HK1244790A1 - Bace1抑制劑 - Google Patents
Bace1抑制劑Info
- Publication number
- HK1244790A1 HK1244790A1 HK18103983.3A HK18103983A HK1244790A1 HK 1244790 A1 HK1244790 A1 HK 1244790A1 HK 18103983 A HK18103983 A HK 18103983A HK 1244790 A1 HK1244790 A1 HK 1244790A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- bace1 inhibitors
- bace1
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15160101 | 2015-03-20 | ||
PCT/EP2016/055649 WO2016150785A1 (en) | 2015-03-20 | 2016-03-16 | Bace1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1244790A1 true HK1244790A1 (zh) | 2018-08-17 |
Family
ID=52780400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18103983.3A HK1244790A1 (zh) | 2015-03-20 | 2018-03-22 | Bace1抑制劑 |
Country Status (19)
Country | Link |
---|---|
US (4) | US10047081B2 (zh) |
EP (1) | EP3271355B1 (zh) |
JP (1) | JP6674960B2 (zh) |
KR (1) | KR20170129745A (zh) |
CN (1) | CN107406440B (zh) |
AU (1) | AU2016236402B2 (zh) |
BR (1) | BR112017015474A2 (zh) |
CA (1) | CA2979113A1 (zh) |
CL (1) | CL2017002229A1 (zh) |
CO (1) | CO2017007691A2 (zh) |
CR (1) | CR20170426A (zh) |
HK (1) | HK1244790A1 (zh) |
IL (1) | IL253322A0 (zh) |
MX (1) | MX2017012188A (zh) |
PE (1) | PE20171349A1 (zh) |
PH (1) | PH12017501668A1 (zh) |
RU (1) | RU2712272C2 (zh) |
SG (1) | SG11201707050VA (zh) |
WO (1) | WO2016150785A1 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10047081B2 (en) | 2015-03-20 | 2018-08-14 | Hoffman-La Roche Inc. | BACE1 inhibitors |
CN110467611B (zh) * | 2018-05-11 | 2022-09-27 | 广东东阳光药业有限公司 | 亚氨基噻二嗪二氧化物衍生物及其用途 |
AR115495A1 (es) | 2018-06-06 | 2021-01-27 | Syngenta Crop Protection Ag | Derivados heterocíclicos con sustituyentes que contienen azufre activos como plaguicidas |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
CN101952260B (zh) | 2008-02-18 | 2013-02-13 | 弗·哈夫曼-拉罗切有限公司 | 4,5-二氢-*唑-2-基胺衍生物 |
US8461160B2 (en) | 2009-05-08 | 2013-06-11 | Hoffmann-La Roche, Inc. | Dihydropyrimidinones |
US8188079B2 (en) | 2009-08-19 | 2012-05-29 | Hoffman-La Roche Inc. | 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines |
US20110065695A1 (en) | 2009-09-11 | 2011-03-17 | Jeremy Beauchamp | Use of aminodihydrothiazines for the treatment or prevention of diabetes |
US7964594B1 (en) | 2009-12-10 | 2011-06-21 | Hoffmann-La Roche Inc. | Amino oxazine derivatives |
UA103272C2 (uk) | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
US8673894B2 (en) | 2010-05-07 | 2014-03-18 | Hoffmann-La Roche Inc. | 2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine or 2,3,6,7-tetrahydro-[1,4]oxazepin-5-ylamine compounds |
US8815881B2 (en) | 2010-08-09 | 2014-08-26 | Hoffmann-La Roche Inc. | 1,4,5,6-tetrahydro-pyrimidin-2-ylamine compounds |
US20120053200A1 (en) | 2010-09-01 | 2012-03-01 | Harald Mauser | Bace 2 inhibitors |
US9242943B2 (en) | 2011-01-18 | 2016-01-26 | Siena Biotech S.P.A. | 1,4 oxazines as BACE1 and/or BACE2 inhibitors |
US8399459B2 (en) | 2011-02-02 | 2013-03-19 | Hoffmann-La Roche Inc. | 1,4 oxazines as BACE1 and/or BACE2 inhibitors |
