HRP20120091T1 - Epoksi spoj i postupak za njegovu proizvodnju - Google Patents

Epoksi spoj i postupak za njegovu proizvodnju Download PDF

Info

Publication number: HRP20120091T1
Authority: HR; Croatia
Prior art keywords: group; phenyl; lower alkyl; halogen; substituted lower
Prior art date: 2007-05-08

Application number

HR20120091T

Other languages

English (en)

Croatian (hr)

Inventor

Tsubouchi Hidetsugu

Haraguchi Yoshikazu

Hayakawa Satoshi

Utsumi Naoto

Taira Shinichi

Tanada Yoshihisa

Fujita Nobuhisa

Shinhama Koichi

Annaka Kimiyoshi

Furuta Takuya

Original Assignee

Otsuka Pharmaceutical Co.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-05-08

Filing date

2012-01-26

Publication date

2012-02-29

2012-01-26 Application filed by Otsuka Pharmaceutical Co. filed Critical Otsuka Pharmaceutical Co.

2012-02-29 Publication of HRP20120091T1 publication Critical patent/HRP20120091T1/hr

Links

150000001875 compounds Chemical class 0.000 title claims abstract 9
239000004593 Epoxy Substances 0.000 title claims abstract 6
238000004519 manufacturing process Methods 0.000 title claims 3
238000000034 method Methods 0.000 title claims 3
125000000217 alkyl group Chemical group 0.000 claims abstract 46
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 39
125000001424 substituent group Chemical group 0.000 claims abstract 28
125000003545 alkoxy group Chemical group 0.000 claims abstract 10
150000003839 salts Chemical class 0.000 claims abstract 9
125000003342 alkenyl group Chemical group 0.000 claims abstract 6
229910052736 halogen Inorganic materials 0.000 claims abstract 6
150000002367 halogens Chemical class 0.000 claims abstract 5
-1 piperazyl group Chemical group 0.000 claims abstract 5
125000003277 amino group Chemical group 0.000 claims abstract 4
125000004432 carbon atom Chemical group C* 0.000 claims abstract 4
229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
239000001257 hydrogen Substances 0.000 claims abstract 4
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims abstract 4
125000003386 piperidinyl group Chemical group 0.000 claims abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
238000006243 chemical reaction Methods 0.000 claims 2
125000005843 halogen group Chemical group 0.000 claims 2
WPVZKVNCGYZPAQ-FQEVSTJZSA-N 1-(4-chlorophenyl)-4-[4-[[(2r)-2-methyloxiran-2-yl]methoxy]phenyl]piperazine Chemical compound C=1C=C(N2CCN(CC2)C=2C=CC(Cl)=CC=2)C=CC=1OC[C@@]1(C)CO1 WPVZKVNCGYZPAQ-FQEVSTJZSA-N 0.000 claims 1
IGFBGNHNWFKBRS-IBGZPJMESA-N 1-(4-chlorophenyl)-4-[4-[[(2r)-oxiran-2-yl]methoxy]phenyl]piperazine Chemical compound C1=CC(Cl)=CC=C1N1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 IGFBGNHNWFKBRS-IBGZPJMESA-N 0.000 claims 1
VROZDUDKUZGDFC-QHCPKHFHSA-N 1-[4-[[(2R)-2-methyloxiran-2-yl]methoxy]phenyl]-4-[3-[4-(trifluoromethoxy)phenyl]prop-2-enyl]piperazine Chemical compound C=1C=C(N2CCN(CC=CC=3C=CC(OC(F)(F)F)=CC=3)CC2)C=CC=1OC[C@@]1(C)CO1 VROZDUDKUZGDFC-QHCPKHFHSA-N 0.000 claims 1
