HK1257499A1 - 用於治療的聚集性微粒 - Google Patents
用於治療的聚集性微粒Info
- Publication number
- HK1257499A1 HK1257499A1 HK18116289.6A HK18116289A HK1257499A1 HK 1257499 A1 HK1257499 A1 HK 1257499A1 HK 18116289 A HK18116289 A HK 18116289A HK 1257499 A1 HK1257499 A1 HK 1257499A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- therapy
- aggregating microparticles
- aggregating
- microparticles
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562254707P | 2015-11-12 | 2015-11-12 | |
US201562257608P | 2015-11-19 | 2015-11-19 | |
US201662276530P | 2016-01-08 | 2016-01-08 | |
PCT/US2016/061706 WO2017083779A1 (en) | 2015-11-12 | 2016-11-11 | Aggregating microparticles for therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1257499A1 true HK1257499A1 (zh) | 2019-10-25 |
Family
ID=58690442
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18116289.6A HK1257499A1 (zh) | 2015-11-12 | 2018-12-19 | 用於治療的聚集性微粒 |
Country Status (15)
Country | Link |
---|---|
US (4) | US10441548B2 (zh) |
EP (1) | EP3373978A4 (zh) |
JP (2) | JP2018533596A (zh) |
KR (1) | KR20180102069A (zh) |
CN (2) | CN114469872A (zh) |
AU (1) | AU2016353355B9 (zh) |
BR (1) | BR112018009644A2 (zh) |
CA (1) | CA3004886A1 (zh) |
EA (1) | EA038755B1 (zh) |
HK (1) | HK1257499A1 (zh) |
IL (1) | IL259167A (zh) |
MX (1) | MX2018005932A (zh) |
PH (1) | PH12018500905A1 (zh) |
SG (1) | SG11201803663XA (zh) |
WO (1) | WO2017083779A1 (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3046668A1 (en) * | 2017-01-03 | 2018-07-12 | Vitrean, Inc. | Methods and devices for treating a retinal detachment |
CA3057875A1 (en) * | 2017-05-10 | 2018-11-15 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
EP3784705A4 (en) * | 2018-04-23 | 2022-03-02 | Graybug Vision, Inc. | IMPROVED CONTINUOUS PRODUCTION OF MICROPARTICLES |
EP3880182A4 (en) * | 2018-11-15 | 2022-08-10 | Graybug Vision, Inc. | ENHANCED AGGREGATED MICROPARTICLES |
KR102039582B1 (ko) * | 2018-12-12 | 2019-11-01 | 주식회사 라파스 | 인장 공정으로 제조하기에 적합한 마이크로니들 재료의 적합성 시험 방법 및 이를 포함하는 마이크로니들 제조 방법 |
JP6792900B1 (ja) * | 2020-05-08 | 2020-12-02 | エム・テクニック株式会社 | 生理活性物質が均一に分散されたマイクロスフェアー及びそれを含有する徐放性製剤 |
EP4164617B1 (en) | 2020-06-11 | 2023-09-27 | Universitat Internacional De Catalunya, Fundació Privada | Composition comprising nanoparticles, method for the preparation of a composition comprising nanoparticles and uses of the composition for dental treatment |
WO2022187511A1 (en) * | 2021-03-03 | 2022-09-09 | Veramorph Llc | Dissociating polymer matrix compositions of fulvestrant and methods of their making and use |
WO2022221537A1 (en) * | 2021-04-16 | 2022-10-20 | The Johns Hopkins University | Ophthalmic formulations for sustained neuroprotection |
CN113350268B (zh) * | 2021-06-17 | 2023-09-05 | 复旦大学附属眼耳鼻喉科医院 | 一种用于眼结膜下植入的药物缓释凝胶及其制备方法 |
CN113577083B (zh) * | 2021-08-13 | 2022-07-05 | 中山大学中山眼科中心 | 一种小分子化合物组合在制备预防和治疗视网膜损伤性疾病药物中的应用 |
CN114773220B (zh) * | 2021-12-21 | 2024-01-26 | 西安阿伯塔资环分析测试技术有限公司 | 一种刚性双尾表面活性剂及其制备方法和清洁压裂液 |
WO2024037982A1 (en) | 2022-08-16 | 2024-02-22 | Boehringer Ingelheim International Gmbh | Pharmaceutical formulations of nintedanib for intraocular use |
WO2024074585A2 (en) | 2022-10-05 | 2024-04-11 | Mireca Medicines Gmbh | MICROPARTICLE AND IMPLANT FORMULATIONS FOR cGMP ANALOG THERAPY |
CN116637069B (zh) * | 2023-07-19 | 2023-09-19 | 成都金瑞基业生物科技有限公司 | 一种和厚朴酚脂质体透皮凝胶剂及其制备方法和应用 |
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- 2016-11-11 US US15/349,985 patent/US10441548B2/en active Active
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2018
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IL259167A (en) | 2018-06-28 |
US10441548B2 (en) | 2019-10-15 |
PH12018500905A1 (en) | 2018-11-05 |
EP3373978A1 (en) | 2018-09-19 |
CN114469872A (zh) | 2022-05-13 |
BR112018009644A2 (pt) | 2018-11-06 |
US11331276B2 (en) | 2022-05-17 |
CA3004886A1 (en) | 2017-05-18 |
AU2016353355B9 (en) | 2022-09-29 |
EA038755B1 (ru) | 2021-10-14 |
WO2017083779A1 (en) | 2017-05-18 |
US20170135960A1 (en) | 2017-05-18 |
EP3373978A4 (en) | 2019-06-26 |
US11564890B2 (en) | 2023-01-31 |
SG11201803663XA (en) | 2018-05-30 |
MX2018005932A (es) | 2019-05-20 |
CN108367079A (zh) | 2018-08-03 |
AU2016353355B2 (en) | 2022-09-15 |
CN108367079B (zh) | 2022-11-22 |
KR20180102069A (ko) | 2018-09-14 |
US20200000735A1 (en) | 2020-01-02 |
JP2018533596A (ja) | 2018-11-15 |
US20200000734A1 (en) | 2020-01-02 |
JP2023052493A (ja) | 2023-04-11 |
EA201891147A1 (ru) | 2018-10-31 |
US20240041783A1 (en) | 2024-02-08 |
AU2016353355A1 (en) | 2018-05-17 |
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