HK1244000B - 多環氨基甲酰吡啶酮化合物及其藥物用途 - Google Patents

多環氨基甲酰吡啶酮化合物及其藥物用途

Info

Publication number
HK1244000B
HK1244000B HK18103442.8A HK18103442A HK1244000B HK 1244000 B HK1244000 B HK 1244000B HK 18103442 A HK18103442 A HK 18103442A HK 1244000 B HK1244000 B HK 1244000B
Authority
HK
Hong Kong
Prior art keywords
polycyclic
pharmaceutical use
carbamoylpyridone compounds
carbamoylpyridone
compounds
Prior art date
Application number
HK18103442.8A
Other languages
English (en)
Inventor
M Bacon Elizabeth
R Cai Zhenhong
J Cottell Jeromy
Ji Mingzhe
Jin Haolun
E Lazerwith Scott
Anthony Morganelli Philip
Pyun Hyung-Jung
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of HK1244000B publication Critical patent/HK1244000B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
HK18103442.8A 2014-12-23 2018-03-12 多環氨基甲酰吡啶酮化合物及其藥物用途 HK1244000B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462096291P 2014-12-23 2014-12-23
PCT/US2015/067155 WO2016106237A1 (en) 2014-12-23 2015-12-21 Polycyclic-carbamoylpyridone compounds and their pharmaceutical use

Publications (1)

Publication Number Publication Date
HK1244000B true HK1244000B (zh) 2020-05-22

Family

ID=55168426

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103442.8A HK1244000B (zh) 2014-12-23 2018-03-12 多環氨基甲酰吡啶酮化合物及其藥物用途

Country Status (24)

Country Link
US (4) US9522912B2 (zh)
EP (2) EP3237416B1 (zh)
JP (3) JP6393835B2 (zh)
KR (4) KR102020004B1 (zh)
CN (2) CN107108643B (zh)
AR (1) AR103251A1 (zh)
AU (3) AU2015369817B2 (zh)
BR (1) BR102015032109A2 (zh)
CA (1) CA2969244C (zh)
EA (1) EA201791019A1 (zh)
ES (1) ES2732482T3 (zh)
HK (1) HK1244000B (zh)
IL (1) IL252532A0 (zh)
MA (1) MA45613A (zh)
MX (1) MX2017007814A (zh)
NZ (1) NZ732391A (zh)
PL (1) PL3237416T3 (zh)
PT (1) PT3237416T (zh)
SG (1) SG11201704421QA (zh)
SI (1) SI3237416T1 (zh)
TR (1) TR201909152T4 (zh)
TW (2) TWI695003B (zh)
UY (1) UY36465A (zh)
WO (1) WO2016106237A1 (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY191741A (en) 2012-12-21 2022-07-13 Gilead Sciences Inc Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
HUE056470T2 (hu) 2014-12-26 2022-02-28 Univ Emory Vírusellenes N4-Hidroxicitidin származékok
PL3277691T3 (pl) * 2015-04-02 2019-07-31 Gilead Sciences, Inc. Policykliczne związki karbamoilopirydonowe i ich zastosowanie farmaceutyczne
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
US11939320B2 (en) 2017-11-02 2024-03-26 Abbvie Inc. Modulators of the integrated stress pathway
EP3704091A1 (en) * 2017-11-02 2020-09-09 Calico Life Sciences LLC Modulators of the integrated stress pathway
GB2590198B (en) 2017-12-07 2022-02-23 Univ Emory N4-hydroxycytidine derivatives and anti-viral uses related thereto
EP3723751A4 (en) * 2017-12-08 2021-07-07 The Rockefeller University PYRANO [3,4-B] PYRAZIN-KAPPA-OPIOID RECEPTOR LIGANDS FOR THE TREATMENT OF ADDICTION, PRURITUS, PAIN AND INFLAMMATION
EP3805221A4 (en) 2018-05-31 2022-01-05 Shionogi & Co., Ltd POLYCYCLIC PYRIDONE DERIVATIVE
PE20210477A1 (es) * 2018-05-31 2021-03-11 Shionogi & Co Derivado policiclico de carbamoilpiridona
UA127822C2 (uk) 2019-03-22 2024-01-10 Гіліад Сайєнсіз, Інк. Місткові трициклічні карбамоїлпіридонові сполуки та їх фармацевтичне застосування
WO2021093846A1 (zh) * 2019-11-13 2021-05-20 上海拓界生物医药科技有限公司 新型四环杂环化合物及其药物用途
WO2021107065A1 (ja) * 2019-11-28 2021-06-03 塩野義製薬株式会社 多環性ピリドピラジン誘導体
JPWO2021107066A1 (zh) 2019-11-28 2021-06-03
US11697652B2 (en) 2020-02-24 2023-07-11 Gilead Sciences, Inc. Tetracyclic compounds and uses thereof
SI4196479T1 (sl) 2021-01-19 2024-01-31 Gilead Sciences, Inc. Substituirane piridotriazinske spojine in njihove uporabe
CN114736173A (zh) * 2022-05-24 2022-07-12 无锡捷化医药科技有限公司 一种3-（二氟甲基）氧杂环丁烷-3-胺盐酸盐的制备方法

