HRP20161682T1 - Cjepivo koje sadrži konjugate polisaharida iz kapsule bakterije streptococcus pneumoniae - Google Patents
Cjepivo koje sadrži konjugate polisaharida iz kapsule bakterije streptococcus pneumoniae Download PDFInfo
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- HRP20161682T1 HRP20161682T1 HRP20161682TT HRP20161682T HRP20161682T1 HR P20161682 T1 HRP20161682 T1 HR P20161682T1 HR P20161682T T HRP20161682T T HR P20161682TT HR P20161682 T HRP20161682 T HR P20161682T HR P20161682 T1 HRP20161682 T1 HR P20161682T1
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- Prior art keywords
- immunogenic preparation
- pneumoniae
- bacterium
- accordance
- capsule
- Prior art date
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- 229960005486 vaccine Drugs 0.000 title claims 4
- 241000193998 Streptococcus pneumoniae Species 0.000 title claims 2
- 150000004676 glycans Chemical class 0.000 title 1
- 229920001282 polysaccharide Polymers 0.000 title 1
- 239000005017 polysaccharide Substances 0.000 title 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 title 1
- 230000002163 immunogen Effects 0.000 claims 14
- 238000002360 preparation method Methods 0.000 claims 14
- 241000894006 Bacteria Species 0.000 claims 7
- 150000001720 carbohydrates Chemical class 0.000 claims 6
- 230000001580 bacterial effect Effects 0.000 claims 5
- 239000002775 capsule Substances 0.000 claims 5
- 101100420868 Anuroctonus phaiodactylus phtx gene Proteins 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 2
- 101710183389 Pneumolysin Proteins 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- 229960003983 diphtheria toxoid Drugs 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 208000031729 Bacteremia Diseases 0.000 claims 1
- 101710164918 Choline-binding protein Proteins 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 206010033078 Otitis media Diseases 0.000 claims 1
- 101710099976 Photosystem I P700 chlorophyll a apoprotein A1 Proteins 0.000 claims 1
- 208000035109 Pneumococcal Infections Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000005713 exacerbation Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229920002704 polyhistidine Polymers 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
Classifications
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- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
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Claims (14)
1. Imunogeni pripravak, naznačen time što sadrži konjugate saharida iz kapsule bakterije S. pneumoniae iz serotipova 19A i 19F, gdje je 19A konjugiran s prvim bakterijskim toksoidom, a 19F je konjugiran s drugim bakterijskim toksoidom, koji je difterijski toksoid ili CRM197, te što dodatno sadrži konjugate saharida 1, 4, 5, 6B, 7F, 9V, 14, 18C i 23F iz kapsule bakterije S. pneumoniae, gdje je prvi bakterijski toksoid različiti protein u odnosu na drugi bakterijski toksoid.
2. Imunogeni pripravak u skladu s patentnim zahtjevom 1, naznačen time što se prvi bakterijski toksoid bira između tetanusnog toksoida, pneumolizina, difterijskog toksoida ili CRM197.
3. Imunogeni pripravak u skladu s patentnim zahtjevima 1-2, naznačen time što dodatno sadrži konjugat saharida 3 iz kapsule bakterije S. pneumoniae.
4. Imunogeni pripravak u skladu s patentnim zahtjevima 1-3, naznačen time što dodatno sadrži konjugat saharida 6A iz kapsule bakterije S. pneumoniae.
5. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što dodatno sadrži jedan ili više nekonjugiranih ili konjugiranih proteina iz bakterije S. pneumoniae.
6. Imunogeni pripravak u skladu s patentnim zahtjevom 5, naznačen time što se navedeni jedan ili više proteina iz bakterije S. pneumoniae biraju između obitelji polihistidinske trijade (PhtX), obitelj kolinski vežućih proteina (CbpX), skraćenih CbpX, obitelji LytX, skraćenih LytX, kimernih proteina skraćenog CbpX-skraćenog LytX, detoksiciranog pneumolizina (Ply), PspA, PsaA, Sp128, Sp101, Sp130, Sp125 i Sp133.
