HK1211021A1 - -取代- -聯芳基甲基氨基- -環戊基- -嘌呤衍生物、其作為藥物的用途及藥物組合物 - Google Patents

-取代- -聯芳基甲基氨基- -環戊基- -嘌呤衍生物、其作為藥物的用途及藥物組合物

Info

Publication number
HK1211021A1
HK1211021A1 HK15111650.1A HK15111650A HK1211021A1 HK 1211021 A1 HK1211021 A1 HK 1211021A1 HK 15111650 A HK15111650 A HK 15111650A HK 1211021 A1 HK1211021 A1 HK 1211021A1
Authority
HK
Hong Kong
Prior art keywords
biarylmethylamino
medicaments
cyclopentyl
substituted
pharmaceutical compositions
Prior art date
Application number
HK15111650.1A
Other languages
English (en)
Inventor
托馬斯．伽基
拉德克．約爾達
馬雷克．扎特盧卡爾
弗拉基米爾．克里斯托夫
露西．拉羅瓦
伊娃．雷茲尼科瓦
沃爾夫岡．米庫利茨
米羅斯拉夫．斯特爾納德
Original Assignee
Univ Palackeho
Biopatterns S R O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Palackeho, Biopatterns S R O filed Critical Univ Palackeho
Publication of HK1211021A1 publication Critical patent/HK1211021A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK15111650.1A 2013-02-08 2015-11-26 -取代- -聯芳基甲基氨基- -環戊基- -嘌呤衍生物、其作為藥物的用途及藥物組合物 HK1211021A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ2013-88A CZ306894B6 (cs) 2013-02-08 2013-02-08 2-Substituované-6-biarylmethylamino-9-cyklopentyl-9H-purinové deriváty, jejich použití jako léčiva a farmaceutické přípravky tyto sloučeniny obsahující
PCT/CZ2014/000014 WO2014121764A2 (en) 2013-02-08 2014-02-05 2-substituted-6-biarylmethylamino-9-cyclopentyl-9h-purine derivatives, use thereof as medicaments, and pharmaceutical compositions

Publications (1)

Publication Number Publication Date
HK1211021A1 true HK1211021A1 (zh) 2016-05-13

Family

ID=50289324

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15111650.1A HK1211021A1 (zh) 2013-02-08 2015-11-26 -取代- -聯芳基甲基氨基- -環戊基- -嘌呤衍生物、其作為藥物的用途及藥物組合物

Country Status (12)

Country Link
US (1) US20150368248A1 (zh)
EP (1) EP2953951B1 (zh)
CN (1) CN105026396A (zh)
AU (1) AU2014214355B2 (zh)
CA (1) CA2900292C (zh)
CZ (1) CZ306894B6 (zh)
EA (1) EA028206B1 (zh)
HK (1) HK1211021A1 (zh)
NZ (1) NZ710291A (zh)
SG (1) SG11201505640VA (zh)
WO (1) WO2014121764A2 (zh)
ZA (1) ZA201505318B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105348298B (zh) * 2014-07-04 2019-03-19 沈阳中化农药化工研发有限公司 取代芳基吡啶类化合物及其用途
PT3244891T (pt) 2015-01-16 2022-10-20 Massachusetts Gen Hospital Compostos para melhorar o splicing do arnm
CZ307147B6 (cs) * 2015-05-14 2018-02-07 Ústav experimentální botaniky AV ČR, v. v. i. 5-Substituované 7-[4-(2-pyridyl)fenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako léčiva, a farmaceutické přípravky
CZ308029B6 (cs) * 2017-03-20 2019-11-06 Univerzita PalackĂ©ho v Olomouci 2,6-Disubstituované-9-cyklopentyl-9H-puriny, jejich použití jako léčiva a farmaceutické přípravky
CN111217814B (zh) * 2018-11-26 2022-08-26 天津科技大学 一类联哌啶衍生物及其作为抗肿瘤药物的应用
CN113307765A (zh) * 2021-05-24 2021-08-27 上海泰坦科技股份有限公司 吡啶甲胺类化合物及其制备方法
WO2023140640A1 (ko) * 2022-01-21 2023-07-27 한양대학교 산학협력단 헤테로아릴 유도체 및 이의 용도
CN117659016A (zh) * 2022-08-26 2024-03-08 嘉兴优博生物技术有限公司 细胞周期蛋白调节剂

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US696970A (en) 1902-01-27 1902-04-08 Michigan Specialty Company Ltd Harness-hook.
TR200102714T2 (tr) * 1999-02-01 2002-01-21 Cv Therapeutics, Inc. Sikline bağımlı kinaz 2 ve IkB-&'nın pürün inhibitörleri
US6969720B2 (en) * 1999-03-17 2005-11-29 Amr Technology, Inc. Biaryl substituted purine derivatives as potent antiproliferative agents
US6627633B2 (en) * 1999-03-17 2003-09-30 Albany Molecular Research, Inc. 6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
CZ294535B6 (cs) 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
US6667311B2 (en) * 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
US6812232B2 (en) * 2001-09-11 2004-11-02 Amr Technology, Inc. Heterocycle substituted purine derivatives as potent antiproliferative agents
CZ294538B6 (cs) 2002-12-30 2005-01-12 Ústav Experimentální Botaniky Akademie Vědčeské Re Substituční deriváty N6-benzyladenosinu, způsob jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
CZ302225B6 (cs) 2007-07-04 2010-12-29 Univerzita Palackého v Olomouci Substituované 6-anilinopurinové deriváty jako inhibitory cytokinin oxidasy a prípravky obsahující tyto slouceniny
CZ300774B6 (cs) 2007-10-05 2009-08-05 Univerzita Palackého Substituované 6-(alkylbenzylamino)purinové deriváty pro použití jako antagonisté cytokininových receptoru a prípravky obsahující tyto slouceniny
CZ302122B6 (cs) * 2009-01-28 2010-10-20 Univerzita Palackého v Olomouci Substituované deriváty 6-(2-aminobenzylamino)purinu, jejich použití jako léciva a prípravky tyto slouceniny obsahující
US20130005747A1 (en) * 2010-12-21 2013-01-03 Cyclacel Limited Method for selecting a cancer therapy

Also Published As

Publication number Publication date
CA2900292A1 (en) 2014-08-14
WO2014121764A2 (en) 2014-08-14
WO2014121764A3 (en) 2014-10-16
NZ710291A (en) 2016-03-31
EA028206B1 (ru) 2017-10-31
AU2014214355A1 (en) 2015-08-13
CA2900292C (en) 2017-01-10
SG11201505640VA (en) 2015-08-28
CZ306894B6 (cs) 2017-08-30
AU2014214355B2 (en) 2016-05-19
ZA201505318B (en) 2016-03-30
EP2953951A2 (en) 2015-12-16
EP2953951B1 (en) 2017-05-03
EA201500821A1 (ru) 2016-03-31
US20150368248A1 (en) 2015-12-24
CN105026396A (zh) 2015-11-04
CZ201388A3 (cs) 2014-08-20

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