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5204466A (en) 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US6642245B1 (en) 1990-02-01 2003-11-04 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5922695A (en) 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
US5935946A (en) 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
GB2345058A (en) 1998-12-01 2000-06-28 Cerebrus Pharm Ltd Hydroxypyridone compounds useful in the treatment of oxidative damage to the central nervous system
IL143958A0 (en) 1998-12-25 2002-04-21 Shionogi & Co Heteroaromatic derivatives having an inhibitory activity against hiv integrase
AU2001262732A1 (en) 2000-06-14 2001-12-24 Shionogi And Co., Ltd. Inhibitor for enzyme having two divalent metal ions as active centers
WO2003016275A1 (en) 2001-08-10 2003-02-27 Shionogi & Co., Ltd. Antiviral agent
US20050004180A1 (en) 2001-10-03 2005-01-06 ZOU Dong Pyrrolidinone derivatives
RS51542B (sr) 2001-10-26 2011-06-30 Istituto Di Ricerche Di Biologia Molecolare P.Angeletti Spa. N-supstituisani hidroksipirimidinon karboksamidni inhibitori hiv integraze
US7109186B2 (en) 2002-07-09 2006-09-19 Bristol-Myers Squibb Company HIV integrase inhibitors
JP2006506352A (ja) 2002-09-11 2006-02-23 メルク　エンド　カムパニー　インコーポレーテッド Ｈｉｖインテグラーゼ阻害剤として有用なジヒドロキシピリドピラジン−１，６−ジオン化合物
SI1564210T1 (sl) 2002-11-20 2010-01-29 Japan Tobacco Inc 4-oksokinolinske spojine in njihova uporaba kot inhibitorji HIV integraze
EP1566049A4 (en) * 2002-11-26 2006-05-03 Ambient Corp ARRANGEMENT OF AN INDUCTIVE COUPLER FOR POWER SUPPLY COMMUNICATION
ES2308136T3 (es) 2003-01-14 2008-12-01 Gilead Sciences, Inc. Composiciones y procedimientos para la politerapia antiviral.
PT1628685E (pt) 2003-04-25 2011-03-16 Gilead Sciences Inc Análogos de fosfonatos antivirais
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
TW200528440A (en) 2003-10-31 2005-09-01 Fujisawa Pharmaceutical Co 2-cyanopyrrolidinecarboxamide compound
US20070155744A1 (en) 2004-01-30 2007-07-05 Istituto Di Ricerche Di Biologia Molecolare P, Angeletti S.P.A. N-benzyl-3,4-dihyroxypyridine-2-carboxamide and n-benzyl-2,3-dihydroxypyridine-4- carboxamide compounds useful as hiv integrase inhibitors
WO2005086700A2 (en) 2004-03-09 2005-09-22 Merck & Co., Inc. Hiv integrase inhibitors
WO2005110414A2 (en) 2004-05-07 2005-11-24 Merck & Co., Inc. Hiv integrase inhibitors
US7273859B2 (en) 2004-05-12 2007-09-25 Bristol-Myers Squibb Company HIV integrase inhibitors: cyclic pyrimidinone compounds
MY134672A (en) 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
US7531554B2 (en) 2004-05-20 2009-05-12 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as HIV integrase inhibitor
EP1758581A1 (en) 2004-05-21 2007-03-07 Japan Tobacco, Inc. Combinations comprising a 4-isoquinolone derivative and anti-hiv agents
ME01945B (me) 2004-07-27 2011-12-31 Gilead Sciences Inc Nukleozid-fosfonatni konjugati kao sredstva protiv hiv-a
JP4953297B2 (ja) 2004-09-15 2012-06-13 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有するカルバモイルピリドン誘導体
CA2634499A1 (en) 2004-12-23 2006-06-29 Virochem Pharma Inc. Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase
US7858788B2 (en) 2005-02-21 2010-12-28 Shionogi & Co., Ltd. Bicyclic carbamoylpyridone derivative having HIV integrase inhibitory activity
EA014162B1 (ru) 2005-04-28 2010-10-29 Смитклайн Бичем Корпорейшн Полициклическое карбамоилпиридоновое производное, обладающее ингибиторной активностью в отношении интегразы вич
US20060249072A1 (en) * 2005-05-05 2006-11-09 Csillag Frank J Method of synthesizing a fluoride growth material for improved outgassing
