HRP20201432T1 - Il-17a sredstvo za vezivanje i njegove uporabe - Google Patents
Il-17a sredstvo za vezivanje i njegove uporabe Download PDFInfo
- Publication number
- HRP20201432T1 HRP20201432T1 HRP20201432TT HRP20201432T HRP20201432T1 HR P20201432 T1 HRP20201432 T1 HR P20201432T1 HR P20201432T T HRP20201432T T HR P20201432TT HR P20201432 T HRP20201432 T HR P20201432T HR P20201432 T1 HRP20201432 T1 HR P20201432T1
- Authority
- HR
- Croatia
- Prior art keywords
- seq
- antibody
- antigen
- binding
- binding fragment
- Prior art date
Links
- 239000011230 binding agent Substances 0.000 title 1
- 102000013691 Interleukin-17 Human genes 0.000 claims 8
- 108050003558 Interleukin-17 Proteins 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Plant Pathology (AREA)
- Physical Education & Sports Medicine (AREA)
Claims (7)
1. Protutijelo koje veže IL-17A ili njegov fragment koji veže antigen, koje sadrži:
varijabilna regija lakog lanca protutijela, koji sadrži LCDR1, LCDR2 i LCDR3 kao što je prikazano u SEQ ID NO: 13, SEQ ID NO: 14, i SEQ ID NO: 15 odnosno; i
varijabilna regija teškog lanca protutijela, koja sadrži HCDR1, HCDR2 i HCDR3 kao što je prikazano u SEQ ID NO: 10, SEQ ID NO: 11, i SEQ ID NO: 12, odnosno;
naznačeno time da je varijabilna regija teškog lanca protutijela odabrana od varijabilne regije teškog lanca prikazane u SEQ ID NO: 5, SEQ ID NO: 6 i SEQ ID NO: 7;
i naznačeno time da varijabilna regija lakog lanca protutijela je odabrana između varijabilne regije lakog lanca u SEQ ID NO: 9.
2. Protutijelo koje veže IL-17A ili njegov fragment koji veže antigen sukladno patentnom zahtjevu 1, koje dodatno sadrži konstantnu regiju lakog lanca izvedena iz ljudskog κ lanca, ili konstantnu regiju lakog lanca izvedena iz ljudskog λ lanca.
3. Protutijelo koje veže IL-17A ili njegov fragment koji veže antigen sukladno patentnom zahtjevu 1 ili 2, koje dodatno sadrži konstantnu regiju lakog lanca izvedenu iz ljudskog IgG1, konstantnu regiju teškog lanca izvedenu iz ljudskog IgG2, konstantnu regiju teškog lanca izvedenu iz ljudskog IgG3, ili konstantnu regiju teškog lanca izvedenu iz ljudskog IgG4.
4. Vektor s ekspresijom IL-17A vezivno protutijelo ili fragment koji se veže na n-vezujući fragment sukladno bilo kojem od prethodnih patentnih zahtjeva.
5. Vektor sukladno patentnom zahtjevu 4, koji sadrži nukleotid koji kodira IL-17A vezujuće protutijelo ili njegov antigen-vezujući fragment sukladno bilo kojem od prethodnih patentnih zahtjeva.
6. Farmaceutska kompozicija, koja sadrži: IL-17A vezujuće protutijelo ili njegov antigen-vezujući fragment sukladno bilo kojem od prethodnih patentnih zahtjeva 1-3; i farmaceutski prihvatljiv ekscipijens, otapalo ili nosač.
