem za uporabu prema zahtjevu 8, naznačen time što je doza nesteroidnog protuupalnog lijeka 4.65 do 5 mg/ml.
11. Pripravak s produljenim otpuštanjem za uporabu prema bilo kojem od zahtjeva 1 do 3, naznačen time što terapeutsko sredstvo sadrži anti-reumatski lijek koji modificira bolest (DMARD).
12. Pripravak s produljenim otpuštanjem za uporabu prema zahtjevu 11, naznačen time što DMARD sadrži antagonist TNF-α ili metotreksat.
13. Pripravak s produljenim otpuštanjem za uporabu prema zahtjevu 12, naznačen time što je antagonist TNF-α etanercept ili Humira.
14. Pripravak s produljenim otpuštanjem za uporabu prema zahtjevu 13, naznačen time što je doza etanercepta 42.8 mg/ml do 50 mg/ml.
15. Pripravak s produljenim otpuštanjem za uporabu prema zahtjevu 12, naznačen time što je DMARD natrijev metotreksat.
16. Pripravak s produljenim otpuštanjem za uporabu prema zahtjevu 12, naznačen time što je doza metotreksata 2.3 do 2.5 mg/ml.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261668446P | 2012-07-05 | 2012-07-05 | |
| US201361791650P | 2013-03-15 | 2013-03-15 | |
| EP13813286.5A EP2854769B1 (en) | 2012-07-05 | 2013-07-05 | Methods of treating arthritis |
| PCT/US2013/049442 WO2014008469A2 (en) | 2012-07-05 | 2013-07-05 | Methods of treating arthritis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20230655T1 true HRP20230655T1 (hr) | 2023-10-13 |
Family
ID=49882628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20230655TT HRP20230655T1 (hr) | 2012-07-05 | 2013-07-05 | Metode liječenja artritisa |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US9789062B2 (hr) |
| EP (1) | EP2854769B1 (hr) |
| JP (2) | JP6535281B2 (hr) |
| KR (2) | KR102176971B1 (hr) |
| CN (1) | CN105377238B (hr) |
| AU (1) | AU2013286575B2 (hr) |
| BR (1) | BR112015000174A2 (hr) |
| CA (1) | CA2878152C (hr) |
| CY (1) | CY1126136T1 (hr) |
| DK (1) | DK2854769T3 (hr) |
| ES (1) | ES2949093T3 (hr) |
| FI (1) | FI2854769T3 (hr) |
| HK (1) | HK1219414A1 (hr) |
| HR (1) | HRP20230655T1 (hr) |
| HU (1) | HUE062466T2 (hr) |
| LT (1) | LT2854769T (hr) |
| NZ (1) | NZ703532A (hr) |
| PL (1) | PL2854769T3 (hr) |
| PT (1) | PT2854769T (hr) |
| RU (1) | RU2677658C2 (hr) |
| SG (2) | SG11201408810TA (hr) |
| SI (1) | SI2854769T1 (hr) |
| TW (1) | TWI556838B (hr) |
| WO (1) | WO2014008469A2 (hr) |
| ZA (1) | ZA201500152B (hr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012058483A1 (en) | 2010-10-28 | 2012-05-03 | Pacira Pharmaceuticals, Inc. | A sustained release formulation of a non-steroidal anti-inflammatory drug |
| EP3463304A4 (en) * | 2016-05-24 | 2020-01-08 | Bol Pharma Ltd. | COMPOSITIONS COMPRISING CANNABIDIOL AND HYALURONIC ACID FOR THE TREATMENT OF INFLAMMATORY JOINT DISEASES |
| US20190262363A1 (en) * | 2016-07-26 | 2019-08-29 | INSERM (Institut National de la Santé et de la Recherche Médicale | Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis |
| CN107670020B (zh) * | 2016-08-02 | 2020-09-18 | 富比积生物科技股份有限公司 | 四胜肽gekg在治疗退化性关节炎中的用途 |
| WO2018094253A1 (en) | 2016-11-18 | 2018-05-24 | Pacira Pharmaceuticals, Inc. | Zinc meloxicam complex microparticle multivesicular liposome formulations and processes for making the same |
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