EP1888581A2 (en) 2005-05-16 2008-02-20 Gilead Sciences, Inc. Hiv-integrase inhibitor compounds
EP1906971A2 (en) 2005-07-27 2008-04-09 Gilead Sciences, Inc. Antiviral compounds
AU2006307101A1 (en) * 2005-10-27 2007-05-03 Shionogi & Co., Ltd. Polycyclic carbamoylpyridone derivative having inhibitory activity on HIV integrase
KR20140082858A (ko) 2005-12-30 2014-07-02 길리애드 사이언시즈, 인코포레이티드 Ｈｉｖ 인테그라제 억제제의 약동학을 개선하기 위한 방법
WO2007089030A1 (en) 2006-02-01 2007-08-09 Japan Tobacco Inc. Use of 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or salt thereof for treating retrovirus infection
CN101437801B (zh) 2006-03-06 2013-02-06 日本烟草产业株式会社 制备4-氧代喹啉化合物的方法
EA017861B9 (ru) 2006-03-06 2014-05-30 Джапан Тобакко Инк. Способ получения 4-оксохинолинового соединения
US7893055B2 (en) * 2006-06-28 2011-02-22 Bristol-Myers Squibb Company HIV integrase inhibitors
CA2657034A1 (en) 2006-07-19 2008-01-24 University Of Georgia Research Foundation, Inc. Pyridinone diketo acids: inhibitors of hiv replication in combination therapy
TWI411602B (zh) 2006-09-12 2013-10-11 Gilead Sciences Inc 製造整合酶抑制劑的方法及彼所用的中間物
WO2008048538A1 (en) 2006-10-18 2008-04-24 Merck & Co., Inc. Hiv integrase inhibitors
BRPI0807581A2 (pt) 2007-02-23 2014-07-01 Gilead Science Inc Moduladores de propriedades farmacocinéticas de produtos terapêuticos
US20080280945A1 (en) 2007-05-09 2008-11-13 Sachin Lohani Crystalline forms of an HIV integrase inhibitor
WO2009006203A1 (en) 2007-06-29 2009-01-08 Gilead Sciences, Inc. Therapeutic compositions and the use thereof
NZ582086A (en) 2007-06-29 2012-07-27 Gilead Sciences Inc Therapeutic compositions and the use thereof
US20090012103A1 (en) * 2007-07-05 2009-01-08 Matthew Abelman Substituted heterocyclic compounds
AR068403A1 (es) 2007-09-11 2009-11-18 Gilead Sciences Inc Proceso e intermediarios para la preparacion de inhibidores de integrasa
EP2757096A1 (en) 2007-11-16 2014-07-23 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US8129398B2 (en) 2008-03-19 2012-03-06 Bristol-Myers Squibb Company HIV integrase inhibitors
US20100272811A1 (en) 2008-07-23 2010-10-28 Alkermes,Inc. Complex of trospium and pharmaceutical compositions thereof
EP2660239B1 (en) 2008-07-25 2016-11-23 VIIV Healthcare Company Chemical compounds as synthetic intermediates
WO2010011819A1 (en) 2008-07-25 2010-01-28 Smithkline Beecham Corporation Chemical compounds
SI2320908T1 (sl) 2008-07-25 2014-05-30 Viiv Healthcare Company Predzdravila dolutegravirja
WO2010011818A1 (en) 2008-07-25 2010-01-28 Smithkline Beecham Corporation Chemical compounds
ES2449752T3 (es) 2008-07-25 2014-03-21 Viiv Healthcare Company Proceso para la preparación de un derivado de pirido[1,2-a]pirrolo[1',2':3,4]imidazo[1,2-d]piracin-8-carboxamida
WO2010011815A1 (en) 2008-07-25 2010-01-28 Smithkline Beecham Corporation Chemical compounds
CA2744019C (en) 2008-12-11 2017-03-14 Shionogi & Co., Ltd. Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates
JP2012512246A (ja) * 2008-12-17 2012-05-31 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃ環修飾型三環式ベンゾナフチリジノン・タンパク質キナーゼ阻害薬及びこれらの使用
TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
US8338441B2 (en) 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
EA025176B1 (ru) 2010-01-27 2016-11-30 Вайв Хелткер Компани Комбинация для лечения вич-инфекции
EP2540720B1 (en) 2010-02-26 2015-04-15 Japan Tobacco, Inc. 1,3,4,8-tetrahydro-2h-pyrido[1,2-a]pyrazine derivative and use of same as hiv integrase inhibitor
TWI582097B (zh) 2010-03-23 2017-05-11 Ｖｉｉｖ醫療保健公司 製備胺甲醯吡啶酮衍生物及中間體之方法
