HK1253536A1 - 使用超小納米粒子通過鐵死亡誘導營養素剝奪癌細胞的細胞死亡的治療方法 - Google Patents

使用超小納米粒子通過鐵死亡誘導營養素剝奪癌細胞的細胞死亡的治療方法

Info

Publication number
HK1253536A1
HK1253536A1 HK18112736.4A HK18112736A HK1253536A1 HK 1253536 A1 HK1253536 A1 HK 1253536A1 HK 18112736 A HK18112736 A HK 18112736A HK 1253536 A1 HK1253536 A1 HK 1253536A1
Authority
HK
Hong Kong
Prior art keywords
nutrient
treatment
methods
cancer cells
cell death
Prior art date
Application number
HK18112736.4A
Other languages
English (en)
Inventor
Michelle S Bradbury
Ulrich Wiesner
Michael Overholtzer
Howard Scher
Kai Ma
Original Assignee
Memorial Sloan Kettering Cancer Center
Univ Cornell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center, Univ Cornell filed Critical Memorial Sloan Kettering Cancer Center
Publication of HK1253536A1 publication Critical patent/HK1253536A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ceramic Engineering (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK18112736.4A 2015-05-29 2018-10-05 使用超小納米粒子通過鐵死亡誘導營養素剝奪癌細胞的細胞死亡的治療方法 HK1253536A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562168636P 2015-05-29 2015-05-29
US201662280960P 2016-01-20 2016-01-20

Publications (1)

Publication Number Publication Date
HK1253536A1 true HK1253536A1 (zh) 2019-06-21

Family

ID=56134596

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18112736.4A HK1253536A1 (zh) 2015-05-29 2018-10-05 使用超小納米粒子通過鐵死亡誘導營養素剝奪癌細胞的細胞死亡的治療方法

Country Status (10)

Country Link
US (3) US10736972B2 (zh)
EP (1) EP3302568B1 (zh)
JP (2) JP6974178B2 (zh)
KR (1) KR20180012299A (zh)
CN (2) CN108377643B (zh)
AU (1) AU2016271040A1 (zh)
BR (1) BR112017024328A2 (zh)
CA (1) CA2985126A1 (zh)
HK (1) HK1253536A1 (zh)
WO (1) WO2016196201A1 (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011003109A1 (en) 2009-07-02 2011-01-06 Sloan-Kettering Institute For Cancer Research Fluorescent silica-based nanoparticles
RU2015132626A (ru) 2013-03-15 2017-04-25 Слоун-Кеттеринг Инститьют Фо Кэнсэ Рисерч Мультимодальные наночастицы на основе диоксида кремния
DK3148591T3 (da) 2014-05-29 2020-04-14 Memorial Sloan Kettering Cancer Center Nanopartikel-lægemiddelkonjugater
KR20180012299A (ko) 2015-05-29 2018-02-05 메모리얼 슬로안-케터링 캔서 센터 초소형 나노입자를 사용하여 페로토시스를 통해 영양분-결핍 암 세포의 세포 사멸을 유도하는 치료 방법
KR20190003630A (ko) 2016-04-29 2019-01-09 메모리얼 슬로안 케터링 캔서 센터 악성 뇌 종양에서의 표적화된 입자 침투, 분포, 및 반응을 위한 조성물 및 방법
WO2018218087A1 (en) * 2017-05-24 2018-11-29 K-Gen, Inc. Methods of cancer treatment
JP2020520953A (ja) * 2017-05-25 2020-07-16 メモリアル スローン ケタリング キャンサー センター ジルコニウム−８９で標識した超小型ナノ粒子およびその方法
WO2019006005A2 (en) * 2017-06-28 2019-01-03 The Regents Of The University Of California METHODS AND COMPOSITIONS FOR THE TREATMENT OF MELANOMA
WO2019113004A1 (en) * 2017-12-04 2019-06-13 Memorial Sloan Kettering Cancer Center Methods of cancer treatment via regulated ferroptosis
WO2019151813A1 (ko) 2018-01-31 2019-08-08 주식회사 엘지화학 음극 활물질, 이를 포함하는 음극 및 리튬 이차전지
CN112041301A (zh) 2018-02-28 2020-12-04 费罗治疗公司 具有铁死亡诱导活性的化合物及其使用方法
WO2019200343A1 (en) * 2018-04-13 2019-10-17 The Wistar Institute Of Anatomy And Biology S6k2 blockade perturbs redox balance and fatty acid metabolism, leading to oxidative cell death in mapk inhibitor resistant cancers
WO2019212945A1 (en) * 2018-05-02 2019-11-07 Memorial Sloan Kettering Cancer Center Nanotherapeutic systems and methods using particle-driven photodynamic therapy (pdt)
WO2020077361A1 (en) * 2018-10-12 2020-04-16 The General Hospital Corporation Compounds and methods of their use
WO2020131930A1 (en) * 2018-12-17 2020-06-25 Memorial Sloan Kettering Cancer Center Inducing favorable effects on tumor microenvironment via administration of nanoparticle compositions
US11040964B2 (en) 2019-02-27 2021-06-22 Ferro Therapeutics, Inc. Compounds and methods of use
DK4103236T3 (en) 2020-10-27 2023-11-13 Elucida Oncology Inc Folate receptor targeted nanoparticle drug conjugates and uses thereof
CN112274495B (zh) * 2020-10-31 2022-05-03 郑州大学 一种h2o2自供型过氧化钙负载姜黄素纳米粒的制备方法及其应用
WO2022271619A1 (en) * 2021-06-21 2022-12-29 Memorial Sloan-Kettering Cancer Center Nanoparticle-mediated enhancement of immunotherapy to promote ferroptosis-induced cytotoxicity and antitumor immune responses
WO2023023288A1 (en) * 2021-08-19 2023-02-23 Arpeggio Biosciences, Inc. Small molecule modulators of ferroptosis
US11541116B1 (en) 2022-01-07 2023-01-03 Kojin Therapeutics, Inc. Methods and compositions for inducing ferroptosis in vivo
CN115120595B (zh) * 2022-08-02 2023-06-30 广西医科大学第一附属医院 Liproxstatin-1在制备防治白血病的药物中的应用和其药物组合物
CN116270624A (zh) * 2023-02-14 2023-06-23 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） Tubastatin A的新应用

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3870791A (en) 1972-04-24 1975-03-11 Heskel M Haddad Solid state ophthalmic medication delivery method
US3867519A (en) 1972-04-27 1975-02-18 Alza Corp Bioerodible drug delivery device
US4051842A (en) 1975-09-15 1977-10-04 International Medical Corporation Electrode and interfacing pad for electrical physiological systems
DE2626348C3 (de) 1976-06-11 1980-01-31 Siemens Ag, 1000 Berlin Und 8000 Muenchen Implantierbare Dosiereinrichtung
US4136177A (en) 1977-01-31 1979-01-23 American Home Products Corp. Xanthan gum therapeutic compositions
US4255415A (en) 1978-11-22 1981-03-10 Schering Corporation Polyvinyl alcohol ophthalmic gel
US4383529A (en) 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
US4931279A (en) 1985-08-16 1990-06-05 Bausch & Lomb Incorporated Sustained release formulation containing an ion-exchange resin
US4688506A (en) 1985-09-03 1987-08-25 Breems Martinus Van Boat sail control system
US4788603A (en) 1985-10-19 1988-11-29 Fuji Photo Film Co., Ltd. Camera for sequentially photographing a subject using a reference optical system and a telescopic optical system
US4812409A (en) 1986-01-31 1989-03-14 Eastman Kodak Company Hydrolyzable fluorescent substrates and analytical determinations using same
US4713224A (en) 1986-03-31 1987-12-15 The Boc Group, Inc. One-step process for purifying an inert gas
US4810636A (en) 1986-12-09 1989-03-07 Miles Inc. Chromogenic acridinone enzyme substrates
US4774339A (en) 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
US5274113A (en) 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5433896A (en) 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5248782A (en) 1990-12-18 1993-09-28 Molecular Probes, Inc. Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes
US5187288A (en) 1991-05-22 1993-02-16 Molecular Probes, Inc. Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis
US5776427A (en) 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
US5830912A (en) 1996-11-15 1998-11-03 Molecular Probes, Inc. Derivatives of 6,8-difluoro-7-hydroxycoumarin
UA61970C2 (en) * 1997-08-15 2003-12-15 Combined use of tyrosine kinase inhibitor and a chemical castration agent for treating prostate cancer
GB2330907A (en) 1997-10-28 1999-05-05 Applied Imaging Int Ltd A karyotyper and methods for producing karyotypes
US6268222B1 (en) 1998-01-22 2001-07-31 Luminex Corporation Microparticles attached to nanoparticles labeled with flourescent dye
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US7279150B2 (en) 2002-01-24 2007-10-09 Barnes-Jewish Hospital Chelating agents with lipophilic carriers
WO2003066066A1 (en) 2002-02-01 2003-08-14 Vanderbilt University Targeted drug delivery methods
US8620410B2 (en) 2002-03-12 2013-12-31 Beth Israel Deaconess Medical Center Multi-channel medical imaging system
US20040101822A1 (en) 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
WO2004108902A2 (en) 2003-06-04 2004-12-16 Visen Medical, Inc. Biocompatible fluorescent silicon nanoparticles
WO2006042233A1 (en) 2004-10-08 2006-04-20 The Cleveland Clinic Foundation Medical imaging using quantum dots
US7653427B2 (en) 2004-11-12 2010-01-26 Intra-Medical Imaging LLC Method and instrument for minimally invasive sentinel lymph node location and biopsy
EP1957045A2 (en) 2005-03-14 2008-08-20 Board of Regents, The University of Texas System Bioactive fus1 peptides and nanoprticle-polypeptide complexes
WO2006099445A2 (en) 2005-03-14 2006-09-21 Massachusetts Institute Of Technology Nanocells for diagnosis and treatment of diseases and disorders
US8084001B2 (en) 2005-05-02 2011-12-27 Cornell Research Foundation, Inc. Photoluminescent silica-based sensors and methods of use
WO2007053189A2 (en) 2005-06-01 2007-05-10 Northwestern University Compositions and methods for altering immune function
EP1893245A4 (en) 2005-06-24 2009-06-24 Univ Pennsylvania RADIOACTIVELY MARKED PEGYLATION OF LIGANDS FOR USE AS A CONTRAST
FR2888753B1 (fr) 2005-07-21 2008-04-04 Commissariat Energie Atomique Vecteur cible avec fonction d'imagerie activable
WO2007136413A2 (en) 2005-12-22 2007-11-29 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
WO2008044138A1 (en) 2006-10-12 2008-04-17 Syddansk Universitet Optical nanosensor for detection of reactive oxygen species
WO2008049118A2 (en) 2006-10-19 2008-04-24 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s)
US7902332B2 (en) 2006-11-30 2011-03-08 General Electric Company Fluorine-labeled compounds
EP2099496A2 (en) 2006-12-08 2009-09-16 Massachusetts Institute of Technology Delivery of nanoparticles and/or agents to cells
US20080255425A1 (en) 2007-04-13 2008-10-16 Ethicon Endo-Surgery, Inc. Nanoparticle treated medical devices
EP1995327A1 (en) 2007-05-21 2008-11-26 Humboldt Universität zu Berlin Probe for detecting a particular nucleic acid sequence
US20110028662A1 (en) 2007-08-31 2011-02-03 Hybrid Silica Technologies, Inc. Peg-coated core-shell silica nanoparticles and methods of manufacture and use
DE102007052517A1 (de) 2007-10-29 2009-04-30 Autoimmun Diagnostika Gmbh ELISPOT-Verfahren mit zwei Filtersystemen
US8968699B2 (en) 2007-11-15 2015-03-03 The Regents Of The University Of California Switchable nano-vehicle delivery systems, and methods for making and using them
JP5526036B2 (ja) 2007-12-21 2014-06-18 プレジデント アンド フェローズ オブ ハーバード カレッジ 三次元の回折限界未満の画像解像技術
US8389679B2 (en) 2009-02-05 2013-03-05 The Regents Of The University Of California Targeted antimicrobial moieties
CN102459062B (zh) 2009-04-15 2017-03-22 康奈尔大学 通过二氧化硅致密化改进的荧光二氧化硅纳米颗粒
WO2011005380A2 (en) 2009-06-12 2011-01-13 Stc. Unm Arg-gly-asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same
WO2011003109A1 (en) * 2009-07-02 2011-01-06 Sloan-Kettering Institute For Cancer Research Fluorescent silica-based nanoparticles
US20230158180A1 (en) 2009-07-02 2023-05-25 Sloan-Kettering Institute For Cancer Research Multimodal silica-based nanoparticles
US9238069B2 (en) * 2009-12-16 2016-01-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method of sensitizing cancer cells to the cytotoxic effects of death receptor ligands in cancer treatment
EP2512522A4 (en) 2009-12-16 2013-09-25 Brigham & Womens Hospital PARTICULARS FOR THE DELIVERY OF SEVERAL ACTIVE SUBSTANCES
