HK1214739A1 - 工程化的分泌蛋白質和方法 - Google Patents

工程化的分泌蛋白質和方法

Info

Publication number
HK1214739A1
HK1214739A1 HK16102843.7A HK16102843A HK1214739A1 HK 1214739 A1 HK1214739 A1 HK 1214739A1 HK 16102843 A HK16102843 A HK 16102843A HK 1214739 A1 HK1214739 A1 HK 1214739A1
Authority
HK
Hong Kong
Prior art keywords
methods
secreted proteins
engineered secreted
engineered
proteins
Prior art date
Application number
HK16102843.7A
Other languages
English (en)
Inventor
‧巴薩
‧戈拉
‧陳
‧楊
‧希爾弗
‧哈米爾
‧貝瑞
Original Assignee
Axcella Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axcella Health Inc filed Critical Axcella Health Inc
Publication of HK1214739A1 publication Critical patent/HK1214739A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2428—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2445—Beta-glucosidase (3.2.1.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477—Hemicellulases not provided in a preceding group
    • C12N9/248—Xylanases
    • C12N9/2482—Endo-1,4-beta-xylanase (3.2.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Immunology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK16102843.7A 2012-11-20 2016-03-11 工程化的分泌蛋白質和方法 HK1214739A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261728427P 2012-11-20 2012-11-20
PCT/US2013/071091 WO2014081884A1 (en) 2012-11-20 2013-11-20 Engineered secreted proteins and methods

Publications (1)

Publication Number Publication Date
HK1214739A1 true HK1214739A1 (zh) 2016-09-30

Family

ID=50776536

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16102843.7A HK1214739A1 (zh) 2012-11-20 2016-03-11 工程化的分泌蛋白質和方法

Country Status (7)

