HK1244805A1 - 一種新毒素及其中間體的製備方法 - Google Patents

一種新毒素及其中間體的製備方法

Info

Publication number
HK1244805A1
HK1244805A1 HK18104330.1A HK18104330A HK1244805A1 HK 1244805 A1 HK1244805 A1 HK 1244805A1 HK 18104330 A HK18104330 A HK 18104330A HK 1244805 A1 HK1244805 A1 HK 1244805A1
Authority
HK
Hong Kong
Prior art keywords
preparing intermediate
new toxin
toxin
new
preparing
Prior art date
Application number
HK18104330.1A
Other languages
English (en)
Inventor
許建烟
章瑛
屈博磊
蔣貴陽
Original Assignee
江蘇恒瑞醫藥股份有限公司
上海恒瑞醫藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江蘇恒瑞醫藥股份有限公司, 上海恒瑞醫藥有限公司 filed Critical 江蘇恒瑞醫藥股份有限公司
Publication of HK1244805A1 publication Critical patent/HK1244805A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
HK18104330.1A 2016-02-26 2018-03-29 一種新毒素及其中間體的製備方法 HK1244805A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610107901 2016-02-26
PCT/CN2017/074756 WO2017144015A1 (zh) 2016-02-26 2017-02-24 一种新毒素及其中间体的制备方法

Publications (1)

Publication Number Publication Date
HK1244805A1 true HK1244805A1 (zh) 2018-08-17

Family

ID=59685835

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18104330.1A HK1244805A1 (zh) 2016-02-26 2018-03-29 一種新毒素及其中間體的製備方法

Country Status (13)

Country Link
US (1) US10513510B2 (zh)
EP (1) EP3421463A4 (zh)
JP (1) JP2019510000A (zh)
KR (1) KR20180115743A (zh)
CN (1) CN107531680B (zh)
AU (1) AU2017223532A1 (zh)
BR (1) BR112018016983A2 (zh)
CA (1) CA3015098A1 (zh)
HK (1) HK1244805A1 (zh)
MX (1) MX2018010128A (zh)
RU (1) RU2018132749A (zh)
TW (1) TWI732826B (zh)
WO (1) WO2017144015A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201912626A (zh) * 2017-09-04 2019-04-01 大陸商江蘇恆瑞醫藥股份有限公司 一種新毒素及其中間體的製備方法
CN112390853A (zh) * 2019-08-11 2021-02-23 复旦大学 海兔毒素10类似物及其制备方法
CA3184724A1 (en) 2020-07-27 2022-02-03 Wenming REN Anti-cd79b antibody-drug conjugate, and preparation method therefor and pharmaceutical use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861170B1 (fr) 2003-10-16 2006-01-20 Tijani Gharbi Dispositif optique pour determiner au moins une caracteristique dimensionnelle d'une goutte de liquide
CA2841741C (en) * 2003-11-06 2020-01-07 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
NZ580115A (en) * 2004-09-23 2010-10-29 Genentech Inc Cysteine engineered antibody light chains and conjugates
TW200833328A (en) * 2006-12-28 2008-08-16 Actelion Pharmaceuticals Ltd 2-aza-bicyclo[3.1.0]hexane derivatives
TWI476190B (zh) * 2009-03-30 2015-03-11 必治妥美雅史谷比公司 Ｃ型肝炎病毒抑制劑
TWI582112B (zh) 2011-04-21 2017-05-11 西雅圖遺傳學公司 新穎結合劑－藥物接合物（ＡＤＣｓ）及其用途（二）
EP2780039B9 (en) 2011-11-17 2018-08-22 Pfizer Inc Cytotoxic peptides and antibody drug conjugates thereof
CA2859255A1 (en) 2011-12-14 2013-06-20 Seattle Genetics, Inc. New antibody drug conjugates (adcs) and the use thereof
FR3005051A1 (fr) * 2013-04-25 2014-10-31 Pf Medicament Derives de la dolastatine 10 et d'auristatines
EP3134125B1 (en) * 2014-04-25 2019-10-09 Pierre Fabre Medicament Antibody-drug-conjugate and its use for the treatment of cancer
WO2016127790A1 (zh) 2015-02-15 2016-08-18 江苏恒瑞医药股份有限公司 配体-细胞毒性药物偶联物、其制备方法及其应用
CN106188293A (zh) * 2015-04-17 2016-12-07 江苏恒瑞医药股份有限公司 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途

Also Published As

Publication number Publication date
US20190055223A1 (en) 2019-02-21
CA3015098A1 (en) 2017-08-31
TWI732826B (zh) 2021-07-11
CN107531680B (zh) 2020-09-11
MX2018010128A (es) 2019-01-21
US10513510B2 (en) 2019-12-24
RU2018132749A (ru) 2020-03-26
JP2019510000A (ja) 2019-04-11
KR20180115743A (ko) 2018-10-23
WO2017144015A1 (zh) 2017-08-31
TW201730185A (zh) 2017-09-01
EP3421463A1 (en) 2019-01-02
EP3421463A4 (en) 2019-10-23
AU2017223532A1 (en) 2018-08-30
CN107531680A (zh) 2018-01-02
BR112018016983A2 (zh) 2018-12-26
RU2018132749A3 (zh) 2020-04-14

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