JPXTYHMPPOZFFB-QFIPXVFZSA-N 1-[4-[[(2R)-oxiran-2-yl]methoxy]phenyl]-4-[3-[4-(trifluoromethoxy)phenyl]prop-2-enyl]piperazine Chemical compound C1=CC(OC(F)(F)F)=CC=C1C=CCN1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 JPXTYHMPPOZFFB-QFIPXVFZSA-N 0.000 claims 1
GSWKAUPDNWHGDX-NRFANRHFSA-N 1-[4-[[(2r)-2-methyloxiran-2-yl]methoxy]phenyl]-4-[4-(trifluoromethoxy)phenoxy]piperidine Chemical compound C=1C=C(N2CCC(CC2)OC=2C=CC(OC(F)(F)F)=CC=2)C=CC=1OC[C@@]1(C)CO1 GSWKAUPDNWHGDX-NRFANRHFSA-N 0.000 claims 1
PVGHVBZCRXTUEE-QFIPXVFZSA-N 1-[4-[[(2r)-2-methyloxiran-2-yl]methoxy]phenyl]-4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidine Chemical compound C=1C=C(N2CCC(CC2)OCC=2C=CC(OC(F)(F)F)=CC=2)C=CC=1OC[C@@]1(C)CO1 PVGHVBZCRXTUEE-QFIPXVFZSA-N 0.000 claims 1
PDWDJZNJOXCSCC-QFIPXVFZSA-N 1-[4-[[(2r)-2-methyloxiran-2-yl]methoxy]phenyl]-4-[[4-(trifluoromethoxy)phenyl]methyl]piperidine Chemical compound C=1C=C(N2CCC(CC=3C=CC(OC(F)(F)F)=CC=3)CC2)C=CC=1OC[C@@]1(C)CO1 PDWDJZNJOXCSCC-QFIPXVFZSA-N 0.000 claims 1
ZBCHTXWIWJNCIA-QFIPXVFZSA-N 1-[4-[[(2r)-2-methyloxiran-2-yl]methoxy]phenyl]-4-[[4-(trifluoromethyl)phenoxy]methyl]piperidine Chemical compound C=1C=C(N2CCC(COC=3C=CC(=CC=3)C(F)(F)F)CC2)C=CC=1OC[C@@]1(C)CO1 ZBCHTXWIWJNCIA-QFIPXVFZSA-N 0.000 claims 1
UFSOFSKPBYRGID-FQEVSTJZSA-N 1-[4-[[(2r)-oxiran-2-yl]methoxy]phenyl]-4-[4-(trifluoromethoxy)phenoxy]piperidine Chemical compound C1=CC(OC(F)(F)F)=CC=C1OC1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 UFSOFSKPBYRGID-FQEVSTJZSA-N 0.000 claims 1
QADQISDMQZKVIY-NRFANRHFSA-N 1-[4-[[(2r)-oxiran-2-yl]methoxy]phenyl]-4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidine Chemical compound C1=CC(OC(F)(F)F)=CC=C1COC1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 QADQISDMQZKVIY-NRFANRHFSA-N 0.000 claims 1
NVBADBIVWJJSRI-NRFANRHFSA-N 1-[4-[[(2r)-oxiran-2-yl]methoxy]phenyl]-4-[[4-(trifluoromethoxy)phenyl]methyl]piperidine Chemical compound C1=CC(OC(F)(F)F)=CC=C1CC1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 NVBADBIVWJJSRI-NRFANRHFSA-N 0.000 claims 1
PNOUQWXAUPCBJQ-NRFANRHFSA-N 1-[4-[[(2r)-oxiran-2-yl]methoxy]phenyl]-4-[[4-(trifluoromethyl)phenoxy]methyl]piperidine Chemical compound C1=CC(C(F)(F)F)=CC=C1OCC1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 PNOUQWXAUPCBJQ-NRFANRHFSA-N 0.000 claims 1
LSWCZCBNHGSJFW-QHCPKHFHSA-N 4-[(4-chlorophenyl)methoxymethyl]-1-[4-[[(2r)-2-methyloxiran-2-yl]methoxy]phenyl]piperidine Chemical compound C=1C=C(N2CCC(COCC=3C=CC(Cl)=CC=3)CC2)C=CC=1OC[C@@]1(C)CO1 LSWCZCBNHGSJFW-QHCPKHFHSA-N 0.000 claims 1
AEVBBWAFVMGCMP-QFIPXVFZSA-N 4-[(4-chlorophenyl)methoxymethyl]-1-[4-[[(2r)-oxiran-2-yl]methoxy]phenyl]piperidine Chemical compound C1=CC(Cl)=CC=C1COCC1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 AEVBBWAFVMGCMP-QFIPXVFZSA-N 0.000 claims 1
LWMPFIOTEAXAGV-UHFFFAOYSA-N piperidin-1-amine Chemical compound NN1CCCCC1 LWMPFIOTEAXAGV-UHFFFAOYSA-N 0.000 claims 1
238000006467 substitution reaction Methods 0.000 claims 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Life Sciences & Earth Sciences (AREA)
Oncology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

