HRP20192006T1 - Antitijela specifična za fcrn - Google Patents
Antitijela specifična za fcrn Download PDFInfo
- Publication number
- HRP20192006T1 HRP20192006T1 HRP20192006TT HRP20192006T HRP20192006T1 HR P20192006 T1 HRP20192006 T1 HR P20192006T1 HR P20192006T T HRP20192006T T HR P20192006TT HR P20192006 T HRP20192006 T HR P20192006T HR P20192006 T1 HRP20192006 T1 HR P20192006T1
- Authority
- HR
- Croatia
- Prior art keywords
- seq
- antibody
- fcrn
- binding fragment
- fragment
- Prior art date
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- 101150050927 Fcgrt gene Proteins 0.000 title 1
- 239000012634 fragment Substances 0.000 claims 18
- 208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 108010068617 neonatal Fc receptor Proteins 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- XGWFJBFNAQHLEF-UHFFFAOYSA-N 9-anthroic acid Chemical compound C1=CC=C2C(C(=O)O)=C(C=CC=C3)C3=CC2=C1 XGWFJBFNAQHLEF-UHFFFAOYSA-N 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 206010001889 Alveolitis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010056370 Congestive cardiomyopathy Diseases 0.000 claims 1
- 201000010046 Dilated cardiomyopathy Diseases 0.000 claims 1
- 208000001654 Drug Resistant Epilepsy Diseases 0.000 claims 1
- 208000024869 Goodpasture syndrome Diseases 0.000 claims 1
- 208000003807 Graves Disease Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 claims 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 201000011152 Pemphigus Diseases 0.000 claims 1
- 241000721454 Pemphigus Species 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 206010036105 Polyneuropathy Diseases 0.000 claims 1
- 206010038546 Renal vasculitis Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
- 201000007023 Thrombotic Thrombocytopenic Purpura Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 1
- 201000001383 blood group incompatibility Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 claims 1
- 208000007475 hemolytic anemia Diseases 0.000 claims 1
- 102000047279 human B2M Human genes 0.000 claims 1
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 208000008795 neuromyelitis optica Diseases 0.000 claims 1
- 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000007824 polyneuropathy Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
Claims (22)
1. Anti-FcRn antitijelo ili njegov vezujući fragment koji se sastoji od (i) teškog lanca ili fragmenta teškog lanca koji sadrži varijabilnu regiju koja se sastoji od sekvence navedene u SEQ ID NO:25 i (ii) lakog lanca ili fragmenta lakog lanca koji sadrži varijabilnu regiju koja se sastoji od sekvence navedene u SEQ ID NO: 16.
2. Anti-FcRn antitijelo ili njegov vezujući fragment prema patentnom zahtjevu 1, naznačen time, što, je antitijelo ili vezujući fragment scFv, Fv, Fab ili Fab' fragment.
3. Fab' fragment anti-FcRn antitijela prema patentnom zahtjevu 2 koji sadrži teški lanac koji se sastoji od sekvence navedene u SEQ ID NO: 33 i laki lanac koji se sastoji od sekvence navedene u SEQ ID NO: 20.
4. Fab fragment anti-FcRn antitijela prema patentnom zahtjevu 2 koji sadrži teški lanac koji se sastoji od sekvence navedene u SEQ ID NO: 29 i laki lanac koji se sastoji od sekvence navedene u SEQ ID NO: 20.
5. Anti-FcRn antitijelo ili njegov vezujući fragment prema bilo kojem patentnom zahtjevu od 1 do 4, naznačen time, što je antitijelo ili vezujući fragment konjugiran na polimer, primjerice odabran iz škroba, albumina i polietilenglikola.
6. Anti-FcRn antitijelo ili njegov fragment prema patentnom zahtjevu 5, naznačen time, što je polimer PEG, primjerice s molekularnom masom u rasponu od 5 do 50 kDa.
