HRP20190960T1 - Poboljšane adjuvantne formulacije koje sadrže agoniste tlr4 i postupci njihove upotrebe - Google Patents
Poboljšane adjuvantne formulacije koje sadrže agoniste tlr4 i postupci njihove upotrebe Download PDFInfo
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- HRP20190960T1 HRP20190960T1 HRP20190960TT HRP20190960T HRP20190960T1 HR P20190960 T1 HRP20190960 T1 HR P20190960T1 HR P20190960T T HRP20190960T T HR P20190960TT HR P20190960 T HRP20190960 T HR P20190960T HR P20190960 T1 HRP20190960 T1 HR P20190960T1
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- oil
- alkyl
- water emulsion
- following structure
- pharmaceutically acceptable
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- 239000000556 agonist Substances 0.000 title claims 5
- 239000002671 adjuvant Substances 0.000 title claims 2
- 238000009472 formulation Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000007764 o/w emulsion Substances 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 239000000839 emulsion Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 4
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 4
- 239000003963 antioxidant agent Substances 0.000 claims 3
- 230000003078 antioxidant effect Effects 0.000 claims 3
- 235000006708 antioxidants Nutrition 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- 125000006538 C11 alkyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- GZDFHIJNHHMENY-UHFFFAOYSA-N Dimethyl dicarbonate Chemical compound COC(=O)OC(=O)OC GZDFHIJNHHMENY-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 1
- CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 claims 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 1
- HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical group OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000015788 innate immune response Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 229920001993 poloxamer 188 Polymers 0.000 claims 1
- 229940031439 squalene Drugs 0.000 claims 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Tropical Medicine & Parasitology (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Claims (15)
1. Emulzija ulja u vodi koja sadrži agonist TLR4 i metabolizirajuće ulje, naznačena time što je metabolizirajuće ulje prisutno u emulziji ulja u vodi u koncentraciji od 0,01%-1% vol./vol., te što je ravnoteža hidrofobno:lipofilno (HLB) emulzije ulja u vodi veća od 9, ili veća od 10, ili između 9 i 12, gdje se agonist TLR4 bira iz skupine koju čine monofosforilirani lipid A (MPL), 3-O-deacilirani monofosforilirani lipid A i sintetski glukopiranozilirani lipidni adjuvans (GLA).
2. Emulzija ulja u vodi u skladu s patentnim zahtjevom, naznačena time što je metabolizirajuće ulje prisutno u emulziji ulja u vodi u koncentraciji od 0,01 %-0.5% vol./vol.
3. Emulzija ulja u vodi u skladu s patentnim zahtjevom 1, naznačena time što emulzija dodatno sadrži 1,2-dimiristoil-sn-glycero-3-fosfocholine (DMPC), izborno gdje emulzija ne sadrži antioksidans.
4. Emulzija ulja u vodi u skladu s patentnim zahtjevom 1, naznačena time što agonist TLR4 sadrži sintetski GLA.
5. Emulzija ulja u vodi u skladu s patentnim zahtjevom 4, naznačena time što sintetski GLA ima sljedeću strukturu: (i)
,
gdje:
R1, R3, R5 i R6 su C11-C20 alkil; i
R2 i R4 su C12-C20 alkil;
ili, gdje sintetski GLA ima sljedeću strukturu: (ii)
,
ili njegova farmaceutski prihvatljiva sol, gdje:
R1, R3, R5 i R6 su C11-20 alkil; i
R2 i R4 su C9-20 alkil;
ili, gdje sintetski GLA ima sljedeću strukturu: (iii)
,
ili njegova farmaceutski prihvatljiva sol, gdje:
R1, R3, R5 i R6 su C11-C20 alkil; i
R2 i R4 su C9-C20 alkil;
ili gdje sintetski GLA ima sljedeću strukturu: (iv)
,
ili njegova farmaceutski prihvatljiva sol.
6. Emulzija ulja u vodi u skladu s patentnim zahtjevom 5(i), naznačena time što R1, R3, R5 i R6 su C11 alkil; i R2 i R4 su C13 alkil.
7. Emulzija ulja u vodi u skladu s bilo kojim od patentnih zahtjeva 1 do 6, naznačena time što emulzija dodatno sadrži surfaktant, izborno gdje je surfaktant Pluronic F68.
8. Emulzija ulja u vodi u skladu s bilo kojim od patentnih zahtjeva 1 do 7, naznačena time što je metabolizirajuće ulje skvalen.
9. Emulzija ulja u vodi u skladu s bilo kojim od patentnih zahtjeva 1 do 8, naznačena time što emulzija dodatno sadrži antioksidans, izborno gdje je antioksidans vitamin E.
10. Emulzija ulja u vodi u skladu s bilo kojim od patentnih zahtjeva 1 do 9, naznačena time što emulzija dodatno sadrži najmanje jedan antigen.