7. Protutijelo koje veže IL-17A ili njegov fragment koji veže antigen sukladno bilo kojem od zahtjeva 1-3, ili farmaceutski pripravak prema zahtjevu 6, naznačeno time, da se koristi u liječenju IL-17 uzrokovanih upalnih ili autoimunih bolesti; pri čemu se bolest bira između psorijaze, psorijatičnog artritisa, ankilozirajućeg spondilitisa, multiple skleroze ili upalnog artritisa.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310580942 | 2013-11-18 | ||
| PCT/CN2014/089542 WO2015070697A1 (zh) | 2013-11-18 | 2014-10-27 | Il-17a结合物及其用途 |
| EP14862443.0A EP3072905B1 (en) | 2013-11-18 | 2014-10-27 | Il-17a binding agent and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201432T1 true HRP20201432T1 (hr) | 2020-12-11 |
Family
ID=53056748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201432TT HRP20201432T1 (hr) | 2013-11-18 | 2020-09-08 | Il-17a sredstvo za vezivanje i njegove uporabe |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9862765B2 (hr) |
| EP (2) | EP3670533A1 (hr) |
| JP (1) | JP6513657B2 (hr) |
| KR (1) | KR102278487B1 (hr) |
| CN (1) | CN104936981B (hr) |
| AU (1) | AU2014350758B2 (hr) |
| CA (1) | CA2929662C (hr) |
| CY (1) | CY1123493T1 (hr) |
| ES (1) | ES2818074T3 (hr) |
| HK (1) | HK1212993A1 (hr) |
| HR (1) | HRP20201432T1 (hr) |
| HU (1) | HUE052184T2 (hr) |
| LT (1) | LT3072905T (hr) |
| MX (1) | MX2016006101A (hr) |
| PL (1) | PL3072905T3 (hr) |
| PT (1) | PT3072905T (hr) |
| RS (1) | RS61034B1 (hr) |
| RU (1) | RU2682046C1 (hr) |
| SI (1) | SI3072905T1 (hr) |
| TW (1) | TWI674273B (hr) |
| WO (1) | WO2015070697A1 (hr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106336459B (zh) * | 2015-07-13 | 2020-12-08 | 三生国健药业（上海）股份有限公司 | 抗人白细胞介素-17a单克隆抗体、其制备方法和应用 |
| CN106474470B (zh) * | 2015-08-28 | 2020-05-22 | 江苏恒瑞医药股份有限公司 | 一种抗il-17a抗体的组合物 |
| CN107236041B (zh) * | 2016-03-29 | 2020-07-24 | 舒泰神（北京）生物制药股份有限公司 | Il-17抗体 |
| CN107488227A (zh) * | 2016-06-12 | 2017-12-19 | 三生国健药业（上海）股份有限公司 | 抗人白细胞介素‑17a单克隆抗体、其制备方法和应用 |
| US11072651B2 (en) * | 2016-09-14 | 2021-07-27 | Beijing Hanmi Pharm. Co., Ltd. | Antibody specifically binding to IL-17A, encoding nucleic acid, and method of using the antibody |
| CN108359011B (zh) | 2017-07-21 | 2019-06-25 | 华博生物医药技术（上海）有限公司 | 靶向于白介素17a的抗体、其制备方法和应用 |
| CN107522783B (zh) * | 2017-09-30 | 2020-07-07 | 华博生物医药技术（上海）有限公司 | 一种抗白介素17a的抗体、其制备方法和应用 |
| KR102048475B1 (ko) * | 2017-11-10 | 2019-11-26 | 주식회사 와이바이오로직스 | IL-17A (Interleukin-17A)에 특이적으로 결합하는 항체 및 이의 용도 |
| EP3689907A1 (en) | 2019-01-31 | 2020-08-05 | Numab Therapeutics AG | Antibodies targeting il-17a and methods of use thereof |
| JP2022523908A (ja) | 2019-01-31 | 2022-04-27 | ヌマブ セラピューティクス アクチェンゲゼルシャフト | ＴＮＦα及びＩＬ－１７Ａに対する特異性を有する多重特異性抗体、ＩＬ－１７Ａを標的とする抗体、及びそれらの使用方法 |
| EP4006053A4 (en) * | 2019-07-30 | 2022-10-26 | Jiangsu Hengrui Medicine Co., Ltd. | METHOD OF TREATMENT OF AUTOIMMUNE DISEASE BY IL-17 ANTAGONISTS |
| WO2022144023A1 (zh) * | 2021-01-04 | 2022-07-07 | 江苏恒瑞医药股份有限公司 | 抗il-17抗体治疗自身免疫性疾病和炎症的方法 |
| TW202246329A (zh) * | 2021-03-03 | 2022-12-01 | 大陸商蘇州盛迪亞生物醫藥有限公司 | 抗il-17抗體治療自體免疫性疾病和炎症的方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6309636B1 (en) * | 1995-09-14 | 2001-10-30 | Cancer Research Institute Of Contra Costa | Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides |
| GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
| HUE039353T2 (hu) * | 2005-12-13 | 2018-12-28 | Lilly Co Eli | Anti-IL-17 ellenanyagok |
| MX2009001620A (es) | 2006-08-11 | 2009-02-23 | Schering Corp | Anticuerpos para il-17a. |
| GB0620729D0 (en) * | 2006-10-18 | 2006-11-29 | Ucb Sa | Biological products |
