HRP20190861T1 - Modificirani kolagen - Google Patents
Modificirani kolagen Download PDFInfo
- Publication number
- HRP20190861T1 HRP20190861T1 HRP20190861TT HRP20190861T HRP20190861T1 HR P20190861 T1 HRP20190861 T1 HR P20190861T1 HR P20190861T T HRP20190861T T HR P20190861TT HR P20190861 T HRP20190861 T HR P20190861T HR P20190861 T1 HRP20190861 T1 HR P20190861T1
- Authority
- HR
- Croatia
- Prior art keywords
- collagen
- period
- mature
- dehydrated
- stored
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title claims 17
- 108010035532 Collagen Proteins 0.000 title claims 17
- 229920001436 collagen Polymers 0.000 title claims 17
- 238000002360 preparation method Methods 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 1
- 229930182566 Gentamicin Natural products 0.000 claims 1
- 208000031737 Tissue Adhesions Diseases 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 229960002518 gentamicin Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
- C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
- C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (11)
1. Zreli kolagen koji se može dobiti osiguravanjem izoliranog kolagena, smrzavanjem izoliranog kolagena, dehidriranjem smrznutog kolagena, i zrenjem dehidriranog kolagena, gdje zreli kolagen sadrži dehidrirani kolagen koji je pohranjen na temperaturi od:
(a) najmanje 40 °C kroz razdoblje od najmanje šest tjedana, ili
(b) najmanje 65 °C kroz razdoblje od najmanje tjedan dana, ili
(c) najmanje 30 °C kroz razdoblje od najmanje dva mjeseca.
2. Zreli kolagen prema patentnom zahtjevu 1, naznačen time što se je dehidrirani kolagen pohranjen na temperaturi od najmanje 40 °C kroz razdoblje od najmanje šest tjedana i uz relativnu vlažnost manju od 80%.
3. Zreli kolagen prema patentnom zahtjevu 1, naznačen time što je dehidrirani kolagen pohranjen na temperaturi od 40 °C kroz razdoblje od šest tjedana.
4. Zreli kolagen prema patentnom zahtjevu 1, naznačen time što je dehidrirani kolagen pohranjen na temperaturi od 40 °C kroz razdoblje od dva mjeseca, četiri mjeseca ili šest mjeseci.
5. Zreli kolagen prema patentnom zahtjevu 3 ili 4, naznačen time što je dehidrirani kolagen pohranjen uz relativnu vlažnost od 75% .
6. Pripravak koji sadrži zreli kolagen prema bilo kojem od prethodnih patentnih zahtjeva.
7. Pripravak prema patentnom zahtjevu 6 koji dodatno sadrži lijek.
8. Pripravak prema patentnom zahtjevu 7, naznačen time što je lijek gentamicin, bupivakain ili njihova sol ili predlijek.