HR20120091T 2007-05-08 2012-01-26 Epoksi spoj i postupak za njegovu proizvodnju HRP20120091T1 (hr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2007123097		2007-05-08
PCT/JP2008/058798 WO2008140090A1 (en)	2007-05-08	2008-05-07	Epoxy compound and method for manufacturing the same

Publications (1)

Publication Number	Publication Date
HRP20120091T1 true HRP20120091T1 (hr)	2012-02-29

Family

ID=39683776

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20120091T HRP20120091T1 (hr)	2007-05-08	2012-01-26	Epoksi spoj i postupak za njegovu proizvodnju

Country Status (27)

Country	Link
US (2)	US8344148B2 (es)
EP (1)	EP2144899B1 (es)
JP (1)	JP4971343B2 (es)
KR (1)	KR101191072B1 (es)
CN (1)	CN101675044B (es)
AR (1)	AR070301A1 (es)
AT (1)	ATE536352T1 (es)
AU (1)	AU2008250097B2 (es)
BR (1)	BRPI0810780A2 (es)
CA (1)	CA2686092C (es)
CO (1)	CO6260137A2 (es)
CY (1)	CY1112279T1 (es)
DK (1)	DK2144899T3 (es)
ES (1)	ES2375245T3 (es)
HK (1)	HK1137023A1 (es)
HR (1)	HRP20120091T1 (es)
IL (1)	IL201976A (es)
MX (1)	MX2009011888A (es)
MY (1)	MY149301A (es)
NZ (1)	NZ580918A (es)
PL (1)	PL2144899T3 (es)
PT (1)	PT2144899E (es)
RU (1)	RU2459822C2 (es)
SI (1)	SI2144899T1 (es)
TW (1)	TWI432428B (es)
UA (1)	UA99455C2 (es)
WO (1)	WO2008140090A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102008053240A1 (de)	2008-10-25	2010-04-29	Saltigo Gmbh	Herstellung von (N-Heterozyklyl)-Arylethern
TW201200523A (en) *	2010-01-29	2012-01-01	Otsuka Pharma Co Ltd	Synthetic intermediate of oxazole compound and method for producing the same
WO2015068712A1 (ja) *	2013-11-05	2015-05-14	公立大学法人横浜市立大学	超弾性材料、ならびに当該超弾性材料を用いた、エネルギー貯蔵材料、エネルギー吸収材料、弾性材料、アクチュエータおよび形状記憶材料
MD20160099A2 (ro)	2014-03-17	2017-02-28	Pfizer Inc.	Inhibitori ai diacilglicerol aciltransferazei 2 pentru utilizare în tratamentul tulburărilor metabolice şi a celor asociate
US10227362B2 (en)	2015-01-29	2019-03-12	Medshine Discovery Inc.	Anti-pulmonary tuberculosis nitroimidazole derivative
WO2016158737A1 (ja) *	2015-03-27	2016-10-06	大塚製薬株式会社	１－（４－ヒドロキシフェニル）－４－（４－トリフルオロメトキシフェノキシ）ピペリジン又はその塩の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES512316A0 (es) *	1982-05-19	1983-02-01	Romikim S A	Procedimiento de preparacion de la cis-1-acetil-4 4-4-(2,4-diclorofenil)-2-(1h-imidazol-1-ilmetil)-1,3-dioxolano-4-ilmetoxi-fenil piperacina.
WO2001034569A1 (fr) *	1999-11-11	2001-05-17	Senju Pharmaceutical Co., Ltd.	Medicaments contre la pancreatite
TWI347946B (en)	2002-10-11	2011-09-01	Otsuka Pharma Co Ltd	2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound
ES2526892T3 (es)	2002-10-15	2015-01-16	Otsuka Pharmaceutical Co., Ltd.	Método para preparar un compuesto 2-halo-4-nitroimidazol
AR046777A1 (es) *	2003-10-31	2005-12-21	Otsuka Pharma Co Ltd	Compuesto de 2,3-dihidro-6-nitroimidazo(2,1-b)oxazol
JP4787529B2 (ja) *	2004-04-09	2011-10-05	大塚製薬株式会社	医薬組成物
JP2009269859A (ja) *	2008-05-08	2009-11-19	Otsuka Pharmaceut Co Ltd	Ｎ−含有複素環化合物

