HRP20160632T1 - Vezivne molekule specifične za rsv i sredstva za njihovu proizvodnju - Google Patents
Vezivne molekule specifične za rsv i sredstva za njihovu proizvodnju Download PDFInfo
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- HRP20160632T1 HRP20160632T1 HRP20160632TT HRP20160632T HRP20160632T1 HR P20160632 T1 HRP20160632 T1 HR P20160632T1 HR P20160632T T HRP20160632T T HR P20160632TT HR P20160632 T HRP20160632 T HR P20160632T HR P20160632 T1 HRP20160632 T1 HR P20160632T1
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- 230000009870 specific binding Effects 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 23
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 8
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 8
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 241000725643 Respiratory syncytial virus Species 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 2
- 230000002411 adverse Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000002330 Congenital Heart Defects Diseases 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000001010 compromised effect Effects 0.000 claims 1
- 208000028831 congenital heart disease Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Claims (11)
1. Izolirano protutijelo ili njegov funkcionalni dio koji je sposoban specifično vezati F antigen respiratornog sincicijskog virusa (RSV), te je naznačeno time da protutijelo ili njegov funkcionalni dio sadrži:
a. regiju koja određuje komplementarnost (CDR) 1 teškog lanca koja sadrži sekvencu amino kiseline NYIIN (SEQ ID NO: 1), CDR2 teškog lanca koja sadrži sekvencu amino kiseline GIIPVLGTVHYAPKFQG (SEQ ID NO: 2), CDR3 teškog lanca koja sadrži sekvencu amino kiseline ETALVVSTTYLPHYFDN (SEQ ID NO: 3), CDR1 lakog lanca koja sadrži sekvencu amino kiseline QASQDIVNYLN (SEQ ID NO: 4), CDR2 lakog lanca koja sadrži sekvencu amino kiseline VASNLET (SEQ ID NO: 5), te CDR3 lakog lanca koja sadrži sekvencu amino kiseline QQYDNLP (SEQ ID NO: 6); ili
b. CDR1 teškog lanca koja sadrži sekvencu amino kiseline GFSFSHYA (SEQ ID NO: 73), sekvencu CDR2 teškog lanca koja sadrži sekvencu amino kiseline ISYDGENT (SEQ ID NO: 74), sekvencu CDR3 teškog lanca koja sadrži sekvencu amino kiseline ARDRIVDDYYYYGMDV (SEQ ID NO: 75), CDR1 lakog lanca koja sadrži sekvencu amino kiseline QDIKKY (SEQ ID NO:76), CDR2 lakog lanca koja sadrži sekvencu amino kiseline DAS, te CDR3 lakog lanca koja sadrži sekvencu amino kiseline QQYDNLPPLT (SEQ ID NO: 77); ili
c. CDR1 teškog lanca koja sadrži sekvencu amino kiseline GFTFSSYN (SEQ ID NO: 80), sekvencu CDR2 teškog lanca koja sadrži sekvencu amino kiseline ISAGSSYI (SEQ ID NO: 81), sekvencu CDR3 teškog lanca koja sadrži sekvencu amino kiseline AREDYGPGNYYSPNWFDP (SEQ ID NO: 82), CDR1 lakog lanca koja sadrži sekvencu amino kiseline SSNIGAGYD (SEQ ID NO:83), CDR2 lakog lanca koja sadrži sekvencu amino kiseline GNT, te CDR3 lakog lanca koja sadrži sekvencu amino kiseline HSYDRSLSG (SEQ ID NO: 84); ili
d. CDR1 teškog lanca koja sadrži sekvencu amino kiseline GFNFHNYG (SEQ ID NO: 87), sekvencu CDR2 teškog lanca koja sadrži sekvencu amino kiseline VWYDGSKK (SEQ ID NO: 88), sekvencu CDR3 teškog lanca koja sadrži sekvencu amino kiseline VRDKVGPTPYFDS (SEQ ID NO: 89), CDR1 lakog lanca koja sadrži sekvencu amino kiseline NIGSET (SEQ ID NO:90), CDR2 lakog lanca koja sadrži sekvencu amino kiseline DDD , te CDR3 lakog lanca koja sadrži sekvencu amino kiseline QVWDRSNYHQV (SEQ ID NO: 91).
