HRP20080478T3 - Derivati 4-(2-fenilsulfanil-fenil)-piperidina kaoinhibitori ponovne pohrane serotonina - Google Patents
Derivati 4-(2-fenilsulfanil-fenil)-piperidina kaoinhibitori ponovne pohrane serotoninaInfo
- Publication number
- HRP20080478T3 HRP20080478T3 HR20080478T HRP20080478T HRP20080478T3 HR P20080478 T3 HRP20080478 T3 HR P20080478T3 HR 20080478 T HR20080478 T HR 20080478T HR P20080478 T HRP20080478 T HR P20080478T HR P20080478 T3 HRP20080478 T3 HR P20080478T3
- Authority
- HR
- Croatia
- Prior art keywords
- phenylsulfanyl
- phenyl
- serotonin reuptake
- reuptake inhibitors
- piperidine derivatives
- Prior art date
Links
- OITWUTJGZGVOKQ-UHFFFAOYSA-N 4-(2-phenylsulfanylphenyl)piperidine Chemical class C1CNCCC1C1=CC=CC=C1SC1=CC=CC=C1 OITWUTJGZGVOKQ-UHFFFAOYSA-N 0.000 title 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 title 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000017194 Affective disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Spoj naznačen time da je prikazan općom formulom Iu kojoj suR1, R2, R3, R4, R5 neovisno odabrani izvodika, halogena, cijana, C1-6-alk(en/in)ila, C1-6-alk(en/in)iloksi, C1-6-alk(en/in)ilsulfanila, hidroksi, hidroksi-C1-6-alk(en/in)ila, halo-C1-6-alk(en/in)ila, halo-C1-6-alk(en/in)iloksi ili NRXRY gdje su RX i RY neovisno odabrani iz vodika, C1-6-alk(en/in)ila, cijano-C1-6-alk(en/in)ila, C3-8-cikloalk(en)ila, C3-8-cikloalk(en)il-C1-6-alk(en/in)ila ili NRZRW-C1-6-alk(en/in)ila gdje su RZ i RW neovisno odabrani iz vodika, C1-6-alk(en/in)ila, C3-8-cikloalk(en)ila ili C3-8-cikloalk(en)il-C1-6-alk(en/in)ila; ili RX i RY zajedno s dušikom na koji su vezani tvore 3-7-člani prsten koji opcionalno sadrži još jedan heteroatom; iliR6, R7, R8, R9 su neovisno odabrani iz vodika, halogena, C1-6-alk(en/in)ila, C1-6-alk(en/in)iloksi, C1-6-alk(en/in)ilsulfanila, hidroksi, hidroksi-C1-6-alk(en/in)ila, halo-C1-6-alk(en/in)ila, halo-C1-6-alk(en/in)iloksi ili NRXRY gdje su RX i RY neovisno odabrani iz vodika, C1-6-alk(en/in)ila, cijano-C1-6-alk(en/in)ila,C3-8-cikloalk(en)ila, C3-8-cikloalk(en)il-C1-6-alk(en/in)ila ili NRZRW-C1-6-alk(en/in)ila, gdje su RZ i RW neovisno odabrani iz vodika, C1-6-alk(en/in)ila, C3-8-cikloalk(en)ila, C3-8-cikloalk(en)il-C1-6-alk(en/in)ila; ili RX i RY zajedno s dušikom na koji su vezani tvore 3-7-člani prsten koji opcionalno sadrži još jedan heteroatom; pod uvjetom da bar jedan od R1, R2, R3, R4, R5, R6, R7, R8 i R9 bude različit od vodika; također pod uvjetom da akoje R3 metil, onda je bar jedan od R1, R2, R4, R5,R6, R7, R8, R9 različit od vodika; ili od njegovesoli. Patent sadrži još 24 patentna zahtjeva.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46052803P | 2003-04-04 | 2003-04-04 | |
DKPA200300520 | 2003-04-04 | ||
PCT/DK2004/000244 WO2004087156A1 (en) | 2003-04-04 | 2004-04-02 | 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20080478T3 true HRP20080478T3 (hr) | 2009-02-28 |
Family