2008
- 2008-05-05 AR ARP080101894A patent/AR070301A1/es unknown
- 2008-05-07 BR BRPI0810780-7A2A patent/BRPI0810780A2/pt not_active IP Right Cessation
- 2008-05-07 PT PT08764285T patent/PT2144899E/pt unknown
- 2008-05-07 NZ NZ580918A patent/NZ580918A/en unknown
- 2008-05-07 AU AU2008250097A patent/AU2008250097B2/en not_active Ceased
- 2008-05-07 PL PL08764285T patent/PL2144899T3/pl unknown
- 2008-05-07 SI SI200830521T patent/SI2144899T1/sl unknown
- 2008-05-07 TW TW097116853A patent/TWI432428B/zh not_active IP Right Cessation
- 2008-05-07 CN CN2008800150834A patent/CN101675044B/zh active Active
- 2008-05-07 ES ES08764285T patent/ES2375245T3/es active Active
- 2008-05-07 EP EP08764285A patent/EP2144899B1/en active Active
- 2008-05-07 JP JP2008536669A patent/JP4971343B2/ja active Active
- 2008-05-07 UA UAA200911599A patent/UA99455C2/ru unknown
- 2008-05-07 KR KR1020087016495A patent/KR101191072B1/ko active Protection Beyond IP Right Term
- 2008-05-07 RU RU2009145273/04A patent/RU2459822C2/ru not_active IP Right Cessation
- 2008-05-07 US US12/599,214 patent/US8344148B2/en active Active
- 2008-05-07 WO PCT/JP2008/058798 patent/WO2008140090A1/en active Application Filing
- 2008-05-07 AT AT08764285T patent/ATE536352T1/de active
- 2008-05-07 CA CA2686092A patent/CA2686092C/en not_active Expired - Fee Related
- 2008-05-07 DK DK08764285.6T patent/DK2144899T3/da active
- 2008-05-07 MX MX2009011888A patent/MX2009011888A/es active IP Right Grant
- 2008-05-07 MY MYPI20094651A patent/MY149301A/en unknown
2009
- 2009-10-30 CO CO09122664A patent/CO6260137A2/es active IP Right Grant
- 2009-11-05 IL IL201976A patent/IL201976A/en not_active IP Right Cessation
2010
- 2010-04-23 HK HK10104035.7A patent/HK1137023A1/xx not_active IP Right Cessation
2012
- 2012-01-17 CY CY20121100055T patent/CY1112279T1/el unknown
- 2012-01-26 HR HR20120091T patent/HRP20120091T1/hr unknown
- 2012-11-15 US US13/677,727 patent/US8552188B2/en active Active