US8404680B2 (en) | 2011-02-08 | 2013-03-26 | Hoffmann-La Roche Inc. | N-[3-(5-amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides as BACE1 and/or BACE2 inhibitors |
US8815841B2 (en) | 2011-02-18 | 2014-08-26 | Hoffmann-La Roche Inc. | 1,4-Oxazepines as BACE1 and/or BACE2 inhibitors |
US9067924B2 (en) | 2011-03-04 | 2015-06-30 | Hoffmann-La Roche Inc. | 1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors |
US8748418B2 (en) | 2011-03-18 | 2014-06-10 | Hoffmann-La Roche Inc. | 1,4-oxazepines as BACE1 and/or BACE2 inhibitors |
US8877744B2 (en) | 2011-04-04 | 2014-11-04 | Hoffmann-La Roche Inc. | 1,4-Oxazepines as BACE1 and/or BACE2 inhibitors |
US8754075B2 (en) | 2011-04-11 | 2014-06-17 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE1 and/or BACE2 inhibitors |
CN103596939A (zh) * | 2011-04-13 | 2014-02-19 | 默沙东公司 | 作为bace抑制剂的5-取代的亚氨基噻嗪类及其单和二氧化物、组合物及其应用 |
RU2013150349A (ru) * | 2011-04-13 | 2015-05-20 | Мерк Шарп И Доум Корп. | 5-замещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов васе, содержащие их композиции и их применение |
US8785436B2 (en) | 2011-05-16 | 2014-07-22 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE 1 and/or BACE2 inhibitors |
US9079919B2 (en) | 2011-05-27 | 2015-07-14 | Hoffmann-La Roche Inc. | Spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines as BACE1 and/or BACE2 inhibitors |
AU2012266544A1 (en) | 2011-06-07 | 2013-11-21 | F. Hoffmann-La Roche Ag | Halogen-alkyl-1,3 oxazines as BACE1 and/or BACE2 inhibitors |
MX2013014007A (es) | 2011-06-07 | 2014-03-12 | Hoffmann La Roche | [1,3] oxazinas. |
US8927535B2 (en) | 2011-07-06 | 2015-01-06 | Hoffman-La Roche Inc. | Cyclopropyl-fused-1,3-thiazepines as BACE1 and/or BACE2 inhibitors |
MX2014002113A (es) * | 2011-08-22 | 2014-04-25 | Merck Sharp & Dohme | Iminotiazinas sustituidas en 2-espiro y sus mono y bioxidos como inhibidores de enzima de disociacion de proteina precursora amiloide del sitio beta, composiciones, y su uso. |
US8476264B2 (en) | 2011-09-21 | 2013-07-02 | Hoffmann-La Roche Inc. | N-(3-(2-amino-6,6-difluoro-4,4A,5,6,7,7A-hexahydro-cyclopenta[E][1,3]oxazin-4-yl)-phenylamides as BACE1 inhibitors |
US9067926B2 (en) | 2012-01-26 | 2015-06-30 | Hoffmann-La Roche Inc. | Fluoromethyl-5,6-dihydro-4H-[1,3]OXAZINES |
EP2855469B1 (en) * | 2012-05-24 | 2019-06-19 | F.Hoffmann-La Roche Ag | 5-amino[1,4]thiazines as bace 1 inhibitors |
US9181232B2 (en) | 2012-06-26 | 2015-11-10 | Hoffmann-La Roche Inc. | Difluoro-hexahydro-cyclopentaoxazinyls and difluoro-hexahydro-benzooxazinyls as BACE1 inhibitors |
US9422277B2 (en) * | 2012-10-17 | 2016-08-23 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use |
CN104968660A (zh) | 2013-01-22 | 2015-10-07 | 霍夫曼-拉罗奇有限公司 | 作为bace1抑制剂的氟-[1,3]噁嗪类化合物 |
WO2014150340A1 (en) | 2013-03-15 | 2014-09-25 | Merck Sharp & Dohme Corp. | S-imino-s-oxo iminothiadiazine compounds as bace inhibitors, compositions, and their use |
EP2968357B1 (en) * | 2013-03-15 | 2018-07-04 | Merck Sharp & Dohme Corp. | S-imino-s-oxo iminothiazine compounds as bace inhibitors, compositions, and their use |
