HRP20191828T1 - Postupci i pripravci za produljeno davanje lijekova - Google Patents
Postupci i pripravci za produljeno davanje lijekova Download PDFInfo
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- HRP20191828T1 HRP20191828T1 HRP20191828TT HRP20191828T HRP20191828T1 HR P20191828 T1 HRP20191828 T1 HR P20191828T1 HR P20191828T T HRP20191828T T HR P20191828TT HR P20191828 T HRP20191828 T HR P20191828T HR P20191828 T1 HRP20191828 T1 HR P20191828T1
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- 239000003814 drug Substances 0.000 title claims 10
- 239000000203 mixture Substances 0.000 title claims 5
- 229940079593 drug Drugs 0.000 title 1
- 230000002459 sustained effect Effects 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 claims 9
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 210000000744 eyelid Anatomy 0.000 claims 5
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 4
- 206010028293 Muscle contractions involuntary Diseases 0.000 claims 4
- 229960001948 caffeine Drugs 0.000 claims 4
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 4
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- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 4
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- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 claims 2
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
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- 208000034698 Vitreous haemorrhage Diseases 0.000 claims 1
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- 239000000695 adrenergic alpha-agonist Substances 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 claims 1
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- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical group CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims 1
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 claims 1
- 229960002394 lisinopril Drugs 0.000 claims 1
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- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
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- 208000020911 optic nerve disease Diseases 0.000 claims 1
- 239000011505 plaster Substances 0.000 claims 1
- 208000014733 refractive error Diseases 0.000 claims 1
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- 238000000926 separation method Methods 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
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Claims (11)
1. Topikalni oftalmički pripravak, s produljenim otpuštanjem, naznačen time, da se upotrebljava kod transdermalne primjene preko očnih kapaka ili sistemskom davanju najmanje jednog terapijskog sredstva za liječenje oftalmičkog stanja, pri čemu navedeni sastav sadržava terapijski učinkovitu količinu navedenog barem jednog terapijskog sredstva pogodnog za liječenje oftalmičkog stanja, te od oko 0,001 do 50 % težinskih udjela sredstva za fascikulaciju mišića, odabranog iz skupine koja se sastoji od kofeina, teofilina, pentoksifilina i teobromida, pri čemu se pripravak nanosi na vanjsku površinu jednog ili oba gornja i / ili donja kapka ljudskog pacijenta, a pri čemu je oftalmičko stanje odabrano iz skupine koja se sastoji od blefaritisa, trahomatoznog suhog oka, retinopatije, degeneracije mrežnice, epifore, alergijskog konjunktivitisa i keratitisa, infektivnog konjunktivitisa i keratitisa, pterigiuma, pinguiculuma, iritisa, uveitisa, keratitisa, vitritisa, plutajućih tijela, odvajanje staklastog tkiva, krvarenje staklastog tkiva, odvajanje mrežnice, subretinalno krvarenje, koridna neovaskularna membrana, edema mrežnice, makularnog edema, dijabetičke retinopatije, koridnog maligniteta, orbitalne malignosti, optičkog neuritisa, optičke neuropatije, strabizma, refrakcijske greške i glaukoma.
2. Pripravak za uporabu u skladu s patentnim zahtjevom 1, naznačen time, da je sredstvo za fascikulaciju mišića kofein.
3. Pripravak za uporabu u skladu s patentnim zahtjevom 1, naznačen time, da je navedeni pripravak pripravljen u obliku kreme, gela, losiona, spreja, pjene, filma, trake, masti, gipsa, aplikatora za kapke ili ljepila za nanošenje na gornji i / ili donji kapak ljudskog pacijenta.
4. Pripravak za uporabu u skladu s patentnim zahtjevom 2, naznačen time, da je pripravak namijenjen za liječenje glaukoma.
5. Pripravak za uporabu u skladu s patentnim zahtjevom 4, naznačen time, da je terapeutsko sredstvo odabrano iz skupine koja se sastoji od b-antagonista, a- antagonista, analoga prostaglandina, alfa-adrenergičkog agonista, inhibitora ugljične anhidraze, antikolinergičkog sredstva, vazodilatatora i njihove kombinacije, po izboru u kombinaciji s neuroprotektivnim sredstvom.
6. Pripravak za uporabu u skladu s patentnim zahtjevom 2, naznačen time, da je oftalmičko stanje povišeni intraokularni tlak, a terapijsko sredstvo je latanoprost ili brimonidin.
7. Pripravak za lokalno kontinuirano oslobađanje za upotrebu u sistemskoj primjeni barem jednog terapeutskog sredstva, pri čemu navedeni pripravak sadržava terapijski učinkovitu količinu navedenog barem jednog terapeutskog sredstva, i od oko 0,001 do 50 % težinskih udjela sredstva za fascikulaciju mišića iz skupine koja se sastoji od kofeina, teofilina, pentoksifilina i teobromida, pri čemu se pripravak primjenjuje na vanjsku površinu jednog ili oba gornja i / ili donja kapka ljudskog pacijenta i pri čemu je terapijsko sredstvo za liječenje stanja odabranog od dijabetesa, sistemske infekcije, bubrežne bolesti, hipertenzije, bolesti srca, odvajanje od nikotina i nedostatak hormona.
