HRP20140307T1 - Citotoksiäśna sredstva koja sadrže nove derivate tomamicina i njihova upotreba u terapiji - Google Patents
Citotoksiäśna sredstva koja sadrže nove derivate tomamicina i njihova upotreba u terapiji Download PDFInfo
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- HRP20140307T1 HRP20140307T1 HRP20140307TT HRP20140307T HRP20140307T1 HR P20140307 T1 HRP20140307 T1 HR P20140307T1 HR P20140307T T HRP20140307T T HR P20140307TT HR P20140307 T HRP20140307 T HR P20140307T HR P20140307 T1 HRP20140307 T1 HR P20140307T1
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- UQVNRKBFAXNOGA-LWTNMJDUSA-N (E)-tomaymycin Chemical class CO[C@H]1NC2=CC(O)=C(OC)C=C2C(=O)N2C\C(=C\C)C[C@@H]12 UQVNRKBFAXNOGA-LWTNMJDUSA-N 0.000 title 1
- 229940127089 cytotoxic agent Drugs 0.000 title 1
- 239000002254 cytotoxic agent Substances 0.000 title 1
- 231100000599 cytotoxic agent Toxicity 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 12
- 239000011230 binding agent Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims 3
- 239000005556 hormone Substances 0.000 claims 3
- 229940088597 hormone Drugs 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 claims 2
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 2
- POVMPWRYMPKDCR-KYJUHHDHSA-N (6as)-3-[[3-[[(6as)-8-ethylidene-2-methoxy-11-oxo-7,9-dihydro-6ah-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxymethyl]-5-(3-aminopropoxy)phenyl]methoxy]-8-ethylidene-2-methoxy-7,9-dihydro-6ah-pyrrolo[2,1-c][1,4]benzodiazepin-11-one Chemical compound N1=C[C@@H]2CC(=CC)CN2C(=O)C(C=C2OC)=C1C=C2OCC1=CC(OCCCN)=CC(COC2=CC3=C(C(N4CC(C[C@H]4C=N3)=CC)=O)C=C2OC)=C1 POVMPWRYMPKDCR-KYJUHHDHSA-N 0.000 claims 1
- WMZYAQQKYLKWGI-UHFFFAOYSA-N 1-hydroxypyrrolidine-2,5-dione 4-(pyridin-2-yldisulfanyl)butanoic acid Chemical compound ON1C(=O)CCC1=O.OC(=O)CCCSSC1=CC=CC=N1 WMZYAQQKYLKWGI-UHFFFAOYSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims 1
- WODNFCXCOFBOSS-PXLJZGITSA-N CN(CCCC=1C=C(C=C(C=1)COC1=CC\2=C(C(N3[C@H](/C=N/2)CC(C3)=CC)=O)C=C1OC)COC1=CC\2=C(C(N3[C@H](/C=N/2)CC(C3)=CC)=O)C=C1OC)C(=O)OC(C)(C)C Chemical compound CN(CCCC=1C=C(C=C(C=1)COC1=CC\2=C(C(N3[C@H](/C=N/2)CC(C3)=CC)=O)C=C1OC)COC1=CC\2=C(C(N3[C@H](/C=N/2)CC(C3)=CC)=O)C=C1OC)C(=O)OC(C)(C)C WODNFCXCOFBOSS-PXLJZGITSA-N 0.000 claims 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 1
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 1
- 102000014429 Insulin-like growth factor Human genes 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 108010074338 Lymphokines Proteins 0.000 claims 1
- 102000008072 Lymphokines Human genes 0.000 claims 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 101710098940 Pro-epidermal growth factor Proteins 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- 102000006747 Transforming Growth Factor alpha Human genes 0.000 claims 1
- 101800004564 Transforming growth factor alpha Proteins 0.000 claims 1
- 229940094957 androgens and estrogen Drugs 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 229940047120 colony stimulating factors Drugs 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 125000002228 disulfide group Chemical group 0.000 claims 1
- 229940014144 folate Drugs 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 229940047124 interferons Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- 239000003270 steroid hormone Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- XSIXXACWIYMCKZ-ACHIHNKUSA-N tert-butyl N-[3-[2,6-bis[[(6aS)-8-ethylidene-2-methoxy-11-oxo-7,9-dihydro-6aH-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxymethyl]pyridin-4-yl]oxypropyl]carbamate Chemical compound C(C)(C)(C)OC(=O)NCCCOC1=CC(=NC(=C1)COC1=CC\2=C(C(N3[C@H](/C=N/2)CC(C3)=CC)=O)C=C1OC)COC1=CC\2=C(C(N3[C@H](/C=N/2)CC(C3)=CC)=O)C=C1OC XSIXXACWIYMCKZ-ACHIHNKUSA-N 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Claims (15)
1. Spoj, naznačen time što ga se bira iz sljedećeg spiska:
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kao i odgovarajući merkapto derivati,
ili njihovi farmaceutski prihvatljiv soli, hidrati, ili hidratirane soli, ili polimorfne kristalne strukture tih spojeva ili njihovi optički izomeri, racemati, dijastereomeri ili enantiomeri.
