HRP20080478T3 - Derivati 4-(2-fenilsulfanil-fenil)-piperidina kaoinhibitori ponovne pohrane serotonina - Google Patents

Derivati 4-(2-fenilsulfanil-fenil)-piperidina kaoinhibitori ponovne pohrane serotonina

Info

Publication number
HRP20080478T3
HRP20080478T3 HR20080478T HRP20080478T HRP20080478T3 HR P20080478 T3 HRP20080478 T3 HR P20080478T3 HR 20080478 T HR20080478 T HR 20080478T HR P20080478 T HRP20080478 T HR P20080478T HR P20080478 T3 HRP20080478 T3 HR P20080478T3
Authority
HR
Croatia
Prior art keywords
phenylsulfanyl
phenyl
serotonin reuptake
reuptake inhibitors
piperidine derivatives
Prior art date
Application number
HR20080478T
Other languages
English (en)
Inventor
Pschl Ask
Jorgensen Morten
Ruhland Thomas
Bryan Tine
Bang-Andersen Benny
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of HRP20080478T3 publication Critical patent/HRP20080478T3/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Spoj naznačen time da je prikazan općom formulom Iu kojoj suR1, R2, R3, R4, R5 neovisno odabrani izvodika, halogena, cijana, C1-6-alk(en/in)ila, C1-6-alk(en/in)iloksi, C1-6-alk(en/in)ilsulfanila, hidroksi, hidroksi-C1-6-alk(en/in)ila, halo-C1-6-alk(en/in)ila, halo-C1-6-alk(en/in)iloksi ili NRXRY gdje su RX i RY neovisno odabrani iz vodika, C1-6-alk(en/in)ila, cijano-C1-6-alk(en/in)ila, C3-8-cikloalk(en)ila, C3-8-cikloalk(en)il-C1-6-alk(en/in)ila ili NRZRW-C1-6-alk(en/in)ila gdje su RZ i RW neovisno odabrani iz vodika, C1-6-alk(en/in)ila, C3-8-cikloalk(en)ila ili C3-8-cikloalk(en)il-C1-6-alk(en/in)ila; ili RX i RY zajedno s dušikom na koji su vezani tvore 3-7-člani prsten koji opcionalno sadrži još jedan heteroatom; iliR6, R7, R8, R9 su neovisno odabrani iz vodika, halogena, C1-6-alk(en/in)ila, C1-6-alk(en/in)iloksi, C1-6-alk(en/in)ilsulfanila, hidroksi, hidroksi-C1-6-alk(en/in)ila, halo-C1-6-alk(en/in)ila, halo-C1-6-alk(en/in)iloksi ili NRXRY gdje su RX i RY neovisno odabrani iz vodika, C1-6-alk(en/in)ila, cijano-C1-6-alk(en/in)ila,C3-8-cikloalk(en)ila, C3-8-cikloalk(en)il-C1-6-alk(en/in)ila ili NRZRW-C1-6-alk(en/in)ila, gdje su RZ i RW neovisno odabrani iz vodika, C1-6-alk(en/in)ila, C3-8-cikloalk(en)ila, C3-8-cikloalk(en)il-C1-6-alk(en/in)ila; ili RX i RY zajedno s dušikom na koji su vezani tvore 3-7-člani prsten koji opcionalno sadrži još jedan heteroatom; pod uvjetom da bar jedan od R1, R2, R3, R4, R5, R6, R7, R8 i R9 bude različit od vodika; također pod uvjetom da akoje R3 metil, onda je bar jedan od R1, R2, R4, R5,R6, R7, R8, R9 različit od vodika; ili od njegovesoli. Patent sadrži još 24 patentna zahtjeva.
HR20080478T 2003-04-04 2008-09-26 Derivati 4-(2-fenilsulfanil-fenil)-piperidina kaoinhibitori ponovne pohrane serotonina HRP20080478T3 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46052803P 2003-04-04 2003-04-04
DKPA200300520 2003-04-04
PCT/DK2004/000244 WO2004087156A1 (en) 2003-04-04 2004-04-02 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors

Publications (1)

Publication Number Publication Date
HRP20080478T3 true HRP20080478T3 (hr) 2009-02-28

Family

ID=33132909

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20080478T HRP20080478T3 (hr) 2003-04-04 2008-09-26 Derivati 4-(2-fenilsulfanil-fenil)-piperidina kaoinhibitori ponovne pohrane serotonina

Country Status (19)

Country Link
US (1) US7732463B2 (hr)
EP (1) EP1626720B1 (hr)
JP (1) JP4667366B2 (hr)
AT (1) ATE406894T1 (hr)
AU (1) AU2004226838B8 (hr)
CA (1) CA2521258C (hr)
CO (1) CO5700748A2 (hr)
CY (1) CY1108464T1 (hr)
DE (1) DE602004016316D1 (hr)
DK (1) DK1626720T3 (hr)
ES (1) ES2309514T3 (hr)
HR (1) HRP20080478T3 (hr)
IL (1) IL171087A (hr)
MX (1) MXPA05009592A (hr)
NO (1) NO20055208L (hr)
PL (1) PL1626720T3 (hr)
PT (1) PT1626720E (hr)
SI (1) SI1626720T1 (hr)
WO (1) WO2004087156A1 (hr)

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Also Published As

Publication number Publication date
DK1626720T3 (da) 2008-12-01
AU2004226838A1 (en) 2004-10-14
US7732463B2 (en) 2010-06-08
CO5700748A2 (es) 2006-11-30
PL1626720T3 (pl) 2009-02-27
MXPA05009592A (es) 2005-10-18
ES2309514T3 (es) 2008-12-16
JP4667366B2 (ja) 2011-04-13
DE602004016316D1 (de) 2008-10-16
CA2521258A1 (en) 2004-10-14
WO2004087156A1 (en) 2004-10-14
EP1626720A1 (en) 2006-02-22
AU2004226838B2 (en) 2009-02-12
US20060100242A1 (en) 2006-05-11
IL171087A (en) 2011-01-31
EP1626720B1 (en) 2008-09-03
JP2006522030A (ja) 2006-09-28
CY1108464T1 (el) 2014-04-09
NO20055208L (no) 2005-11-04
ATE406894T1 (de) 2008-09-15
AU2004226838B8 (en) 2009-06-11
SI1626720T1 (sl) 2008-12-31
CA2521258C (en) 2009-12-01
PT1626720E (pt) 2008-11-10

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