HK1257844A1 - 藥物化合物的嘌呤和氮雜嘌呤衍生物 - Google Patents
藥物化合物的嘌呤和氮雜嘌呤衍生物Info
- Publication number
- HK1257844A1 HK1257844A1 HK19100201.4A HK19100201A HK1257844A1 HK 1257844 A1 HK1257844 A1 HK 1257844A1 HK 19100201 A HK19100201 A HK 19100201A HK 1257844 A1 HK1257844 A1 HK 1257844A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- purine
- pharmaceutical compounds
- deazapurine derivatives
- deazapurine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0608179A GB0608179D0 (en) | 2006-04-25 | 2006-04-25 | Pharmaceutical compounds |
| GB0608176A GB0608176D0 (en) | 2006-04-25 | 2006-04-25 | Pharmaceutical Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1257844A1 true HK1257844A1 (zh) | 2019-11-01 |
Family
ID=38255445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK19100201.4A HK1257844A1 (zh) | 2006-04-25 | 2009-08-20 | 藥物化合物的嘌呤和氮雜嘌呤衍生物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8796293B2 (zh) |
| EP (3) | EP3421471B1 (zh) |
| JP (1) | JP5606734B2 (zh) |
| DK (1) | DK3421471T3 (zh) |
| ES (1) | ES2878130T3 (zh) |
| HK (1) | HK1257844A1 (zh) |
| WO (1) | WO2007125321A2 (zh) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| US8796293B2 (en) | 2006-04-25 | 2014-08-05 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
| US8227603B2 (en) * | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
| ES2558517T3 (es) | 2006-08-02 | 2016-02-04 | Cytokinetics, Inc. | Ciertas entidades químicas, composiciones y métodos que comprenden imidazopirimidinas |
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| EP2139478A4 (en) | 2007-03-30 | 2010-05-05 | Cytokinetics Inc | CHEMICAL ENTITIES, COMPOSITIONS AND METHODS |
| UA99284C2 (ru) | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
| UY31384A1 (es) | 2007-10-11 | 2009-05-29 | Novedosos compuestos heterociclicos para la inhibicion de la proteina quinasa b | |
| EP2215089B1 (en) * | 2007-11-02 | 2012-06-27 | Vertex Pharmaceuticals Incorporated | [1h- pyrazolo [3, 4-b]pyridine-4-yl]-phenyle or -pyridin-2-yle derivatives as protein kinase c-theta |
| WO2009089352A1 (en) | 2008-01-08 | 2009-07-16 | Array Biopharma Inc. | Pyrrolopyridines as kinase inhibitors |
| WO2009089359A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Pyrazolopyridines as kinase inhibitors |
| EP2674433A1 (en) * | 2008-04-21 | 2013-12-18 | Lexicon Pharmaceuticals, Inc. | LIMK2 inhibitors, compositions comprising them and methods of their use |
| AU2013218743B2 (en) * | 2008-05-13 | 2016-04-28 | Array Biopharma Inc. | Pyrrolopyridines as kinase inhibitors |
| AR071717A1 (es) * | 2008-05-13 | 2010-07-07 | Array Biopharma Inc | Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer. |
| GB0906579D0 (en) * | 2009-04-16 | 2009-05-20 | Vernalis R&D Ltd | Pharmaceuticals, compositions and methods of making and using the same |
| AR074072A1 (es) | 2008-11-11 | 2010-12-22 | Lilly Co Eli | Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme |
| AU2010310786B2 (en) | 2009-10-23 | 2014-03-27 | Eli Lilly And Company | AKT inhibitors |
| EP2531194B1 (en) | 2010-02-03 | 2018-04-18 | Signal Pharmaceuticals, LLC | Identification of lkb1 mutation as a predictive biomarker for sensitivity to tor kinase inhibitors |
| PL2651417T3 (pl) | 2010-12-16 | 2017-08-31 | Calchan Limited | Pochodne pirolopirymidyny hamujące ASK1 |
| SG193505A1 (en) | 2011-04-01 | 2013-10-30 | Astrazeneca Ab | Therapeutic treatment |
| IN2014DN00200A (zh) | 2011-07-13 | 2015-06-05 | Cytokinetics Inc | |
| WO2013040044A1 (en) * | 2011-09-12 | 2013-03-21 | Merck Patent Gmbh | Aminopyrimidine derivatives for use as modulators of kinase activity |
| US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
| US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