9. Pripravak prema patentnom zahtjevu 8, koji je u obliku spužve.
10. Postupak prema bilo kojem od patentnih zahtjeva 6 do 9 za upotrebu kao lijek.
11. Pripravak prema bilo kojem od patentnih zahtjeva 6 do 9 za upotrebu u liječenju ili sprečavanju kirurških adhezija.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20120150527 EP2612888A1 (en) | 2012-01-09 | 2012-01-09 | A modified collagen |
| GBGB1220868.2A GB201220868D0 (en) | 2012-11-20 | 2012-11-20 | A modified collagen |
| EP17181156.5A EP3255106B1 (en) | 2012-01-09 | 2013-01-09 | A modified collagen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20190861T1 true HRP20190861T1 (hr) | 2019-08-09 |
Family
ID=47559477
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171635TT HRP20171635T1 (hr) | 2012-01-09 | 2017-10-25 | Modificirani kolagen |
| HRP20190861TT HRP20190861T1 (hr) | 2012-01-09 | 2019-05-09 | Modificirani kolagen |
| HRP20210699TT HRP20210699T1 (hr) | 2012-01-09 | 2021-05-05 | Izmijenjeni kolagen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171635TT HRP20171635T1 (hr) | 2012-01-09 | 2017-10-25 | Modificirani kolagen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20210699TT HRP20210699T1 (hr) | 2012-01-09 | 2021-05-05 | Izmijenjeni kolagen |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US10487134B2 (hr) |
| EP (4) | EP2802624B1 (hr) |
| JP (3) | JP6494285B2 (hr) |
| AU (1) | AU2013208952B2 (hr) |
| CA (1) | CA2860552C (hr) |
| CY (3) | CY1119524T1 (hr) |
| DK (3) | DK3536748T3 (hr) |
| EA (2) | EA027745B1 (hr) |
| ES (3) | ES2728205T3 (hr) |
| HK (1) | HK1244296B (hr) |
| HR (3) | HRP20171635T1 (hr) |
| HU (3) | HUE054838T2 (hr) |
| LT (3) | LT2802624T (hr) |
| MX (1) | MX368037B (hr) |
| NO (1) | NO2802624T3 (hr) |
| PL (3) | PL3255106T3 (hr) |
| PT (2) | PT2802624T (hr) |
| RS (3) | RS56564B1 (hr) |
| SI (3) | SI3255106T1 (hr) |
| TR (1) | TR201907156T4 (hr) |
| WO (1) | WO2013104687A2 (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2802624T (lt) * | 2012-01-09 | 2017-12-27 | Innocoll Pharmaceuticals Limited | Modifikuotas kolagenas |
| US20180237259A1 (en) * | 2017-02-22 | 2018-08-23 | Otis Elevator Company | Method for detecting trapped passengers in elevator car |
| RU2704248C1 (ru) * | 2018-10-02 | 2019-10-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет инженерных технологий" (ФГБОУ ВО "ВГУИТ") | Способ получения пористого коллагенового материала |
| RU2760326C1 (ru) * | 2021-03-04 | 2021-11-24 | Общество с ограниченной ответственностью научно-производственное объединение «Велис» | Способ получения пористого влагоемкого материала на коллагеновой основе |
| WO2022219009A1 (en) | 2021-04-12 | 2022-10-20 | Innocoll Pharmaceuticals Limited | Drug-release implant for laparoscopic surgery |
| CN113201569B (zh) * | 2021-06-21 | 2022-08-30 | 江南大学 | 一种牛ⅰ型胶原蛋白的纯化方法 |
| IL310517A (en) * | 2021-07-28 | 2024-03-01 | Innocoll Pharm Ltd | Bupivacaine-collagen drug delivery implant and methods for its preparation and use |
| WO2023084005A1 (en) * | 2021-11-12 | 2023-05-19 | Innocoll Pharmaceuticals Limited | Resorbable collagen scaffold for dural repair |
| WO2024079289A1 (en) | 2022-10-12 | 2024-04-18 | Innocoll Pharmaceuticals Limited | A kit for implanting a drug-release implant for laparoscopic surgery |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5246282B2 (hr) * | 1972-11-15 | 1977-11-24 | ||
| US4097234A (en) * | 1976-12-10 | 1978-06-27 | Nippi, Incorporated | Method for preparing dispersion of collagen fiber |
| US4279812A (en) * | 1979-09-12 | 1981-07-21 | Seton Company | Process for preparing macromolecular biologically active collagen |
| US5206028A (en) | 1991-02-11 | 1993-04-27 | Li Shu Tung | Dense collagen membrane matrices for medical uses |
| FR2720945B1 (fr) | 1994-06-08 | 1996-08-30 | Coletica | Membrane collagénique anti-adhérence post-opératoire. |
| US5945125A (en) | 1995-02-28 | 1999-08-31 | Temple University | Controlled release tablet |