2. Spoj, naznačen time što ga se bira iz sljedećeg spiska:
• 8,8′-[4-(3-tert-butoksikarbonilaminopropiloksi)-2,6-piridinediilbis(metilenoksi)]bis[(S)-2-et-(E)-iliden-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on];
• 8,8′-[5-(3-aminopropiloksi)-1,3-benzenediilbis(metilenoksi)]bis[(S)-2-et-(E)-iliden-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]banzodiazepin-5-on];
• 8,8′-[5-(N-metil-3-tert-butoksikarbonilaminopropil)-1,3-benzenediilbis(metilenoksi)]bis[(S)-2-et-(E)-iliden-7-metoksi-1,2,3,11a-tetrahidro-5H-pirolo[2,1-c][1,4]benzodiazepin-5-on].
3. Konjugat, naznačen time što sadrži jedan ili više spojeva u skladu s patentnim zahtjevom 1 ili 2, kovalentno vezanih na sredstvo za vezanje na stanicu preko povezujuće skupine jedne ili više spojnice.
4. Konjugat u skladu s patentnim zahtjevom 3, naznačen time što je navedena povezujuća skupina tiolna, sulfidna ili disulfidna skupina.
5. Konjugat u skladu s patentnim zahtjevom 3, naznačen time što je navedena povezujuća skupina -S- ili -S-S-.
6. Konjugat u skladu s patentnim zahtjevom 3 do 5, naznačen time što sredstvo za vezanje na stanicu se modificira modificirajućim sredstvom kako bi se povećala reaktivnost sredstva za vezanje na stanicu prema povezujućoj skupini spojnice.
7. Konjugat u skladu s patentnim zahtjevom 6, naznačen time što je modificirajuće sredstvo N-sulfosukcinimidil-4-(5-nitro-2-piridilditio)butanoat (SSNPB), sukcinimidil-4-[N-maleimidometil]cikloheksan-1-karboksilat (SMCC) ili N-hidroksisukcinimidni ester 4-(2-piridilditio)butanske kiseline (SPDB).
8. Konjugat u skladu s patentnim zahtjevom 3 do 7 naznačen time što se navedeno sredstvo za vezanje na stanicu bira između protutijela ili fragmenta protutijela koji sadrži najmanje jedno vežuće mjesto, limfokina, hormona, čimbenika rasta, molekula za prijenos nutrijenata ili bilo koje druge molekule ili tvari koja se veže na stanicu.
9. Konjugat u skladu s patentnim zahtjevom 3 do 8, naznačen time što se navedeno sredstvo za vezanje na stanicu bira između monoklonskih protutijela; kimernih protutijela; humaniziranih protutijela; posve ljudskih protutijela; jednolančanih protutijela; fragmenata protutijela, poput Fab, Fab′, F(ab′)2 i Fv, interferona; peptida; limfokina, poput IL-2, IL-3, IL-4, IL-6; hormona, poput inzulina, TRH (tireooslobađajućih hormona), MSH (melanostimulirajućeg hormona), steroidnih hormona, poput androgena i estrogena; čimbenika rasta i čimbenika stimulacije kolonija, poput EGF, TGFα, inzulinu sličnog čimbenika rasta (IGF-I, IGF-II) G-CSF, M-CSF i GM-CSF; vitamina, poput folata i transferina.
10. Postupak dobivanja konjugata u skladu s bilo kojim od patentnih zahtjeva 3 do 9, naznačen time što uključuje korak u kojem spoj u skladu s patentnim zahtjevom 1 koji sadrži sulfidnu, disulfidnu ili tiolnu skupinu, ili njegov preteča, reagira sa sredstvom za vezanje na stanicu, koje sadrži funkcionalnu skupinu reaktivnu prema disulfidu ili tiolu, tako da se spoj i sredstvo za vezanje na stanicu poveže zajedno preko sulfidne ili disulfidne veze.
