HK1248772A1 - 序列特異性檢測和表型確定 - Google Patents

序列特異性檢測和表型確定

Info

Publication number
HK1248772A1
HK1248772A1 HK18108242.9A HK18108242A HK1248772A1 HK 1248772 A1 HK1248772 A1 HK 1248772A1 HK 18108242 A HK18108242 A HK 18108242A HK 1248772 A1 HK1248772 A1 HK 1248772A1
Authority
HK
Hong Kong
Prior art keywords
sequence
specific detection
phenotype determination
phenotype
determination
Prior art date
Application number
HK18108242.9A
Other languages
English (en)
Inventor
Diego Ariel Rey
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1248772A1 publication Critical patent/HK1248772A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK18108242.9A 2015-04-30 2018-06-27 序列特異性檢測和表型確定 HK1248772A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562155011P 2015-04-30 2015-04-30
PCT/EP2016/059518 WO2016174151A1 (en) 2015-04-30 2016-04-28 Sequence-specific detection and phenotype determination

Publications (1)

Publication Number Publication Date
HK1248772A1 true HK1248772A1 (zh) 2018-10-19

Family

ID=55953128

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18108242.9A HK1248772A1 (zh) 2015-04-30 2018-06-27 序列特異性檢測和表型確定

Country Status (9)

