HRP20220133T1 - Optimizirana anti-cd3 bispecifična antitijela i njihove upotrebe - Google Patents
Optimizirana anti-cd3 bispecifična antitijela i njihove upotrebe Download PDFInfo
- Publication number
- HRP20220133T1 HRP20220133T1 HRP20220133TT HRP20220133T HRP20220133T1 HR P20220133 T1 HRP20220133 T1 HR P20220133T1 HR P20220133T T HRP20220133T T HR P20220133TT HR P20220133 T HRP20220133 T HR P20220133T HR P20220133 T1 HRP20220133 T1 HR P20220133T1
- Authority
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- Croatia
- Prior art keywords
- bispecific antibody
- cancer
- antigen
- use according
- cytotoxic
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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Claims (15)
1. Citotoksično bispecifično antitijelo za upotrebu u liječenju raka kod subjekta, gdje se bispecifično antitijelo sastoji iz prvog kraka koji vezuje antigen koji očituje slabo do nedetektibilno vezivanje za humani CD3 i CD3 cinomolgusa, i drugog kraka koji vezuje antigen koji se veže za antigen koji je povezan sa tumorom, pri čemu se svaki od prvog kraka koji vezuje antigen i drugog kraka koji vezuje antigen sastoji iz teškog lanca i lakog lanca, pri čemu je laki lanac zajednički za oba, prvi krak koji vezuje antigen i drugi krak koji vezuje antigen, i pri čemu težak lanac prvog kraka koji vezuje antigen sadrži varijabilni dio teškog lanca (HCVR) koji se sastoji iz dijela koji određuju komplementarnost HCDR1, HCDR2 i HCDR3 koji se sastoje iz aminokiselinskih sekvenci, redom, SEQ ID NOs: 36, 38, i 40 SEQ ID NOs: 140, 142 i 144.
2. Citotoksično bispecifično antitijelo za upotrebu prema zahtjevu 1, pri čemu bispecifično antitijelo očituje aktivaciju T stanica in vitro.
3. Citotoksično bispecifično antitijelo za upotrebu prema zahtjevu 1 ili 2, pri čemu je antigen povezan sa tumorom izražen na humanoj tumorskoj stanici.
4. Citotoksično bispecifično antitijelo za upotrebu prema bilo kojem od zahtjeva 1-3, gdje bispecifično antitijelo inducira ubijanje tumorskih stanica posredstvom T stanica sa vrijednošću EC50 manjom od oko 1.3 nM, kao što je mjereno u in vitro testu ubijanja tumorskih stanica posredstvom T stanica.
5. Citotoksično bispecifično antitijelo za upotrebu prema bilo kojem od zahtjeva 1-4, pri čemu ciljna stanica tumora izražava antigen povezan sa tumorom izabran iz grupe koja se sastoji iz AFP, ALK, BAGE proteina, BIRC5 (survivin), BIRC7, β-katenina, brc-abl, BRCA1, BORIS, CA9, karbonatne dehidrataze IX, kaspaza-8, CALR, CCR5, CD19, CD20 (MS4A1), CD22, CD30, CD40, CDK4, CEA, CTLA4, ciklin-B1, CYP1B1, EGFR, EGFRvIII, ErbB2/Her2, ErbB3, ErbB4, ETV6-AML, EpCAM, EphA2, Fra-1, FOLR1, GAGE proteina (npr., GAGE-1, -2), GD2, GD3, GloboH, glipikan-3, GM3, gp100, Her2, HLA/B-raf, HLA/k-ras, HLA/MAGE-A3, hTERT, LMP2, MAGE proteina (npr., MAGE-1, -2, -3, -4, -6, i -12), MART-1, mezotelina, ML-IAP, Muc1, Muc2, Muc3, Muc4, Muc5, Muc16 (CA-125), MUM1, NA17, NY-BR1, NY-BR62, NY-BR85, NY-ESO1, OX40, p15, p53, PAP, PAX3, PAX5, PCTA-1, PLAC1, PRLR, PRAME, PSMA (FOLH1), RAGE proteina, Ras, RGS5, Rho, SART-1, SART-3, STEAP1, STEAP2, TAG-72, TGF-β, TMPRSS2, Thompson-nouvelle antigena (Tn), TRP-1, TRP-2, tirozinaze, i uroplakina-3.
6. Citotoksično bispecifično antitijelo za upotrebu prema bilo kojem od zahtjeva 1-5, pri čemu se laki lanac sastoji od varijabilnog dijela lakog lanca (LCVR) koji se sastoji od područja koji određuju komplementarnost LCDR1, LCDR2 i LCDR3 koji se sastoje iz aminokiselinskih sekvenci, redom, SEQ ID NOs: 164, 166 i 168.
