HRP20171797T1 - Antibakterijski oralni pripravak - Google Patents

Antibakterijski oralni pripravak Download PDF

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Publication number
HRP20171797T1
HRP20171797T1 HRP20171797TT HRP20171797T HRP20171797T1 HR P20171797 T1 HRP20171797 T1 HR P20171797T1 HR P20171797T T HRP20171797T T HR P20171797TT HR P20171797 T HRP20171797 T HR P20171797T HR P20171797 T1 HRP20171797 T1 HR P20171797T1
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Croatia
Prior art keywords
use according
dye
acid
red
preparation
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HRP20171797TT
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English (en)
Inventor
Remigio Piergallini
Nikolaos Loupis
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Klox Technologies Inc.
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Publication of HRP20171797T1 publication Critical patent/HRP20171797T1/hr

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/327—Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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Claims (15)

1. Upotreba fotoaktivatable pripravka u proizvodnji medikamenta za liječenje bolesti usne šupljine, naznačena time što navedeni pripravak sadrži: najmanje jedan oksidans, najmanje jedan fotoaktivator koji može aktivirati oksidans; i najmanje jedan ljekoviti čimbenik, koji se bira između hijaluronske kiseline, glukozamina i alantoina, uz farmakološki prihvatljivu podlogu gdje se navedeno liječenje sastoji u: a) primjeni navedenog pripravka u pacijentova usta; i b) liječenju navedenih usta iz koraka a) aktiničnim svjetlom u vremenu dovoljnom da navedeni fotoaktivator uzrokuje aktiviranje navedenog oksidansa.
2. Upotreba u skladu s patentnim zahtjevom 1, naznačena time što se navedenu bolest usne šupljine bira između gingivitisa, periodontitisa, bolesti periodonta, oralne kandidijaze, lihena planusa, stomatitisa, lezija zbog herpesa simpleksa, oralnog mukozitisa, oralnih ulceracija, fibroze oralne submukoze, te glositisa.
3. Upotreba u skladu s patentnim zahtjevom 2, naznačena time što je navedena bolest usne šupljine periodontitis.
4. Upotreba u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačena time što se oksidans bira između vodikovog peroksida, karbamid-peroksida, benzoil-peroksida, peroksikiseline i perkarbonata alkalnog metala.
5. Upotreba u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačena time što pripravak dodatno sadrži najmanje jedno hidrofilno sredstvo za želiranje, poput glukoze, modificiranog škroba, metilceluloze, karboksimetilceluloze, propilceluloze, hidroksipropilceluloze, Carbopol® polimera, alginske kiseline, natrijevog alginata, kalijevog alginata, amonijevog alginata, kalcijevog alginata, agara, karagenana, karuba gume, pektina, te želatine.
6. Upotreba u skladu s bilo kojim od patentnih zahtjeva 1 do 5, naznačena time što se fotoaktivator bira između bojila na bazi ksantena, azo bojila, biološke boje, te karotenoida.
7. Upotreba u skladu s patentnim zahtjevom 6, naznačena time što se navedeno bojilo na bazi ksantena bira između fluornog bojila, fluoronskog bojila, te rodolnog bojila.
8. Upotreba u skladu s patentnim zahtjevom 7, naznačena time što se navedeno fluorensko bojilo bira između pironinskog bojila, poput pironina Y i pironina B, te rodaminskog bojila, poput rodamina B, rodamina G i rodamina WT.
9. Upotreba u skladu s patentnim zahtjevom 7, naznačena time što se navedeno fluoronsko bojilo bira između fluoresceina i derivata fluoresceina.
10. Upotreba u skladu s patentnim zahtjevom 9, naznačena time što se navedeni derivat fluoresceina bira između floksina B, bengalskog ružičastog, merbromina, eozina Y, eozina B i eritrozina B.
11. Upotreba u skladu s patentnim zahtjevom 10, naznačena time što je navedeni derivat fluoresceina eozin Y.
12. Upotreba u skladu s patentnim zahtjevom 6, naznačena time što se navedeno azo bojilo bira između metilnog ljubičastog, neutralnog crvenila, para crvenila, amaranta, azorubina, alura crvenila AC, tartrazina, narančastog G, košenilovog crvenila 4R, metilnog crvenila, te mureksid-amonijevog purpurata.
13. Upotreba u skladu s patentnim zahtjevom 6, naznačena time što se navedena biološka boja bira između safranina O, bazičnog fuksina, kiselog fuksina, 3,3′-diheksilokarbocijanin-jodida, karminske kiseline, te indocijaninskog zelenila.
14. Upotreba u skladu s patentnim zahtjevom 6, naznačena time što se navedeni karotenoid bira između krocetina, a-krocina (S,S-diapo-S,S-karotenske kiseline), zeaksantina, likopena, α-karotena, β-karotena, biksina, te fukoksantina, ili gdje je navedeni karotenoid prisutan u pripravku u obliku smjese koju se bira između crvenog praha iz šafrana, ekstrakta anata i ekstrakta smeđih algi.
15. Upotreba u skladu s bilo kojim od patentnih zahtjeva 1-14, naznačena time što navedeni pripravak dodatno sadrži najmanje jedno kelirajuće sredstvo, koje se bira između etilendiamintetraoctene kiseline (EDTA) i etilen-glikol-tetraoctene kiseline (EGTA).
HRP20171797TT 2009-07-17 2017-11-20 Antibakterijski oralni pripravak HRP20171797T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22635409P 2009-07-17 2009-07-17
PCT/CA2010/001134 WO2011006263A1 (en) 2009-07-17 2010-07-19 Antibacterial oral composition
EP10799337.0A EP2453922B1 (en) 2009-07-17 2010-07-19 Antibacterial oral composition

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HRP20171797T1 true HRP20171797T1 (hr) 2018-01-26

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US (6) US8685466B2 (hr)
EP (2) EP3318274A1 (hr)
JP (4) JP5794984B2 (hr)
KR (2) KR101782956B1 (hr)
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