2. Protutijelo ili njegov funkcionalni dio prema zahtjevu 1, naznačeno time da protutijelo sadrži varijabilnu sekvencu teškog lanca koja sadrži sekvencu amino kiseline QVQLVQSGAEVKKPGSSVMVSCQASGGPLRNYIINWLRQAPGQGPEWMGGIIPVLG TVHYAPKFQGRVTITADESTDTAYIHLISLRSEDTAMYYCATETA LVVSTTYLPHYFDN WGQGTLVTVSS (SEQ ID NO: 7) i/ili varijabilnu sekvencu lakog lanca koja sadrži sekvencu amino kiseline DIQMTQSPSSLSAAVGDRVTITCQASQDIVNYLNWYQQKPGKAPKLLIYVASNLETG VPSRFSGSGSGTDFSLTISSLQPEDVATYYCQQYDNLPLTFGGGT KVEIKRTV (SEQ ID NO: 8).
3. Protutijelo ili njegov funkcionalni dio prema zahtjevu 1 , naznačeno time da je njegov funkcionalni dio protutijelo jednostruke domene, protutijelo jednostrukog lanca, varijabilni fragment jednostrukog lanca (scFv), Fab fragment, ili F(ab')2 fragment.
4. Izolirana nukleinska kiselina naznačena time da kodira protutijelo ili njegov funkcionalni dio prema bilo kojem od zahtjeva 1 do 3.
5. Izolirana sekvenca nukleinske kiseline prema zahtjevu 4, naznačena time da sekvenca nukleinske kiseline sadrži nukleotidne sekvence teškog i lakog lanca koje su izabrane iz skupine koju čine:
(i) SEQ ID NO: 9 i SEQ ID NO: 10;
(ii) SEQ ID NO: 139 i SEQ ID NO: 141; i
(iii) SEQ ID NO: 140 i SEQ ID NO: 142;
6. Stanica naznačena time da izražava sekvencu nukleinske kiseline prema zahtjevu 4 ili 5.
7. Postupak proizvodnje protutijela ili njegovog funkcionalnog dijela o prema bilo kojem od zahtjeva 1 do 3, naznačen time da postupci sadrže kultiviranje stanice prema zahtjevu 6 in vitro, te dobivanje protutijela ili njihovih funkcionalnih dijelova koje proizvode stanice.
8. Pripravak naznačen time da sadrži protutijelo ili njegov funkcionalni dio prema bilo kojem od zahtjeva 1 do 6, i farmaceutski prihvatljiv nosač, razrjeđivač i/ili pomoćnu tvar.
9. Protutijelo ili njegov funkcionalni dio prema bilo kojem od zahtjeva 1 do 3, ili pripravak prema zahtjevu 8, ili sekvenca nukleinske kiseline prema zahtjevu 4 ili 5 naznačeno time da je za uporabu za liječenje ili sprječavanje poremećaja povezanog s RSV, ili za sprječavanje ili suzbijanje štetnih učinaka RSV infekcije kod subjekta koji je čovjek.
10. Uporaba protutijela ili njegovog funkcionalnog dijela prema bilo kojem od zahtjeva 1 do 3, ili pripravka prema zahtjevu 8, ili sekvence nukleinske kiseline prema zahtjevu 4 ili 5 naznačena time da je za pripremanje lijeka za liječenje ili sprječavanje poremećaja povezanog s RSV, ili za sprječavanje ili suzbijanje štetnih učinaka RSV infekcije kod subjekta koji je čovjek.
11. Protutijelo ili njegov funkcionalni dio, pripravak ili sekvenca nukleinske kiseline prema zahtjevu 9 za uporabu prema zahtjevu 9, ili uporaba prema zahtjevu 10, naznačeni time da subjekt koji je čovjek ima kroničnu bolest pluća, prirođenu bolest srca ili ugrožen imunitet, ili je ljudski subjekt dijete mlađe od 6 tjedana ili starija osoba, proizvoljno pri čemu je protutijelo ili njegov funkcionalni dio formuliran za primjenu u dozi od 0.1 do 10 mg/kg tjelesne težine čovjeka.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07109472A EP1997830A1 (en) | 2007-06-01 | 2007-06-01 | RSV specific binding molecules and means for producing them |
| PCT/NL2008/050333 WO2008147196A2 (en) | 2007-06-01 | 2008-05-30 | Rsv-specific binding molecules and means for producing them |
| EP08766756.4A EP2170952B1 (en) | 2007-06-01 | 2008-05-30 | Rsv-specific binding molecules and means for producing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160632T1 true HRP20160632T1 (hr) | 2016-07-15 |
Family
ID=38578633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160632TT HRP20160632T1 (hr) | 2007-06-01 | 2016-06-08 | Vezivne molekule specifične za rsv i sredstva za njihovu proizvodnju |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US8562996B2 (hr) |