BR112012026213B1 (pt) 2010-04-15 2021-12-28 Medimmune Limited Compostos de pirrolobenzodiazepinas, conjugado das mesmas, composição farmacêutica compreendendo o conjugado e uso do mesmo para o tratamento de uma doença proliferativa
GB201121288D0 (en) 2011-12-12 2012-01-25 Univ Muenster Wilhelms Functionalised silicon nanoparticles
US9006987B2 (en) 2012-05-07 2015-04-14 Lighting Science Group, Inc. Wall-mountable luminaire and associated systems and methods
US10732115B2 (en) 2012-06-22 2020-08-04 Cornell University Mesoporous oxide nanoparticles and methods of making and using same
US9695133B2 (en) 2012-07-13 2017-07-04 The Trustees Of Columbia University In The City Of New York Quinazolinone-based oncogenic-RAS-selective lethal compounds and their use
CN112587671A (zh) 2012-07-18 2021-04-02 博笛生物科技有限公司 癌症的靶向免疫治疗
EP2959299B1 (en) 2013-02-20 2019-01-02 Cornell University Multilayer fluorescent nanoparticles and methods of making and using same
RU2015132626A (ru) 2013-03-15 2017-04-25 Слоун-Кеттеринг Инститьют Фо Кэнсэ Рисерч Мультимодальные наночастицы на основе диоксида кремния
WO2015103420A1 (en) 2013-12-31 2015-07-09 Memorial Sloan Kettering Cancer Center Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time
DK3148591T3 (da) 2014-05-29 2020-04-14 Memorial Sloan Kettering Cancer Center Nanopartikel-lægemiddelkonjugater
CA2954725A1 (en) 2014-07-25 2016-01-28 Northeastern University Biopolymer-nanoparticle composite implant for tumor cell tracking
EP3029032A1 (en) 2014-12-05 2016-06-08 Centre National de la Recherche Scientifique (CNRS) Bifunctional do2pa derivatives, chelates with metallic cations and use thereof
KR20170094268A (ko) 2014-12-15 2017-08-17 메모리얼 슬로안-케터링 캔서 센터 향상된 신경-결합 선택성을 갖는 고리형 펩티드, 상기 고리형 펩티드와 결합된 나노입자, 및 실시간 생체내 신경 조직 영상화를 위한 이들의 용도
EP3280454A1 (en) 2015-04-07 2018-02-14 Memorial Sloan Kettering Cancer Center Nanoparticle immunoconjugates
CN107835696B (zh) 2015-05-04 2024-06-04 康奈尔大学 超小型纳米颗粒以及制备和使用其的方法
KR20180012299A (ko) 2015-05-29 2018-02-05 메모리얼 슬로안-케터링 캔서 센터 초소형 나노입자를 사용하여 페로토시스를 통해 영양분-결핍 암 세포의 세포 사멸을 유도하는 치료 방법
US20180296595A1 (en) 2015-09-11 2018-10-18 Memorial Sloan Kettering Cancer Center Methods and compositions for cancer treatment
BR112019010947A2 (pt) 2016-11-30 2019-10-01 Univ Cornell nanopartículas ultrapequenas funcionalizadas por inibidores e métodos das mesmas
WO2018191316A1 (en) 2017-04-10 2018-10-18 Cornell University Sulfur- or heavy atom-containing nanoparticles, methods of making same, and uses thereof
CN111182891B (zh) 2017-05-19 2022-08-09 康奈尔大学 官能化纳米颗粒及其制备和使用方法
WO2018218087A1 (en) 2017-05-24 2018-11-29 K-Gen, Inc. Methods of cancer treatment
JP2020520953A (ja) 2017-05-25 2020-07-16 メモリアル スローン ケタリング キャンサー センター ジルコニウム−８９で標識した超小型ナノ粒子およびその方法
EP3642599A1 (en) 2017-06-23 2020-04-29 Memorial Sloan-Kettering Cancer Center Method of imaging in vivo tissues using nanoparticles comprising a reference dye and a sensor dye.
WO2019113004A1 (en) 2017-12-04 2019-06-13 Memorial Sloan Kettering Cancer Center Methods of cancer treatment via regulated ferroptosis

