HRP20192302T1 - Amorfni lerkanidipin hidroklorid - Google Patents
Amorfni lerkanidipin hidroklorid Download PDFInfo
- Publication number
- HRP20192302T1 HRP20192302T1 HRP20192302TT HRP20192302T HRP20192302T1 HR P20192302 T1 HRP20192302 T1 HR P20192302T1 HR P20192302T T HRP20192302T T HR P20192302TT HR P20192302 T HRP20192302 T HR P20192302T HR P20192302 T1 HRP20192302 T1 HR P20192302T1
- Authority
- HR
- Croatia
- Prior art keywords
- lercanidipine hydrochloride
- amorphous lercanidipine
- amorphous
- determined
- hydrochloride
- Prior art date
Links
- WMFYOYKPJLRMJI-UHFFFAOYSA-N Lercanidipine hydrochloride Chemical compound Cl.COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 WMFYOYKPJLRMJI-UHFFFAOYSA-N 0.000 title claims 5
- 229960002162 lercanidipine hydrochloride Drugs 0.000 title claims 5
- 206010020772 Hypertension Diseases 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 238000002356 laser light scattering Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
- C07B63/04—Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
Claims (3)
1. Amorfni lerkanidipin hidroklorid ima čistoću od najmanje 99,5% utvrđenu HPLC analizom i koji sadrži manje od 0,5% kristalnog lerkanidipin hidroklorida.
2. Amorfni lerkanidipin hidroklorid prema zahtjevu 1, koji je mikroniziran na veličinu čestica D (90%) <15 µm, što je utvrđeno laserskim raspršivanjem svjetlosti.
3. Amorfni lerkanidipin hidroklorid definiran u zahtjevu 1 ili 2 za uporabu u liječenju hipertenzije.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65683605P | 2005-02-25 | 2005-02-25 | |
| EP06723128.2A EP1856051B1 (en) | 2005-02-25 | 2006-02-24 | Amorphous lercanidipine hydrochloride |
| PCT/EP2006/001782 WO2006089787A1 (en) | 2005-02-25 | 2006-02-24 | Amorphous lercanidipine hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20192302T1 true HRP20192302T1 (hr) | 2020-03-06 |
Family
ID=36585434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20192302TT HRP20192302T1 (hr) | 2005-02-25 | 2019-12-20 | Amorfni lerkanidipin hidroklorid |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7820701B2 (hr) |
| EP (1) | EP1856051B1 (hr) |
| JP (1) | JP2008531515A (hr) |
| KR (1) | KR20070105979A (hr) |
| CN (1) | CN101124204A (hr) |
| AR (1) | AR052918A1 (hr) |
| AU (1) | AU2006218026B9 (hr) |
| BR (1) | BRPI0608138A2 (hr) |
| CA (1) | CA2598016A1 (hr) |
| CY (1) | CY1122429T1 (hr) |
| DK (1) | DK1856051T3 (hr) |
| EA (1) | EA014383B1 (hr) |
| ES (1) | ES2339213T3 (hr) |
| HR (1) | HRP20192302T1 (hr) |
| HU (1) | HUE046910T2 (hr) |
| IL (1) | IL184349A0 (hr) |
| LT (1) | LT1856051T (hr) |
| ME (1) | ME03659B (hr) |
| MX (1) | MX2007010093A (hr) |
| MY (1) | MY142129A (hr) |
| NO (1) | NO344559B1 (hr) |
| NZ (1) | NZ556667A (hr) |
| PE (1) | PE20061014A1 (hr) |
| PL (1) | PL1856051T3 (hr) |
| PT (1) | PT1856051T (hr) |
| RS (1) | RS59654B1 (hr) |
| SI (1) | SI1856051T1 (hr) |
| TW (1) | TW200640861A (hr) |
| UA (1) | UA90130C2 (hr) |
| UY (1) | UY29401A1 (hr) |
| WO (1) | WO2006089787A1 (hr) |
| ZA (1) | ZA200708127B (hr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE427352T1 (de) * | 2002-07-26 | 2009-04-15 | Novartis Vaccines & Diagnostic | Modifizierte kleine irns molekule und methoden zu deren anwendung |