Also Published As

Publication number	Publication date
ATE536352T1 (de)	2011-12-15
MX2009011888A (es)	2009-11-18
AR070301A1 (es)	2010-03-31
PT2144899E (pt)	2011-12-27
JP4971343B2 (ja)	2012-07-11
US20130072683A1 (en)	2013-03-21
TW200911793A (en)	2009-03-16
US8552188B2 (en)	2013-10-08
TWI432428B (zh)	2014-04-01
RU2459822C2 (ru)	2012-08-27
IL201976A0 (en)	2010-06-16
CA2686092A1 (en)	2008-11-20
CO6260137A2 (es)	2011-03-22
RU2009145273A (ru)	2011-06-20
UA99455C2 (ru)	2012-08-27
US20100217005A1 (en)	2010-08-26
MY149301A (en)	2013-08-30
SI2144899T1 (sl)	2012-03-30
NZ580918A (en)	2011-09-30
CN101675044A (zh)	2010-03-17
WO2008140090A1 (en)	2008-11-20
CA2686092C (en)	2015-04-28
AU2008250097B2 (en)	2011-07-14
JP2009534291A (ja)	2009-09-24
PL2144899T3 (pl)	2012-04-30
EP2144899B1 (en)	2011-12-07
BRPI0810780A2 (pt)	2014-10-29
US8344148B2 (en)	2013-01-01
AU2008250097A1 (en)	2008-11-20
ES2375245T3 (es)	2012-02-28
DK2144899T3 (da)	2012-02-13
KR20090010943A (ko)	2009-01-30
CY1112279T1 (el)	2015-12-09
IL201976A (en)	2015-05-31
KR101191072B1 (ko)	2012-10-15
EP2144899A1 (en)	2010-01-20
HK1137023A1 (en)	2010-07-16
CN101675044B (zh)	2012-10-03

Publication	Publication Date	Title
HRP20120091T1 (hr)	2012-02-29	Epoksi spoj i postupak za njegovu proizvodnju
RU2453543C2 (ru)	2012-06-20	Новые производные пиридона, обладающие антагонистической активностью в отношении mch, и лекарственные средства, включающие такие соединения
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ATE476427T1 (de)	2010-08-15	Difluormethyl thiazolyl carboxanilide
RS28004A (en)	2007-04-10	Azabicycle-substituted fused- heteroaryl compounds for the treatment of disease
JP2012532239A5 (es)	2013-02-28
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MX2009013213A (es)	2010-03-30	Indazoles 5-sustituidos 5-heteroarilo como inhibidores de cinasa.
WO2004098518A3 (en)	2005-01-27	Pyrazole-amide compounds useful as kinase inhibitors
DE60318583D1 (de)	2008-02-21	N-äphenyl(piperidin-2-yl)methylübenzamid-derivate, verfahren zu deren herstellung und ihre therapeutische verwendung
MX2007001022A (es)	2007-04-12	Derivados de n-hidroxiamida y uso de los mismos.
AR058928A1 (es)	2008-03-05	Piperazinas y piperidinas como potenciadoras de mglur5. usos y composiciones farmaceuticas.
BRPI0614692A2 (pt)	2009-05-19	derivados de indol-3-il-carbonil-piperidina e piperazina
ES2421448T3 (es)	2013-09-02	Derivados de piperazina como agentes contra la malaria
CY1106857T1 (el)	2012-05-23	Βενζαμιδια 4-(αμινομεθυλ)-πιπεριδινης ως 5ht4-ανταγωνιστες
NO20060383L (no)	2006-01-24	Substituerte diketopiperaziner og deres anvendelse som oksytocinantagonister
NO20060718L (no)	2006-03-01	Substituerte tiofoner og deres anvendelse
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EA200501526A1 (ru)	2006-04-28	Производные 4-замещённых хинолинов, способ и промежуточные продукты для их получения и содержащие их фармацевтические композиции
NO20023251L (no)	2002-09-06	Nye tetrahydropyridiner, fremgangsmåte for deres fremstilling og farmasöytiske preparater inneholdende de samme
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