7. Citotoksično bispecifično antitijelo za upotrebu prema zahtjevu 6, gdje LCVR sadrži aminokiselinsku sekvencu SEQ ID NO: 162.
8. Citotoksično bispecifično antitijelo za upotrebu prema bilo kojem od zahtjeva 1-5, pri čemu je laki lanac srodni laki lanac teškog lanca drugog kraka koji se vezuje za antigen koji vezuje antigen povezan sa tumorom.
9. Citotoksično bispecifično antitijelo za upotrebu prema zahtjevu 6, gdje prvi krak koji vezuje antigen sadrži područja koja određuju komplementarnost HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 i LCDR3 koji se sastoje iz aminokiselinskih sekvenci, redom, SEQ ID NOs: 36, 38, 40, 164, 166 i 168.
10. Citotoksično bispecifično antitijelo za upotrebu prema zahtjevu 6, gdje prvi krak koji vezuje antigen sadrži područja koja određuju komplementarnost HCDR1, HCDR2, HCDR3, LCDR1, LCDR2 i LCDR3 koji se sastoje iz aminokiselinskih sekvenci, redom, SEQ ID NOs: 140, 142, 144, 164, 166 i 168.
11. Citotoksično bispecifično antitijelo za upotrebu prema zahtjevu 7, gdje bispecifično antitijelo sadrži par HCVR i LCVR aminokiselinskih sekvenci (HCVR/LCVR) koje se sastoje iz aminokiselinskih sekvenci SEQ ID NOs: 34/162.
12. Citotoksično bispecifično antitijelo za upotrebu prema zahtjevu 7, gdje bispecifično antitijelo sadrži par HCVR and LCVR aminokiselinskih sekvenci (HCVR/LCVR) koje se sastoje iz aminokiselinskih sekvenci SEQ ID NOs: 138/162.
13. Farmaceutski sastav koji se sastoji iz (i) bispecifičnog antitijela prema bilo kojem od zahtjeva 1-12, i (ii) farmaceutski prihvatljivog nosača ili razblaživača.
14. Farmaceutski sastav prema zahtjevu 13 za upotrebu u postupku liječenja raka kod subjekta, postupak obuhvaća davanje subjektu farmaceutskog sastava.
15. Farmaceutski sastav za upotrebu prema zahtjevu 14, pri čemu je rak izabran iz grupe koja se sastoji iz: raka gušterače, melanoma, glioblastoma, raka glave i vrata, raka prostate, malignih glioma, osteosarkoma, kolorektalnog raka, raka želuca, malignog mezotelioma, multiplog mijeloma, raka jajnika, raka malih stanica pluća, raka ne-malih stanica pluća, sinovijalnog sarkoma, raka tireoidee, raka dojke, melanoma glioma, raka dojke, raka skvamoznih stanica, raka jednjaka, raka bubrežnih bistrih stanica, kromofobnog raka stanica bubrega, onkocitoma bubrega, prijelaznog raka stanica bubrega, urotelnog karcinoma, adenokarcinoma, ili karcinoma malih stanica, opcionalno kada je subjekt pogođen sa tumorom koji je otporan na, ili nepotpuno reagira samo na monspecifičnu terapiju.
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Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| DK3221359T3 (da) | 2014-11-17 | 2020-06-22 | Regeneron Pharma | Fremgangsmåder til tumorbehandling ved anvendelse af CD3XCD20-bispecifikt antistof |
| EP3277725B1 (en) | 2015-03-30 | 2020-11-25 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| CA2987403A1 (en) * | 2015-05-28 | 2016-12-01 | Genentech, Inc. | Cell-based assay for detecting anti-cd3 homodimers |
| TW202330904A (zh) | 2015-08-04 | 2023-08-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| MX2018012868A (es) | 2016-04-20 | 2019-03-11 | Regeneron Pharma | Composiciones y metodos para generar anticuerpos basado en el uso de loci potenciadores de expresion. |
| TW201803981A (zh) | 2016-04-20 | 2018-02-01 | 再生元醫藥公司 | 用於以使用增強表現基因座爲基礎製造抗體之組成物及方法 |
| MD3515487T2 (ro) | 2016-09-23 | 2023-11-30 | Regeneron Pharma | Anticorpi bispecifici anti-MUC16-CD3 și conjugate anticorp anti-MUC16-medicament |
