HK1220692A1 - 作為布羅莫結構域抑制劑的苯並咪唑酮衍生物 - Google Patents

作為布羅莫結構域抑制劑的苯並咪唑酮衍生物

Info

Publication number
HK1220692A1
HK1220692A1 HK16108876.4A HK16108876A HK1220692A1 HK 1220692 A1 HK1220692 A1 HK 1220692A1 HK 16108876 A HK16108876 A HK 16108876A HK 1220692 A1 HK1220692 A1 HK 1220692A1
Authority
HK
Hong Kong
Prior art keywords
bromodomain inhibitors
benzimidazolone derivatives
benzimidazolone
derivatives
bromodomain
Prior art date
Application number
HK16108876.4A
Other languages
English (en)
Inventor
Evangelos Aktoudianakis
Gregory Chin
Britton Kenneth Corkey
Jinfa Du
Kristyna Elbel
Robert H Jiang
Tetsuya Kobayashi
Ruben Martinez
Samuel E Metobo
Michael Mish
Sophie Shevick
David Sperandio
Hai Yang
Jeff Zablocki
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of HK1220692A1 publication Critical patent/HK1220692A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
HK16108876.4A 2013-03-28 2016-07-25 作為布羅莫結構域抑制劑的苯並咪唑酮衍生物 HK1220692A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361805995P 2013-03-28 2013-03-28
US201361860230P 2013-07-30 2013-07-30
PCT/US2014/032031 WO2014160873A1 (en) 2013-03-28 2014-03-27 Benzimidazolone derivatives as bromodomain inhibitors

Publications (1)

Publication Number Publication Date
HK1220692A1 true HK1220692A1 (zh) 2017-05-12

Family

ID=50897885

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16108876.4A HK1220692A1 (zh) 2013-03-28 2016-07-25 作為布羅莫結構域抑制劑的苯並咪唑酮衍生物

Country Status (35)

Country Link
US (2) US20160031868A1 (zh)
EP (1) EP2978759B1 (zh)
JP (1) JP6339175B2 (zh)
KR (1) KR101847698B1 (zh)
CN (1) CN105102453B (zh)
AP (1) AP2015008741A0 (zh)
AU (1) AU2014241152B2 (zh)
BR (1) BR112015024078A2 (zh)
CA (1) CA2907502C (zh)
CL (1) CL2015002871A1 (zh)
CR (1) CR20150515A (zh)
CY (1) CY1119165T1 (zh)
DK (1) DK2978759T3 (zh)
EA (1) EA029497B1 (zh)
ES (1) ES2626397T3 (zh)
HK (1) HK1220692A1 (zh)
HR (1) HRP20170750T1 (zh)
HU (1) HUE034772T2 (zh)
IL (1) IL241186A0 (zh)
LT (1) LT2978759T (zh)
MD (1) MD4531C1 (zh)
MX (1) MX2015013798A (zh)
MY (1) MY176634A (zh)
NZ (1) NZ711586A (zh)
PE (1) PE20151982A1 (zh)
PH (1) PH12015502246A1 (zh)
PL (1) PL2978759T3 (zh)
PT (1) PT2978759T (zh)
RS (1) RS56050B1 (zh)
SG (1) SG11201507926RA (zh)
SI (1) SI2978759T1 (zh)
TW (1) TWI530499B (zh)
UY (1) UY35516A (zh)
WO (1) WO2014160873A1 (zh)
ZA (1) ZA201506356B (zh)