8. Pripravak za uporabu u skladu s patentnim zahtjevom 7, naznačen time, da nadalje obuhvaća od oko 0,001 do 50 % težinskih udjela ionotropnog sredstva.
9. Pripravak za uporabu u skladu s patentnim zahtjevom 7, naznačen time, da je sredstvo za fascikulaciju mišića kofein.
10. Pripravak za uporabu u skladu s patentnim zahtjevom 7 ili zahtjevom 9, naznačen time, da je terapijsko sredstvo inzulin ili rekombinantni inzulin.
11. Pripravak za uporabu u skladu s patentnim zahtjevom 9, naznačen time, da je terapijsko sredstvo lizinopril.
Applications Claiming Priority (4)
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US25661409P | 2009-10-30 | 2009-10-30 | |
US28947109P | 2009-12-23 | 2009-12-23 | |
EP10827530.6A EP2493474B1 (en) | 2009-10-30 | 2010-10-29 | Methods and compositions for sustained delivery of drugs |
PCT/US2010/054736 WO2011053792A2 (en) | 2009-10-30 | 2010-10-29 | Methods and compositions for sustained delivery of drugs |
Publications (1)
Publication Number | Publication Date |
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HRP20191828T1 true HRP20191828T1 (hr) | 2019-12-27 |
Family
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HRP20191828TT HRP20191828T1 (hr) | 2009-10-30 | 2019-10-10 | Postupci i pripravci za produljeno davanje lijekova |
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US (3) | US20110104083A1 (hr) |
EP (3) | EP2493474B1 (hr) |
CY (1) | CY1122417T1 (hr) |
DK (1) | DK2493474T3 (hr) |
ES (1) | ES2752008T3 (hr) |
HR (1) | HRP20191828T1 (hr) |
HU (1) | HUE046071T2 (hr) |
LT (1) | LT2493474T (hr) |
PL (1) | PL2493474T3 (hr) |
PT (1) | PT2493474T (hr) |
RS (1) | RS59483B1 (hr) |
SI (1) | SI2493474T1 (hr) |
WO (2) | WO2011053792A2 (hr) |
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-
2010
- 2010-10-29 HU HUE10827530A patent/HUE046071T2/hu unknown
- 2010-10-29 PL PL10827530T patent/PL2493474T3/pl unknown
- 2010-10-29 PT PT108275306T patent/PT2493474T/pt unknown
- 2010-10-29 WO PCT/US2010/054736 patent/WO2011053792A2/en active Application Filing
- 2010-10-29 EP EP10827530.6A patent/EP2493474B1/en active Active
- 2010-10-29 DK DK10827530.6T patent/DK2493474T3/da active
- 2010-10-29 US US12/916,136 patent/US20110104083A1/en not_active Abandoned
- 2010-10-29 EP EP10827537.1A patent/EP2493475A4/en not_active Withdrawn
- 2010-10-29 SI SI201031935T patent/SI2493474T1/sl unknown
- 2010-10-29 RS RS20191286A patent/RS59483B1/sr unknown
- 2010-10-29 LT LTEP10827530.6T patent/LT2493474T/lt unknown
- 2010-10-29 WO PCT/US2010/054752 patent/WO2011053801A2/en active Application Filing
- 2010-10-29 US US12/915,823 patent/US9034830B2/en active Active
- 2010-10-29 ES ES10827530T patent/ES2752008T3/es active Active
- 2010-10-29 EP EP19182493.7A patent/EP3569223A1/en active Pending
-
2015
- 2015-03-09 US US14/642,717 patent/US20150174211A1/en not_active Abandoned
-
2019
- 2019-10-10 HR HRP20191828TT patent/HRP20191828T1/hr unknown
- 2019-11-11 CY CY20191101182T patent/CY1122417T1/el unknown
Also Published As
Publication number | Publication date |
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PT2493474T (pt) | 2019-11-26 |
LT2493474T (lt) | 2019-10-10 |
WO2011053792A4 (en) | 2011-11-24 |
DK2493474T3 (da) | 2019-10-14 |
US9034830B2 (en) | 2015-05-19 |
US20110104206A1 (en) | 2011-05-05 |
WO2011053801A4 (en) | 2011-11-10 |
EP3569223A1 (en) | 2019-11-20 |
WO2011053801A3 (en) | 2011-09-29 |
SI2493474T1 (sl) | 2019-11-29 |
EP2493474A4 (en) | 2014-04-23 |
WO2011053792A3 (en) | 2011-09-22 |
EP2493475A2 (en) | 2012-09-05 |
EP2493475A4 (en) | 2014-10-29 |
RS59483B1 (sr) | 2019-12-31 |
ES2752008T3 (es) | 2020-04-02 |
HUE046071T2 (hu) | 2020-01-28 |
PL2493474T3 (pl) | 2020-03-31 |
EP2493474A2 (en) | 2012-09-05 |
US20150174211A1 (en) | 2015-06-25 |
EP2493474B1 (en) | 2019-09-04 |
US20110104083A1 (en) | 2011-05-05 |
CY1122417T1 (el) | 2021-01-27 |
WO2011053792A2 (en) | 2011-05-05 |
WO2011053801A2 (en) | 2011-05-05 |
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