| EP3409322A1 (en) | 2017-06-01 | 2018-12-05 | F. Hoffmann-La Roche AG | Treatment method |
| WO2018237364A1 (en) * | 2017-06-22 | 2018-12-27 | Development Center For Biotechnology | BISPECIFIC ANTI-GLOBO H ANTIBODY AND ANTI-CD3 FUSION FC-SCFV ASYMMETRIC HETERODIMER AND ASSOCIATED USES IN ANTICANCER THERAPY |
| EA039842B1 (ru) * | 2017-09-14 | 2022-03-18 | Ридженерон Фармасьютикалз, Инк. | Биспецифичные анти-muc16-cd3 антитела и конъюгаты анти-muc16-лекарственное средство |
| SG11202001160XA (en) * | 2017-09-29 | 2020-03-30 | Regeneron Pharma | Bispecific antigen-binding molecules that bind a staphylococcus target antigen and a complement component and uses thereof |
| SG11202006042SA (en) * | 2017-12-27 | 2020-07-29 | Teneobio Inc | Cd3-delta/epsilon heterodimer specific antibodies |
| TW202005985A (zh) * | 2018-06-21 | 2020-02-01 | 美商再生元醫藥公司 | 用雙特異性抗ＣＤ３ｘＭＵＣ１６抗體及抗ＰＤ－１抗體治療癌症的方法 |
| MX2020013804A (es) | 2018-06-21 | 2021-03-31 | Regeneron Pharma | Anticuerpos anti-psma x anti-cd28 biespecíficos y usos de estos. |
| WO2020010079A2 (en) | 2018-07-02 | 2020-01-09 | Amgen Inc. | Anti-steap1 antigen-binding protein |
| MX2021000488A (es) | 2018-07-19 | 2021-04-12 | Regeneron Pharma | Anticuerpos anti-bcma x anti-cd3 biespecificos y usos de estos. |
| BR112021003023A2 (pt) | 2018-08-23 | 2021-05-11 | Regeneron Pharmaceuticals, Inc. | anticorpos anti-fc epsilon-r1 alfa (fcer1a), moléculas biespecíficas de ligação ao antígeno que ligam fcer1a e cd3, e usos dos mesmos |
| AU2019331024A1 (en) | 2018-08-31 | 2021-03-18 | Regeneron Pharmaceuticals, Inc. | Dosing strategy that mitigates cytokine release syndrome for CD3/C20 bispecific antibodies |
| JP2022504822A (ja) | 2018-10-11 | 2022-01-13 | インヒブルクス インコーポレイテッド | Ｄｌｌ３シングルドメイン抗体およびその治療用組成物 |
| EP3864044A1 (en) | 2018-10-11 | 2021-08-18 | Inhibrx, Inc. | B7h3 single domain antibodies and therapeutic compositions thereof |
| CN113518647A (zh) | 2018-10-11 | 2021-10-19 | 印希比股份有限公司 | 5t4单域抗体及其治疗性组合物 |
| JP7453219B2 (ja) | 2018-10-11 | 2024-03-19 | インヒブリックス， インコーポレイテッド | Ｐｄ－１単一ドメイン抗体およびその治療用組成物 |
| KR20210099614A (ko) * | 2018-12-04 | 2021-08-12 | 노파르티스 아게 | Cd3에 대한 결합 분자 및 이의 용도 |
| CN112955471B (zh) * | 2018-12-07 | 2022-11-22 | 江苏恒瑞医药股份有限公司 | Cd3抗体及其药物用途 |
| JP2022515611A (ja) | 2018-12-19 | 2022-02-21 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 二重特異性抗ｍｕｃ１６×抗ｃｄ２８抗体およびその使用 |
| CN113164598A (zh) | 2018-12-19 | 2021-07-23 | 里珍纳龙药品有限公司 | 双特异性抗cd28 x抗cd22抗体以及其用途 |
| US11912767B2 (en) | 2019-03-22 | 2024-02-27 | Regeneron Pharmaceuticals, Inc. | EGFR × CD28 multispecific antibodies |
| WO2020257681A1 (en) * | 2019-06-21 | 2020-12-24 | Regeneron Pharmaceuticals, Inc. | Use of bispecific antigen-binding molecules that bind psma and cd3 in combination with 4-1bb co-stimulation |
| EP3998081A4 (en) | 2019-07-05 | 2023-07-12 | Ono Pharmaceutical Co., Ltd. | TREATMENT OF BLOOD CANCER WITH PD-1/CD3 DUAL SPECIFICITY PROTEIN |
| AU2020330063A1 (en) | 2019-08-15 | 2022-03-24 | Regeneron Pharmaceuticals, Inc. | Multispecific antigen-binding molecules for cell targeting and uses thereof |
| CN110551222B (zh) * | 2019-08-27 | 2023-06-06 | 重庆市畜牧科学院 | 一种新型双功能抗体及其用途 |
| CN114929343A (zh) * | 2019-12-06 | 2022-08-19 | 瑞泽恩制药公司 | 用双特异性抗BCMA x抗CD3抗体治疗多发性骨髓瘤的方法 |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| JP2023542257A (ja) | 2020-09-16 | 2023-10-05 | アムジェン インコーポレイテッド | 癌の治療のために二重特異性ｔ細胞誘導分子の治療用量を投与する方法 |