7. Anti-FcRn antitijelo prema patentnom zahtjevu 1, naznačeno time, što je antitijelo antitijelo pune dužine.
8. Anti-FcRn antitijelo prema patentnom zahtjevu 7, naznačeno time, što je antitijelo pune dužine odabrano iz skupine koja se sastoji od IgG1, IgG4 i IgG4 S241P.
9. Anti-FcRn antitijelo prema patentnom zahtjevu 1, patentnom zahtjevu 7 ili patentnom zahtjevu 8 koje sadrži teški lanac koji se sastoji od sekvence navedene u SEQ ID NO: 37, SEQ ID NO:39 ili SEQ ID NO:73 i laki lanac koji se sastoji od sekvence navedene u SEQ ID NO: 20.
10. Anti-FcRn antitijelo ili njegov fragment prema patentnom zahtjevu 1 ili patentnom zahtjevu 2, naznačen time, što je antitijelo ili njegov vezujući fragment Fab-dsFv koji sadrži teški lanac koji se sastoji od sekvence navedene u SEQ ID NO: 42 i laki lanac koji se sastoji od sekvence navedene u SEQ ID NO: 40.
11. Anti-FcRn antitijelo ili njegov vezujući fragment prema bilo kojem patentnom zahtjevu od 1 do 10, koji blokira vezivanje ljudskog IgG-a za ljudski FcRn.
12. Anti-FcRn antitijelo ili njegov vezujući fragment prema bilo kojem patentnom zahtjevu od 1 do 11 koji se ne vezuje za ljudski β2 mikroglobulin (SEQ ID NO:72).
13. Izolirana sekvenca DNK koja šifrira teški/e i laki/e lanac/lance antitijela prema bilo kojem patentnom zahtjevu od 1 do 12.
14. Klonirajući ili ekspresijski vektor koji se sastoji od jedne ili više sekvenci DNK prema patentnom zahtjevu 13.
15. Vektor prema patentnom zahtjevu 14, naznačen time, što se vektor sastoji od (i) sekvence navedene u SEQ ID NO: 30, 32, 34 ili 36 i sekvence navedene u SEQ ID NO: 21 ili 24 ili (ii) sekvence navedene u SEQ ID NO: 38 i sekvence navedene u SEQ ID NO: 22 ili (iii) sekvence navedene u SEQ ID NO: 74 i sekvence navedene u SEQ ID NO: 22 ili (iv) sekvence navedene u SEQ ID NO: 41 i sekvence navedene u SEQ ID NO: 43.
16. Domaćinska stanica koja se sastoji od jednog ili više klonirajućih ili ekspresijskih vektora prema patentnom zahtjevu 14 ili patentnom zahtjevu 15.
17. Proces za proizvodnju antitijela koje se specifično vezuje za ljudski FcRn, koji se sastoji od uzgajanja domaćinske stanice prema patentnom zahtjevu 16 i izoliranja antitijela.
18. Farmaceutski pripravak koji sadrži anti-FcRn antitijelo ili njegov vezujući fragment kako je definirano u bilo kojem patentnom zahtjevu od 1 do 12 u kombinaciji s jednim ili više farmaceutski prihvatljivih ekscipijensa, razrjeđivača ili nosača.
19. Farmaceutski pripravak prema patentnom zahtjevu 18 koji sadrži druge djelatne tvari.
20. Antitijelo ili njegov vezujući fragment kako je definirano u bilo kojem patentnom zahtjevu od 1 do 12 ili pripravak kako je definirano u patentnom zahtjevu 18 ili 19 za primjenu u terapiji.
21. Antitijelo ili njegov vezujući fragment kako je definirano u bilo kojem patentnom zahtjevu od 1 do 12 ili pripravak kako je definirano u patentnom zahtjevu 18 ili 19, za primjenu u liječenju autoimune bolesti, kao što je miastenija gravis, obični pemfigus, optički neuromijelitis, Guillan-Barreov sindrom, lupus, idiopatska trombocitopenična purpura i trombotična trombocitopenična purpura.