11. Emulzija ulja u vodi u skladu s patentnim zahtjevom 1, naznačena time što je agonist TLR4 sintetski GLA, gdje je HLB emulzije veći od otprilike 10 i gdje emulzija dodatno sadrži DMPC u koncentraciji od otprilike 0,002%-2%.
12. Emulzija ulja u vodi u skladu s patentnim zahtjevom 11, naznačena time što sintetski GLA ima sljedeću strukturu:
,
gdje:
R1, R3, R5 i R6 su C11-C20 alkil; i R2 i R4 su C12-C20 alkil, izborno,
gdje su R1, R3, R5 i R6 C11 alkil; i R2 i R4 su C13 alkil;
ili, gdje sintetski GLA ima sljedeću strukturu:
,
ili njegova farmaceutski prihvatljiva sol, gdje:
L1, L2, L3, L4, L5 i L6 su isti ili različiti i neovisno -O-, -NH-ili -(CH2)-;
L7, L8, L9 i L10 su isti ili različiti i neovisno odsutni ili -C(=O)-;
Y1 je kiselinska funkcionalna skupina;
Y2 i Y3 su isti ili različiti i neovisno -OH, -SH, ili kiselinska funkcionalna skupina;
Y4 je -OH ili -SH;
R1, R3, R5 i R6 su isti ili različiti i neovisno C8-13 alkil; i
R2 i R4 su isti ili različiti i neovisno C6-11 alkil, izborno gdje su R1, R3, R5 i R6 C10 alkil; i R2 i R4 su C8 alkil;
ili gdje sintetski GLA ima sljedeću strukturu:
,
ili njegova farmaceutski prihvatljiva sol, gdje:
R1, R3, R5 i R6 su C11-20 alkil; i
R2 i R4 su C9-20 alkil;
ili, gdje sintetski GLA ima sljedeću strukturu:
,
ili njegova farmaceutski prihvatljiva sol, gdje:
R1, R3, R5 i R6 su C11-C20 alkil; i
R2 i R4 su C9-C20 alkil;
ili, gdje sintetski GLA ima sljedeću strukturu:
,
ili njegova farmaceutski prihvatljiva sol.
13. Emulzija ulja u vodi u skladu s bilo kojim od patentnih zahtjeva 1-12, naznačena time što je namijenjena upotrebi u terapijskom postupku stimuliranja imunosnog odgovora kod subjekta.
14. Emulzija ulja u vodi namijenjena upotrebi u skladu s patentnim zahtjevom 13, naznačena time što je imunosni odgovor nespecifični imunosni odgovor ili imunosni odgovor specifičan za antigen.
15. Emulzija ulja u vodi namijenjena upotrebi u skladu s patentnim zahtjevom 13 ili patentnim zahtjevom 14,
naznačena time što se emulziju ulja u vodi primjenjuje intradermalno.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261596066P | 2012-02-07 | 2012-02-07 | |
EP13746983.9A EP2811981B1 (en) | 2012-02-07 | 2013-02-07 | Improved adjuvant formulations comprising tlr4 agonists and methods of using the same |
PCT/US2013/025204 WO2013119856A1 (en) | 2012-02-07 | 2013-02-07 | Improved adjuvant formulations comprising tlr4 agonists and methods of using the same |
Publications (1)
Publication Number | Publication Date |
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HRP20190960T1 true HRP20190960T1 (hr) | 2019-07-26 |
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ID=48948023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HRP20190960TT HRP20190960T1 (hr) | 2012-02-07 | 2019-05-27 | Poboljšane adjuvantne formulacije koje sadrže agoniste tlr4 i postupci njihove upotrebe |
Country Status (16)
Country | Link |
---|---|
US (2) | US11510875B2 (hr) |
EP (2) | EP3563834A1 (hr) |
CN (2) | CN110339160A (hr) |
CY (1) | CY1121666T1 (hr) |
DK (1) | DK2811981T3 (hr) |
ES (1) | ES2729967T3 (hr) |
HR (1) | HRP20190960T1 (hr) |
HU (1) | HUE044841T2 (hr) |
LT (1) | LT2811981T (hr) |
PL (1) | PL2811981T3 (hr) |
PT (1) | PT2811981T (hr) |
RS (1) | RS58868B1 (hr) |
SI (1) | SI2811981T1 (hr) |
TR (1) | TR201908003T4 (hr) |
WO (1) | WO2013119856A1 (hr) |
ZA (2) | ZA201405890B (hr) |
Families Citing this family (22)
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DK2437753T3 (en) | 2009-06-05 | 2016-12-19 | Infectious Disease Res Inst | Synthetic glucopyranosyl lipid adjuvants and vaccine compositions containing them |
US8957047B2 (en) | 2013-04-18 | 2015-02-17 | Immune Design Corp. | GLA monotherapy for use in cancer treatment |
US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
US9017698B2 (en) * | 2013-09-25 | 2015-04-28 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
