HK1209644A1 - 變體 - Google Patents

變體

Info

Publication number: HK1209644A1
Authority: HK; Hong Kong
Prior art keywords: ctla; variants; variants ctla
Prior art date: 2012-05-11

Application number

HK15110585.3A

Other languages

English (en)

Inventor

Ralph Minter

Julie Douthwaite

Jacques Moisan

Michael Bowen

Steve Rust

Cyril Privezentzev

Original Assignee

Medimmune Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-05-11

Filing date

2015-10-28

Publication date

2016-04-08

2015-10-28 Application filed by Medimmune Llc filed Critical Medimmune Llc

2016-04-08 Publication of HK1209644A1 publication Critical patent/HK1209644A1/zh

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C07K14/425—Zeins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Cell Biology (AREA)
Zoology (AREA)
Toxicology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Botany (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Transplantation (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

HK15110585.3A 2012-05-11 2015-10-28 變體 HK1209644A1 (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201261645686P	2012-05-11	2012-05-11
PCT/US2013/030179 WO2013169338A1 (en)	2012-05-11	2013-03-11	Ctla-4 variants

Publications (1)

Publication Number	Publication Date
HK1209644A1 true HK1209644A1 (zh)	2016-04-08

Family

ID=49551120

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK15110585.3A HK1209644A1 (zh)	2012-05-11	2015-10-28	變體

Country Status (17)

Country	Link
US (2)	US9884902B2 (zh)
EP (2)	EP3207938B1 (zh)
JP (1)	JP6228971B2 (zh)
KR (1)	KR102133060B1 (zh)
CN (2)	CN107540742B (zh)
AU (1)	AU2013260172B2 (zh)
BR (1)	BR112014026718B1 (zh)
CA (1)	CA2868748C (zh)
DK (1)	DK3207938T3 (zh)
ES (1)	ES2777778T3 (zh)
HK (1)	HK1209644A1 (zh)
HU (1)	HUE048925T2 (zh)
MX (1)	MX355234B (zh)
PL (1)	PL3207938T3 (zh)
RU (1)	RU2671465C2 (zh)
SG (2)	SG11201405968SA (zh)
WO (1)	WO2013169338A1 (zh)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
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BR112014026718B1 (pt) *	2012-05-11	2021-05-18	Medimmune Limited.	polipeptídeo isolado de ctla-4, célula hospedeira, composição e uso de um polipeptídeo ctla-4
HUE047077T2 (hu) *	2012-06-29	2020-04-28	Bristol Myers Squibb Co	Eljárások glikoprotein aggregáció csökkentésére
US9944689B2 (en) *	2013-03-07	2018-04-17	The General Hospital Corporation	Human CTLA4 mutants and use thereof
WO2015113494A1 (zh) *	2014-01-28	2015-08-06	北京韩美药品有限公司	双功能融合蛋白及其制备方法和用途
WO2016115275A1 (en) *	2015-01-13	2016-07-21	City Of Hope	Ctla4-binding protein peptide-linker masks
MA41459A (fr)	2015-02-03	2017-12-12	Als Therapy Development Inst	Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l
US11319359B2 (en)	2015-04-17	2022-05-03	Alpine Immune Sciences, Inc.	Immunomodulatory proteins with tunable affinities
US11053295B2 (en)	2015-08-21	2021-07-06	Iucf-Hyu (Industry-University Cooperation Foundation Hanyang University)	Peptides having effects of preventing or treating central nervous system diseases and pharmaceutical compositions for preventing or treating central nervous system diseases containing same as active ingredient
WO2017034244A1 (ko) *	2015-08-21	2017-03-02	한양대학교 산학협력단	중추신경계 질환에 대한 예방 또는 치료효과를 갖는 펩타이드 및 이를 유효성분으로 하는 중추신경계 질환 예방 및 치료용 약학적 조성물
US11351224B2 (en)	2015-08-21	2022-06-07	Iucf-Hyu (Industry-University Cooperation Foundation Hanyang University)	Pharmaceutical composition for preventing and treating transplant rejection
CN108513576A (zh) *	2015-09-14	2018-09-07	高山免疫科学股份有限公司	可调变体免疫球蛋白超家族结构域和工程改造的细胞治疗
GEP20217328B (en)	2015-12-14	2021-12-10	Macrogenics Inc	Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof
KR101918456B1 (ko) *	2015-12-15	2018-11-16	앱클론(주)	Cd80 및 cd86에 특이적으로 결합하는 항체
AU2017250358B2 (en)	2016-04-15	2023-06-01	Alpine Immune Sciences, Inc.	ICOS ligand variant immunomodulatory proteins and uses thereof
KR20190006495A (ko)	2016-04-15	2019-01-18	알파인 이뮨 사이언시즈, 인코포레이티드	Cd80 변이체 면역조절 단백질 및 그의 용도
WO2018022945A1 (en)	2016-07-28	2018-02-01	Alpine Immune Sciences, Inc.	Cd112 variant immunomodulatory proteins and uses thereof
US11471488B2 (en)	2016-07-28	2022-10-18	Alpine Immune Sciences, Inc.	CD155 variant immunomodulatory proteins and uses thereof
JP2020511144A (ja)	2017-03-16	2020-04-16	アルパインイミューンサイエンシズインコーポレイテッド	Ｐｄ−ｌ２バリアント免疫調節タンパク質及びその使用
BR112019018747A2 (pt)	2017-03-16	2020-05-05	Alpine Immune Sciences Inc	proteínas imunomoduladoras variantes de cd80 e usos das mesmas
JP2020521745A (ja)	2017-05-24	2020-07-27	エイエルエス・セラピー・デベロップメント・インスティテュートＡＬＳＴｈｅｒａｐｙＤｅｖｅｌｏｐｍｅｎｔＩｎｓｔｉｔｕｔｅ	治療用抗ｃｄ４０リガンド抗体
KR20230020022A (ko) *	2017-10-10	2023-02-09	알파인 이뮨 사이언시즈, 인코포레이티드	Ctla-4 변이체 면역조절 단백질 및 이의 용도
KR20200085777A (ko)	2017-10-18	2020-07-15	알파인 이뮨 사이언시즈, 인코포레이티드	변이체 icos 리간드 면역조절 단백질 및 관련 조성물 및 방법
WO2020088645A1 (en) *	2018-11-02	2020-05-07	Beijing Vdjbio Co., Ltd.	Modified ctla4 and methods of use thereof
US20220153805A1 (en) *	2019-04-10	2022-05-19	University Of Kentucky Research Foundation	A Novel Prostate Apoptosis Response-4 (Par-4) Protein Entity with an Extended Duration of Action for Therapeutic Treatment of Cancer
AU2021205976A1 (en) *	2020-01-11	2022-07-07	Yale University	Compositions and methods for treating, ameliorating, and/or preventing diseases or disorders caused by or associated with DNAse1 and/or DNAse1L3 deficiency
AU2022361768A1 (en) *	2021-10-08	2024-05-02	Kashiv Biosciences, Llc	Separation of pre-peak and post-peak in fusion protein sample by using size exclusion high performance liquid chromatography
CA3234491A1 (en) *	2021-10-08	2023-04-13	Kashiv Biosciences, Llc	Separation of pre-peak in fusion protein sample by using size exclusion high performance liquid chromatography
WO2023112001A2 (en) *	2021-12-17	2023-06-22	Kashiv Biosciences, Llc	An improved assay method for determining the potency of recombinant protein
TW202342510A (zh)	2022-02-18	2023-11-01	英商Ｒｑ生物科技有限公司	抗體