| CA2277814A1 (en) * | 1997-01-16 | 1998-07-23 | Cohesion Corporation | Lyophilized collagen-based biomaterials, process of preparation and uses thereof |
| US20010014667A1 (en) * | 1998-01-05 | 2001-08-16 | Chen Charles C. | Compositions with enhanced osteogenic potential, methods for making the same and therapeutic uses thereof |
| US20050208114A1 (en) * | 1998-03-24 | 2005-09-22 | Petito George D | Composition and method for healing tissues |
| GB2345638A (en) * | 1998-09-11 | 2000-07-19 | Tissue Science Lab Limited | Injectable collagen compositions |
| US6682760B2 (en) * | 2000-04-18 | 2004-01-27 | Colbar R&D Ltd. | Cross-linked collagen matrices and methods for their preparation |
| ATE481097T1 (de) * | 2001-01-16 | 2010-10-15 | Vascular Therapies Llc | Implantierbare vorrichtung enthaltend resorbierbares matrixmaterial und antiproliferative wirkstoffe zur vorbeugung oder behandlung von versagen vaskulärer hämodialysezugänge und anderer vaskulärer transplantate |
| US7098315B2 (en) * | 2001-01-25 | 2006-08-29 | Nycomed Pharma As | Method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge |
| JP2004099513A (ja) * | 2002-09-09 | 2004-04-02 | Toshiba Corp | クラゲのコラーゲン回収方法及びクラゲのコラーゲン回収システム |
| EP1616019B1 (en) * | 2003-04-11 | 2008-12-10 | Ecodynamic BioLab Inc. | Method for extracting collagen comprising microbial fermentation |
| US7534422B2 (en) * | 2004-07-09 | 2009-05-19 | Viscofan, S.A. | Universal fishing bait based on fibrous collagen and the procedure for its preparation |
| USRE47826E1 (en) * | 2007-03-28 | 2020-01-28 | Innocoll Pharmaceuticals Limited | Drug delivery device for providing local analgesia, local anesthesia or nerve blockage |
| US8034368B2 (en) * | 2007-03-28 | 2011-10-11 | Innocoll Technologies Limited | Drug delivery device for providing local analgesia, local anesthesia or nerve blockage |
| ES2582368T3 (es) | 2007-03-28 | 2016-09-12 | Innocoll Pharmaceuticals Limited | Dispositivo de suministro de medicamentos para proporcionar analgesia local, anestesia local o bloqueo nervioso |
| US7820794B2 (en) * | 2008-09-11 | 2010-10-26 | Sunmax Biotechnology Co., Ltd. | Long-lasting collagen and manufacturing method thereof |
| WO2010052694A2 (en) * | 2008-11-06 | 2010-05-14 | Innocoll Technologies Limited | Drug delivery implants and processes for their preparation |
| EP2459011B1 (en) * | 2009-07-27 | 2016-04-13 | National Cheng Kung University | Preparation of high purity collagen |
| JP2011225462A (ja) * | 2010-04-16 | 2011-11-10 | Ihara Suisan Kk | 多孔質コラーゲン、その製造方法およびその用途 |
| US8951598B2 (en) * | 2010-05-07 | 2015-02-10 | Empire Technology Development Llc | Nanoscale collagen particles and membranes |
| EP2510929A1 (en) * | 2011-04-11 | 2012-10-17 | Innocoll Technologies Limited | Methods for treating bacterial infection |
| LT2802624T (lt) * | 2012-01-09 | 2017-12-27 | Innocoll Pharmaceuticals Limited | Modifikuotas kolagenas |
| US11623947B2 (en) * | 2013-04-08 | 2023-04-11 | Innocoll Pharmaceuticals Limited | Collagen powder |
-
2013
- 2013-01-09 LT LTEP13700286.1T patent/LT2802624T/lt unknown
- 2013-01-09 LT LTEP17181156.5T patent/LT3255106T/lt unknown
- 2013-01-09 US US14/371,161 patent/US10487134B2/en active Active
- 2013-01-09 EA EA201491278A patent/EA027745B1/ru unknown
- 2013-01-09 PL PL17181156T patent/PL3255106T3/pl unknown
- 2013-01-09 NO NO13700286A patent/NO2802624T3/no unknown
- 2013-01-09 EP EP13700286.1A patent/EP2802624B1/en active Active
- 2013-01-09 JP JP2014550739A patent/JP6494285B2/ja active Active
- 2013-01-09 DK DK19165538.0T patent/DK3536748T3/da active
- 2013-01-09 RS RS20171104A patent/RS56564B1/sr unknown
- 2013-01-09 EA EA201790763A patent/EA037396B1/ru unknown
- 2013-01-09 PT PT137002861T patent/PT2802624T/pt unknown
- 2013-01-09 HU HUE19165538A patent/HUE054838T2/hu unknown
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2016
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2019
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2022
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