11. Farmaceutski pripravak, naznačen time što sadrži molekulu konjugata u skladu s bilo kojim od patentnih zahtjeva 3 do 9 ili spoj u skladu s bilo kojim od patentnih zahtjeva 1 ili 2, uz farmaceutski prihvatljivu podlogu.
12. Upotreba djelotvorne količine molekule konjugata u skladu s bilo kojim od patentnih zahtjeva 3 do 9 ili spoja u skladu s bilo kojim od patentnih zahtjeva 1 ili 2, u pripravi medikamenta za ubijanje ili inhibiranje rasta stanica, naznačena time što se sastoji u stavljanju u kontakt molekule konjugata ili spoja s ciljanim stanicama ili tkivom koje sadrži ciljane stanice.
13. Upotreba djelotvorne količine molekule konjugata u skladu s bilo kojim od patentnih zahtjeva 3 do 9 ili spoja u skladu s bilo kojim od patentnih zahtjeva 1 ili 2, naznačena time što su molekula konjugata ili spoj namijenjeni pripravi medikamenta za liječenje raka.
14. Molekula konjugata namijenjena upotrebi u skladu s bilo kojim od patentnih zahtjeva 3 do 9, naznačena time što je namijenjena upotrebi kao sredstvo protiv raka.
15. Spoj u skladu s bilo kojim od patentnih zahtjeva 1 ili 2, naznačen time što je namijenjen upotrebi kao sredstvo protiv raka.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06290154A EP1813614B1 (en) | 2006-01-25 | 2006-01-25 | Cytotoxic agents comprising new tomaymycin derivatives |
| PCT/IB2007/000142 WO2007085930A1 (en) | 2006-01-25 | 2007-01-22 | Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140307T1 true HRP20140307T1 (hr) | 2014-06-20 |
Family
ID=35953949
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110955T HRP20110955T1 (hr) | 2006-01-25 | 2011-12-19 | Citotoksična sredstva koja sadrže nove derivate tomamicina |
| HRP20140307TT HRP20140307T1 (hr) | 2006-01-25 | 2014-03-31 | Citotoksiäśna sredstva koja sadrže nove derivate tomamicina i njihova upotreba u terapiji |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110955T HRP20110955T1 (hr) | 2006-01-25 | 2011-12-19 | Citotoksična sredstva koja sadrže nove derivate tomamicina |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US8163736B2 (hr) |
| EP (4) | EP1813614B1 (hr) |
| JP (1) | JP5116696B2 (hr) |
| KR (1) | KR101428112B1 (hr) |
| CN (1) | CN101374846B (hr) |
| AR (1) | AR059201A1 (hr) |
| AT (1) | ATE527262T1 (hr) |
| AU (1) | AU2007209072C1 (hr) |
| BR (1) | BRPI0707264A2 (hr) |
| CA (1) | CA2635482C (hr) |
| CR (1) | CR10149A (hr) |
| CY (2) | CY1112495T1 (hr) |
| DK (2) | DK1813614T3 (hr) |
| DO (1) | DOP2007000016A (hr) |
| EA (1) | EA017196B1 (hr) |
| EC (1) | ECSP088632A (hr) |
| ES (2) | ES2374964T3 (hr) |
| GT (1) | GT200800147A (hr) |
| HK (1) | HK1129106A1 (hr) |
| HN (1) | HN2008001103A (hr) |
| HR (2) | HRP20110955T1 (hr) |
| IL (1) | IL192472A0 (hr) |
| MA (1) | MA30226B1 (hr) |
| ME (1) | ME01814B (hr) |
| MX (1) | MX2008009582A (hr) |
| MY (1) | MY157715A (hr) |
| NI (1) | NI200800207A (hr) |
| NO (1) | NO341074B1 (hr) |
| NZ (1) | NZ569789A (hr) |
| PE (1) | PE20071110A1 (hr) |
| PL (2) | PL1813614T3 (hr) |
| PT (2) | PT1813614E (hr) |
| RS (2) | RS52060B (hr) |
| SI (2) | SI1813614T1 (hr) |
| TN (1) | TNSN08283A1 (hr) |
| TW (1) | TWI389909B (hr) |
| UA (1) | UA97794C2 (hr) |
| WO (1) | WO2007085930A1 (hr) |
| ZA (1) | ZA200805649B (hr) |
Families Citing this family (178)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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