Country Link
US (1) US20150307562A1 (zh)
EP (1) EP2922416A4 (zh)
JP (1) JP2016500250A (zh)
CN (1) CN104936466A (zh)
CA (1) CA2892021A1 (zh)
HK (1) HK1214739A1 (zh)
WO (1) WO2014081884A1 (zh)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3502264A3 (en) 2013-05-31 2019-11-06 DSM IP Assets B.V. Microorganisms for diterpene production
BR112016002045A2 (pt) * 2013-07-29 2017-08-29 Danisco Us Inc Variantes de enzimas
EP3048904A2 (en) 2013-09-25 2016-08-03 Pronutria Biosciences, Inc. Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof
GB201401699D0 (en) * 2014-01-31 2014-03-19 Dupont Nutrition Biosci Aps Protein
CN103881994B (zh) * 2014-04-14 2020-03-27 中国农业科学院生物技术研究所 一种具有高转糖苷活性的β-半乳糖苷酶突变体及其制备方法和应用
FR3022558B1 (fr) 2014-06-20 2019-01-25 Proteus Variants d'exoglucanases a activite amelioree et leurs utilisations
ES2896401T3 (es) * 2014-09-22 2022-02-24 Tanea Medical Ab Proteínas recombinantes exentas de Phe para su uso en el tratamiento de la fenilcetonuria
CN107135653A (zh) * 2014-10-01 2017-09-05 安迅生物制药公司 大肠杆菌素变体
MX2017006127A (es) 2014-11-11 2017-11-08 Clara Foods Co Metodos y composiciones para produccion de proteina de clara de huevo.
EP3234143B1 (en) 2014-12-19 2023-06-28 Novozymes A/S Compositions comprising polypeptides having xylanase activity and polypeptides having arabinofuranosidase activity
GB201501565D0 (en) * 2015-01-30 2015-03-18 Dupont Nutrition Biosci Aps Method
US20180243392A1 (en) * 2015-03-17 2018-08-30 Vanderbilt University Cs21 and lnga protein vaccines
DK3313193T3 (da) * 2015-06-26 2021-06-07 Novozymes As Fremgangsmåde til fremstilling af en kaffeekstrakt
US10188135B2 (en) * 2015-11-04 2019-01-29 Stokley-Van Camp, Inc. Method for inducing satiety
US11167016B2 (en) 2016-02-18 2021-11-09 Amanoenzyme Inc. Intestinal flora improvement agent
WO2017202966A1 (en) 2016-05-24 2017-11-30 Novozymes A/S Polypeptides having alpha-galactosidase activity and polynucleotides encoding same
US11058129B2 (en) * 2016-05-24 2021-07-13 Novozymes A/S Animal feed additives
US11273455B2 (en) 2016-06-27 2022-03-15 Novozymes A/S Method of dewatering post fermentation fluids
DK3481948T3 (da) * 2016-07-08 2024-02-05 Novozymes As Xylanasevarianter og polynukleotider, der koder for dem
US11008600B2 (en) * 2016-07-19 2021-05-18 Suntory Holdings Limited Method for producing mogrol or mogrol glycoside
DK3290436T3 (da) 2016-09-01 2019-08-19 Metax Inst Fuer Diaetetik Gmbh Phenylalanin-fri protein til behandlingen af pku
EA201891926A1 (ru) * 2017-02-03 2019-04-30 Киверди, Инк. Микроорганизмы и искусственные экосистемы для производства белка, продуктов питания и полезных побочных продуктов из субстратов c1
EP3592429A1 (en) * 2017-03-06 2020-01-15 DuPont Nutrition Biosciences ApS Novel fungal fucosidases and their use in preventing and/or treating a pathogenic infection in an animal
AU2019325329A1 (en) * 2018-08-21 2021-04-08 Clara Foods Co. Modification of protein glycosylation in microorganisms
AR118444A1 (es) * 2019-03-19 2021-10-06 Bayer Cropscience Lp Proteínas de fusión, bacterias recombinantes y fragmentos de exosporas para la salud de las plantas
MX2022000374A (es) 2019-07-11 2022-03-25 Clara Foods Co Composiciones de proteina y productos consumibles de las mismas.
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
MX2022002834A (es) 2019-09-16 2022-04-06 Novozymes As Polipeptidos con actividad beta-glucanasa y polinucleotidos que los codifican.
WO2022194375A1 (en) * 2020-03-18 2022-09-22 Numaferm Gmbh Fusion proteins comprising gg repeat sequences
EP3892290A1 (en) * 2020-04-08 2021-10-13 NUMAFERM GmbH Variants of hlya and uses thereof
WO2021207679A1 (en) * 2020-04-10 2021-10-14 Liberty Biosecurity, Llc Polypeptide compositions and uses thereof
CA3210777A1 (en) * 2021-02-10 2022-08-18 Novozymes A/S Polypeptides having pectinase activity, polynucleotides encoding same, and uses thereof
MX2023011028A (es) * 2021-03-25 2023-09-27 Bio Cat Inc Mezclas de proteasas micoticas y usos de las mismas.
CN114015678A (zh) * 2021-09-30 2022-02-08 中南民族大学 一种球形赖氨酸芽孢杆菌C3-41来源的氨肽酶Amp0279及其重组菌株和应用
MX2021014268A (es) * 2021-11-19 2022-02-16 Univ Mexico Nac Autonoma Proteina optimizada que comprende los aminoacidos esenciales para la nutricion humana.
WO2023168396A2 (en) * 2022-03-04 2023-09-07 Cella Farms Inc. Computational system and algorithm for selecting nutritional microorganisms based on in silico protein quality determination
WO2023203080A1 (en) 2022-04-20 2023-10-26 Novozymes A/S Process for producing free fatty acids
WO2023215798A1 (en) * 2022-05-04 2023-11-09 Locus Biosciences, Inc. Phage compositions for escherichia comprising crispr-cas systems and methods of use thereof
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
CN115160420B (zh) * 2022-06-24 2023-06-02 西南大学 盔形毕赤酵母scp类分泌蛋白及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800726B1 (en) * 1996-11-01 2004-10-05 Pioneer Hi-Bred International, Inc. Proteins with increased levels of essential amino acids
AR017831A1 (es) * 1997-12-10 2001-10-24 Pioneer Hi Bred Int Metodo para alterar la composicion de aminoacidos de una proteina nativa de interes, proteina elaborada, y polinucleotido
US20060159724A1 (en) * 2000-08-08 2006-07-20 Bell Stacey J Nutritional supplement for the management of weight
AU2002341828A1 (en) * 2001-09-17 2003-04-01 Monsanto Technology, Llc Enhanced proteins and methods for their use
US7273738B2 (en) * 2002-10-01 2007-09-25 Novozymes A/S Family GH-61 polypeptides
CN1557475A (zh) * 2004-02-04 2004-12-29 高春平 美容、减肥营养组合物
EP2327316B1 (en) * 2009-11-29 2016-11-16 Premier Nutrition Corporation Method of enhancing muscle protein synthesis
BR112012016290A2 (pt) * 2009-12-31 2015-09-01 Pioneer Hi Bred Int Ácido nucléico isolado ou recombinante, cassete de expressão, célula hospedeira não humana, planta e semente transgênica, variante de polipeptídeo oxox isolado ou recombinante, método de modulação do nível de proteina oxalato oxidase (oxox) em uma planta ou célula vegetal, método para aumentar a resistência de uma planta a um patógeno, planta resistente a patógeno, método para identificar variantes oxox com atividade de oxox mantida ou aumentada, método para gerar uma planta que tem resistência aumentada a uma patógeno
CN103429738A (zh) * 2011-03-24 2013-12-04 旭硝子株式会社 裂殖酵母属酵母的转化体、该转化体的制造方法、β-葡糖苷酶的制造方法及纤维素的降解方法
CA2868522A1 (en) * 2012-03-26 2013-10-03 Pronutria, Inc. Charged nutritive proteins and methods

