HK1243439A1 - Pcsk9抗體、其抗原結合片段及其醫藥用途 - Google Patents

Pcsk9抗體、其抗原結合片段及其醫藥用途

Info

Publication number
HK1243439A1
HK1243439A1 HK18102970.0A HK18102970A HK1243439A1 HK 1243439 A1 HK1243439 A1 HK 1243439A1 HK 18102970 A HK18102970 A HK 18102970A HK 1243439 A1 HK1243439 A1 HK 1243439A1
Authority
HK
Hong Kong
Prior art keywords
antigen
binding fragment
medical uses
pcsk9 antibody
pcsk9
Prior art date
Application number
HK18102970.0A
Other languages
English (en)
Inventor
屈向東
葉鑫
金后聰
崔東冰
胡齊悅
陶維康
張連山
孫飄揚
Original Assignee
江蘇恒瑞醫藥股份有限公司
上海恒瑞醫藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江蘇恒瑞醫藥股份有限公司, 上海恒瑞醫藥有限公司 filed Critical 江蘇恒瑞醫藥股份有限公司
Publication of HK1243439A1 publication Critical patent/HK1243439A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
HK18102970.0A 2016-01-05 2018-03-01 Pcsk9抗體、其抗原結合片段及其醫藥用途 HK1243439A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610010241 2016-01-05
PCT/CN2016/112075 WO2017118307A1 (zh) 2016-01-05 2016-12-26 Pcsk9抗体、其抗原结合片段及其医药用途

Publications (1)

Publication Number Publication Date
HK1243439A1 true HK1243439A1 (zh) 2018-07-13

Family

ID=59273241

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18102970.0A HK1243439A1 (zh) 2016-01-05 2018-03-01 Pcsk9抗體、其抗原結合片段及其醫藥用途

Country Status (6)

Country Link
US (1) US20200270365A1 (zh)
EP (1) EP3401336A4 (zh)
JP (1) JP2019509714A (zh)
CN (1) CN107531795B (zh)
HK (1) HK1243439A1 (zh)
WO (1) WO2017118307A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3647325A4 (en) * 2017-06-30 2021-03-17 Shanghai Hengrui Pharmaceutical Co., Ltd PHARMACEUTICAL COMPOSITION OF PCSK-9 ANTIBODIES AND USES THEREOF
AU2018304173A1 (en) 2017-07-17 2020-01-30 Janssen Biotech, Inc. Antigen binding regions against fibronectin type III domains and methods of using the same
WO2021185344A1 (zh) 2020-03-19 2021-09-23 江苏恒瑞医药股份有限公司 一种胆固醇相关疾病的治疗方法

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Also Published As

Publication number Publication date
US20200270365A1 (en) 2020-08-27
EP3401336A1 (en) 2018-11-14
JP2019509714A (ja) 2019-04-11
CN107531795A (zh) 2018-01-02
WO2017118307A1 (zh) 2017-07-13
EP3401336A4 (en) 2020-01-22
CN107531795B (zh) 2021-01-19

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