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AU661854B2 (en)	1991-06-27	1995-08-10	Bristol-Myers Squibb Company	CTL4A receptor, fusion proteins containing it and uses thereof
US6750334B1 (en)	1996-02-02	2004-06-15	Repligen Corporation	CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
WO1997047732A2 (en) *	1996-06-14	1997-12-18	Smithkline Beecham Corporation	Hexameric fusion proteins and uses therefor
US7094874B2 (en) *	2000-05-26	2006-08-22	Bristol-Myers Squibb Co.	Soluble CTLA4 mutant molecules
AR031699A1 (es) *	2000-05-26	2003-10-01	Bristol Myers Squibb Co	Molecula mutante de ctla4 soluble que se enlaza a cd80 y/o cd86, molecula de acido nucleico que la codifica, vector y sistema vector que comprende a esta ultima, celula huesped que lo posee, metodo para producir una proteina mutante y dicha proteina, uso de la molecula mutante para preparar un medic
US20040132101A1 (en) *	2002-09-27	2004-07-08	Xencor	Optimized Fc variants and methods for their generation
US7563443B2 (en) *	2004-09-17	2009-07-21	Domantis Limited	Monovalent anti-CD40L antibody polypeptides and compositions thereof
WO2007007654A1 (ja)	2005-07-07	2007-01-18	Toshiba Lighting & Technology Corporation	放電灯点灯装置および電球形蛍光ランプ
GB0620934D0 (en) *	2006-10-20	2006-11-29	Cambridge Antibody Tech	Protein variants
RU2506275C2 (ru) *	2007-11-01	2014-02-10	Астеллас Фарма Инк.	Иммуносупрессорные полипептиды и нуклеиновые кислоты
SI2536745T1 (sl) *	2010-02-19	2016-10-28	Xencor Inc.	Novi imunoadhezini CTLA4-Ig
CN102822198B (zh) *	2010-03-12	2016-08-31	艾伯维生物医疗股份有限公司	Ctla4蛋白和其用途
BR112014026718B1 (pt) *	2012-05-11	2021-05-18	Medimmune Limited.	polipeptídeo isolado de ctla-4, célula hospedeira, composição e uso de um polipeptídeo ctla-4