US20130165489A1 (en) 2010-05-03 2013-06-27 The Trustees Of The University Of Pennsylvania Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof
KR20130135826A (ko) 2010-07-02 2013-12-11 길리애드 사이언시즈, 인코포레이티드 Ａｉｄｓ를 치료하기 위한 나프트-2-일아세트산 유도체
NZ604716A (en) 2010-07-02 2014-12-24 Gilead Sciences Inc 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds
CN106083891B (zh) 2010-08-05 2018-03-23 盐野义制药株式会社 具有hiv整合酶抑制活性的化合物的制造方法
SI2620436T1 (en) * 2010-09-24 2018-08-31 Shionogi & Co., Ltd. A prodrug substituted polycyclic carbamoyl pyridone derivative
ES2707997T3 (es) 2011-04-21 2019-04-08 Gilead Sciences Inc Compuestos de benzotiazol y su uso farmacéutico
US20140213553A1 (en) 2011-05-03 2014-07-31 Concert Pharmaceuticals Inc. Carbamoylpyridone derivatives
WO2012151567A1 (en) 2011-05-05 2012-11-08 St. Jude Children's Research Hospital Pyrimidinone compounds and methods for preventing and treating influenza
CA2840095A1 (en) 2011-07-06 2013-01-10 Gilead Sciences, Inc. Compounds for the treatment of hiv
CN102863512B (zh) 2011-07-07 2016-04-20 上海泓博智源医药技术有限公司 抗病毒化合物
ES2613180T3 (es) 2011-09-14 2017-05-23 Mapi Pharma Limited Forma amorfa de la sal sódica dolutegravir
AU2012321762A1 (en) 2011-10-12 2014-04-17 Shionogi & Co., Ltd. Polycyclic pyridone derivative having integrase-inhibiting activity
WO2013091096A1 (en) 2011-12-20 2013-06-27 Boehringer Ingelheim International Gmbh Condensed triclyclic compounds as inhibitors of hiv replication
US9284323B2 (en) * 2012-01-04 2016-03-15 Gilead Sciences, Inc. Naphthalene acetic acid derivatives against HIV infection
NZ622769A (en) 2012-04-20 2017-06-30 Gilead Sciences Inc Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection
WO2014008636A1 (en) 2012-07-11 2014-01-16 Merck Sharp & Dohme Corp. Macrocyclic compounds as hiv integrase inhibitors
EP2875024A4 (en) 2012-07-20 2015-12-23 Merck Sharp & Dohme HIV TREATMENT WITH AMIDOSUBSTITUTED PYRIMIDINONE DERIVATIVES
US20150218164A1 (en) 2012-07-25 2015-08-06 Merck Sharp & Dohme Corp. Substituted naphthyridinedione derivatives as hiv integrase inhibitors
IN2015DN01688A (zh) 2012-08-03 2015-07-03 Gilead Sciences Inc
KR20150093819A (ko) 2012-12-14 2015-08-18 글락소스미스클라인 엘엘씨 약제 조성물
WO2014099586A1 (en) 2012-12-17 2014-06-26 Merck Sharp & Dohme Corp. 4-pyridinonetriazine derivatives as hiv integrase inhibitors
MY191741A (en) * 2012-12-21 2022-07-13 Gilead Sciences Inc Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
US20140221355A1 (en) 2012-12-21 2014-08-07 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
EP2934482A4 (en) 2012-12-21 2016-07-20 Merck Sharp & Dohme ADMINISTRATIVE FORMULATIONS
MX2015008467A (es) 2012-12-27 2015-09-23 Japan Tobacco Inc Derivado sustituido de espiropirido[1,2-a]pirazina y uso medico del mismo como inhibidor de la integrasa del virus de inmunodeficiencia humana.
US9493479B2 (en) * 2013-04-16 2016-11-15 Merck Sharp & Dohme Corp. Substituted pyrido[1,2-a]pyrazines as HIV integrase inhibitors
US9951079B2 (en) * 2013-06-13 2018-04-24 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as HIV integrase inhibitors
WO2015039348A1 (en) 2013-09-23 2015-03-26 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
AP2016009157A0 (en) 2013-09-27 2016-04-30 Merck Sharp & Dohme Substituted quinolizine derivatives useful as hiv integrase inhibitors
WO2015089847A1 (en) 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Spirocyclic heterocycle compounds useful as hiv integrase inhibitors
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
PL3277691T3 (pl) * 2015-04-02 2019-07-31 Gilead Sciences, Inc. Policykliczne związki karbamoilopirydonowe i ich zastosowanie farmaceutyczne

