HRP20070025A2 - New pseudopolymorph of desloratadine formed with carbon dioxide - Google Patents

New pseudopolymorph of desloratadine formed with carbon dioxide

Info

Publication number
HRP20070025A2
HRP20070025A2 HR20070025A HRP20070025A HRP20070025A2 HR P20070025 A2 HRP20070025 A2 HR P20070025A2 HR 20070025 A HR20070025 A HR 20070025A HR P20070025 A HRP20070025 A HR P20070025A HR P20070025 A2 HRP20070025 A2 HR P20070025A2
Authority
HR
Croatia
Prior art keywords
desloratadine
carbon dioxide
pseudopolymorph
formula
new pseudopolymorph
Prior art date
Application number
HR20070025A
Other languages
Croatian (hr)
Inventor
Volk Bal�zs
Hoffmann� Fekete Val�ria
Luk�cs Gyula
Mezei Tibor
Moln�r Eniko
Porcs-Makkay M�rta
Simig Gyula
Szent-Kir�llyi Zsuzsanna
Original Assignee
EGIS Gy�gyszergy�r Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0401373A external-priority patent/HU0401373D0/en
Priority claimed from HU0500664A external-priority patent/HU226951B1/en
Application filed by EGIS Gy�gyszergy�r Nyrt filed Critical EGIS Gy�gyszergy�r Nyrt
Publication of HRP20070025A2 publication Critical patent/HRP20070025A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dairy Products (AREA)
  • Grain Derivatives (AREA)

Abstract

Pseudopolimorf deloratadina s formulom (I) nastalog s ugljičnim dioksidom koji posjeduje protu-alergijski učinak te se može rabiti kao farmaceutski aktivni sastojak. Ovaj izum također se odnosi na proces priređivanja desloratadina visoke čistoće. Ovaj izum također se odnosi na uporabu pseudopolimorfa desloratadina s formulom (I) za priređivanje soli desloratadina s formulom (V) (gdje je X anion, a n je 1 ili 2).Pseudopolymorph of deloratadine of formula (I) formed with carbon dioxide which has an anti-allergic effect and can be used as a pharmaceutically active ingredient. The present invention also relates to a process for the preparation of high purity desloratadine. The present invention also relates to the use of a pseudopolymorph of desloratadine of formula (I) for the preparation of a desloratadine salt of formula (V) (wherein X is an anion and n is 1 or 2).

HR20070025A 2004-07-07 2007-01-26 New pseudopolymorph of desloratadine formed with carbon dioxide HRP20070025A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0401373A HU0401373D0 (en) 2004-07-07 2004-07-07 Pseudopolimorphic form of desloratadine with carbondioxide
HU0500664A HU226951B1 (en) 2005-07-06 2005-07-06 Pseudopolimorphic form of desloratadine with carbon dioxide, process for its preparation and its use
PCT/HU2005/000073 WO2006003479A2 (en) 2004-07-07 2005-07-07 New pseudopolymorph of desloratadine formed with carbon dioxide

Publications (1)

Publication Number Publication Date
HRP20070025A2 true HRP20070025A2 (en) 2008-11-30

Family

ID=89986128

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20070025A HRP20070025A2 (en) 2004-07-07 2007-01-26 New pseudopolymorph of desloratadine formed with carbon dioxide

Country Status (9)

Country Link
EP (1) EP1817307A2 (en)
BG (1) BG109814A (en)
CZ (1) CZ200798A3 (en)
EA (1) EA011894B1 (en)
HR (1) HRP20070025A2 (en)
PL (1) PL381813A1 (en)
RS (1) RS20070008A (en)
SK (1) SK50112007A3 (en)
WO (1) WO2006003479A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230417B1 (en) * 2006-10-26 2016-05-30 Egis Gyógyszergyár Zrt Process for producing adduct comprising desloratadine and carbon dioxide
CN103755682A (en) * 2013-12-30 2014-04-30 山东达因海洋生物制药股份有限公司 Novel crystal form for desloratadine and preparation method thereof
US20170240543A1 (en) * 2014-08-14 2017-08-24 Sun Pharmaceutical Industries Limited Crystalline forms of palbociclib
CN104610225B (en) * 2014-12-29 2017-02-01 广东九明制药有限公司 Preparation method of desloratadine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61501205A (en) * 1984-02-15 1986-06-19 シェリング・コ−ポレ−ション 8↓-chloro↓-6,11↓-dihydro↓-11↓-(4↓-piperidylidene)↓-5H↓-benzo[5,6]cyclohepta[1,2-b]pyridine and its salts, compounds thereof and pharmaceutical compositions containing these compounds.
US5595997A (en) * 1994-12-30 1997-01-21 Sepracor Inc. Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine
UA62976C2 (en) * 1997-07-02 2004-01-15 Schering Corp Polymorphs of 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
HU226998B1 (en) * 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
CN1674901A (en) * 2002-08-05 2005-09-28 桑多斯股份公司 Novel salt and polymorphs of desloratadine hemifumarate
AU2002334383A1 (en) * 2002-09-24 2004-04-19 Morepen Laboratories Limited An improved process for the production of desloratadine

Also Published As

Publication number Publication date
EA200700208A1 (en) 2007-08-31
SK50112007A3 (en) 2007-07-06
RS20070008A (en) 2008-11-28
WO2006003479A2 (en) 2006-01-12
CZ200798A3 (en) 2007-06-20
BG109814A (en) 2008-04-30
EP1817307A2 (en) 2007-08-15
WO2006003479A3 (en) 2006-06-08
EA011894B1 (en) 2009-06-30
PL381813A1 (en) 2007-07-23

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
PNAN Change of the applicant name, address/residence

Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUKOEDO RESZVENYTAR

AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
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Payment date: 20090702

Year of fee payment: 5

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