7. Imunogeni pripravak u skladu s bilo kojim od patentnih zahtjeva 5 ili 6, naznačen time što sadrži protein PhtX.
8. Imunogeni pripravak u skladu s patentnim zahtjevom 6, naznačen time što je protein PhtX PhtD.
9. Imunogeni pripravak u skladu s patentnim zahtjevom 8, naznačen time što sadrži najmanje jedan saharid iz kapsule bakterije S. pneumoniae konjugiran s PhtD ili njegovim fuzijskim proteinom, gdje je omjer između PhtD i saharida u konjugatu između 6:1 i 1:5.
10. Imunogeni pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što dodatno sadrži adjuvans.
11. Cjepivo, naznačeno time što sadrži imunogeni pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 10, kao i farmaceutski prihvatljivu pomoćnu tvar.
12. Postupak priprave cjepiva u skladu s patentnim zahtjevom 11, naznačen time što se sastoji u koraku miješanja imunogenog pripravka u skladu s bilo kojim od patentnih zahtjeva 1 do 10 s farmaceutski prihvatljivom pomoćnom tvari.
13. Upotreba imunogenog pripravka u skladu s patentnim zahtjevima 1 do 10 ili cjepiva u skladu s patentnim zahtjevom 11, naznačena time što je imunogeni pripravak namijenjen proizvodnji medikamenta za liječenje ili sprječavanje bolesti koje uzrokuje infekcija bakterijom Streptococcus pneumoniae.
14. Upotreba u skladu s patentnim zahtjevom 13, naznačena time što je bolest bilo ili i pneumonija ili invazivna pneumokokna bolest (IPD) kod starijih osoba, pogoršanje kronične opstruktivne plućne bolesti (COPD) kod starijih osoba, meningitis i/ili bakteriemija kod male djece, upala srednjeg uha kod male djece ili pneumonija i/ili konjunktivitis kod male djece.
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0526232A GB0526232D0 (en) | 2005-12-22 | 2005-12-22 | Vaccine |
GBGB0607088.2A GB0607088D0 (en) | 2006-04-07 | 2006-04-07 | Vaccine |
GB0607087A GB0607087D0 (en) | 2006-04-07 | 2006-04-07 | Vaccine |
GB0609902A GB0609902D0 (en) | 2006-05-18 | 2006-05-18 | Novel composition |
GB0620337A GB0620337D0 (en) | 2006-10-12 | 2006-10-12 | Vaccine |
GBGB0620336.8A GB0620336D0 (en) | 2006-10-12 | 2006-10-12 | Vaccine |
GB0620815A GB0620815D0 (en) | 2006-10-19 | 2006-10-19 | Vaccine |
GB0620816A GB0620816D0 (en) | 2006-10-19 | 2006-10-19 | vaccine |
PCT/GB2006/004634 WO2007068907A2 (en) | 2005-12-13 | 2006-12-12 | Vaccine compositions comprising a saponin adjuvant |
EP06830744.6A EP1973564B1 (en) | 2005-12-22 | 2006-12-20 | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
PCT/EP2006/069977 WO2007071710A2 (en) | 2005-12-22 | 2006-12-20 | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
Publications (1)
Publication Number | Publication Date |
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HRP20161682T1 true HRP20161682T1 (hr) | 2017-01-27 |
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Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20110685T HRP20110685T1 (hr) | 2005-12-22 | 2011-09-23 | Cjepivo od konjugata pneumokoknog polisaharida |
HRP20161681TT HRP20161681T1 (hr) | 2005-12-22 | 2016-12-08 | Cjepivo protiv bakterije streptococcus pneumoniae |
HRP20161682TT HRP20161682T1 (hr) | 2005-12-22 | 2016-12-08 | Cjepivo koje sadrži konjugate polisaharida iz kapsule bakterije streptococcus pneumoniae |
HRP20190037TT HRP20190037T1 (hr) | 2005-12-22 | 2019-01-04 | Cjepivo na bazi konjugata pneumokoknih polisaharida |
Family Applications Before (2)
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HR20110685T HRP20110685T1 (hr) | 2005-12-22 | 2011-09-23 | Cjepivo od konjugata pneumokoknog polisaharida |
HRP20161681TT HRP20161681T1 (hr) | 2005-12-22 | 2016-12-08 | Cjepivo protiv bakterije streptococcus pneumoniae |
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