| AR052918A1 (es) | 2005-02-25 | 2007-04-11 | Recordati Ireland Ltd | Clorhidrato de lercanidipina amorfo |
| US8097729B2 (en) | 2005-09-16 | 2012-01-17 | Glenmark Generics Ltd. | Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof |
| WO2008015248A1 (en) * | 2006-08-04 | 2008-02-07 | Recordati Ireland Limited | Process for preparing amorphous lercanidipine hydrochloride |
| EP2101771A2 (en) * | 2006-12-06 | 2009-09-23 | Torrent Pharmaceuticals Ltd | Stable lercanidipine formulation |
| WO2008107797A2 (en) * | 2007-03-05 | 2008-09-12 | Actavis Group Ptc Ehf | Lercanidipine hydrochloride polymorphs and an improved process for preparation of 1,1,n-trimethyl-n-(3,3-diphenylpropyl)-2-aminoethyl acetoacetate |
| DK2429529T3 (en) * | 2009-05-12 | 2015-03-09 | Corcept Therapeutics Inc | The solid forms and process for preparing |
| DE102010005124A1 (de) * | 2010-01-19 | 2012-03-01 | Stada Arzneimittel Ag | Feste pharmazeutische Zusammensetzung umfassend Lercanidipin |
| EP2444394A1 (en) | 2010-10-21 | 2012-04-25 | Alembic Pharmaceuticals Limited | Process for the preparation of amorphous form of lercanidipine HCI |
| CN102558032B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 一种无定形盐酸乐卡地平及其制备方法 |
| CN102531999B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 无定形盐酸乐卡地平及其制备方法 |
| CN102600146B (zh) * | 2012-04-11 | 2014-10-08 | 兆科药业（合肥）有限公司 | 一种盐酸乐卡地平和氯沙坦钾复方制剂及其制备方法 |
| IN2013MU02828A (hr) * | 2013-08-29 | 2015-07-03 | Cadila Healthcare Ltd |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8403866D0 (en) * | 1984-02-14 | 1984-03-21 | Recordati Chem Pharm | Diphenylalkylaminoalkyl esters |
| US5696139A (en) | 1995-05-12 | 1997-12-09 | Recordati S.A., Chemical And Pharmaceutical Company | Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure |
| IT1274480B (it) | 1995-05-12 | 1997-07-17 | Recordati Chem Pharm | Procedimento migliorato per la preparazione della lercanidipina cloridrato |
| US5912351A (en) | 1995-05-12 | 1999-06-15 | Recordati, S.A. Chemical And Pharmaceutical Company | Anhydrous 1,4-Dihydropyridines and salts thereof |
| US20030069285A1 (en) | 2001-08-06 | 2003-04-10 | Recordati Ireland Limited | Novel solvate and crystalline forms of lercanidipine hydrochloride |
| US6852737B2 (en) | 2001-08-06 | 2005-02-08 | Recordati Ireland Limited | Crude and crystalline forms of lercanidipine hydrochloride |
| ITMI20011727A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Solvati della lercanidipina cloridrato e nuove forme cristalline della lercanidipina cloridrato ottenute da essi |
| ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
| US20030180355A1 (en) | 2001-10-16 | 2003-09-25 | Amedeo Leonardi | Combination therapy for hypertension |
| JP4749660B2 (ja) * | 2002-10-16 | 2011-08-17 | 武田薬品工業株式会社 | 安定な固形製剤 |
| US20040147566A1 (en) | 2002-10-16 | 2004-07-29 | Amedeo Leonardi | Lisinopril/lercanidipine combination therapy |
| US20040198789A1 (en) | 2003-02-28 | 2004-10-07 | Recordati Ireland Limited | Lercanidipine/ARB/diuretic therapeutic combinations |
