HRP20020518B1 - Substituted homopiperidinyl benzimidazole analogues as fundic relaxants - Google Patents

Substituted homopiperidinyl benzimidazole analogues as fundic relaxants

Info

Publication number: HRP20020518B1
Authority: HR; Croatia
Prior art keywords: alkyl; hydroxy; amino; substituted; alkyloxy
Prior art date: 1999-12-21

Application number

HR20020518A

Other languages

English (en)

Croatian (hr)

Inventor

Eduard Janssens Frans

Emile Jerome

Maria Sommen Francois

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-21

Filing date

2002-06-13

Publication date

2009-02-28

2002-06-13 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2004-08-31 Publication of HRP20020518A2 publication Critical patent/HRP20020518A2/hr

2009-02-28 Publication of HRP20020518B1 publication Critical patent/HRP20020518B1/xx

Links

LQDRHXXAOXZUME-UHFFFAOYSA-N 2-(azepan-1-yl)-1h-benzimidazole Chemical class C1CCCCCN1C1=NC2=CC=CC=C2N1 LQDRHXXAOXZUME-UHFFFAOYSA-N 0.000 title 1
239000002249 anxiolytic agent Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 7
-1 nitro, amino, hydroxy Chemical group 0.000 abstract 7
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
125000001475 halogen functional group Chemical group 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 abstract 2
125000005871 1,3-benzodioxolyl group Chemical group 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
125000005493 quinolyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
229920002554 vinyl polymer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cosmetics (AREA)

HR20020518A 1999-12-21 2002-06-13 Substituted homopiperidinyl benzimidazole analogues as fundic relaxants HRP20020518B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP99204441		1999-12-21
PCT/EP2000/012858 WO2001046189A1 (en)	1999-12-21	2000-12-14	Substituted homopiperidinyl benzimidazole analogues as fundic relaxants

Publications (2)

Publication Number	Publication Date
HRP20020518A2 HRP20020518A2 (en)	2004-08-31
HRP20020518B1 true HRP20020518B1 (en)	2009-02-28

Family

ID=8241040

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20020518A HRP20020518B1 (en)	1999-12-21	2002-06-13	Substituted homopiperidinyl benzimidazole analogues as fundic relaxants

Country Status (33)