ID=33132909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20080478T HRP20080478T3 (hr) | 2003-04-04 | 2008-09-26 | Derivati 4-(2-fenilsulfanil-fenil)-piperidina kaoinhibitori ponovne pohrane serotonina |
Country Status (19)
Country | Link |
---|---|
US (1) | US7732463B2 (hr) |
EP (1) | EP1626720B1 (hr) |
JP (1) | JP4667366B2 (hr) |
AT (1) | ATE406894T1 (hr) |
AU (1) | AU2004226838B8 (hr) |
CA (1) | CA2521258C (hr) |
CO (1) | CO5700748A2 (hr) |
CY (1) | CY1108464T1 (hr) |
DE (1) | DE602004016316D1 (hr) |
DK (1) | DK1626720T3 (hr) |
ES (1) | ES2309514T3 (hr) |
HR (1) | HRP20080478T3 (hr) |
IL (1) | IL171087A (hr) |
MX (1) | MXPA05009592A (hr) |
NO (1) | NO20055208L (hr) |
PL (1) | PL1626720T3 (hr) |
PT (1) | PT1626720E (hr) |
SI (1) | SI1626720T1 (hr) |
WO (1) | WO2004087156A1 (hr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
EP2400300A1 (en) | 2004-08-25 | 2011-12-28 | Takeda Pharmaceutical Company Limited | Method of screening preventives/remedies for stress urinary incontinence |
EP2018863B9 (en) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
BRPI0713425A2 (pt) | 2006-06-16 | 2012-03-13 | H. Lundbeck A/S | composto, composição farmacêutica, método para tratar uma doença, uso de um composto, e processos para a preparação de um composto, e para a fabricação de um composto |
TWI432194B (zh) * | 2007-03-20 | 2014-04-01 | Lundbeck & Co As H | 4-〔2-(4-甲基苯硫基)苯基〕哌啶之新穎治療用途 |
TWI405588B (zh) * | 2007-03-20 | 2013-08-21 | Lundbeck & Co As H | 4-〔2-(4-甲苯基硫基)-苯基〕哌啶之鹽類的液體調配物 |
TW200932233A (en) | 2007-11-13 | 2009-08-01 | Lundbeck & Co As H | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity |
JP5520051B2 (ja) | 2007-11-15 | 2014-06-11 | 武田薬品工業株式会社 | 縮合ピリジン誘導体およびその用途 |
TW200938194A (en) * | 2007-12-14 | 2009-09-16 | Lundbeck & Co As H | Therapeutic uses of compounds having affinity to the serotonin transporter, serotonin receptors and noradrenalin transporter |
TW200932225A (en) * | 2007-12-14 | 2009-08-01 | Lundbeck & Co As H | 4-[2,3-difluoro-6-(2-fluoro-4-methyl-phenylsulfanyl)-phenyl]-piperidine |
UA98698C2 (en) * | 2008-03-03 | 2012-06-11 | Х. Луннбек А/С | Phenylsulfanylphenyl-piperidines and process for the preparation thereof |
SI2421534T1 (sl) | 2009-04-24 | 2014-11-28 | H. Lundbeck A/S | Tekoče formulacije soli 1-(2-(2,4-dimetilfenilsulfanil) fenil) piperazina |
JPWO2011071136A1 (ja) | 2009-12-11 | 2013-04-22 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
EP2564837B1 (en) * | 2010-04-30 | 2019-01-30 | Takeda Pharmaceutical Company Limited | Enteric tablet |
MA34261B1 (fr) * | 2010-04-30 | 2013-05-02 | Takeda Pharmaceutcal Company Ltd | Comprime a delitage intestinal |
US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
WO2019170543A1 (en) | 2018-03-07 | 2019-09-12 | Bayer Aktiengesellschaft | Identification and use of erk5 inhibitors |
WO2023218484A1 (en) | 2022-05-11 | 2023-11-16 | Pi Industries Ltd. | Bicyclic compounds and their use as pest control agents |
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WO2000059878A2 (en) | 1999-04-02 | 2000-10-12 | Icos Corporation | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF |
CA2372481A1 (en) | 1999-04-30 | 2000-11-09 | The Trustees Of The University Of Pennsylvania | Spect imaging agents for serotonin transporters |
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AR043633A1 (es) | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
UA81300C2 (en) | 2003-04-04 | 2007-12-25 | Lundbeck & Co As H | Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture |
ATE392896T1 (de) | 2003-04-04 | 2008-05-15 | Lundbeck & Co As H | 4-(2-phenyloxyphenyl)-piperidin- oder -1,2,3,6- tetrahydropyridin-derivate als serotonin- wiederaufnahme-hemmer |
WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
-
2004
- 2004-04-02 SI SI200430864T patent/SI1626720T1/sl unknown
- 2004-04-02 AT AT04725291T patent/ATE406894T1/de active
- 2004-04-02 AU AU2004226838A patent/AU2004226838B8/en not_active Ceased
- 2004-04-02 PL PL04725291T patent/PL1626720T3/pl unknown
- 2004-04-02 WO PCT/DK2004/000244 patent/WO2004087156A1/en active IP Right Grant
- 2004-04-02 CA CA002521258A patent/CA2521258C/en not_active Expired - Fee Related
- 2004-04-02 DK DK04725291T patent/DK1626720T3/da active
- 2004-04-02 JP JP2006504349A patent/JP4667366B2/ja not_active Expired - Fee Related
- 2004-04-02 DE DE602004016316T patent/DE602004016316D1/de not_active Expired - Lifetime
- 2004-04-02 EP EP04725291A patent/EP1626720B1/en not_active Expired - Lifetime
- 2004-04-02 PT PT04725291T patent/PT1626720E/pt unknown
- 2004-04-02 ES ES04725291T patent/ES2309514T3/es not_active Expired - Lifetime
- 2004-04-02 MX MXPA05009592A patent/MXPA05009592A/es active IP Right Grant
- 2004-04-02 US US10/551,883 patent/US7732463B2/en not_active Expired - Fee Related
-
2005
- 2005-09-25 IL IL171087A patent/IL171087A/en not_active IP Right Cessation
- 2005-11-03 CO CO05112440A patent/CO5700748A2/es not_active Application Discontinuation
- 2005-11-04 NO NO20055208A patent/NO20055208L/no not_active Application Discontinuation
-
2008
- 2008-09-26 HR HR20080478T patent/HRP20080478T3/hr unknown
- 2008-10-30 CY CY20081101225T patent/CY1108464T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK1626720T3 (da) | 2008-12-01 |
AU2004226838A1 (en) | 2004-10-14 |
US7732463B2 (en) | 2010-06-08 |
CO5700748A2 (es) | 2006-11-30 |
PL1626720T3 (pl) | 2009-02-27 |
MXPA05009592A (es) | 2005-10-18 |
ES2309514T3 (es) | 2008-12-16 |
JP4667366B2 (ja) | 2011-04-13 |
DE602004016316D1 (de) | 2008-10-16 |
CA2521258A1 (en) | 2004-10-14 |
WO2004087156A1 (en) | 2004-10-14 |
EP1626720A1 (en) | 2006-02-22 |
AU2004226838B2 (en) | 2009-02-12 |
US20060100242A1 (en) | 2006-05-11 |
IL171087A (en) | 2011-01-31 |
EP1626720B1 (en) | 2008-09-03 |
JP2006522030A (ja) | 2006-09-28 |
CY1108464T1 (el) | 2014-04-09 |
NO20055208L (no) | 2005-11-04 |
ATE406894T1 (de) | 2008-09-15 |
AU2004226838B8 (en) | 2009-06-11 |
SI1626720T1 (sl) | 2008-12-31 |
CA2521258C (en) | 2009-12-01 |
PT1626720E (pt) | 2008-11-10 |
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