HK1244515A1 - 用於癌症篩查和胎兒分析的突變檢測 - Google Patents
用於癌症篩查和胎兒分析的突變檢測Info
- Publication number
- HK1244515A1 HK1244515A1 HK18103937.0A HK18103937A HK1244515A1 HK 1244515 A1 HK1244515 A1 HK 1244515A1 HK 18103937 A HK18103937 A HK 18103937A HK 1244515 A1 HK1244515 A1 HK 1244515A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cancer screening
- detecting mutations
- fetal analysis
- fetal
- analysis
- Prior art date
Links
Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/50—Mutagenesis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562114471P | 2015-02-10 | 2015-02-10 | |
US201562271196P | 2015-12-22 | 2015-12-22 | |
PCT/CN2016/073753 WO2016127944A1 (en) | 2015-02-10 | 2016-02-14 | Detecting mutations for cancer screening and fetal analysis |
Publications (1)
Publication Number | Publication Date |
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HK1244515A1 true HK1244515A1 (zh) | 2018-08-10 |
Family
ID=56615337
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18103937.0A HK1244515A1 (zh) | 2015-02-10 | 2018-03-21 | 用於癌症篩查和胎兒分析的突變檢測 |
HK18110258.6A HK1251018A1 (zh) | 2015-02-10 | 2018-08-10 | 用於癌症篩查和胎兒分析的突變檢測 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18110258.6A HK1251018A1 (zh) | 2015-02-10 | 2018-08-10 | 用於癌症篩查和胎兒分析的突變檢測 |
Country Status (15)
Country | Link |
---|---|
US (3) | US10240209B2 (zh) |
EP (2) | EP4012715A1 (zh) |
JP (3) | JP6829211B2 (zh) |
KR (1) | KR20170125044A (zh) |
CN (2) | CN113957124A (zh) |
AU (2) | AU2016218631B2 (zh) |
CA (1) | CA2976303A1 (zh) |
DK (1) | DK3256605T3 (zh) |
ES (1) | ES2908347T3 (zh) |
HK (2) | HK1244515A1 (zh) |
HU (1) | HUE058263T2 (zh) |
PT (1) | PT3256605T (zh) |
SG (1) | SG11201706529TA (zh) |
TW (3) | TWI740817B (zh) |
WO (1) | WO2016127944A1 (zh) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI335354B (en) | 2006-09-27 | 2011-01-01 | Univ Hong Kong Chinese | Methods for the detection of the degree of the methylation of a target dna and kits |
US9260753B2 (en) | 2011-03-24 | 2016-02-16 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
KR102393608B1 (ko) | 2012-09-04 | 2022-05-03 | 가던트 헬쓰, 인크. | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 |
US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
EP3561072A1 (en) | 2012-12-10 | 2019-10-30 | Resolution Bioscience, Inc. | Methods for targeted genomic analysis |
ES2784450T3 (es) | 2013-12-28 | 2020-09-25 | Guardant Health Inc | Métodos y sistemas para detectar variantes genéticas |
CN106795562B (zh) | 2014-07-18 | 2022-03-25 | 香港中文大学 | Dna混合物中的组织甲基化模式分析 |
EP4358097A1 (en) | 2014-07-25 | 2024-04-24 | University of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
ES2908347T3 (es) | 2015-02-10 | 2022-04-28 | Univ Hong Kong Chinese | Detección de mutaciones para cribado de cáncer y análisis fetal |
CA2993362A1 (en) | 2015-07-23 | 2017-01-26 | The Chinese University Of Hong Kong | Analysis of fragmentation patterns of cell-free dna |
DK3374525T3 (da) | 2015-11-11 | 2021-04-06 | Resolution Bioscience Inc | Højeffektiv konstruktion af dna-biblioteker |
JP2019507585A (ja) | 2015-12-17 | 2019-03-22 | ガーダント ヘルス, インコーポレイテッド | 無細胞dnaの分析による腫瘍遺伝子コピー数を決定するための方法 |