Also Published As

Publication number Publication date
KR20190104458A (ko) 2019-09-09
CN107108643A (zh) 2017-08-29
CN107108643B (zh) 2020-06-05
BR102015032109A2 (pt) 2016-07-05
AU2020286299B2 (en) 2022-07-14
US20160176870A1 (en) 2016-06-23
CA2969244C (en) 2020-05-05
US9522912B2 (en) 2016-12-20
WO2016106237A1 (en) 2016-06-30
AU2015369817A1 (en) 2017-06-22
JP6934846B2 (ja) 2021-09-15
US20180110776A1 (en) 2018-04-26
JP2017538713A (ja) 2017-12-28
CA2969244A1 (en) 2016-06-30
JP2018172437A (ja) 2018-11-08
JP6393835B2 (ja) 2018-09-19
AU2020286299A1 (en) 2021-01-21
KR20170097168A (ko) 2017-08-25
SG11201704421QA (en) 2017-07-28
MX2017007814A (es) 2017-09-18
AR103251A1 (es) 2017-04-26
CN111454273A (zh) 2020-07-28
AU2019200422B2 (en) 2020-09-10
EP3388431A1 (en) 2018-10-17
KR102020004B1 (ko) 2019-09-06
EA201791019A1 (ru) 2017-12-29
AU2015369817B2 (en) 2018-10-25
MA45613A (fr) 2021-04-28
JP2020073560A (ja) 2020-05-14
NZ732391A (en) 2018-12-21
KR20210042185A (ko) 2021-04-16
ES2732482T3 (es) 2019-11-22
TWI738321B (zh) 2021-09-01
SI3237416T1 (sl) 2019-06-28
KR102240584B1 (ko) 2021-04-15
US9795602B2 (en) 2017-10-24
EP3237416A1 (en) 2017-11-01
AU2019200422A1 (en) 2019-02-07
US20210015816A1 (en) 2021-01-21
IL252532A0 (en) 2017-07-31
EP3237416B1 (en) 2019-05-01
US20170119764A1 (en) 2017-05-04
UY36465A (es) 2016-07-29
KR20190052172A (ko) 2019-05-15
TW201636347A (zh) 2016-10-16
TWI695003B (zh) 2020-06-01
TR201909152T4 (tr) 2019-07-22
TW202106688A (zh) 2021-02-16
US10646486B2 (en) 2020-05-12
PL3237416T3 (pl) 2019-09-30
KR101978167B1 (ko) 2019-05-14
PT3237416T (pt) 2019-07-23

Similar Documents

Publication Publication Date Title
HK1244000B (zh) 多環氨基甲酰吡啶酮化合物及其藥物用途
HK1249103B (zh) 多環氨甲醯基吡啶酮化合物及其藥物用途
HK1243073A1 (zh) 治療性化合物及其用途
GB201403093D0 (en) Therapeutic compounds and their use
IL283335B (en) Dihydropyrimidine-2-one compounds and their medical use
HK1232211A1 (zh) 二甲基吡啶胺衍生物及其醫藥用途
ZA201701492B (en) Pyrazolothiazole compound and medicine
GB201702464D0 (en) Pharmaceutical agent
GB201406115D0 (en) New pharmaceutical use
GB201517133D0 (en) New pharmaceutical use
GB201409662D0 (en) New pharmaceutical use
GB201616767D0 (en) New pharmaceutical use
GB201517454D0 (en) New pharmaceutical use
GB201517132D0 (en) New pharmaceutical use
GB201508613D0 (en) New pharmaceutical use
GB201508611D0 (en) New pharmaceutical use
GB201507813D0 (en) New pharmaceutical use
GB201410387D0 (en) Compounds and their therapeutic use
GB201403496D0 (en) Compounds and their therapeutic use
GB201413411D0 (en) Novel compounds and their use