Country	Link
US (1)	US7304052B2 (pt)
EP (1)	EP1250337B1 (pt)
JP (1)	JP4852210B2 (pt)
KR (1)	KR100715351B1 (pt)
CN (1)	CN100343251C (pt)
AT (1)	ATE416174T1 (pt)
AU (1)	AU781144B2 (pt)
BG (1)	BG65784B1 (pt)
BR (1)	BRPI0016638B8 (pt)
CA (1)	CA2393158C (pt)
CY (1)	CY1108844T1 (pt)
CZ (1)	CZ299803B6 (pt)
DE (1)	DE60041001D1 (pt)
DK (1)	DK1250337T3 (pt)
EA (1)	EA005851B1 (pt)
EE (1)	EE05182B1 (pt)
ES (1)	ES2317856T3 (pt)
HK (1)	HK1053109B (pt)
HR (1)	HRP20020518B1 (pt)
HU (1)	HU229929B1 (pt)
IL (2)	IL150310A0 (pt)
MX (1)	MXPA02006346A (pt)
MY (1)	MY127758A (pt)
NO (1)	NO322362B1 (pt)
NZ (1)	NZ518816A (pt)
PL (1)	PL199678B1 (pt)
PT (1)	PT1250337E (pt)
SI (1)	SI1250337T1 (pt)
SK (1)	SK287113B6 (pt)
TW (1)	TWI225488B (pt)
UA (1)	UA73963C2 (pt)
WO (1)	WO2001046189A1 (pt)
ZA (1)	ZA200204983B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI225488B (en)	1999-12-21	2004-12-21	Janssen Pharmaceutica Nv	Derivatives of homopiperidinyl substituted benzimidazole analogues
JO2352B1 (en) *	2000-06-22	2006-12-12	جانسين فارماسيوتيكا ان. في	Compounds for the treatment of non-adaptation of the bottom of the uterus
CA2473236A1 (en)	2002-01-10	2003-07-24	Neurogen Corporation	Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1h-benzoimidazole analogues
CA2555409A1 (en) *	2004-02-19	2005-09-01	Banyu Pharmaceutical Co., Ltd.	Novel sulfone amide derivative
EP2121683B1 (en) *	2007-01-25	2011-08-31	Janssen Pharmaceutica, N.V.	2-piperazin-1-yl-3h-imidazo[4,5-b]pyridine derivatives
ES2700542T3 (es)	2010-06-24	2019-02-18	Gilead Sciences Inc	Composición farmacéutica que comprende un derivado de pirazolo[1,5-A]pirimidina como un agente antiviral
WO2012070069A2 (en) *	2010-11-24	2012-05-31	Sequent Scientific Limited	A process for preparation of albendazole
JP2014159375A (ja) *	2011-06-15	2014-09-04	Takeda Chem Ind Ltd	アゼパン化合物
JP6122868B2 (ja)	2011-12-22	2017-04-26	ギリアードサイエンシーズ，インコーポレイテッド	抗ウイルス剤としてのピラゾロ［１，５−ａ］ピリミジン
IN2014DN09173A (pt)	2012-04-17	2015-07-10	Gilead Sciences Inc
WO2015091584A1 (en) *	2013-12-18	2015-06-25	F. Hoffmann-La Roche Ag	Thiazolopyridine compounds, compositions and their use as tyk2 kinase inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2060197A1 (de) *	1970-12-08	1972-06-15	Bayer Ag	Verfahren zur Herstellung von 2-Aminobenzthiazol und dessen N-Alkylsubstitutionsprodukten
US4093726A (en) *	1976-12-02	1978-06-06	Abbott Laboratories	N-(2-benzimidazolyl)-piperazines
EP0079545A1 (en) *	1981-11-06	1983-05-25	Kanebo, Ltd.	Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
EP0580541A1 (en) *	1992-07-20	1994-01-26	Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes)	New piperidine derivatives of benzimidazole as antihistanminic and antiallergic agents

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES482789A0 (es) *	1978-08-25	1980-12-01	Thomae Gmbh Dr K	Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
FR2528526A1 (fr) *	1982-06-09	1983-12-16	Sfr Sa Robinetterie	Butee se fixant dans un alesage d'un dispositif
DE3224512A1 (de) *	1982-07-01	1984-01-05	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
PH23995A (en) *	1984-01-09	1990-02-09	Janssen Pharmaceutica Nv	4((bicycle heterocyclyl)-methyl and hetero)piperidines
DE3634066A1 (de) *	1986-10-07	1988-04-21	Boehringer Mannheim Gmbh	Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
JPH0260197A (ja) *	1988-08-26	1990-02-28	Nec Corp	パッケージ構造
FR2674856B1 (fr) *	1991-04-05	1993-07-30	Esteve Labor Dr	Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments.
IL101851A (en) *	1991-06-13	1996-05-14	Janssen Pharmaceutica Nv	History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
DE4237656A1 (de) *	1992-06-13	1993-12-16	Merck Patent Gmbh	Benzimidazolderivate
KR0144793B1 (ko) *	1992-07-08	1998-07-15	제임스 클리프튼 보올딩	돼지에서 위궤양을 완화시키기 위한 벤즈이미다졸
WO1995032960A1 (fr) *	1994-05-31	1995-12-07	Mitsui Toatsu Chemicals, Incorporated	Derive de benzimidazol
FR2766822B1 (fr) *	1997-07-30	2001-02-23	Adir	Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6150379A (en) *	1997-11-26	2000-11-21	Axys Pharmaceuticals, Inc.	Compounds and compositions as anticoagulants
TWI225488B (en)	1999-12-21	2004-12-21	Janssen Pharmaceutica Nv	Derivatives of homopiperidinyl substituted benzimidazole analogues