22. Antitijelo ili njegov vezujući fragment kako je definirano u bilo kojem patentnom zahtjevu od 1 do 12 ili pripravak kako je definirano u patentnom zahtjevu 18 ili 19, za primjenu u liječenju kronične upalne demijelinacijske polineuropatije (CIDP), paraproteinemičke polineuropatije, refraktorne epilepsije, hemolitičke anemije, Goodpastureovog sindroma, nekompatibilnosti krvnih grupa ABO, lupusnog nefritisa, bubrežnog vaskulitisa, sklerodermije, fibroznog alveolitisa, dilatirane kardiomiopatije, Graveove bolesti, dijabetesa tipa 1, autoimunog dijabetesa, pemfigusa, ANCA-pozitivnog vaskulitisa, dermatomiozitisa, Sjorgenove bolesti i reumatoidnog artritisa.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1320066.2A GB201320066D0 (en) | 2013-11-13 | 2013-11-13 | Biological products |
EP14800000.3A EP3068800B1 (en) | 2013-11-13 | 2014-11-12 | Antibodies specific to fcrn |
PCT/EP2014/074409 WO2015071330A1 (en) | 2013-11-13 | 2014-11-12 | Antibodies specific to fcrn |
Publications (1)
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HRP20192006T1 true HRP20192006T1 (hr) | 2020-02-07 |
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EP (2) | EP3068800B1 (hr) |
JP (2) | JP6584398B2 (hr) |
KR (1) | KR102366114B1 (hr) |
CN (1) | CN105814080B (hr) |
AR (1) | AR098408A1 (hr) |
AU (1) | AU2014350257B2 (hr) |
BR (1) | BR112016010822A2 (hr) |
CA (1) | CA2928341A1 (hr) |
CL (2) | CL2016001147A1 (hr) |
CY (1) | CY1122214T1 (hr) |
DK (1) | DK3068800T3 (hr) |
EA (1) | EA035142B1 (hr) |
ES (1) | ES2748570T3 (hr) |
GB (1) | GB201320066D0 (hr) |
HR (1) | HRP20192006T1 (hr) |
HU (1) | HUE046511T2 (hr) |
IL (1) | IL245265B (hr) |
LT (1) | LT3068800T (hr) |
MA (1) | MA39096B1 (hr) |
MX (1) | MX2016005956A (hr) |
PE (1) | PE20160662A1 (hr) |
PH (1) | PH12016500753A1 (hr) |
PL (1) | PL3068800T3 (hr) |
PT (1) | PT3068800T (hr) |
SG (1) | SG11201603307XA (hr) |
SI (1) | SI3068800T1 (hr) |
TN (1) | TN2016000173A1 (hr) |
TW (1) | TWI651330B (hr) |
UY (1) | UY35835A (hr) |
WO (1) | WO2015071330A1 (hr) |
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GB201320066D0 (en) * | 2013-11-13 | 2013-12-25 | Ucb Pharma Sa | Biological products |
MX2016008782A (es) | 2014-01-15 | 2016-09-08 | Hoffmann La Roche | Variantes de region fc con union mejorada de la proteina a. |
GB201508180D0 (en) | 2015-05-13 | 2015-06-24 | Ucb Biopharma Sprl | Antibodies |
CN106957365B (zh) * | 2016-01-11 | 2021-03-16 | 上海交通大学 | 一种单克隆抗体FnAb8及其应用 |
AU2017257680A1 (en) | 2016-04-25 | 2018-12-06 | Syntimmune, Inc. | Humanized affinity matured anti-FcRn antibodies |
SG11202103801UA (en) | 2018-10-16 | 2021-05-28 | UCB Biopharma SRL | Method for the treatment of myasthenia gravis |
US11926669B2 (en) | 2022-05-30 | 2024-03-12 | Hanall Biopharma Co., Ltd. | Anti-FcRn antibody or antigen binding fragment thereof with improved stability |
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2013
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