2013
- 2013-03-11 BR BR112014026718-9A patent/BR112014026718B1/pt active IP Right Grant
- 2013-03-11 CA CA2868748A patent/CA2868748C/en active Active
- 2013-03-11 US US14/399,685 patent/US9884902B2/en active Active
- 2013-03-11 ES ES17163638T patent/ES2777778T3/es active Active
- 2013-03-11 AU AU2013260172A patent/AU2013260172B2/en active Active
- 2013-03-11 EP EP17163638.4A patent/EP3207938B1/en active Active
- 2013-03-11 EP EP13787673.6A patent/EP2863936A4/en not_active Withdrawn
- 2013-03-11 CN CN201710735648.7A patent/CN107540742B/zh active Active
- 2013-03-11 KR KR1020147031064A patent/KR102133060B1/ko active IP Right Grant
- 2013-03-11 SG SG11201405968SA patent/SG11201405968SA/en unknown
- 2013-03-11 MX MX2014013092A patent/MX355234B/es active IP Right Grant
- 2013-03-11 DK DK17163638.4T patent/DK3207938T3/da active
- 2013-03-11 PL PL17163638T patent/PL3207938T3/pl unknown
- 2013-03-11 RU RU2014150092A patent/RU2671465C2/ru active
- 2013-03-11 CN CN201380024763.3A patent/CN104302309B/zh active Active
- 2013-03-11 WO PCT/US2013/030179 patent/WO2013169338A1/en active Application Filing
- 2013-03-11 JP JP2015511443A patent/JP6228971B2/ja active Active
- 2013-03-11 HU HUE17163638A patent/HUE048925T2/hu unknown
- 2013-03-11 SG SG10201609447XA patent/SG10201609447XA/en unknown
2015
- 2015-10-28 HK HK15110585.3A patent/HK1209644A1/zh unknown
2017
- 2017-12-21 US US15/850,990 patent/US20180208639A1/en not_active Abandoned

Also Published As

Publication number	Publication date
SG10201609447XA (en)	2017-01-27
AU2013260172A1 (en)	2014-10-23
CN104302309B (zh)	2017-07-28
CN107540742A (zh)	2018-01-05
BR112014026718A2 (pt)	2017-07-18
WO2013169338A1 (en)	2013-11-14
HUE048925T2 (hu)	2020-09-28
MX2014013092A (es)	2015-03-03
JP6228971B2 (ja)	2017-11-08
CA2868748A1 (en)	2013-11-14
KR20150014443A (ko)	2015-02-06
RU2671465C2 (ru)	2018-10-31
MX355234B (es)	2018-04-11
JP2015523328A (ja)	2015-08-13
EP2863936A4 (en)	2016-10-05
KR102133060B1 (ko)	2020-07-10
EP3207938A2 (en)	2017-08-23
PL3207938T3 (pl)	2020-07-13
US9884902B2 (en)	2018-02-06
EP2863936A1 (en)	2015-04-29
ES2777778T3 (es)	2020-08-06
SG11201405968SA (en)	2014-11-27
CN107540742B (zh)	2021-06-29
CN104302309A (zh)	2015-01-21
RU2014150092A (ru)	2016-07-10
CA2868748C (en)	2022-07-26
EP3207938B1 (en)	2019-12-25
AU2013260172B2 (en)	2017-11-23
BR112014026718B1 (pt)	2021-05-18
EP3207938A3 (en)	2017-11-01
DK3207938T3 (da)	2020-03-16
US20180208639A1 (en)	2018-07-26
US20150104450A1 (en)	2015-04-16

Publication	Publication Date	Title
HK1209644A1 (zh)	2016-04-08	變體
DK3327112T3 (en)	2020-05-04	Agse-deficient stamme
GB201304182D0 (en)	2013-04-24	No details
GB201403961D0 (en)	2014-04-23	No details
EP2754580A4 (en)	2015-06-24	DUMP TRUCK
DK2830816T3 (en)	2020-02-17	Hidtil ukendt coatingkoncept
EP2935220A4 (en)	2016-04-27	PERI-carbinol
GB201411220D0 (en)	2014-08-06	No details
GB201420527D0 (en)	2014-12-31	Electrical-wire-protecting member
EP2812698A4 (en)	2015-09-23	TIME RESOLVED FREIGHT AND DOUBLE ACCEPTOR
GB2518076B (en)	2017-09-06	Electrical-wire-protecting member
EP2920157A4 (en)	2016-05-11	DI MACRO CYCLEN
GB201313844D0 (en)	2013-09-18	No details
GB201209739D0 (en)	2012-07-18	Aerobars
EP2834250A4 (de)	2015-10-14	Lithiumsilikate
GB201403415D0 (en)	2014-04-16	No details
GB201322955D0 (en)	2014-02-12	No details
GB201400108D0 (en)	2014-02-19	No details
GB201302155D0 (en)	2013-03-27	No details
GB201300109D0 (en)	2013-02-20	No details
GB201310646D0 (en)	2013-07-31	No details
IL224081B (en)	2019-10-31	Show-my-face
GB201221057D0 (en)	2013-01-09	Ezerack
AU345893S (en)	2012-12-04	Treehouse
GB201219307D0 (en)	2012-12-12	Uberloader