| WO2013079964A1 (en) | 2011-11-30 | 2013-06-06 | Astrazeneca Ab | Combination treatment of cancer |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| MX2015002975A (es) * | 2012-10-26 | 2015-06-22 | Hoffmann La Roche | Inhibidores de la tirosina cinasa de bruton. |
| WO2014086453A1 (en) * | 2012-12-07 | 2014-06-12 | Merck Patent Gmbh | Azaheterobicyclic compounds |
| KR102221005B1 (ko) | 2013-04-17 | 2021-02-26 | 시그날 파마소티칼 엘엘씨 | 전립선암 치료를 위한 디하이드로피라지노-피라진 화합물 및 안드로겐 수용체 길항제를 포함하는 조합 요법 |
| NZ730189A (en) | 2013-04-17 | 2018-09-28 | Signal Pharm Llc | Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one |
| KR102271344B1 (ko) | 2013-04-17 | 2021-07-01 | 시그날 파마소티칼 엘엘씨 | 디하이드로피라지노-피라진을 사용한 암의 치료 |
| JP6382948B2 (ja) | 2013-04-17 | 2018-08-29 | シグナル ファーマシューティカルズ，エルエルシー | 癌を治療するためのｔｏｒキナーゼ阻害剤及びシチジン類似体を含む組合せ療法 |
| KR102240356B1 (ko) | 2013-04-17 | 2021-04-14 | 시그날 파마소티칼 엘엘씨 | Ｔｏｒ 키나제 억제제와 5-치환된 퀴나졸리논 화합물을 포함하는 암 치료용 조합 요법 |
| BR112015026021A2 (pt) | 2013-04-17 | 2017-07-25 | Signal Pharm Llc | terapia de combinação compreendendo um inibidor de tor quinase e n-(3-(5-flúor-2-(4-(2-met-oxietoxi)fenilamino)pirimidin-4-ilamino)fenil)acrilamida para o tratamento de câncer |
| AU2014254053B2 (en) | 2013-04-17 | 2019-06-06 | Signal Pharmaceuticals, Llc | Treatment of cancer with Dihydropyrazino-Pyrazines |
| WO2014193912A1 (en) | 2013-05-29 | 2014-12-04 | Signal Pharmaceuticals, Llc | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use |
| US9512129B2 (en) | 2014-04-16 | 2016-12-06 | Signal Pharmaceuticals, Llc | Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| EP3265464A1 (en) * | 2015-03-04 | 2018-01-10 | F. Hoffmann-La Roche AG | Triazolopyridine compounds and methods of use thereof |
| SG11201912403SA (en) | 2017-06-22 | 2020-01-30 | Celgene Corp | Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection |
| WO2021143680A1 (zh) | 2020-01-16 | 2021-07-22 | 浙江海正药业股份有限公司 | 杂芳基类衍生物及其制备方法和用途 |
| MX2022011519A (es) * | 2020-03-25 | 2022-10-07 | Woolsey Pharmaceuticals Inc | Metodos de uso de inhibidores de la quinasa rho para tratar demencia frontotemporal. |
| WO2023183394A1 (en) * | 2022-03-24 | 2023-09-28 | Curasen Therapeutics, Inc. | Alpha 1a-adrenergic receptor agonists and methods of use |
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| BE637271A (zh) | 1963-04-04 | 1900-01-01 | ||
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| AR064416A1 (es) | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| UY31384A1 (es) | 2007-10-11 | 2009-05-29 | Novedosos compuestos heterociclicos para la inhibicion de la proteina quinasa b |
-
2007
- 2007-04-25 US US12/298,462 patent/US8796293B2/en active Active
- 2007-04-25 EP EP18182786.6A patent/EP3421471B1/en active Active
- 2007-04-25 JP JP2009507156A patent/JP5606734B2/ja active Active
- 2007-04-25 WO PCT/GB2007/001518 patent/WO2007125321A2/en active Application Filing
- 2007-04-25 EP EP19216213.9A patent/EP3719018A1/en active Pending
- 2007-04-25 ES ES18182786T patent/ES2878130T3/es active Active
- 2007-04-25 EP EP07732555A patent/EP2043655A2/en not_active Withdrawn
- 2007-04-25 DK DK18182786.6T patent/DK3421471T3/da active
-
2009
- 2009-08-20 HK HK19100201.4A patent/HK1257844A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK3421471T3 (da) | 2021-06-14 |
| WO2007125321A2 (en) | 2007-11-08 |
| ES2878130T3 (es) | 2021-11-18 |
| WO2007125321A3 (en) | 2007-12-27 |
| EP3421471B1 (en) | 2021-05-26 |
| EP3421471A1 (en) | 2019-01-02 |
| JP5606734B2 (ja) | 2014-10-15 |
| EP2043655A2 (en) | 2009-04-08 |
| US8796293B2 (en) | 2014-08-05 |
| EP3719018A1 (en) | 2020-10-07 |
| JP2009534455A (ja) | 2009-09-24 |
| US20100022564A1 (en) | 2010-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AM | Amended specification (according sect 146 of patent law) |
Free format text: GARRETT, MICHELLE, DAWN Effective date: 20211130 |