HK1250706A1 - 2，4-二含氮基團取代嘧啶類化合物及其製備方法和應用 - Google Patents
2，4-二含氮基團取代嘧啶類化合物及其製備方法和應用Info
- Publication number
- HK1250706A1 HK1250706A1 HK18109960.7A HK18109960A HK1250706A1 HK 1250706 A1 HK1250706 A1 HK 1250706A1 HK 18109960 A HK18109960 A HK 18109960A HK 1250706 A1 HK1250706 A1 HK 1250706A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- preparation
- containing group
- nitrogen containing
- pyrimidine compound
- substituted pyrimidine
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- -1 pyrimidine compound Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510552982 | 2015-08-31 | ||
| CN201610471043.7A CN106117185B (zh) | 2015-08-31 | 2016-06-22 | 2,4‑二含氮基团取代嘧啶类化合物及其制备方法和应用 |
| PCT/CN2016/091755 WO2017036263A1 (zh) | 2015-08-31 | 2016-07-26 | 2,4-二含氮基团取代嘧啶类化合物及其制备方法和应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1250706A1 true HK1250706A1 (zh) | 2019-01-11 |
Family
ID=57268890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18109960.7A HK1250706A1 (zh) | 2015-08-31 | 2018-08-02 | 2，4-二含氮基團取代嘧啶類化合物及其製備方法和應用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11267802B2 (zh) |
| EP (1) | EP3345900A4 (zh) |
| CN (1) | CN106117185B (zh) |
| AU (1) | AU2016314898B2 (zh) |
| CA (1) | CA2997039C (zh) |
| HK (1) | HK1250706A1 (zh) |
| WO (1) | WO2017036263A1 (zh) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111171000B (zh) * | 2014-10-11 | 2023-09-01 | 上海翰森生物医药科技有限公司 | Egfr抑制剂及其制备和应用 |
| CN107835811B (zh) * | 2015-07-16 | 2019-11-08 | 正大天晴药业集团股份有限公司 | 苯胺嘧啶衍生物及其用途 |
| CN106928150B (zh) * | 2015-12-31 | 2020-07-31 | 恩瑞生物医药科技（上海）有限公司 | 丙烯酰胺苯胺衍生物及其药学上的应用 |
| JP2019501222A (ja) | 2016-01-07 | 2019-01-17 | シーエス ファーマテック リミテッド | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
| CN106883216B (zh) * | 2017-04-06 | 2020-03-13 | 张家港威胜生物医药有限公司 | 一种奥希替尼的制备方法 |
| CN107266426A (zh) * | 2017-08-15 | 2017-10-20 | 南通因诺威医药科技有限公司 | 2‑氨烃基嘧啶类化合物及其制备方法和用途 |
| CN110790749B (zh) * | 2018-08-03 | 2023-07-14 | 北京普祺医药科技股份有限公司 | 一种含氮杂环化合物、药物组合物以及其用途 |
| CN111747950B (zh) * | 2019-03-29 | 2024-01-23 | 深圳福沃药业有限公司 | 用于治疗癌症的嘧啶衍生物 |
| CN112409192A (zh) * | 2020-11-26 | 2021-02-26 | 启东东岳药业有限公司 | 一种4-氟-2-甲氧基苯胺的纯化方法 |
| CN115701429B (zh) * | 2021-08-02 | 2024-03-12 | 上海和誉生物医药科技有限公司 | 4-(1h-吲哚-1-基)嘧啶-2-氨基衍生物及其制备方法和应用 |
| CN116514723A (zh) * | 2023-03-22 | 2023-08-01 | 上海麦克林生化科技股份有限公司 | 一种5,6-2氯-1-乙基-1h-苯并咪唑-2酮(dcebio)的合成方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110025224A (ko) * | 2008-06-27 | 2011-03-09 | 아빌라 테라퓨틱스, 인크. | 헤테로아릴 화합물 및 이의 용도 |
| CN105348266B (zh) | 2011-07-27 | 2018-04-10 | 阿斯利康(瑞典)有限公司 | 取代的3‑氯‑n‑[3‑(嘧啶‑2‑基氨基)苯基]丙酰胺或其盐 |
| CN104761544B (zh) | 2014-01-03 | 2019-03-15 | 北京轩义医药科技有限公司 | Egfr酪氨酸激酶的临床重要突变体的选择性抑制剂 |
| CN111875585B (zh) * | 2014-06-12 | 2023-06-23 | 上海艾力斯医药科技股份有限公司 | 一类激酶抑制剂 |
| CN110526912B (zh) * | 2014-06-19 | 2023-02-14 | 武田药品工业株式会社 | 用于激酶抑制的杂芳基化合物 |
| CN113121575A (zh) * | 2014-08-25 | 2021-07-16 | 四川海思科制药有限公司 | 一种(取代的苯基)(取代的嘧啶)胺基衍生物及其制备方法和药物用途 |
| CN111171000B (zh) | 2014-10-11 | 2023-09-01 | 上海翰森生物医药科技有限公司 | Egfr抑制剂及其制备和应用 |
| CN105085489B (zh) * | 2014-11-05 | 2019-03-01 | 益方生物科技（上海）有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
| US10266517B2 (en) | 2014-12-23 | 2019-04-23 | Dana-Farber Cancer Institute, Inc. | Pyrimidines as EGFR inhibitors and methods of treating disorders |
| CN105001208A (zh) * | 2015-08-06 | 2015-10-28 | 南京雷科星生物技术有限公司 | 一种表皮生长因子受体egfr抑制剂及其制备方法与用途 |
| CN106928150B (zh) | 2015-12-31 | 2020-07-31 | 恩瑞生物医药科技（上海）有限公司 | 丙烯酰胺苯胺衍生物及其药学上的应用 |
| JP2019501222A (ja) | 2016-01-07 | 2019-01-17 | シーエス ファーマテック リミテッド | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
-
2016
- 2016-06-22 CN CN201610471043.7A patent/CN106117185B/zh active Active
- 2016-07-26 AU AU2016314898A patent/AU2016314898B2/en active Active
- 2016-07-26 EP EP16840692.4A patent/EP3345900A4/en active Pending
- 2016-07-26 CA CA2997039A patent/CA2997039C/en active Active
- 2016-07-26 US US15/755,572 patent/US11267802B2/en active Active
- 2016-07-26 WO PCT/CN2016/091755 patent/WO2017036263A1/zh active Application Filing
-
2018
- 2018-08-02 HK HK18109960.7A patent/HK1250706A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN106117185A (zh) | 2016-11-16 |
| AU2016314898B2 (en) | 2019-06-27 |
| EP3345900A4 (en) | 2019-04-10 |
| US11267802B2 (en) | 2022-03-08 |
| US20200331891A9 (en) | 2020-10-22 |
| CN106117185B (zh) | 2017-11-07 |
| EP3345900A1 (en) | 2018-07-11 |
| WO2017036263A1 (zh) | 2017-03-09 |
| AU2016314898A1 (en) | 2018-04-26 |
| CA2997039A1 (en) | 2017-03-09 |
| CA2997039C (en) | 2020-09-22 |
| US20200165227A1 (en) | 2020-05-28 |
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