| JP2024506831A (ja) | 2021-01-28 | 2024-02-15 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | サイトカイン放出症候群を治療するための組成物及び方法 |
| TW202309071A (zh) | 2021-05-05 | 2023-03-01 | 德商英麥提克生物技術股份有限公司 | 特異性結合ｐｒａｍｅ之抗原結合蛋白 |
| WO2023097219A2 (en) * | 2021-11-24 | 2023-06-01 | Adimab, Llc | Anti-idiotype antibodies |
| TW202346337A (zh) | 2022-03-29 | 2023-12-01 | 美商恩格姆生物製藥公司 | Ilt3及cd3結合劑以及其使用方法 |
| US20230357446A1 (en) | 2022-04-11 | 2023-11-09 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for universal tumor cell killing |
| CN114685675B (zh) * | 2022-04-27 | 2023-02-03 | 深圳市汉科生物工程有限公司 | 双特异性抗体及其在治疗癌症中的用途 |
| WO2024012513A1 (en) * | 2022-07-13 | 2024-01-18 | Hansoh Bio Llc | Antibody, antigen-binding fragment thereof, and pharmaceutical use thereof |
| WO2024077044A1 (en) | 2022-10-05 | 2024-04-11 | Amgen Inc. | Combination therapies comprising t-cell redirecting therapies and agonistic anti-il-2r antibodies or fragments thereof |
| WO2024081180A1 (en) | 2022-10-10 | 2024-04-18 | Regeneron Pharmaceuticals, Inc. | Methods for reducing alloantibody levels in subjects in need of solid organ transplantation |
| WO2024088987A1 (en) | 2022-10-26 | 2024-05-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| JP2005510470A (ja) * | 2001-09-28 | 2005-04-21 | エリューシス セラピューティクス，インコーポレーテッド | 二重特異性分子を用いた癌の予防、診断、および治療の方法ならびに組成物 |
| US7820166B2 (en) | 2002-10-11 | 2010-10-26 | Micromet Ag | Potent T cell modulating molecules |
| CA2523716C (en) | 2003-05-31 | 2014-11-25 | Micromet Ag | Human anti-human cd3 binding molecules |
| US7850962B2 (en) | 2004-04-20 | 2010-12-14 | Genmab A/S | Human monoclonal antibodies against CD20 |
| CN102875681A (zh) | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
| RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
| US20110313134A1 (en) * | 2008-11-06 | 2011-12-22 | Alexion Pharmaceuticals, Inc. | Engineered antibodies with reduced immunogenicity and methods of making |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| EP2496600A1 (en) | 2009-11-04 | 2012-09-12 | Fabrus LLC | Methods for affinity maturation-based antibody optimization |
| US10143186B2 (en) | 2010-02-08 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
| EP3042917B1 (en) | 2010-08-12 | 2018-02-21 | Eli Lilly and Company | Anti-n3pglu amyloid beta peptide antibodies and uses thereof |
| JP6159724B2 (ja) | 2011-08-23 | 2017-07-05 | ロシュ グリクアート アーゲー | Ｔ細胞活性化抗原に対して特異的な二重特異性抗体及び腫瘍抗原および使用方法 |
| WO2013157105A1 (ja) | 2012-04-18 | 2013-10-24 | 公立大学法人大阪市立大学 | ムチンサブタイプ５ａｃ特異的ヒト化抗体およびその利用 |
| CN104582476B (zh) * | 2012-06-05 | 2017-03-08 | 瑞泽恩制药公司 | 使用共同轻链制备完全人双特异性抗体的方法 |
| JOP20200236A1 (ar) * | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| PL2900694T3 (pl) | 2012-09-27 | 2018-12-31 | Merus N.V. | Dwuswoiste przeciwciała igg jako aktywatory komórek t |
| CA2879768A1 (en) | 2012-10-08 | 2014-04-17 | Roche Glycart Ag | Fc-free antibodies comprising two fab-fragments and methods of use |
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| EP3083696B1 (en) * | 2013-12-20 | 2018-02-14 | F.Hoffmann-La Roche Ag | Bispecific her2 antibodies and methods of use |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| JOP20160154B1 (ar) * | 2015-07-31 | 2021-08-17 | Regeneron Pharma | أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها |
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