| TW200613275A (en) | 2004-08-24 | 2006-05-01 | Recordati Ireland Ltd | Lercanidipine salts |
| TW200616681A (en) | 2004-10-05 | 2006-06-01 | Recordati Ireland Ltd | Lercanidipine capsules |
| KR100651212B1 (ko) | 2004-10-27 | 2006-12-01 | 제일약품주식회사 | 무정형 레르카니디핀의 제조방법 |
| AR052918A1 (es) | 2005-02-25 | 2007-04-11 | Recordati Ireland Ltd | Clorhidrato de lercanidipina amorfo |
| US8097729B2 (en) | 2005-09-16 | 2012-01-17 | Glenmark Generics Ltd. | Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof |
| EP1963254A2 (en) | 2005-09-21 | 2008-09-03 | Torrent Pharmaceuticals Ltd | Process for the preparation of lercanidipine and amorphous form of lercanidipine hydrochloride |
| WO2008015248A1 (en) | 2006-08-04 | 2008-02-07 | Recordati Ireland Limited | Process for preparing amorphous lercanidipine hydrochloride |
-
2006
- 2006-02-22 AR ARP060100641A patent/AR052918A1/es not_active Application Discontinuation
- 2006-02-24 AU AU2006218026A patent/AU2006218026B9/en not_active Ceased
- 2006-02-24 UY UY29401A patent/UY29401A1/es not_active Application Discontinuation
- 2006-02-24 PT PT67231282T patent/PT1856051T/pt unknown
- 2006-02-24 DK DK06723128.2T patent/DK1856051T3/da active
- 2006-02-24 SI SI200632364T patent/SI1856051T1/sl unknown
- 2006-02-24 KR KR1020077017758A patent/KR20070105979A/ko not_active Application Discontinuation
- 2006-02-24 JP JP2007556565A patent/JP2008531515A/ja active Pending
- 2006-02-24 PE PE2006000224A patent/PE20061014A1/es active IP Right Grant
- 2006-02-24 NZ NZ556667A patent/NZ556667A/en not_active IP Right Cessation
- 2006-02-24 ES ES06723128T patent/ES2339213T3/es active Active
- 2006-02-24 PL PL06723128T patent/PL1856051T3/pl unknown
- 2006-02-24 RS RS20191591A patent/RS59654B1/sr unknown
- 2006-02-24 MY MYPI20060808A patent/MY142129A/en unknown
- 2006-02-24 CN CNA2006800054950A patent/CN101124204A/zh active Pending
- 2006-02-24 WO PCT/EP2006/001782 patent/WO2006089787A1/en active Application Filing
- 2006-02-24 UA UAA200709786A patent/UA90130C2/ru unknown
- 2006-02-24 TW TW095106337A patent/TW200640861A/zh unknown
- 2006-02-24 EA EA200701687A patent/EA014383B1/ru unknown
- 2006-02-24 ME MEP-2019-352A patent/ME03659B/me unknown
- 2006-02-24 BR BRPI0608138-0A patent/BRPI0608138A2/pt not_active Application Discontinuation
- 2006-02-24 MX MX2007010093A patent/MX2007010093A/es not_active Application Discontinuation
- 2006-02-24 CA CA002598016A patent/CA2598016A1/en not_active Abandoned
- 2006-02-24 LT LTEP06723128.2T patent/LT1856051T/lt unknown
- 2006-02-24 HU HUE06723128A patent/HUE046910T2/hu unknown
- 2006-02-24 EP EP06723128.2A patent/EP1856051B1/en not_active Revoked
- 2006-02-27 US US11/364,862 patent/US7820701B2/en active Active
-
2007
- 2007-07-02 IL IL184349A patent/IL184349A0/en active IP Right Grant
- 2007-09-21 ZA ZA200708127A patent/ZA200708127B/xx unknown
- 2007-09-25 NO NO20074874A patent/NO344559B1/no not_active IP Right Cessation
-
2019
- 2019-12-18 CY CY20191101332T patent/CY1122429T1/el unknown
- 2019-12-20 HR HRP20192302TT patent/HRP20192302T1/hr unknown
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