HK1205192A1 - 使用酶對二環化合物光學拆分的方法 - Google Patents

使用酶對二環化合物光學拆分的方法

Info

Publication number
HK1205192A1
HK1205192A1 HK15105450.5A HK15105450A HK1205192A1 HK 1205192 A1 HK1205192 A1 HK 1205192A1 HK 15105450 A HK15105450 A HK 15105450A HK 1205192 A1 HK1205192 A1 HK 1205192A1
Authority
HK
Hong Kong
Prior art keywords
enzyme
optical resolution
resolution method
bicyclic compound
bicyclic
Prior art date
Application number
HK15105450.5A
Other languages
English (en)
Inventor
嘉孝 中村
幸人 古屋
島田 神生
朗之 大西
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of HK1205192A1 publication Critical patent/HK1205192A1/zh

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/12Formation of amino and carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06Preparation of nitro compounds
    • C07C201/12Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04Formation of amino groups in compounds containing carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/32Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78Separation; Purification; Stabilisation; Use of additives
    • C07C45/85Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/24Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26Ketones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00Separation of optically-active compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/20All rings being cycloaliphatic the ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK15105450.5A 2012-04-10 2015-06-08 使用酶對二環化合物光學拆分的方法 HK1205192A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012089481 2012-04-10
PCT/JP2013/060597 WO2013154066A1 (ja) 2012-04-10 2013-04-08 酵素を用いる二環性化合物の光学分割方法

Publications (1)

Publication Number Publication Date
HK1205192A1 true HK1205192A1 (zh) 2015-12-11

Family

ID=49327629

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15105450.5A HK1205192A1 (zh) 2012-04-10 2015-06-08 使用酶對二環化合物光學拆分的方法

Country Status (14)

Country Link
US (1) US9394235B2 (zh)
EP (1) EP2837689B1 (zh)
JP (1) JP6023794B2 (zh)
KR (1) KR101976891B1 (zh)
CN (1) CN104245951B (zh)
BR (1) BR112014025158B1 (zh)
CA (1) CA2869994C (zh)
ES (1) ES2624314T3 (zh)
HK (1) HK1205192A1 (zh)
HU (1) HUE033397T2 (zh)
IL (1) IL235002B (zh)
IN (1) IN2014DN07923A (zh)
TW (1) TWI639702B (zh)
WO (1) WO2013154066A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI635071B (zh) 2013-07-08 2018-09-11 第一三共股份有限公司 光學活性二環γ-胺基酸衍生物及其製造方法
KR102598202B1 (ko) 2015-05-27 2023-11-03 노바쎄이 에스에이 3-에틸비사이클로[3.2.0]헵트-3-엔-6-온의 거울상이성질체의 분리
CN116903468B (zh) * 2023-07-14 2024-01-26 山东新时代药业有限公司 一种米洛巴林中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60169434A (ja) * 1984-02-14 1985-09-02 Ube Ind Ltd 光学活性なビシクロケトン類の製法
GEP20094817B (en) 1997-10-27 2009-11-10 Warner Lambert Co Cyclic amino acids and derivatives thereof useful as pharmaceutical agents
HN2000000224A (es) 1999-10-20 2001-04-11 Warner Lambert Co Aminoacidos biciclicos como agentes farmaceuticos
CA2444053C (en) 2001-04-19 2008-06-17 Warner-Lambert Company Llc Fused bicyclic or tricyclic amino acids
WO2004006836A2 (en) 2002-07-11 2004-01-22 Merck & Co., Inc. Treatment of neuropathic pain with 6h-pyrrolo[3,4-d]pyridazine compounds
EP2657219B1 (en) * 2007-09-28 2014-12-10 Daiichi Sankyo Company, Limited Intermediate for producing bicyclic y-amino acid derivative
WO2010084798A1 (ja) * 2009-01-21 2010-07-29 第一三共株式会社 3環性化合物
WO2010110361A1 (ja) 2009-03-26 2010-09-30 第一三共株式会社 二環性γ-アミノ酸誘導体の製造方法
ES2649968T3 (es) * 2011-06-08 2018-01-16 Daiichi Sankyo Company, Limited Procedimiento de producción de un compuesto bicíclico vía transposición de Claisen
HUE037046T2 (hu) 2011-06-08 2018-08-28 Daiichi Sankyo Co Ltd Eljárás biciklusos vegyület elõállítására iminium són keresztül

Also Published As

Publication number Publication date
HUE033397T2 (en) 2017-12-28
BR112014025158A2 (pt) 2017-07-18
WO2013154066A1 (ja) 2013-10-17
CN104245951B (zh) 2018-08-24
US9394235B2 (en) 2016-07-19
EP2837689A1 (en) 2015-02-18
IN2014DN07923A (zh) 2015-05-01
CA2869994A1 (en) 2013-10-17
TWI639702B (zh) 2018-11-01
BR112014025158B1 (pt) 2021-09-21
TW201346036A (zh) 2013-11-16
KR20150004804A (ko) 2015-01-13
IL235002B (en) 2018-04-30
EP2837689B1 (en) 2017-02-15
CA2869994C (en) 2017-05-30
US20150038738A1 (en) 2015-02-05
CN104245951A (zh) 2014-12-24
KR101976891B1 (ko) 2019-05-09
ES2624314T3 (es) 2017-07-13
JP6023794B2 (ja) 2016-11-09
EP2837689A4 (en) 2015-09-09
JPWO2013154066A1 (ja) 2015-12-17

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