WO2014150344A1 (en) | 2013-03-15 | 2014-09-25 | Merck Sharp & Dohme Corp. | C2-azaspiro iminothiazine dioxides as bace inhibitors |
US10047081B2 (en) * | 2015-03-20 | 2018-08-14 | Hoffman-La Roche Inc. | BACE1 inhibitors |
-
2016
- 2016-03-16 US US15/558,273 patent/US10047081B2/en active Active
- 2016-03-16 AU AU2016236402A patent/AU2016236402B2/en not_active Ceased
- 2016-03-16 SG SG11201707050VA patent/SG11201707050VA/en unknown
- 2016-03-16 BR BR112017015474-9A patent/BR112017015474A2/pt not_active Application Discontinuation
- 2016-03-16 PE PE2017001451A patent/PE20171349A1/es unknown
- 2016-03-16 CA CA2979113A patent/CA2979113A1/en not_active Abandoned
- 2016-03-16 JP JP2017546991A patent/JP6674960B2/ja not_active Expired - Fee Related
- 2016-03-16 RU RU2017134884A patent/RU2712272C2/ru not_active IP Right Cessation
- 2016-03-16 CR CR20170426A patent/CR20170426A/es unknown
- 2016-03-16 CN CN201680016799.0A patent/CN107406440B/zh not_active Expired - Fee Related
- 2016-03-16 WO PCT/EP2016/055649 patent/WO2016150785A1/en active Application Filing
- 2016-03-16 KR KR1020177026060A patent/KR20170129745A/ko unknown
- 2016-03-16 EP EP16710170.8A patent/EP3271355B1/en active Active
- 2016-03-16 MX MX2017012188A patent/MX2017012188A/es unknown
-
2017
- 2017-07-05 IL IL253322A patent/IL253322A0/en unknown
- 2017-07-28 CO CONC2017/0007691A patent/CO2017007691A2/es unknown
- 2017-09-04 CL CL2017002229A patent/CL2017002229A1/es unknown
- 2017-09-13 PH PH12017501668A patent/PH12017501668A1/en unknown
-
2018
- 2018-03-22 HK HK18103983.3A patent/HK1244790A1/zh unknown
- 2018-07-12 US US16/033,785 patent/US10399969B2/en not_active Expired - Fee Related
-
2019
- 2019-07-16 US US16/512,905 patent/US10723729B2/en active Active
-
2020
- 2020-06-17 US US16/903,616 patent/US11034687B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2016236402B2 (en) | 2019-08-01 |
CN107406440B (zh) | 2021-05-07 |
EP3271355A1 (en) | 2018-01-24 |
CA2979113A1 (en) | 2016-09-29 |
US10723729B2 (en) | 2020-07-28 |
US20190337936A1 (en) | 2019-11-07 |
IL253322A0 (en) | 2017-09-28 |
PH12017501668A1 (en) | 2018-03-19 |
US20180057485A1 (en) | 2018-03-01 |
RU2712272C2 (ru) | 2020-01-28 |
US10399969B2 (en) | 2019-09-03 |
RU2017134884A (ru) | 2019-04-22 |
US11034687B2 (en) | 2021-06-15 |
CR20170426A (es) | 2017-10-23 |
PE20171349A1 (es) | 2017-09-13 |
JP2018507879A (ja) | 2018-03-22 |
SG11201707050VA (en) | 2017-10-30 |
BR112017015474A2 (pt) | 2018-01-30 |
RU2017134884A3 (zh) | 2019-07-17 |
JP6674960B2 (ja) | 2020-04-01 |
CL2017002229A1 (es) | 2018-04-13 |
CN107406440A (zh) | 2017-11-28 |
EP3271355B1 (en) | 2020-07-29 |
AU2016236402A1 (en) | 2017-07-27 |
KR20170129745A (ko) | 2017-11-27 |
WO2016150785A1 (en) | 2016-09-29 |
US20180319787A1 (en) | 2018-11-08 |
CO2017007691A2 (es) | 2017-10-20 |
MX2017012188A (es) | 2017-12-15 |
US20200308166A1 (en) | 2020-10-01 |
US10047081B2 (en) | 2018-08-14 |
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