2000
- 2000-12-11 TW TW089126315A patent/TWI225488B/zh not_active IP Right Cessation
- 2000-12-14 CN CNB008174458A patent/CN100343251C/zh not_active Expired - Fee Related
- 2000-12-14 EE EEP200200326A patent/EE05182B1/xx not_active IP Right Cessation
- 2000-12-14 WO PCT/EP2000/012858 patent/WO2001046189A1/en active IP Right Grant
- 2000-12-14 SK SK854-2002A patent/SK287113B6/sk not_active IP Right Cessation
- 2000-12-14 ES ES00985180T patent/ES2317856T3/es not_active Expired - Lifetime
- 2000-12-14 SI SI200031019T patent/SI1250337T1/sl unknown
- 2000-12-14 CZ CZ20022055A patent/CZ299803B6/cs not_active IP Right Cessation
- 2000-12-14 NZ NZ518816A patent/NZ518816A/xx not_active IP Right Cessation
- 2000-12-14 KR KR1020027006004A patent/KR100715351B1/ko not_active IP Right Cessation
- 2000-12-14 EP EP00985180A patent/EP1250337B1/en not_active Expired - Lifetime
- 2000-12-14 BR BRPI0016638A patent/BRPI0016638B8/pt not_active IP Right Cessation
- 2000-12-14 IL IL15031000A patent/IL150310A0/xx unknown
- 2000-12-14 PL PL355442A patent/PL199678B1/pl unknown
- 2000-12-14 MX MXPA02006346A patent/MXPA02006346A/es active IP Right Grant
- 2000-12-14 JP JP2001547099A patent/JP4852210B2/ja not_active Expired - Fee Related
- 2000-12-14 DE DE60041001T patent/DE60041001D1/de not_active Expired - Lifetime
- 2000-12-14 UA UA2002065092A patent/UA73963C2/uk unknown
- 2000-12-14 US US10/169,011 patent/US7304052B2/en not_active Expired - Fee Related
- 2000-12-14 AT AT00985180T patent/ATE416174T1/de active
- 2000-12-14 AU AU21673/01A patent/AU781144B2/en not_active Ceased
- 2000-12-14 CA CA2393158A patent/CA2393158C/en not_active Expired - Fee Related
- 2000-12-14 EA EA200200700A patent/EA005851B1/ru not_active IP Right Cessation
- 2000-12-14 DK DK00985180T patent/DK1250337T3/da active
- 2000-12-14 HU HU0203847A patent/HU229929B1/hu unknown
- 2000-12-14 PT PT00985180T patent/PT1250337E/pt unknown
- 2000-12-20 MY MYPI20006015A patent/MY127758A/en unknown
2002
- 2002-05-29 BG BG106749A patent/BG65784B1/bg unknown
- 2002-06-13 HR HR20020518A patent/HRP20020518B1/xx not_active IP Right Cessation
- 2002-06-19 IL IL150310A patent/IL150310A/en not_active IP Right Cessation
- 2002-06-20 NO NO20022977A patent/NO322362B1/no not_active IP Right Cessation
- 2002-06-20 ZA ZA200204983A patent/ZA200204983B/en unknown
2003
- 2003-07-23 HK HK03105325.2A patent/HK1053109B/zh not_active IP Right Cessation
2009
- 2009-03-03 CY CY20091100243T patent/CY1108844T1/el unknown

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2060197A1 (de) *	1970-12-08	1972-06-15	Bayer Ag	Verfahren zur Herstellung von 2-Aminobenzthiazol und dessen N-Alkylsubstitutionsprodukten
US4093726A (en) *	1976-12-02	1978-06-06	Abbott Laboratories	N-(2-benzimidazolyl)-piperazines
EP0079545A1 (en) *	1981-11-06	1983-05-25	Kanebo, Ltd.	Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
EP0580541A1 (en) *	1992-07-20	1994-01-26	Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes)	New piperidine derivatives of benzimidazole as antihistanminic and antiallergic agents

