HK1252582B - 具有增强的細胞毒性的修飾的天然殺傷細胞和天然殺傷細胞系 - Google Patents
具有增强的細胞毒性的修飾的天然殺傷細胞和天然殺傷細胞系Info
- Publication number
- HK1252582B HK1252582B HK18111896.2A HK18111896A HK1252582B HK 1252582 B HK1252582 B HK 1252582B HK 18111896 A HK18111896 A HK 18111896A HK 1252582 B HK1252582 B HK 1252582B
- Authority
- HK
- Hong Kong
- Prior art keywords
- natural killer
- cell lines
- increased cytotoxicity
- killer cells
- modified
- Prior art date
Links
- 210000000822 natural killer cell Anatomy 0.000 title 2
- 230000003013 cytotoxicity Effects 0.000 title 1
- 231100000135 cytotoxicity Toxicity 0.000 title 1
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- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
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- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15178899 | 2015-07-29 | ||
GBGB1603655.0A GB201603655D0 (en) | 2016-03-02 | 2016-03-02 | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
GB201605457 | 2016-03-31 | ||
GBGB1610164.4A GB201610164D0 (en) | 2016-06-10 | 2016-06-10 | Modified natural killer cells and natural killer cell lines having increased cytoxicity |
PCT/EP2016/068001 WO2017017184A1 (en) | 2015-07-29 | 2016-07-28 | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
Publications (2)
Publication Number | Publication Date |
---|---|
HK1252582A1 HK1252582A1 (zh) | 2019-05-31 |
HK1252582B true HK1252582B (zh) | 2020-02-07 |
Family
ID=56683913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18111896.2A HK1252582B (zh) | 2015-07-29 | 2018-09-17 | 具有增强的細胞毒性的修飾的天然殺傷細胞和天然殺傷細胞系 |
Country Status (13)
Country | Link |
---|---|
US (3) | US10034925B2 (zh) |
EP (6) | EP3434762B1 (zh) |
JP (3) | JP6974681B2 (zh) |
KR (1) | KR20180028530A (zh) |
CN (3) | CN108026512B (zh) |
AU (2) | AU2016300128B2 (zh) |
BR (1) | BR112018001660A2 (zh) |
CA (2) | CA3156128A1 (zh) |
DK (3) | DK3434762T3 (zh) |
ES (5) | ES2939084T3 (zh) |
HK (1) | HK1252582B (zh) |
MX (2) | MX2018001074A (zh) |
WO (1) | WO2017017184A1 (zh) |
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EP3712257A1 (en) | 2019-03-21 | 2020-09-23 | ONK Therapeutics Limited | Modified natural killer cells with increased resistance to cell death |
CN109970869A (zh) * | 2019-04-12 | 2019-07-05 | 南京卡提医学科技有限公司 | 一种靶向人trail死亡受体的嵌合受体配体及其应用 |
RU2731293C1 (ru) | 2019-04-12 | 2020-09-01 | Игорь Петрович Белецкий | Способ получения генно-модифицированных линий клеток натуральных киллеров с нокаутированным геном PD-1 и повышенной экспрессией белков семейства Фактора Некроза Опухолей для иммунотерапии онкологических заболеваний |
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CN114621969A (zh) * | 2014-09-17 | 2022-06-14 | 诺华股份有限公司 | 用于过继免疫疗法的具有嵌合受体的靶向细胞毒性细胞 |
MX2017012407A (es) | 2015-03-27 | 2018-03-07 | Harvard College | Celulas t modificadas y métodos para hacer y usar las mismas. |
EP4043556B1 (en) * | 2015-06-30 | 2024-02-07 | Cellectis | Methods for improving functionality in nk cell by gene inactivation using specific endonuclease |
EP3325504A1 (en) * | 2015-07-21 | 2018-05-30 | Novartis AG | Methods for improving the efficacy and expansion of immune cells |
AU2016300128B2 (en) | 2015-07-29 | 2022-03-17 | Onk Therapeutics Limited | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
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