US11514289B1 (en) | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
US20190114464A1 (en) * | 2016-03-10 | 2019-04-18 | Genomic Vision | Method of curvilinear signal detection and analysis and associated platform |
CN116445593A (zh) | 2016-08-10 | 2023-07-18 | 格里尔公司 | 测定一生物样品的一甲基化图谱的方法 |
EP3504347A4 (en) | 2016-08-25 | 2020-04-29 | Resolution Bioscience, Inc. | METHODS FOR DETECTING GENOMIC COPY CHANGES IN DNA SAMPLES |
SG11201811159SA (en) | 2016-09-30 | 2019-01-30 | Guardant Health Inc | Methods for multi-resolution analysis of cell-free nucleic acids |
US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
CN110100013A (zh) * | 2016-10-24 | 2019-08-06 | 香港中文大学 | 用于肿瘤检测的方法和*** |
KR20230062684A (ko) | 2016-11-30 | 2023-05-09 | 더 차이니즈 유니버시티 오브 홍콩 | 소변 및 기타 샘플에서의 무세포 dna의 분석 |
CA3047421A1 (en) * | 2016-12-21 | 2018-06-28 | The Regents Of The University Of California | Deconvolution and detection of rare dna in plasma |
CA3051509A1 (en) | 2017-01-25 | 2018-08-02 | The Chinese University Of Hong Kong | Diagnostic applications using nucleic acid fragments |
EP3366780B1 (en) | 2017-02-23 | 2020-05-06 | Siemens Healthcare GmbH | Single-molecule sequence and high sensitivity methylation analysis for tissue-specific analysis |
IT201700045353A1 (it) * | 2017-04-26 | 2018-10-26 | Bioscience Services S R L | Metodo per la ricerca e l'individuazione di una condizione genetica prodromica all'insorgenza di tumori solidi |
EP3625341A4 (en) * | 2017-05-16 | 2021-05-19 | Guardant Health, Inc. | IDENTIFICATION OF SOMATIC ORIGIN OR GERMINAL LINE OF CELLLESS DNA |
US10081829B1 (en) | 2017-06-13 | 2018-09-25 | Genetics Research, Llc | Detection of targeted sequence regions |
US10636512B2 (en) | 2017-07-14 | 2020-04-28 | Cofactor Genomics, Inc. | Immuno-oncology applications using next generation sequencing |
EP3431610A1 (en) * | 2017-07-19 | 2019-01-23 | Noscendo GmbH | Methods and devices for nucleic acid-based real-time determination of disease states |
EP3658684B1 (en) | 2017-07-26 | 2023-08-30 | The Chinese University Of Hong Kong | Enhancement of cancer screening using cell-free viral nucleic acids |
WO2019071219A1 (en) * | 2017-10-06 | 2019-04-11 | Grail, Inc. | SPECIFIC SITE NOISE MODEL FOR TARGETED SEQUENCING |
WO2019090156A1 (en) * | 2017-11-03 | 2019-05-09 | Guardant Health, Inc. | Normalizing tumor mutation burden |
WO2019109086A1 (en) * | 2017-12-01 | 2019-06-06 | Illumina, Inc. | Methods and systems for determining somatic mutation clonality |
KR20200129092A (ko) * | 2018-01-12 | 2020-11-17 | 그레일, 인코포레이티드. | 바이러스 핵산을 분석하기 위한 방법 |
CA3094717A1 (en) | 2018-04-02 | 2019-10-10 | Grail, Inc. | Methylation markers and targeted methylation probe panels |
US20210158895A1 (en) * | 2018-04-13 | 2021-05-27 | Dana-Farber Cancer Institute, Inc. | Ultra-sensitive detection of cancer by algorithmic analysis |
EP3781709A4 (en) * | 2018-04-16 | 2022-11-30 | Grail, LLC | SYSTEMS AND METHODS FOR DETERMINING TUMOR FRACTION IN CELL-FREE NUCLEIC ACID |
AU2019261597A1 (en) * | 2018-04-24 | 2020-11-19 | Grail, Llc | Systems and methods for using pathogen nucleic acid load to determine whether a subject has a cancer condition |
CN108900319B (zh) * | 2018-05-30 | 2021-05-25 | 北京百度网讯科技有限公司 | 故障检测方法和装置 |
SG11202100344WA (en) * | 2018-07-23 | 2021-02-25 | Guardant Health Inc | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage |
WO2020023671A1 (en) * | 2018-07-24 | 2020-01-30 | Protocol Intelligence, Inc. | Methods and systems for treating cancer and predicting and optimizing treatment outcomes in individual cancer patients |
CA3106820A1 (en) * | 2018-07-26 | 2020-01-30 | Lexent Bio, Inc. | Multiple sequencing using a single flow cell |
CN109022619A (zh) * | 2018-08-27 | 2018-12-18 | 郑州安图生物工程股份有限公司 | 一种用于检测人类疱疹病毒4型的试剂盒 |
WO2020069350A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
KR20210089240A (ko) * | 2018-11-13 | 2021-07-15 | 미리어드 제네틱스, 인크. | 체세포성 돌연변이를 위한 방법 및 시스템 그리고 그 용도 |
US20200199656A1 (en) * | 2018-12-19 | 2020-06-25 | The Chinese University Of Hong Kong | Cell-free dna end characteristics |
US11643693B2 (en) | 2019-01-31 | 2023-05-09 | Guardant Health, Inc. | Compositions and methods for isolating cell-free DNA |
CN109841265B (zh) * | 2019-02-22 | 2021-09-21 | 清华大学 | 使用片段化模式确定血浆游离核酸分子组织来源的方法和***及应用 |
BR112021022879A2 (pt) * | 2019-05-20 | 2022-03-22 | Found Medicine Inc | Sistemas e métodos para avaliação de fração tumoral |
US20210366569A1 (en) * | 2019-06-03 | 2021-11-25 | Illumina, Inc. | Limit of detection based quality control metric |
KR20220064951A (ko) * | 2019-06-21 | 2022-05-19 | 쿠퍼서지컬, 인코퍼레이션. | 인간 배아에서의 복제 수 변이의 확인을 위한 단일 뉴클레오티드 변이의 밀도를 사용하는 시스템 및 방법(systems and methods for using density of single nucleotide variations for the verification of copy number variations in human embryos) |
US20210065842A1 (en) * | 2019-07-23 | 2021-03-04 | Grail, Inc. | Systems and methods for determining tumor fraction |
AU2020333348B2 (en) * | 2019-08-19 | 2023-11-23 | Green Cross Genome Corporation | Method for detecting chromosomal abnormality by using information about distance between nucleic acid fragments |
WO2021137770A1 (en) * | 2019-12-30 | 2021-07-08 | Geneton S.R.O. | Method for fetal fraction estimation based on detection and interpretation of single nucleotide variants |
US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
EP4259817A1 (en) * | 2020-12-08 | 2023-10-18 | The Chinese University of Hong Kong | Methods using characteristics of urinary and other dna |
CN113628683B (zh) * | 2021-08-24 | 2024-04-09 | 慧算医疗科技(上海)有限公司 | 一种高通量测序突变检测方法、设备、装置及可读存储介质 |
WO2023129983A1 (en) * | 2021-12-29 | 2023-07-06 | AiOnco, Inc. | Processing encrypted data for artificial intelligence-based analysis |
CN114582429B (zh) * | 2022-03-03 | 2023-06-13 | 四川大学 | 基于层次注意力神经网络的结核分枝杆菌耐药性预测方法及装置 |
KR102491322B1 (ko) * | 2022-03-29 | 2023-01-27 | 주식회사 아이엠비디엑스 | 암 진단을 위한 다중 분석 예측 모델의 제조 방법 |
WO2023225659A2 (en) * | 2022-05-19 | 2023-11-23 | Personalis, Inc. | Methods and system for using methylation data for disease detection and quantification |
CN115394358B (zh) * | 2022-08-31 | 2023-05-12 | 西安理工大学 | 基于深度学习的单细胞测序基因表达数据插补方法和*** |
WO2024051806A1 (zh) * | 2022-09-09 | 2024-03-14 | 南京金斯瑞生物科技有限公司 | 一种设计人源化抗体序列的方法 |
CN115424666B (zh) * | 2022-09-13 | 2023-07-11 | 江苏先声医学诊断有限公司 | 一种基于全基因组重亚硫酸盐测序数据筛选泛癌早筛分子标志物的方法及*** |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1169347B1 (en) | 1999-04-02 | 2008-07-02 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
US20030219765A1 (en) | 2000-03-23 | 2003-11-27 | Jose Costa | Methods for evaluating cancer risk |
JP2005514956A (ja) * | 2002-01-18 | 2005-05-26 | ジェンザイム・コーポレーション | 胎児dnaの検出および対立遺伝子の定量化のための方法 |
US7704687B2 (en) | 2002-11-15 | 2010-04-27 | The Johns Hopkins University | Digital karyotyping |
US8394582B2 (en) | 2003-03-05 | 2013-03-12 | Genetic Technologies, Inc | Identification of fetal DNA and fetal cell markers in maternal plasma or serum |
PL201608B1 (pl) | 2003-06-13 | 2009-04-30 | Cezary Cybulski | Sposób i zestaw do wykrywania wysokiej genetycznie uwarunkowanej predyspozycji do raka prostaty oraz zastosowanie zmiany germinalnej w obrębie genu NBS1 |
DE60328193D1 (de) | 2003-10-16 | 2009-08-13 | Sequenom Inc | Nicht invasiver Nachweis fötaler genetischer Merkmale |
CA2562310A1 (en) | 2004-04-30 | 2005-11-17 | Yale University | Methods and compositions for cancer diagnosis |
US20070122823A1 (en) | 2005-09-01 | 2007-05-31 | Bianchi Diana W | Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis |
ES2739484T3 (es) | 2006-02-02 | 2020-01-31 | Univ Leland Stanford Junior | Prueba genética fetal no invasiva mediante análisis digital |
CA2647793C (en) | 2006-02-28 | 2016-07-05 | University Of Louisville Research Foundation | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
WO2008024009A1 (fr) | 2006-08-15 | 2008-02-28 | Institut Molekulyarnoi Genetiki Rossiiskoi Akademii Nauk (Img Ran) | Niveau de transcription du gène timp3 utilisé en tant que marqueur servant à diagnostiquer le cancer du poumon non à petites cellules |
MX2009012722A (es) | 2007-05-25 | 2009-12-11 | Decode Genetics Ehf | Variantes geneticas sobre chr 5p12 y 10q26 como marcadores para el uso en la evaluacion del riesgo, diagnostico, pronostico y tratamiento del cancer de mama. |
CA2900927C (en) | 2007-07-23 | 2018-08-14 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
US20090053719A1 (en) | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
US20100041048A1 (en) | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
CA3069082C (en) | 2008-09-20 | 2022-03-22 | The Board Of Trustees Of The Leland Stanford Junior University | Noninvasive diagnosis of fetal aneuploidy by sequencing |
US20100136560A1 (en) | 2008-12-02 | 2010-06-03 | The Johns Hopkins University | Integrated Analyses of Breast and Colorectal Cancers |
RU2011143425A (ru) | 2009-03-31 | 2013-05-10 | Оридис Биомаркерс Гмбх | Способ диагностики рака и мониторинга лечения рака |
WO2011038507A1 (en) | 2009-10-02 | 2011-04-07 | Centre For Addiction And Mental Health | Method for analysis of dna methylation profiles of cell-free circulating dna in bodily fluids |
WO2011053790A2 (en) | 2009-10-30 | 2011-05-05 | Fluidigm Corporation | Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis |
ES2720282T3 (es) | 2009-11-05 | 2019-07-19 | Univ Hong Kong Chinese | Análisis genómico fetal a partir de una muestra biológica materna |
