HK1223684A1 - 改進抗體穩定性的方法 - Google Patents
改進抗體穩定性的方法Info
- Publication number
- HK1223684A1 HK1223684A1 HK16111972.1A HK16111972A HK1223684A1 HK 1223684 A1 HK1223684 A1 HK 1223684A1 HK 16111972 A HK16111972 A HK 16111972A HK 1223684 A1 HK1223684 A1 HK 1223684A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- antibody stability
- improving antibody
- improving
- stability
- antibody
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1002—Coronaviridae
- C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/20—Protein or domain folding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C99/00—Subject matter not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Evolutionary Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Computing Systems (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13183389 | 2013-09-06 | ||
EP13184174 | 2013-09-12 | ||
PCT/EP2014/068649 WO2015032776A1 (en) | 2013-09-06 | 2014-09-03 | Method for improving antibody stability |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1223684A1 true HK1223684A1 (zh) | 2017-08-04 |
Family
ID=51485608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16111972.1A HK1223684A1 (zh) | 2013-09-06 | 2016-10-17 | 改進抗體穩定性的方法 |
Country Status (11)
Country | Link |
---|---|
US (2) | US10418126B2 (zh) |
EP (2) | EP3042205B1 (zh) |
JP (1) | JP6580570B2 (zh) |
KR (1) | KR20160052562A (zh) |
CN (1) | CN105518461B (zh) |
CA (1) | CA2918191A1 (zh) |
DK (1) | DK3042205T3 (zh) |
HK (1) | HK1223684A1 (zh) |
MX (1) | MX2016002720A (zh) |
RU (1) | RU2711719C2 (zh) |
WO (1) | WO2015032776A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CR20160132A (es) | 2013-08-12 | 2016-08-25 | Genentech Inc | Composiciones y método para tratar condiciones asociadas con el complemento |
CA2944712A1 (en) | 2014-05-01 | 2015-11-05 | Genentech, Inc. | Anti-factor d antibody variants and uses thereof |
CN108472382A (zh) | 2015-10-30 | 2018-08-31 | 豪夫迈·罗氏有限公司 | 抗-因子d抗体变体缀合物及其用途 |
JP2018534930A (ja) | 2015-10-30 | 2018-11-29 | ジェネンテック, インコーポレイテッド | 抗d因子抗体及びコンジュゲート |
WO2021025940A1 (en) * | 2019-08-02 | 2021-02-11 | Genentech, Inc. | Prediction of side-chain degradation in polymers through physics based simulations |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US100736A (en) * | 1870-03-15 | dundeedale | ||
RU2134724C1 (ru) * | 1992-08-24 | 1999-08-20 | Ниссин Сокухин Кабусики Кайся | Гуманизированное антитело и способ его получения, полинуклеотид (варианты), гибридомная клеточная линия (варианты) |
CA2580881A1 (en) * | 2004-09-21 | 2006-03-30 | Nascacell Technologies Ag | Use of microproteins as tryptase inhibitors |
AU2007227292B2 (en) * | 2006-03-17 | 2012-04-12 | Biogen Ma Inc. | Stabilized polypeptide compositions |
CN101668771B (zh) * | 2007-03-12 | 2013-08-21 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | 单链抗体的基于序列的工程改造和最优化 |
PL2307455T3 (pl) * | 2008-06-25 | 2017-09-29 | Esbatech, An Alcon Biomedical Research Unit Llc | Optymalizacja rozpuszczalności cząsteczek immunowiążących |
KR102000383B1 (ko) * | 2009-09-29 | 2019-07-15 | 유니버시테이트 젠트 | 만노스-1-포스포-6-만노스 결합의 포스포-6-만노스로의 가수분해 |
EP3119490B1 (en) * | 2014-03-21 | 2021-09-08 | F. Hoffmann-La Roche AG | In vitro prediction of in vivo half-life of antibodies |
US20170175098A1 (en) * | 2014-03-28 | 2017-06-22 | Novozymes A/S | Enzyme Variants and Polynucleotides Encoding Same |
EP3149028B1 (en) * | 2014-05-30 | 2021-09-15 | Novozymes A/S | Variants of gh family 11 xylanase and polynucleotides encoding same |
-
2014
- 2014-09-03 JP JP2016539511A patent/JP6580570B2/ja not_active Expired - Fee Related
- 2014-09-03 KR KR1020167005951A patent/KR20160052562A/ko not_active Application Discontinuation
- 2014-09-03 CA CA2918191A patent/CA2918191A1/en not_active Abandoned
- 2014-09-03 MX MX2016002720A patent/MX2016002720A/es unknown
- 2014-09-03 WO PCT/EP2014/068649 patent/WO2015032776A1/en active Application Filing
- 2014-09-03 CN CN201480048544.3A patent/CN105518461B/zh not_active Expired - Fee Related
- 2014-09-03 EP EP14758893.3A patent/EP3042205B1/en active Active
- 2014-09-03 RU RU2016111352A patent/RU2711719C2/ru not_active IP Right Cessation
- 2014-09-03 EP EP19217274.0A patent/EP3761033A3/en not_active Withdrawn
- 2014-09-03 DK DK14758893.3T patent/DK3042205T3/da active
-
2016
- 2016-03-04 US US15/061,130 patent/US10418126B2/en not_active Expired - Fee Related
- 2016-10-17 HK HK16111972.1A patent/HK1223684A1/zh not_active IP Right Cessation
-
2019
- 2019-08-02 US US16/530,375 patent/US20200066372A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP3042205B1 (en) | 2019-12-25 |
MX2016002720A (es) | 2016-06-08 |
CA2918191A1 (en) | 2015-03-12 |
US10418126B2 (en) | 2019-09-17 |
WO2015032776A1 (en) | 2015-03-12 |
US20200066372A1 (en) | 2020-02-27 |
US20160275238A1 (en) | 2016-09-22 |
DK3042205T3 (da) | 2020-03-02 |
EP3761033A2 (en) | 2021-01-06 |
EP3761033A3 (en) | 2021-01-20 |
RU2016111352A (ru) | 2017-10-11 |
JP2016530288A (ja) | 2016-09-29 |
RU2016111352A3 (zh) | 2018-05-23 |
JP6580570B2 (ja) | 2019-09-25 |
KR20160052562A (ko) | 2016-05-12 |
CN105518461A (zh) | 2016-04-20 |
RU2711719C2 (ru) | 2020-01-21 |
EP3042205A1 (en) | 2016-07-13 |
CN105518461B (zh) | 2018-04-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20220909 |