Also Published As

Publication number Publication date
CA2892021A1 (en) 2014-05-30
JP2016500250A (ja) 2016-01-12
US20150307562A1 (en) 2015-10-29
CN104936466A (zh) 2015-09-23
EP2922416A4 (en) 2016-07-20
WO2014081884A9 (en) 2015-05-21
EP2922416A1 (en) 2015-09-30
WO2014081884A1 (en) 2014-05-30

Similar Documents

Publication Publication Date Title
HK1214739A1 (zh) 工程化的分泌蛋白質和方法
HK1209439A1 (zh) 白介素- 融合蛋白及其用途
HK1207092A1 (zh) 抗- 抗體及其用途
HRP20190358T1 (hr) Antitijela protiv asic1 i njihova primjena
EP2877854A4 (en) FUSION PROTEINS AND METHOD THEREFOR
GB2508656B (en) Improved joint structure and method
EP2761014A4 (en) RECOMBINANT PHAGE AND METHOD
GB201201100D0 (en) Polypeptides and methods
HK1203161A1 (zh) 肽和使用該肽的方法
HK1205524A1 (zh) 改造的構象穩定蛋白質
GB201216649D0 (en) Agents and methods
ZA201405056B (en) Engineered pesticidal proteins
EP2868742A4 (en) ITEM AND METHOD OF FILTRATION
EP2930189A4 (en) CHEMOKINE-CYTOKINE FUSION PROTEIN AND USE THEREOF
EP2938415A4 (en) MATERIALS AND METHOD
EP2718432A4 (en) NUCLEASE FUSION PROTEIN AND USES THEREOF
SG11201500474PA (en) Nutriculture member and nutriculture method
EP2837624A4 (en) 4-SUBSTITUTE-2-HYDROXYLMORPHOLIN-3-ON AND METHOD OF MANUFACTURING THEREOF
SG11201501838RA (en) Completion assembly and methods for use thereof
GB201221092D0 (en) Assemblies and methods
GB201208358D0 (en) Construction block and construction block assembly
GB201210303D0 (en) Polypeptides and methods
GB201214769D0 (en) Methodsa and peptides
GB201208372D0 (en) Antibodies and uses thereof
GB201222541D0 (en) Kiddibidet and pottibidet