HRP20130835T1 - Farmaceutske formulacije otopine za davanje kao stlaäśeni inhalat u inhalatoru - Google Patents

Farmaceutske formulacije otopine za davanje kao stlaäśeni inhalat u inhalatoru Download PDF

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Publication number
HRP20130835T1
HRP20130835T1 HRP20130835TT HRP20130835T HRP20130835T1 HR P20130835 T1 HRP20130835 T1 HR P20130835T1 HR P20130835T T HRP20130835T T HR P20130835TT HR P20130835 T HRP20130835 T HR P20130835T HR P20130835 T1 HRP20130835 T1 HR P20130835T1
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HR
Croatia
Prior art keywords
inhaler
metered dose
severe
dose inhalers
pharmaceutical solution
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Application number
HRP20130835TT
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English (en)
Inventor
David Andrew Lewis
Brian John Meakin
Gaetano Brambilla
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Chiesi Farmaceutici S.P.A.
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Application filed by Chiesi Farmaceutici S.P.A. filed Critical Chiesi Farmaceutici S.P.A.
Publication of HRP20130835T1 publication Critical patent/HRP20130835T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (2)

1. Formulacija otopine koja se daje kao stlačeni inahalat u inhalatoru koja kao aktivne tvari sadrži kombinaciju fromeoterol-fumarata i beklometazon-dipropionata otopljenih u smjesi HFA134a propelanta i 12% v/v etanola kao kootapala te 0.024 % v/v klorovodične kiseline (1M), naznačena time da je za upotrebu u prevenciji i/ili liječenju ozbiljnih bronhopulmonarnih bolesti odabranih od sljedećih: ozbiljna trajna astma ili ozbiljna ili vrlo ozbiljna kornična opstuktivna bolest pluća (COPD), s tim da se pokretanjem rečenog inhalatora isporučuje 50 mL rečene otopine koja sadrži dozu od 6 mg formoterol-fumarata te 100 mg beklametozaom-dipropionata po pokretanju.
2. Otopina prema patentnom zahtjevu 1, naznačena time da je inhalator načinjen od aluminija.
HRP20130835TT 2006-04-21 2013-09-09 Farmaceutske formulacije otopine za davanje kao stlaäśeni inhalat u inhalatoru HRP20130835T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/408,026 US20060257324A1 (en) 2000-05-22 2006-04-21 Pharmaceutical solution formulations for pressurised metered dose inhalers
PCT/EP2007/003420 WO2007121913A2 (en) 2006-04-21 2007-04-19 Pharmaceutical solution formulations for pressurised metered dose inhalers

Publications (1)

Publication Number Publication Date
HRP20130835T1 true HRP20130835T1 (hr) 2013-10-25

Family

ID=38230023

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20130835TT HRP20130835T1 (hr) 2006-04-21 2013-09-09 Farmaceutske formulacije otopine za davanje kao stlaäśeni inhalat u inhalatoru

Country Status (21)

Country Link
US (4) US20060257324A1 (hr)
EP (1) EP2010190B1 (hr)
JP (1) JP5289306B2 (hr)
KR (1) KR101311662B1 (hr)
CN (4) CN102908308A (hr)
AU (1) AU2007241336C1 (hr)
BR (1) BRPI0709510A2 (hr)
CA (1) CA2649556C (hr)
CY (1) CY1114215T1 (hr)
DK (1) DK2010190T3 (hr)
EA (1) EA016262B1 (hr)
ES (1) ES2424753T3 (hr)
HR (1) HRP20130835T1 (hr)
ME (1) ME02342B (hr)
MX (1) MX2008013460A (hr)
PL (1) PL2010190T3 (hr)
PT (1) PT2010190E (hr)
RS (1) RS52940B (hr)
SI (1) SI2010190T1 (hr)
WO (1) WO2007121913A2 (hr)
ZA (1) ZA200808965B (hr)

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EP2010190A2 (en) 2009-01-07
US10525006B2 (en) 2020-01-07
DK2010190T3 (da) 2013-08-26
BRPI0709510A2 (pt) 2011-07-19
CN106074359A (zh) 2016-11-09
KR101311662B1 (ko) 2013-09-25
WO2007121913A2 (en) 2007-11-01
AU2007241336B2 (en) 2012-12-06
ES2424753T3 (es) 2013-10-08
RS52940B (en) 2014-02-28
KR20080110985A (ko) 2008-12-22
EA016262B1 (ru) 2012-03-30
US20060257324A1 (en) 2006-11-16
CN105963249A (zh) 2016-09-28
CY1114215T1 (el) 2016-08-31
CA2649556C (en) 2014-04-15
MX2008013460A (es) 2008-10-29
CN102908308A (zh) 2013-02-06
EA200802012A1 (ru) 2009-04-28
ZA200808965B (en) 2009-12-30
ME02342B (me) 2016-06-20
EP2010190B1 (en) 2013-06-12
PT2010190E (pt) 2013-08-26
WO2007121913A3 (en) 2008-03-06
SI2010190T1 (sl) 2013-10-30
AU2007241336C1 (en) 2023-06-29
CN101389341A (zh) 2009-03-18
US20090130026A1 (en) 2009-05-21
PL2010190T3 (pl) 2013-11-29
JP5289306B2 (ja) 2013-09-11
US20200085729A1 (en) 2020-03-19
JP2009534333A (ja) 2009-09-24
US20170065518A1 (en) 2017-03-09
AU2007241336A1 (en) 2007-11-01
US11213485B2 (en) 2022-01-04
CA2649556A1 (en) 2007-11-01

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