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WO2015095492A1 (en) 2013-12-19 2015-06-25 Incyte Corporation Tricyclic heterocycles as bet protein inhibitors
NZ763740A (en) 2014-04-23 2023-06-30 Incyte Holdings Corp 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins
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WO2016061144A1 (en) 2014-10-14 2016-04-21 The Regents Of The University Of California Use of cdk9 and brd4 inhibitors to inhibit inflammation
CA2966303A1 (en) 2014-12-01 2016-06-09 Zenith Epigenetics Ltd. Substituted pyridines as bromodomain inhibitors
EP3227281A4 (en) 2014-12-01 2018-05-30 Zenith Epigenetics Ltd. Substituted pyridinones as bromodomain inhibitors
CA2966449A1 (en) 2014-12-11 2016-06-16 Zenith Epigenetics Ltd. Substituted heterocycles as bromodomain inhibitors
JP2017538721A (ja) 2014-12-17 2017-12-28 ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． ブロモドメインの阻害剤
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GB201504694D0 (en) 2015-03-19 2015-05-06 Glaxosmithkline Ip Dev Ltd Covalent conjugates
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WO2016203335A1 (en) 2015-06-18 2016-12-22 Pfizer Inc. Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors
WO2017075377A1 (en) 2015-10-29 2017-05-04 Incyte Corporation Amorphous solid form of a bet protein inhibitor
EP3397640B1 (en) 2015-12-29 2021-08-04 INSERM - Institut National de la Santé et de la Recherche Médicale Xanthine derivative inhibitors of bet proteins
FI3472157T3 (fi) 2016-06-20 2023-06-01 Incyte Corp Bet-inhibiittorin kiteisiä kiinteitä muotoja
US20180179191A1 (en) * 2016-11-22 2018-06-28 Gilead Sciences, Inc. Synthesis of a compound that modulates the activity of bromodomain-containing proteins
JP7254075B2 (ja) 2017-11-06 2023-04-07 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィック キサンチン誘導体及びｂｅｔタンパク質のブロモドメインの阻害剤としてのその使用
JP2021506903A (ja) 2017-12-20 2021-02-22 貝達薬業股▲ふん▼有限公司Ｂｅｔｔａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．，Ｌｔｄ ブロモドメインタンパク質阻害剤である化合物、および組成物
CN113365699A (zh) * 2019-02-02 2021-09-07 石药集团中奇制药技术（石家庄）有限公司 靶向泛素化降解brd4蛋白化合物及其制备方法和应用
CN109912584B (zh) * 2019-03-22 2021-08-13 中国药科大学 一种具有抗肿瘤活性的brd4蛋白抑制剂及其制备方法和应用
KR20220077138A (ko) 2019-09-30 2022-06-08 쿄와 기린 가부시키가이샤 Bet 분해제
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Also Published As

Publication number Publication date
EP2978759A1 (en) 2016-02-03
EP2978759B1 (en) 2017-03-15
MD4531C1 (ro) 2018-06-30
JP2016515584A (ja) 2016-05-30
HUE034772T2 (en) 2018-02-28
PE20151982A1 (es) 2016-01-28
CN105102453A (zh) 2015-11-25
EA029497B1 (ru) 2018-04-30
WO2014160873A1 (en) 2014-10-02
BR112015024078A2 (pt) 2017-07-18
JP6339175B2 (ja) 2018-06-06
CY1119165T1 (el) 2018-02-14
SG11201507926RA (en) 2015-10-29
TW201504233A (zh) 2015-02-01
TWI530499B (zh) 2016-04-21
IL241186A0 (en) 2015-11-30
SI2978759T1 (sl) 2017-05-31
DK2978759T3 (da) 2017-06-19
CA2907502C (en) 2018-02-27
PH12015502246A1 (en) 2016-02-01
PL2978759T3 (pl) 2017-08-31
US9255089B2 (en) 2016-02-09
LT2978759T (lt) 2017-05-25
MD4531B1 (ro) 2017-11-30
ZA201506356B (en) 2017-08-30
NZ711586A (en) 2016-09-30
AP2015008741A0 (en) 2015-09-30
US20160031868A1 (en) 2016-02-04
RS56050B1 (sr) 2017-09-29
KR101847698B1 (ko) 2018-04-10
KR20150135476A (ko) 2015-12-02
MD20150104A2 (ro) 2016-02-29
UY35516A (es) 2014-09-30
US20140296246A1 (en) 2014-10-02
CA2907502A1 (en) 2014-10-02
EA201591455A1 (ru) 2016-01-29
AU2014241152A1 (en) 2015-09-17
AU2014241152B2 (en) 2016-11-03
MX2015013798A (es) 2016-02-16
MY176634A (en) 2020-08-19
HRP20170750T1 (hr) 2017-07-28
CL2015002871A1 (es) 2016-05-13
CN105102453B (zh) 2018-04-06
PT2978759T (pt) 2017-05-31
CR20150515A (es) 2015-12-01
ES2626397T3 (es) 2017-07-24

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