| EP (3) | EP1997830A1 (hr) |
| JP (4) | JP5450395B2 (hr) |
| KR (2) | KR101599556B1 (hr) |
| CN (2) | CN104961825A (hr) |
| AU (1) | AU2008257801B8 (hr) |
| BR (1) | BRPI0812878C1 (hr) |
| CA (2) | CA2689290C (hr) |
| CY (1) | CY1117767T1 (hr) |
| DK (1) | DK2170952T3 (hr) |
| ES (1) | ES2575129T3 (hr) |
| HK (1) | HK1146073A1 (hr) |
| HR (1) | HRP20160632T1 (hr) |
| HU (1) | HUE029225T2 (hr) |
| IL (1) | IL202288A (hr) |
| MX (2) | MX350375B (hr) |
| NZ (3) | NZ581512A (hr) |
| PL (1) | PL2170952T3 (hr) |
| PT (1) | PT2170952E (hr) |
| RU (2) | RU2628095C2 (hr) |
| SI (1) | SI2170952T1 (hr) |
| WO (1) | WO2008147196A2 (hr) |
| ZA (1) | ZA200908320B (hr) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2649037T3 (es) | 2000-12-12 | 2018-01-09 | Medimmune, Llc | Moléculas con semividas prolongadas, composiciones y usos de las mismas |
| US9005974B2 (en) | 2005-12-09 | 2015-04-14 | Academish Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
| PL2540820T3 (pl) | 2005-12-09 | 2018-05-30 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | Środki i sposoby wpływania na stabilność komórek wytwarzających przeciwciała |
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| EP2201040A1 (en) | 2007-09-24 | 2010-06-30 | Vanderbilt University | Monoclonal antibodies to respiratory syncytial virus and uses thereof |
| US8775090B2 (en) | 2008-12-12 | 2014-07-08 | Medimmune, Llc | Crystals and structure of a human IgG Fc variant with enhanced FcRn binding |
| AU2015200208B2 (en) * | 2009-07-15 | 2016-10-20 | Kling Biotherapeutics B.V. | Means and methods for producing high affinity antibodies |
| DK2454283T3 (en) * | 2009-07-15 | 2018-05-07 | Aimm Therapeutics Bv | METHODS AND PROCEDURES FOR MANUFACTURING HIGH EFFICIENCY ANTIBODIES |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| CN104628850B (zh) * | 2009-10-06 | 2020-07-28 | 医学免疫有限公司 | Rsv-特异性结合分子 |
| WO2011043643A1 (en) * | 2009-10-06 | 2011-04-14 | Medimmune Ltd | Rsv-specific binding molecule |
| EP2591000B1 (en) * | 2010-07-09 | 2017-05-17 | Janssen Vaccines & Prevention B.V. | Anti-human respiratory syncytial virus (rsv) antibodies and methods of use |
| JP6013356B2 (ja) * | 2010-12-02 | 2016-10-25 | アイム・セラピューティクス・べー・フェー | 高親和性抗体を製造するための手段および方法 |
| CN103380145B (zh) | 2010-12-17 | 2016-10-12 | 生物控股有限公司 | 人类抗-sod1抗体 |
| RU2624046C2 (ru) * | 2011-11-07 | 2017-06-30 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретэри, Департмент Оф Хелт Энд Хьюман Сервисиз | Gp41-нейтрализующие антитела и их применение |
| US9718876B2 (en) | 2011-11-17 | 2017-08-01 | Aimm Therapeutics B.V. | RSV G protein specific antibodies |
| EA030319B1 (ru) * | 2012-03-20 | 2018-07-31 | Хумабс Биомед Са | Антитела, нейтрализующие rsv, mpv и pvm, и их применения |
| US10017739B2 (en) * | 2012-09-06 | 2018-07-10 | Duke University | Methods of expanding and assessing B cells and using expanded B cells to treat disease |
| PT2950886T (pt) * | 2013-02-01 | 2020-03-26 | Medimmune Llc | Epítopos de proteína f do vírus sincicial respiratório |
| WO2014160463A1 (en) | 2013-03-13 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Prefusion rsv f proteins and their use |
| US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| US9060975B2 (en) | 2013-03-14 | 2015-06-23 | Mucosis Bv | Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions |
| JP6462599B2 (ja) * | 2013-03-15 | 2019-01-30 | シャアメン ユニバーシティ | Ｒｓｖ融合タンパク質のエピトープ及びそのエピトープを認識する抗体 |
| US10047145B2 (en) | 2013-07-24 | 2018-08-14 | Humabs Biomed Sa | Antibodies that potently neutralize RSV and uses thereof |
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