HK125893A - Morpholino-ethylester of mycophenolic acid and derivatives thereof,their preparation and use in pharmaceutical compositions - Google Patents

Morpholino-ethylester of mycophenolic acid and derivatives thereof,their preparation and use in pharmaceutical compositions

Info

Publication number
HK125893A
HK125893A HK1258/93A HK125893A HK125893A HK 125893 A HK125893 A HK 125893A HK 1258/93 A HK1258/93 A HK 1258/93A HK 125893 A HK125893 A HK 125893A HK 125893 A HK125893 A HK 125893A
Authority
HK
Hong Kong
Prior art keywords
pharmaceutical compositions
ethylester
morpholino
derivatives
preparation
Prior art date
Application number
HK1258/93A
Other languages
English (en)
Inventor
Peter H Nelson
Anthony C Allison
William A Lee
Chee-Liang Leo Gu
Elsie M Eugui
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK125893(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of HK125893A publication Critical patent/HK125893A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Furan Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
HK1258/93A 1987-01-30 1993-11-11 Morpholino-ethylester of mycophenolic acid and derivatives thereof,their preparation and use in pharmaceutical compositions HK125893A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/008,717 US4753935A (en) 1987-01-30 1987-01-30 Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions

Publications (1)

Publication Number Publication Date
HK125893A true HK125893A (en) 1993-11-19

Family

ID=21733252

Family Applications (1)

Application Number Title Priority Date Filing Date
HK1258/93A HK125893A (en) 1987-01-30 1993-11-11 Morpholino-ethylester of mycophenolic acid and derivatives thereof,their preparation and use in pharmaceutical compositions

Country Status (26)

Country Link
US (7) US4753935A (de)
EP (1) EP0281713B1 (de)
JP (1) JPS63188672A (de)
KR (1) KR940003758B1 (de)
AT (1) ATE68180T1 (de)
AU (1) AU599728B2 (de)
CA (1) CA1333285C (de)
DE (2) DE19675020I2 (de)
DK (1) DK166675B1 (de)
ES (1) ES2038190T3 (de)
FI (1) FI85141C (de)
GE (1) GEP20094816B (de)
GR (1) GR3002866T3 (de)
HK (1) HK125893A (de)
HU (2) HU201927B (de)
IE (1) IE60750B1 (de)
IL (1) IL84833A (de)
LU (1) LU88795I2 (de)
LV (1) LV5748B4 (de)
MX (1) MX9203163A (de)
NL (1) NL960019I2 (de)
NO (2) NO171680C (de)
NZ (1) NZ222922A (de)
PH (1) PH23819A (de)
PT (1) PT86343B (de)
ZA (1) ZA879414B (de)

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US5219851A (en) * 1991-03-05 1993-06-15 Warner-Lambert Company Tetrahydroisoquinoline-type renin inhibiting peptides
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WO1994012184A1 (en) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
WO1995000157A1 (en) * 1993-06-25 1995-01-05 Mobius Consultancy Pty. Ltd. Therapeutic agent
DE69414720T2 (de) 1993-09-15 1999-04-08 Syntex (U.S.A.) Inc., Palo Alto, Calif. Kristallines, wasserfreies mofetilmycophenolat und zubereitungen zu deren intravenösen anwendung
PT721335E (pt) * 1993-10-01 2005-11-30 Roche Palo Alto Llc Suspensoes orais em altas doses de micofenolato de mofetil
US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
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US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
JP2003531205A (ja) * 2000-04-24 2003-10-21 ブリストル−マイヤーズ スクイブ カンパニー Ｉｍｐｄｈ酵素の阻害剤である複素環化合物
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
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AU2003261354A1 (en) * 2002-08-02 2004-02-23 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
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CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
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US20100010082A1 (en) * 2008-07-09 2010-01-14 Aspreva International Ltd. Formulations for treating eye disorders
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US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
US11918684B2 (en) 2017-03-13 2024-03-05 Liqmeds Worldwide Limited Pharmaceutical composition of oral suspension of immunosuppressive agents
US10835489B2 (en) * 2018-03-09 2020-11-17 University Of Saskatchewan Modified release formulations of mycophenolate mofetil
CN110526885A (zh) * 2019-08-20 2019-12-03 上海英诺富成生物科技有限公司 麦考酚酸的前体药物及其制备方法
CN113549040B (zh) * 2020-04-23 2024-08-06 鲁南制药集团股份有限公司 一种吗替麦考酚酯杂质d的制备方法
CN112121173B (zh) * 2020-08-22 2022-05-06 浙江大学 脂肪酸修饰的免疫抑制剂mmf及fk506纳米制剂及其制备方法和应用
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Also Published As

Publication number Publication date
IE873397L (en) 1988-07-30
LV5748A4 (lv) 1996-10-20
US4948793A (en) 1990-08-14
ATE68180T1 (de) 1991-10-15
US4952579A (en) 1990-08-28
US4808592A (en) 1989-02-28
IL84833A (en) 1992-03-29
US4992467A (en) 1991-02-12
NZ222922A (en) 1990-09-26
HU201927B (en) 1991-01-28
FI875502A0 (fi) 1987-12-15
HUT47567A (en) 1989-03-28
FI85141C (fi) 1992-03-10
AU8254087A (en) 1988-08-04
LU88795I2 (fr) 1996-11-05
KR940003758B1 (ko) 1994-04-30
MX9203163A (es) 1992-07-31
PT86343A (en) 1988-01-01
FI85141B (fi) 1991-11-29
AU599728B2 (en) 1990-07-26
PT86343B (pt) 1991-02-08
US4868153A (en) 1989-09-19
DK166675B1 (da) 1993-06-28
JPH0571591B2 (de) 1993-10-07
EP0281713B1 (de) 1991-10-09
NL960019I2 (nl) 1997-06-02
NO875240D0 (no) 1987-12-15
EP0281713A1 (de) 1988-09-14
US4786637A (en) 1988-11-22
US4753935A (en) 1988-06-28
GR3002866T3 (en) 1993-01-25
CA1333285C (en) 1994-11-29
KR880009016A (ko) 1988-09-13
IL84833A0 (en) 1988-06-30
HU210350A9 (en) 1995-03-28
LV5748B4 (lv) 1997-02-20
ZA879414B (en) 1989-08-30
NO171680C (no) 1993-04-21
NO171680B (no) 1993-01-11
NO1997007I1 (no) 1997-07-01
DE19675020I2 (de) 2002-11-07
FI875502A (fi) 1988-07-31
GEP20094816B (en) 2009-11-10
ES2038190T3 (es) 1993-07-16
DE3773660D1 (de) 1991-11-14
NO875240L (no) 1988-08-01
NL960019I1 (nl) 1996-10-01
IE60750B1 (en) 1994-08-10
PH23819A (en) 1989-11-23
DK658787A (da) 1988-07-31
DK658787D0 (da) 1987-12-15
JPS63188672A (ja) 1988-08-04

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Effective date: 20071214