Also Published As

Publication number	Publication date
EA200200700A1 (ru)	2003-06-26
CZ20022055A3 (cs)	2003-06-18
BR0016638A (pt)	2002-10-01
EA005851B1 (ru)	2005-06-30
BG106749A (en)	2003-01-31
CN100343251C (zh)	2007-10-17
HUP0203847A3 (en)	2004-07-28
CN1411460A (zh)	2003-04-16
DK1250337T3 (da)	2009-03-30
EE200200326A (et)	2003-10-15
HU229929B1 (en)	2015-01-28
NO20022977D0 (no)	2002-06-20
NO20022977L (no)	2002-08-08
IL150310A (en)	2008-07-08
CY1108844T1 (el)	2014-07-02
JP2003518118A (ja)	2003-06-03
SK287113B6 (sk)	2009-12-07
DE60041001D1 (de)	2009-01-15
PT1250337E (pt)	2009-03-05
CA2393158A1 (en)	2001-06-28
US7304052B2 (en)	2007-12-04
EP1250337B1 (en)	2008-12-03
KR20020062643A (ko)	2002-07-26
SI1250337T1 (sl)	2009-04-30
EE05182B1 (et)	2009-06-15
MY127758A (en)	2006-12-29
UA73963C2 (uk)	2005-10-17
CZ299803B6 (cs)	2008-12-03
CA2393158C (en)	2010-10-19
NO322362B1 (no)	2006-09-25
HRP20020518A2 (en)	2004-08-31
ZA200204983B (en)	2003-09-22
MXPA02006346A (es)	2002-12-13
HK1053109B (zh)	2008-08-01
KR100715351B1 (ko)	2007-05-08
WO2001046189A1 (en)	2001-06-28
PL199678B1 (pl)	2008-10-31
IL150310A0 (en)	2002-12-01
BR0016638B1 (pt)	2013-02-05
AU781144B2 (en)	2005-05-05
JP4852210B2 (ja)	2012-01-11
ES2317856T3 (es)	2009-05-01
ATE416174T1 (de)	2008-12-15
PL355442A1 (en)	2004-04-19
AU2167301A (en)	2001-07-03
TWI225488B (en)	2004-12-21
BG65784B1 (bg)	2009-11-30
NZ518816A (en)	2003-01-31
HUP0203847A2 (hu)	2003-03-28
EP1250337A1 (en)	2002-10-23
US20030139393A1 (en)	2003-07-24
BRPI0016638B8 (pt)	2017-04-25
SK8542002A3 (en)	2003-07-01
HK1053109A1 (en)	2003-10-10

Legal Events

Date	Code	Title	Description
2004-08-31	A1OB	Publication of a patent application
2005-02-04	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2009-02-28	B1PR	Patent granted
2017-11-10	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20171110 Year of fee payment: 18
2019-06-18	PBON	Lapse due to non-payment of renewal fee	Effective date: 20181214

Publication	Publication Date	Title
HRP20020518B1 (en)	2009-02-28	Substituted homopiperidinyl benzimidazole analogues as fundic relaxants
NO2015020I2 (no)	2015-09-10	Ceritinib eller et farmasøytisk akseptabelt salt derav
ME00615B (me)	2011-12-20	DERIVATI 2-ARIL-6-FENIL-IMIDAZO[1,2-α]PIRIDINA, NJIHOVO DOBIJANJE I NJIHOVA TERAPEUTSKA PRIMjENA
RS50164B (sr)	2009-05-06	Formulacije sa neprekidnim oslobađanjem
AR035991A1 (es)	2004-08-04	Derivados de benzimidazoles e imidazopiridinas, un procedimiento para su preparacion, composiciones farmaceuticas, un procedimiento para su preparacion, y un medicamento utiles como inhibidores de la replicacion del virus sincitial respiratorio
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NO20061416L (no)	2006-05-23	Pyrimidotiofenforbindelser
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DK317679A (da)	1980-01-29	N-substituerede heterocycliske forbindelser femgangsmaade til deres fremstilling samt deres anvendelse
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MX2010003950A (es)	2010-04-30	Derivado de amina que tiene actividad antagonista del receptor y5 de neuropeptido y (npy) y uso del mismo.
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