EA200700208A1 - NEW PSEUDOPOLYMORPH FORM OF DESLORATADINE FORMED WITH CARBON DIOXIDE - Google Patents

NEW PSEUDOPOLYMORPH FORM OF DESLORATADINE FORMED WITH CARBON DIOXIDE

Info

Publication number
EA200700208A1
EA200700208A1 EA200700208A EA200700208A EA200700208A1 EA 200700208 A1 EA200700208 A1 EA 200700208A1 EA 200700208 A EA200700208 A EA 200700208A EA 200700208 A EA200700208 A EA 200700208A EA 200700208 A1 EA200700208 A1 EA 200700208A1
Authority
EA
Eurasian Patent Office
Prior art keywords
desloratadine
carbon dioxide
formula
pseudopolymorph form
new pseudopolymorph
Prior art date
Application number
EA200700208A
Other languages
Russian (ru)
Other versions
EA011894B1 (en
Inventor
Тибор Мезеи
Дьюла Шимиг
Дьюла Лукач
Марта Порч-Маккаи
Балаж Вольк
Эникё Мольнар
Валерия Хофманне Фекете
Жужанна Сент-Кирайи
Original Assignee
Эгиш Дьёдьсердьяр Нирт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0401373A external-priority patent/HU0401373D0/en
Priority claimed from HU0500664A external-priority patent/HU226951B1/en
Application filed by Эгиш Дьёдьсердьяр Нирт. filed Critical Эгиш Дьёдьсердьяр Нирт.
Publication of EA200700208A1 publication Critical patent/EA200700208A1/en
Publication of EA011894B1 publication Critical patent/EA011894B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Grain Derivatives (AREA)
  • Dairy Products (AREA)

Abstract

Псевдополиморфная форма деслоратадина, образованная с диоксидом углерода, формулы (I) обладает полезным противоаллергическим действием и ее можно применять в качестве фармацевтически активного вещества. Настоящее изобретение также относится к получению высокочистого деслоратадина. Настоящее изобретение также относится к применению псевдополиморфной формы деслоратадина формулы (I) для получения солей деслоратадина формулы (VI) (где Х обозначает анион и n обозначает 1 или 2).The pseudopolymorphic form of desloratadine formed with carbon dioxide of the formula (I) has a useful anti-allergic effect and can be used as a pharmaceutically active substance. The present invention also relates to the production of highly pure desloratadine. The present invention also relates to the use of a pseudopolymorphic form of desloratadine of formula (I) for the preparation of salts of desloratadine of formula (VI) (where X is an anion and n is 1 or 2).

EA200700208A 2004-07-07 2005-07-07 New pseudopolymorph of desloratadine formed with carbon dioxide EA011894B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0401373A HU0401373D0 (en) 2004-07-07 2004-07-07 Pseudopolimorphic form of desloratadine with carbondioxide
HU0500664A HU226951B1 (en) 2005-07-06 2005-07-06 Pseudopolimorphic form of desloratadine with carbon dioxide, process for its preparation and its use
PCT/HU2005/000073 WO2006003479A2 (en) 2004-07-07 2005-07-07 New pseudopolymorph of desloratadine formed with carbon dioxide

Publications (2)

Publication Number Publication Date
EA200700208A1 true EA200700208A1 (en) 2007-08-31
EA011894B1 EA011894B1 (en) 2009-06-30

Family

ID=89986128

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700208A EA011894B1 (en) 2004-07-07 2005-07-07 New pseudopolymorph of desloratadine formed with carbon dioxide

Country Status (9)

Country Link
EP (1) EP1817307A2 (en)
BG (1) BG109814A (en)
CZ (1) CZ200798A3 (en)
EA (1) EA011894B1 (en)
HR (1) HRP20070025A2 (en)
PL (1) PL381813A1 (en)
RS (1) RS20070008A (en)
SK (1) SK50112007A3 (en)
WO (1) WO2006003479A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230417B1 (en) * 2006-10-26 2016-05-30 Egis Gyógyszergyár Zrt Process for producing adduct comprising desloratadine and carbon dioxide
CN103755682A (en) * 2013-12-30 2014-04-30 山东达因海洋生物制药股份有限公司 Novel crystal form for desloratadine and preparation method thereof
WO2016024249A1 (en) * 2014-08-14 2016-02-18 Sun Pharmaceutical Industries Limited Crystalline forms of palbociclib
CN104610225B (en) * 2014-12-29 2017-02-01 广东九明制药有限公司 Preparation method of desloratadine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU570306B2 (en) * 1984-02-15 1988-03-10 Schering Corporation 8-chloro-6, 11-dihydro-11-(4-piperidylidene)-5h-benzo (5,6) cyclohepta (1,2-b) pyridine and its salts.
US5595997A (en) * 1994-12-30 1997-01-21 Sepracor Inc. Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine
UA62976C2 (en) * 1997-07-02 2004-01-15 Schering Corp Polymorphs of 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
HU226998B1 (en) * 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
BR0313231A (en) * 2002-08-05 2007-07-24 Sandoz Ag desloratadine hemifumarate salt and polymorphs
DE60217934T2 (en) * 2002-09-24 2007-05-24 Morepen Laboratories Ltd. PROCESS FOR THE PRODUCTION OF DESLORATADIN

Also Published As

Publication number Publication date
WO2006003479A3 (en) 2006-06-08
BG109814A (en) 2008-04-30
SK50112007A3 (en) 2007-07-06
EP1817307A2 (en) 2007-08-15
PL381813A1 (en) 2007-07-23
RS20070008A (en) 2008-11-28
HRP20070025A2 (en) 2008-11-30
CZ200798A3 (en) 2007-06-20
WO2006003479A2 (en) 2006-01-12
EA011894B1 (en) 2009-06-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU