HK1244287A1 - 作為製備類固醇FXR調節劑的中間體的6α-烷基-3，7-二酮類固醇 - Google Patents

作為製備類固醇FXR調節劑的中間體的6α-烷基-3，7-二酮類固醇

Info

Publication number
HK1244287A1
HK1244287A1 HK18103794.2A HK18103794A HK1244287A1 HK 1244287 A1 HK1244287 A1 HK 1244287A1 HK 18103794 A HK18103794 A HK 18103794A HK 1244287 A1 HK1244287 A1 HK 1244287A1
Authority
HK
Hong Kong
Prior art keywords
intermediates
alpha
alkyl
production
fxr modulators
Prior art date
Application number
HK18103794.2A
Other languages
English (en)
Inventor
Alexander Weymouth-Wilson
Zofia Komsta
James Boydell
Laura Wallis
Rhys Batchelor
Carl Otter
Ieuan Davies
Original Assignee
Nzp Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505676.5A external-priority patent/GB201505676D0/en
Application filed by Nzp Uk Ltd filed Critical Nzp Uk Ltd
Publication of HK1244287A1 publication Critical patent/HK1244287A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK18103794.2A 2014-11-19 2018-03-19 作為製備類固醇FXR調節劑的中間體的6α-烷基-3，7-二酮類固醇 HK1244287A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505676.5A GB201505676D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053518 WO2016079519A1 (en) 2014-11-19 2015-11-19 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators

Publications (1)

Publication Number Publication Date
HK1244287A1 true HK1244287A1 (zh) 2018-08-03

Family

ID=54704021

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103794.2A HK1244287A1 (zh) 2014-11-19 2018-03-19 作為製備類固醇FXR調節劑的中間體的6α-烷基-3，7-二酮類固醇

Country Status (14)

Country Link
US (1) US10538550B2 (zh)
EP (1) EP3221333B1 (zh)
JP (1) JP6735748B2 (zh)
KR (1) KR102546748B1 (zh)
CN (1) CN107108688B (zh)
CA (1) CA2968305A1 (zh)
DK (1) DK3221333T3 (zh)
EA (1) EA034739B1 (zh)
ES (1) ES2748692T3 (zh)
HK (1) HK1244287A1 (zh)
MX (1) MX2017006565A (zh)
PL (1) PL3221333T3 (zh)
TW (1) TWI686401B (zh)
WO (1) WO2016079519A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017006567A (es) 2014-11-19 2018-01-26 Nzp Uk Ltd Esteroides 6.alfa.-alquil-6,7-diona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr).
TWI686400B (zh) 2014-11-19 2020-03-01 英商Ｎｚｐ英國有限公司 化合物（二）
EP3221331B1 (en) 2014-11-19 2019-09-18 Nzp Uk Limited 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators
KR20180095070A (ko) * 2015-12-22 2018-08-24 인터셉트 파마슈티컬즈, 인크. 오베티콜산의 다형성 결정질 형태들
GB201608779D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
EP3431486A1 (en) 2017-07-18 2019-01-23 Bionice, S.L.U. Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CN111138509B (zh) * 2018-11-02 2022-12-06 东莞东阳光药物研发有限公司 奥贝胆酸的制备方法
EP3890745A4 (en) * 2018-12-04 2022-09-14 President and Fellows of Harvard College SYNTHETIC CHOLIC ACID 7-SULPHATE DERIVATIVES AND USES THEREOF

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2624748A (en) 1950-09-09 1953-01-06 Upjohn Co Bisnorchola-4, 6-dien-3-one-22-al
US4289872A (en) 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
US5229490A (en) 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
CA2118130A1 (en) 1992-04-14 1993-10-28 Jean M. J. Frechet Dendritic based macromolecules and method of production
AU6392894A (en) 1993-02-26 1994-09-14 Magainin Pharmaceuticals, Inc. Chemical synthesis of squalamine
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
WO2002072598A1 (en) * 2001-03-12 2002-09-19 Roberto Pellicciari Steroids as agonists for fxr
US20090062256A1 (en) 2001-06-01 2009-03-05 Bristol-Myers Squibb Pharma Company LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
US7026440B2 (en) 2001-11-07 2006-04-11 Nektar Therapeutics Al, Corporation Branched polymers and their conjugates
EP1568706A1 (en) * 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
ITMI20050912A1 (it) 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
JP2007210888A (ja) 2006-01-12 2007-08-23 Mitsubishi Chemicals Corp ステロイド化合物の製造方法
CA2642220A1 (en) 2006-02-14 2007-08-23 Intercept Pharmaceuticals, Inc. Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated diseases or conditions
ES2523591T3 (es) 2006-06-27 2014-11-27 Intercept Pharmaceuticals Inc. Derivados de ácidos biliares como ligandos de FXR para la prevención o el tratamiento de enfermedades o estados mediados por FXR
ES2438271T3 (es) 2007-01-19 2014-01-16 Intercept Pharmaceuticals, Inc. Ácidos biliares 23-sustituidos como moduladores de TGR5 y métodos de uso de los mismos
AU2009276507B2 (en) 2008-07-30 2015-11-19 Intercept Pharmaceuticals, Inc. TGR5 modulators and methods of use thereof
US8999964B2 (en) * 2008-11-19 2015-04-07 Intercept Pharmaceuticals, Inc. TGR5 modulators and methods of use thereof
EP2698375B1 (en) 2008-11-19 2018-02-21 Intercept Pharmaceuticals, Inc. TGR5 modulators and method of use thereof
WO2011014661A2 (en) 2009-07-29 2011-02-03 The University Of Chicago Liver x receptor agonists
NZ734451A (en) * 2012-06-19 2018-12-21 Intercept Pharmaceuticals Inc Preparation, uses and solid forms of obeticholic acid
DK2912013T3 (en) 2012-10-26 2018-01-15 Intercept Pharmaceuticals Inc Process for the preparation of bile acid derivatives
CN104853758A (zh) 2012-11-28 2015-08-19 英特赛普特医药品公司 肺部疾病的治疗
US20140206657A1 (en) * 2013-01-18 2014-07-24 City Of Hope Bile acid analog tgr5 agonists
SI3360882T1 (sl) 2013-05-14 2021-06-30 Intercept Pharmaceuticals, Inc. 11-hidroksil-6-substituirani derivati žolčnih kislin in aminokislinski konjugati le-teh kot modulatorji receptorja farnezoid X
KR20160013163A (ko) 2013-05-24 2016-02-03 네스텍 소시에테아노님 과민성 대장 증후군 진단을 예측하기 위한 경로 특이적 검정법
WO2015183794A1 (en) 2014-05-27 2015-12-03 City Of Hope Tgr5 agonist complexes for treating diabetes and cancer
DK3626725T3 (da) 2014-05-29 2023-02-27 Bar Pharmaceuticals S R L Cholan-derivater til anvendelse ved behandlingen og/eller forebyggelsen af fxr- og tgr5/gpbar1-medierede sygdomme
AU2015343025A1 (en) 2014-11-06 2017-06-08 Enanta Pharmaceuticals, Inc. Bile acid analogs an FXR/TGR5 agonists and methods of use thereof
EP3221331B1 (en) 2014-11-19 2019-09-18 Nzp Uk Limited 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators
TWI686400B (zh) 2014-11-19 2020-03-01 英商Ｎｚｐ英國有限公司 化合物（二）
MX2017006567A (es) 2014-11-19 2018-01-26 Nzp Uk Ltd Esteroides 6.alfa.-alquil-6,7-diona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr).
WO2016086115A1 (en) 2014-11-26 2016-06-02 Enanta Pharmaceuticals, Inc. Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof
US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
JP2017535570A (ja) 2014-11-26 2017-11-30 エナンタ ファーマシューティカルズ インコーポレイテッド Ｆｘｒ／ｔｇｒ５アゴニストとしての胆汁酸類似体およびその使用方法
WO2016086134A1 (en) 2014-11-26 2016-06-02 Enanta Pharmaceuticals, Inc. Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
CN106279328A (zh) 2015-05-20 2017-01-04 重庆药友制药有限责任公司 一种制备6α-烷基鹅去氧胆酸的方法
EP3310801B1 (en) 2015-06-19 2021-04-07 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
CN106397522A (zh) 2015-07-31 2017-02-15 中国人民解放军军事医学科学院毒物药物研究所 3,7‑二（叔丁基二甲基硅基氧基）‑6‑烯‑5β‑胆烷‑24‑酸甲酯
CN106478759A (zh) 2015-08-31 2017-03-08 陕西合成药业股份有限公司 奥贝胆酸衍生物及其制备方法和用途
CN106478756A (zh) 2015-09-02 2017-03-08 中美华世通生物医药科技（武汉）有限公司 Oca-e单晶及其制备方法和用途
CN106518946A (zh) 2015-09-10 2017-03-22 上海迪诺医药科技有限公司 磺酰脲衍生物、其药物组合物及应用

Also Published As

Publication number Publication date
JP6735748B2 (ja) 2020-08-05
JP2017538690A (ja) 2017-12-28
CA2968305A1 (en) 2016-05-26
US20180340006A1 (en) 2018-11-29
MX2017006565A (es) 2018-01-26
TWI686401B (zh) 2020-03-01
EP3221333A1 (en) 2017-09-27
DK3221333T3 (da) 2019-09-30
KR20170104453A (ko) 2017-09-15
EA201790879A1 (ru) 2017-11-30
ES2748692T3 (es) 2020-03-17
TW201632538A (zh) 2016-09-16
CN107108688B (zh) 2019-10-29
WO2016079519A9 (en) 2018-08-09
EP3221333B1 (en) 2019-07-24
KR102546748B1 (ko) 2023-06-22
PL3221333T3 (pl) 2020-01-31
US10538550B2 (en) 2020-01-21
EA034739B1 (ru) 2020-03-16
CN107108688A (zh) 2017-08-29
WO2016079519A1 (en) 2016-05-26

Similar Documents

Publication Publication Date Title
HK1244286A1 (zh) 作為製備類固醇FXR調節劑的中間體的6α-烷基-6，7-二酮類固醇
HK1244287A1 (zh) 作為製備類固醇FXR調節劑的中間體的6α-烷基-3，7-二酮類固醇
HK1244285B (zh) 作為製備類固醇FXR調節劑的中間體的5β-6-烷基-7-羥基-3-酮類固醇
HK1246801A1 (zh) 作為製備類固醇fxr調節劑的中間體的6-烷基-7-羥基-4-烯-3-酮類固醇
EP3230441A4 (en) Compositions and methods for the production of scaav
EP3189083A4 (en) Polycyclic photoinitiators
EP3119401A4 (en) Cenicriviroc for the treatment of fibrosis
EP3199169A4 (en) Composition containing mesenchymal stem cell-hydrogel and method for producing the composition
EP3186230A4 (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
EP3186229A4 (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
EP3183238A4 (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
EP3215361A4 (en) High-strength refractory fibrous materials
EP3191455A4 (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
EP3174856A4 (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
EP3166931A4 (en) An improved process for the preparation of enzalutamide
EP3126278A4 (en) Removable car operating panel
EP3238710A4 (en) External composition for screen foamers
EP3227276A4 (en) Combinations for the treatment of neuroblastoma
EP3188701A4 (en) Reduction kits
PT3458467T (pt) Processo para a epoxidação 6,7-alfa de esteroide-4,6-dienos
IL248267A0 (en) A process for preparing converted cycloserines
SI3160985T1 (sl) Postopek za pripravo D-arginil-2,6-dimetil-L-tirosil-L-lisil-L- fenilalaninamida
EP3161006A4 (en) Assays for vitamin d epimers
EP3099304A4 (en) Novel therapeutics for the treatment of glaucoma
EP3141543A4 (en) New vortioxetine intermediate and synthesis process thereof