Also Published As

Publication number Publication date
EP3302568B1 (en) 2023-12-06
JP2018516249A (ja) 2018-06-21
US20180169264A1 (en) 2018-06-21
CN108377643A (zh) 2018-08-07
US20220118106A1 (en) 2022-04-21
US11931425B2 (en) 2024-03-19
AU2016271040A1 (en) 2017-11-23
BR112017024328A2 (pt) 2018-07-24
CN108377643B (zh) 2021-09-21
KR20180012299A (ko) 2018-02-05
CA2985126A1 (en) 2016-12-08
JP7263485B2 (ja) 2023-04-24
WO2016196201A1 (en) 2016-12-08
JP2022023210A (ja) 2022-02-07
CN113559279A (zh) 2021-10-29
EP3302568A1 (en) 2018-04-11
US10736972B2 (en) 2020-08-11
US20200316219A1 (en) 2020-10-08
JP6974178B2 (ja) 2021-12-01
US11246946B2 (en) 2022-02-15

Similar Documents

Publication Publication Date Title
HK1253536A1 (zh) 使用超小納米粒子通過鐵死亡誘導營養素剝奪癌細胞的細胞死亡的治療方法
IL290744A (en) Methods for the production of autologous t cells used in the treatment of b-cell malignancies and other types of cancer and preparations thereof
IL243408A0 (en) Diagnosis and treatment of cancer involving cancer stem cells
EP2943565A4 (en) COMPOSITIONS AND METHODS FOR ADMINISTRATION OF IMMUNE CELLS FOR TREATING TUMOR CELLS THAT ARE NOT RESTRICTED OR UNREQUIRED AND A TUMOR RECIPIENT
IL236336A0 (en) Methods of treating breast cancer with gemcitabine therapy
EP2904106A4 (en) COMPOSITIONS AND METHODS FOR TARGETING STROMAL CELLS FOR THE TREATMENT OF CANCER
IL280039B (en) Preparations and methods related to the diagnosis of prostate cancer
EP3060680A4 (en) Methods relating to circulating tumor cell clusters and the treatment of cancer
HK1245132A1 (zh) 改善細胞治療的方法
SG10201801965RA (en) Treatment of cancer with dihydropyrazino-pyrazines
EP2820423A4 (en) MATERIALS AND METHOD FOR DIFFERENTIATED TREATMENT OF CANCER
ZA201507733B (en) Treatment of cancer with dihydropyrazino-pyrazines
HK1213817A1 (zh) 治療癌症的方法
IL246607B (en) Improved cellular preparations and methods for cancer treatment
EP2950808A4 (en) GENERATING CELLULAR LINES SPECIFIC TO A CYTOTOXIC TUMOR AND USES THEREOF
GB201420533D0 (en) Use of Nanomaterials in treating cancer
IL245272A0 (en) pif-transfected cells and methods of use
HK1219513A1 (zh) 治療癌症的方法
EP2958591A4 (en) METHODS AND COMPOSITIONS RELATED TO THE TREATMENT OF CANCER
EP3233102C0 (en) USE OF AN ANTIMICROBIAL PEPTIDE TO INDUCE CELL DEATH IN BREAST CANCER
EP2994118A4 (en) USE OF LAPPAOL F TO INHIBIT THE GROWTH OF TUMOR CELLS
PL3027208T3 (pl) Diagnoza i terapia nowotworu z udziałem nowotworowych komórek macierzystych
GB201322958D0 (en) Uses of oligouronates in cancer treatment