Country Link
US (2) US10227661B2 (zh)
EP (1) EP3289100B1 (zh)
JP (1) JP6826048B2 (zh)
CN (1) CN107532215A (zh)
CA (1) CA2983217C (zh)
ES (1) ES2761631T3 (zh)
HK (1) HK1248772A1 (zh)
SG (1) SG11201708841SA (zh)
WO (1) WO2016174151A1 (zh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013066438A2 (en) 2011-07-22 2013-05-10 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US9322037B2 (en) 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
US11053481B2 (en) 2013-12-12 2021-07-06 President And Fellows Of Harvard College Fusions of Cas9 domains and nucleic acid-editing domains
AU2015298571B2 (en) 2014-07-30 2020-09-03 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
US9879328B2 (en) * 2014-11-21 2018-01-30 GeneWeave Biosciences, Inc. Mechanisms of antimicrobial susceptibility
JP7109784B2 (ja) 2015-10-23 2022-08-01 プレジデント アンド フェローズ オブ ハーバード カレッジ 遺伝子編集のための進化したＣａｓ９蛋白質
JP2019509746A (ja) 2016-03-28 2019-04-11 ザ・チャールズ・スターク・ドレイパ・ラボラトリー・インコーポレイテッド バクテリオファージ改変法
CN110214183A (zh) 2016-08-03 2019-09-06 哈佛大学的校长及成员们 腺苷核碱基编辑器及其用途
US11661590B2 (en) 2016-08-09 2023-05-30 President And Fellows Of Harvard College Programmable CAS9-recombinase fusion proteins and uses thereof
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
SG11201903089RA (en) 2016-10-14 2019-05-30 Harvard College Aav delivery of nucleobase editors
US10745677B2 (en) 2016-12-23 2020-08-18 President And Fellows Of Harvard College Editing of CCR5 receptor gene to protect against HIV infection
EP3592853A1 (en) 2017-03-09 2020-01-15 President and Fellows of Harvard College Suppression of pain by gene editing
JP2020510439A (ja) 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ シトシンからグアニンへの塩基編集因子
IL306092A (en) 2017-03-23 2023-11-01 Harvard College Nucleic base editors that include nucleic acid programmable DNA binding proteins
WO2018209320A1 (en) 2017-05-12 2018-11-15 President And Fellows Of Harvard College Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
EP3658573A1 (en) 2017-07-28 2020-06-03 President and Fellows of Harvard College Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
EP3676376A2 (en) 2017-08-30 2020-07-08 President and Fellows of Harvard College High efficiency base editors comprising gam
CN111757937A (zh) 2017-10-16 2020-10-09 布罗德研究所股份有限公司 腺苷碱基编辑器的用途
CN107904208B (zh) * 2017-12-25 2019-11-01 云舟生物科技（广州）有限公司 细胞表型研究用的细胞克隆及其筛选方法和应用
US10450616B1 (en) 2018-05-09 2019-10-22 Talis Biomedical Corporation Polynucleotides for the amplification and detection of Chlamydia trachomatis
CN109628616A (zh) * 2018-12-17 2019-04-16 博奥生物集团有限公司 用于检测碳青霉烯类耐药基因ndm1-24亚型的lamp引物组合及其应用
CN113227404A (zh) * 2018-12-27 2021-08-06 豪夫迈·罗氏有限公司 用于检测鲍氏不动杆菌的非复制型转导颗粒和基于转导颗粒的报告***
US20220073969A1 (en) * 2018-12-29 2022-03-10 Roche Molecular Systems, Inc. Use of sideromycins to limit cross-reactivity and improve species identification in antibiotic susceptibility assays
WO2020191241A1 (en) 2019-03-19 2020-09-24 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
WO2020245123A1 (en) * 2019-06-06 2020-12-10 F. Hoffmann-La Roche Ag Use of peptidomimetic antimicrobial peptides to limit cross-reactivity and improve bacterial identification in antibiotic susceptibility assays
US10954572B2 (en) 2019-07-25 2021-03-23 Talis Biomedical Corporation Polynucleotides for the amplification and detection of Neisseria gonorrhoeae
US11891662B2 (en) 2019-12-02 2024-02-06 Talis Biomedical Corporation Polynucleotides for amplification and detection of human beta actin
CA3177481A1 (en) 2020-05-08 2021-11-11 David R. Liu Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE149208T1 (de) * 1988-10-04 1997-03-15 Dna Plant Techn Corp Bakterieller nachweis durch phagentransduktion von nachweisbaren phenotypen
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5736388A (en) 1994-12-30 1998-04-07 Chada; Sunil Bacteriophage-mediated gene transfer systems capable of transfecting eukaryotic cells
US6274316B1 (en) * 1997-07-03 2001-08-14 Id Biomedical Corporation Compositions and methods for detecting vancomycin resistant enterococci by cycling probe reactions
WO2001012803A2 (en) * 1999-08-17 2001-02-22 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for restoring antibiotic susceptibility in glycopeptide-resistant enterococcus
AU2277401A (en) * 1999-12-23 2001-07-09 Elitra Pharmaceuticals, Inc. Genes identified as required for proliferation of e. coli
WO2002079467A2 (en) 2001-03-29 2002-10-10 Københavns Universitet Antibiotic-free bacterial strain selection with antisense molecules
US20090155768A1 (en) * 2004-04-07 2009-06-18 Dean Scholl Reporter plasmid phage packaging system for detection of bacteria
EP2147125A4 (en) * 2007-04-18 2010-12-15 Univ Cornell METHOD AND APPARATUS FOR DETECTING MICROORGANISM
US8329889B2 (en) * 2008-02-15 2012-12-11 Trustees Of Boston University In vivo gene sensors
WO2010048511A1 (en) * 2008-10-24 2010-04-29 Becton, Dickinson And Company Antibiotic susceptibility profiling methods
US9801948B2 (en) 2011-09-21 2017-10-31 Yale University Antimicrobial compositions and methods of use thereof
WO2014124226A1 (en) 2013-02-07 2014-08-14 The Rockefeller University Sequence specific antimicrobials
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
BR112015023108A8 (pt) * 2013-03-13 2018-01-23 Geneweave Biosciences Inc sistema de acondicionamento de célula bacteriana, método para acondicionamento de uma molécula de ácido nucléico repórter, composição, método para detectar uma presença ou uma ausência de uma célula bacteriana em uma amostra, vetor, método para detectar um transcrito alvo em uma célula, método para detectar a presença de uma célula bacteriana em uma amostra e kit.
DK3041498T3 (da) 2013-09-05 2022-05-09 Massachusetts Inst Technology Afstemning af mikrobielle populationer med programmerbare nukleaser
US9540675B2 (en) 2013-10-29 2017-01-10 GeneWeave Biosciences, Inc. Reagent cartridge and methods for detection of cells

Also Published As

Publication number Publication date
CA2983217A1 (en) 2016-11-03
CN107532215A (zh) 2018-01-02
US10822664B2 (en) 2020-11-03
US20160319378A1 (en) 2016-11-03
CA2983217C (en) 2022-01-11
EP3289100B1 (en) 2019-10-09
EP3289100A1 (en) 2018-03-07
JP2018520640A (ja) 2018-08-02
US10227661B2 (en) 2019-03-12
WO2016174151A1 (en) 2016-11-03
JP6826048B2 (ja) 2021-02-03
SG11201708841SA (en) 2017-11-29
US20190127810A1 (en) 2019-05-02
ES2761631T3 (es) 2020-05-20

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