BE1022373B1 (fr) * | 2013-12-20 | 2016-03-25 | Glaxosmithkline Biologicals S.A. | Nouveaux vaccins antipaludeens |
IL310015A (en) * | 2013-12-31 | 2024-03-01 | Access To Advanced Health Inst | Formulations will be assembled into a single vial |
US20160030349A1 (en) * | 2014-08-01 | 2016-02-04 | Boehringer Ingelheim Vetmedica Gmbh | Nanoparticles, methods of preparation, and uses thereof |
CN104548101B (zh) * | 2015-01-31 | 2017-02-22 | 广东海大畜牧兽医研究院有限公司 | 一种诱导哺乳动物乳腺黏膜产生IgA的免疫增强剂及其制备方法和应用 |
EP3270962A4 (en) * | 2015-03-17 | 2018-08-22 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
KR102483033B1 (ko) | 2016-05-16 | 2022-12-30 | 액세스 투 어드밴스드 헬스 인스티튜트 | 페길화된 리포솜 및 이의 용도 |
US11173207B2 (en) * | 2016-05-19 | 2021-11-16 | The Regents Of The University Of Michigan | Adjuvant compositions |
KR102494651B1 (ko) * | 2017-12-07 | 2023-01-31 | 머크 샤프 앤드 돔 엘엘씨 | 뎅기 바이러스 백신 조성물의 제제 |
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CN115151559A (zh) | 2019-10-02 | 2022-10-04 | 扬森疫苗与预防公司 | 葡萄球菌肽和使用方法 |
WO2021144369A1 (en) | 2020-01-16 | 2021-07-22 | Janssen Pharmaceuticals, Inc. | Fimh mutant, compositions therewith and use thereof |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
WO2022136952A1 (en) | 2020-12-23 | 2022-06-30 | Infectious Disease Research Institute | Solanesol vaccine adjuvants and methods of preparing same |
MX2023008251A (es) | 2021-01-12 | 2023-07-26 | Janssen Pharmaceuticals Inc | Mutantes de fimh, composiciones con estos y uso de estos. |
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-
2013
- 2013-02-07 CN CN201910261589.3A patent/CN110339160A/zh active Pending
- 2013-02-07 EP EP19167108.0A patent/EP3563834A1/en active Pending
- 2013-02-07 TR TR2019/08003T patent/TR201908003T4/tr unknown
- 2013-02-07 EP EP13746983.9A patent/EP2811981B1/en active Active
- 2013-02-07 LT LTEP13746983.9T patent/LT2811981T/lt unknown
- 2013-02-07 CN CN201380016135.0A patent/CN104363892A/zh active Pending
- 2013-02-07 PL PL13746983T patent/PL2811981T3/pl unknown
- 2013-02-07 SI SI201331471T patent/SI2811981T1/sl unknown
- 2013-02-07 ES ES13746983T patent/ES2729967T3/es active Active
- 2013-02-07 WO PCT/US2013/025204 patent/WO2013119856A1/en active Application Filing
- 2013-02-07 US US14/377,488 patent/US11510875B2/en active Active
- 2013-02-07 PT PT13746983T patent/PT2811981T/pt unknown
- 2013-02-07 DK DK13746983.9T patent/DK2811981T3/da active
- 2013-02-07 RS RS20190701A patent/RS58868B1/sr unknown
- 2013-02-07 HU HUE13746983 patent/HUE044841T2/hu unknown
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2014
- 2014-08-12 ZA ZA2014/05890A patent/ZA201405890B/en unknown
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2018
- 2018-08-10 ZA ZA2018/05284A patent/ZA201805284B/en unknown
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2019
- 2019-05-27 HR HRP20190960TT patent/HRP20190960T1/hr unknown
- 2019-06-03 CY CY20191100586T patent/CY1121666T1/el unknown
-
2022
- 2022-10-04 US US17/960,110 patent/US20230116042A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3563834A1 (en) | 2019-11-06 |
ZA201405890B (en) | 2018-11-28 |
EP2811981A4 (en) | 2015-08-26 |
ES2729967T3 (es) | 2019-11-07 |
RS58868B1 (sr) | 2019-08-30 |
TR201908003T4 (tr) | 2019-06-21 |
US20230116042A1 (en) | 2023-04-13 |
EP2811981A1 (en) | 2014-12-17 |
US20150017191A1 (en) | 2015-01-15 |
PL2811981T3 (pl) | 2019-09-30 |
US11510875B2 (en) | 2022-11-29 |
DK2811981T3 (da) | 2019-06-11 |
LT2811981T (lt) | 2019-06-10 |
CN104363892A (zh) | 2015-02-18 |
PT2811981T (pt) | 2019-06-12 |
CY1121666T1 (el) | 2020-07-31 |
WO2013119856A1 (en) | 2013-08-15 |
CN110339160A (zh) | 2019-10-18 |
EP2811981B1 (en) | 2019-05-08 |
SI2811981T1 (sl) | 2019-08-30 |
HUE044841T2 (hu) | 2019-11-28 |
ZA201805284B (en) | 2020-02-26 |
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