HK1251593A1 - Bace1抑制劑肽 - Google Patents

Bace1抑制劑肽

Info

Publication number
HK1251593A1
HK1251593A1 HK18111170.9A HK18111170A HK1251593A1 HK 1251593 A1 HK1251593 A1 HK 1251593A1 HK 18111170 A HK18111170 A HK 18111170A HK 1251593 A1 HK1251593 A1 HK 1251593A1
Authority
HK
Hong Kong
Prior art keywords
inhibitor peptides
bace1 inhibitor
bace1
peptides
inhibitor
Prior art date
Application number
HK18111170.9A
Other languages
English (en)
Inventor
杰里米‧比徹姆
佩爾-奧拉‧弗雷斯克加德
埃里克‧A‧基塔斯
維克托‧利亞米切夫
吉加爾‧帕特爾
Original Assignee
豪夫邁‧羅氏有限公司
羅氏寧博根公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 豪夫邁‧羅氏有限公司, 羅氏寧博根公司 filed Critical 豪夫邁‧羅氏有限公司
Publication of HK1251593A1 publication Critical patent/HK1251593A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HK18111170.9A 2015-07-24 2018-08-30 Bace1抑制劑肽 HK1251593A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15178162 2015-07-24

Publications (1)

Publication Number Publication Date
HK1251593A1 true HK1251593A1 (zh) 2019-02-01

Family

ID=53776361

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18111170.9A HK1251593A1 (zh) 2015-07-24 2018-08-30 Bace1抑制劑肽

Country Status (6)

Country Link
US (1) US10947272B2 (zh)
EP (1) EP3325500A1 (zh)
JP (1) JP6814754B2 (zh)
CN (1) CN107849092A (zh)
HK (1) HK1251593A1 (zh)
WO (1) WO2017016982A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019094608A1 (en) 2017-11-08 2019-05-16 Denali Therapeutics Inc. Anti-bace1 antibodies and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003285892A1 (en) 2002-10-15 2004-05-04 Bristol-Myers Squibb Company Bace binding peptides and uses thereof
US20070149763A1 (en) 2003-10-15 2007-06-28 Bristol-Myers Squibb Company Beta secretase exosite binding peptides and methods for identifying beta secretase modulators
AU2005231622B2 (en) 2004-04-08 2011-05-26 Jadolabs Gmbh Tripartite conjugates containing a structure interacting with cell membrane rafts and their use
US20080255076A1 (en) * 2004-06-29 2008-10-16 Jadolabs Gmbh Steroid-Derived Pharmaceutical Compositions
RU2599256C2 (ru) * 2011-06-07 2016-10-10 Ф. Хоффманн-Ля Рош Аг [1,3]оксазины
WO2013056054A2 (en) 2011-10-14 2013-04-18 Genentech, Inc Peptide inhibitors of bace1
CN104368009B (zh) * 2014-06-25 2018-01-30 中国人民解放军第二军医大学 一种双功能肽修饰的阿尔茨海默病靶向基因递释复合物及其制备方法
EP3332767B1 (en) 2014-09-15 2019-03-20 Verona Pharma PLC Liquid inhalation formulation comprising rpl554
EP3197443A4 (en) 2014-09-25 2018-03-14 The Hospital for Sick Children Compositions and methods for enhancing hair growth, promoting skin regeneration, and wound healing
US10683329B2 (en) 2014-11-28 2020-06-16 Hoffmann-La Roche Inc. Dual-site BACE1 inhibitors

Also Published As

Publication number Publication date
JP6814754B2 (ja) 2021-01-20
US20180179252A1 (en) 2018-06-28
US10947272B2 (en) 2021-03-16
JP2018523636A (ja) 2018-08-23
CN107849092A (zh) 2018-03-27
WO2017016982A1 (en) 2017-02-02
EP3325500A1 (en) 2018-05-30

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