| EP2142568B1 (en) * | 2007-04-27 | 2014-03-19 | ZymoGenetics, Inc. | Antibodies that bind both il-17a and il-17f and methods of using the same |
| WO2008156709A1 (en) * | 2007-06-13 | 2008-12-24 | Amgen Inc. | Il-17 heteromeric receptor complex |
| WO2009082624A2 (en) * | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
| EP2288382B1 (en) * | 2008-05-05 | 2018-08-29 | NovImmune SA | Anti- il-17a/il-17f cross-reactive antibodies and methods of use thereof |
| CN102617735B (zh) * | 2008-09-29 | 2015-09-09 | 罗氏格黎卡特股份公司 | 针对人il17的抗体及其应用 |
| PE20160651A1 (es) * | 2009-03-05 | 2016-07-24 | Abbvie Inc | Proteinas de union a il-17 |
| BR112012010280B1 (pt) * | 2009-10-30 | 2020-09-24 | Janssen Biotech, Inc. | Anticorpo isolado ou fragmento do mesmo que se liga especificamente a il-17a humana, seu uso, e composição farmacêutica |
| ME02734B (me) * | 2011-01-14 | 2017-10-20 | Ucb Biopharma Sprl | Antitelo koje vezuje il-17a i il-17f |
| BR112014009810A2 (pt) * | 2011-10-24 | 2017-04-25 | Abbvie Inc | imunoligantes biespecíficos dirigidos contra tnf e il-17 |
-
2014
- 2014-10-27 PT PT148624430T patent/PT3072905T/pt unknown
- 2014-10-27 LT LTEP14862443.0T patent/LT3072905T/lt unknown
- 2014-10-27 RU RU2016122340A patent/RU2682046C1/ru active
- 2014-10-27 US US15/035,550 patent/US9862765B2/en active Active
- 2014-10-27 CN CN201480003663.7A patent/CN104936981B/zh active Active
- 2014-10-27 SI SI201431656T patent/SI3072905T1/sl unknown
- 2014-10-27 WO PCT/CN2014/089542 patent/WO2015070697A1/zh active Application Filing
- 2014-10-27 JP JP2016528824A patent/JP6513657B2/ja active Active
- 2014-10-27 KR KR1020167014455A patent/KR102278487B1/ko active IP Right Grant
- 2014-10-27 CA CA2929662A patent/CA2929662C/en active Active
- 2014-10-27 MX MX2016006101A patent/MX2016006101A/es active IP Right Grant
- 2014-10-27 PL PL14862443T patent/PL3072905T3/pl unknown
- 2014-10-27 EP EP20151513.7A patent/EP3670533A1/en active Pending
- 2014-10-27 HU HUE14862443A patent/HUE052184T2/hu unknown
- 2014-10-27 ES ES14862443T patent/ES2818074T3/es active Active
- 2014-10-27 AU AU2014350758A patent/AU2014350758B2/en active Active
- 2014-10-27 EP EP14862443.0A patent/EP3072905B1/en active Active
- 2014-10-27 RS RS20201086A patent/RS61034B1/sr unknown
- 2014-11-14 TW TW103139516A patent/TWI674273B/zh active
-
2016
- 2016-01-22 HK HK16100774.4A patent/HK1212993A1/zh unknown
-
2020
- 2020-09-08 HR HRP20201432TT patent/HRP20201432T1/hr unknown
- 2020-09-09 CY CY20201100852T patent/CY1123493T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS61034B1 (sr) | 2020-12-31 |
| RU2682046C1 (ru) | 2019-03-14 |
| MX2016006101A (es) | 2016-07-21 |
| RU2016122340A (ru) | 2017-12-26 |
| KR102278487B1 (ko) | 2021-07-19 |
| AU2014350758A1 (en) | 2016-06-30 |
| WO2015070697A1 (zh) | 2015-05-21 |
| BR112016009948A2 (pt) | 2017-12-05 |
| SI3072905T1 (sl) | 2020-12-31 |
| CN104936981A (zh) | 2015-09-23 |
| TW201520228A (zh) | 2015-06-01 |
| CA2929662A1 (en) | 2015-05-21 |
| EP3670533A1 (en) | 2020-06-24 |
| TWI674273B (zh) | 2019-10-11 |
| HK1212993A1 (zh) | 2016-06-24 |
| PT3072905T (pt) | 2020-09-17 |
| CY1123493T1 (el) | 2022-03-24 |
| CN104936981B (zh) | 2018-02-27 |
| JP6513657B2 (ja) | 2019-05-15 |
| EP3072905A1 (en) | 2016-09-28 |
| PL3072905T3 (pl) | 2021-03-08 |
| JP2017502924A (ja) | 2017-01-26 |
| CA2929662C (en) | 2023-05-02 |
| EP3072905A4 (en) | 2017-06-28 |
| HUE052184T2 (hu) | 2021-12-28 |
| ES2818074T3 (es) | 2021-04-09 |
| AU2014350758B2 (en) | 2019-07-25 |
| LT3072905T (lt) | 2020-12-10 |
| EP3072905B1 (en) | 2020-08-19 |
| US20160289321A1 (en) | 2016-10-06 |
| US9862765B2 (en) | 2018-01-09 |
| KR20160085793A (ko) | 2016-07-18 |
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