MX357692B (es) | 2009-11-06 | 2018-07-19 | Univ Hong Kong Chinese | Analisis genomico a base de tamaño. |
GB0922006D0 (en) | 2009-12-17 | 2010-02-03 | Genome Res Ltd | Diagnostic |
EP2848703A1 (en) | 2010-01-19 | 2015-03-18 | Verinata Health, Inc | Simultaneous determination of aneuploidy and fetal fraction |
AU2011207544A1 (en) | 2010-01-19 | 2012-09-06 | Verinata Health, Inc. | Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing |
US20130210645A1 (en) | 2010-02-18 | 2013-08-15 | The Johns Hopkins University | Personalized tumor biomarkers |
EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
EP4269623A3 (en) | 2010-11-30 | 2024-03-06 | The Chinese University Of Hong Kong | Analysis of a biological sample of an organism for chromosomal deletions or amplifications associated with cancer |
GB2485635B (en) | 2011-07-26 | 2012-11-28 | Verinata Health Inc | Method for determining the presence or absence of different aneuploidies in a sample |
EP3922731A3 (en) | 2011-10-06 | 2022-01-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10214775B2 (en) | 2011-12-07 | 2019-02-26 | Chronix Biomedical | Prostate cancer associated circulating nucleic acid biomarkers |
US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
CA2867293C (en) | 2012-03-13 | 2020-09-01 | Abhijit Ajit PATEL | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
WO2013179443A1 (ja) | 2012-05-31 | 2013-12-05 | 住友電気工業株式会社 | 酸化物超電導薄膜とその製造方法 |
US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
KR102393608B1 (ko) * | 2012-09-04 | 2022-05-03 | 가던트 헬쓰, 인크. | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 |
US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
DK3536807T3 (da) | 2012-09-20 | 2024-02-05 | Univ Hong Kong Chinese | Ikkeinvasiv bestemmelse af foster- eller tumormethylom fra plasma |
JP2016513959A (ja) * | 2013-02-21 | 2016-05-19 | トマ バイオサイエンシーズ, インコーポレイテッド | 核酸分析のための方法、組成物およびキット |
US10017807B2 (en) | 2013-03-15 | 2018-07-10 | Verinata Health, Inc. | Generating cell-free DNA libraries directly from blood |
US10174375B2 (en) * | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
US10262755B2 (en) * | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
US20160002717A1 (en) | 2014-07-02 | 2016-01-07 | Boreal Genomics, Inc. | Determining mutation burden in circulating cell-free nucleic acid and associated risk of disease |
EP4358097A1 (en) | 2014-07-25 | 2024-04-24 | University of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
EP3224380A1 (en) | 2014-11-25 | 2017-10-04 | The Broad Institute Inc. | Clonal haematopoiesis |
CA2967447A1 (en) | 2014-12-05 | 2016-06-09 | Foundation Medicine, Inc. | Multigene analysis of tumor samples |
WO2016109452A1 (en) | 2014-12-31 | 2016-07-07 | Guardant Health , Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
ES2908347T3 (es) | 2015-02-10 | 2022-04-28 | Univ Hong Kong Chinese | Detección de mutaciones para cribado de cáncer y análisis fetal |
JP2018513508A (ja) | 2015-03-16 | 2018-05-24 | パーソナル ジノーム ダイアグノスティクス, インコーポレイテッド | 核酸を分析するためのシステムおよび方法 |
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