HK1203958A1 - Sulfonamide compounds and uses as tnap inhibitors tnap - Google Patents
Sulfonamide compounds and uses as tnap inhibitors tnapInfo
- Publication number
- HK1203958A1 HK1203958A1 HK15104653.3A HK15104653A HK1203958A1 HK 1203958 A1 HK1203958 A1 HK 1203958A1 HK 15104653 A HK15104653 A HK 15104653A HK 1203958 A1 HK1203958 A1 HK 1203958A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- tnap
- inhibitors
- sulfonamide compounds
- sulfonamide
- compounds
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
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US201261601957P | 2012-02-22 | 2012-02-22 | |
PCT/US2013/027191 WO2013126608A1 (en) | 2012-02-22 | 2013-02-21 | Sulfonamide compounds and uses as tnap inhibitors |
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HK1203958A1 true HK1203958A1 (en) | 2015-11-06 |
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EP (1) | EP2817292B1 (pt) |
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KR (1) | KR102083041B1 (pt) |
CN (1) | CN104334527B (pt) |
AU (1) | AU2013222345B2 (pt) |
BR (1) | BR112014020773A2 (pt) |
CA (1) | CA2865071C (pt) |
HK (1) | HK1203958A1 (pt) |
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WO (1) | WO2013126608A1 (pt) |
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CA2865071C (en) | 2012-02-22 | 2020-06-23 | Sanford-Burnham Medical Research Institute | Sulfonamide compounds and uses as tnap inhibitors |
GEP20196983B (en) | 2014-01-14 | 2019-06-25 | Millennium Pharm Inc | Heteroaryls and uses thereof |
WO2015108881A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
CN103755628B (zh) * | 2014-01-27 | 2015-07-29 | 河北科技大学 | 2-氨基-3-碘-5-溴吡啶的合成方法 |
WO2016054056A1 (en) * | 2014-10-01 | 2016-04-07 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Methods of treating pxe with tnap inhibitors |
HUE046994T2 (hu) * | 2015-07-08 | 2020-04-28 | Daiichi Sankyo Co Ltd | Pirido-oxazinon származékok TNAP inhibitorokként |
ITUA20161994A1 (it) * | 2016-03-24 | 2017-09-24 | Azienda Ospedaliera Univ Senese | Uso degli inibitori ddx3 come agenti anti-iperproliferativi |
EP3468554B1 (en) * | 2016-06-08 | 2023-08-09 | Clementia Pharmaceuticals Inc. | Methods for treating heterotopic ossification |
CA3045492C (en) * | 2016-12-23 | 2021-10-19 | Daiichi Sankyo Company, Limited | Sulfonamide compounds having tnap inhibitory activity |
TW201829417A (zh) | 2016-12-23 | 2018-08-16 | 日商第一三共股份有限公司 | 氧氮呯化合物 |
US20210301318A1 (en) * | 2018-07-10 | 2021-09-30 | Academia Sinica | A biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis |
CA3113805C (en) | 2018-10-23 | 2023-03-28 | Daiichi Sankyo Company, Limited | Biaryl derivative |
KR20220110263A (ko) | 2019-12-04 | 2022-08-05 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 내인성 조절인자의 표적화에 의한 혈액-뇌 장벽 약물 수송의 향상 |
CN113683563B (zh) * | 2021-08-31 | 2024-01-30 | 合肥工业大学 | 一种多取代3-磺酰胺喹啉化合物的合成方法 |
CN115837023B (zh) * | 2023-02-20 | 2023-05-16 | 中山大学附属第八医院(深圳福田) | 1-甲基烟酰胺在制备抗血管钙化药物中的应用 |
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TW352384B (en) * | 1992-03-24 | 1999-02-11 | Hoechst Ag | Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals |
JP2000247949A (ja) | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
KR100767000B1 (ko) * | 2000-02-03 | 2007-10-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 인테그린 발현 저해제 |
AU2002346620A1 (en) * | 2001-11-30 | 2003-06-17 | Department Of Veteran Affairs | Induction of apoptosis in cancer cells |
GB0206219D0 (en) * | 2002-03-15 | 2002-05-01 | Ferring Bv | Non-Peptide GnRH antagonists |
US20040110802A1 (en) | 2002-08-23 | 2004-06-10 | Atli Thorarensen | Antibacterial benzoic acid derivatives |
AU2003265382A1 (en) * | 2002-08-23 | 2004-03-11 | Pharmacia & Upjohn Company Llc | Antibacterial benzoic acid derivatives |
DK1562940T3 (da) | 2002-11-18 | 2007-10-01 | Chemocentryx Inc | Arylsulfonamider |
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US20090142347A1 (en) * | 2004-09-29 | 2009-06-04 | The Burnham Institute For Medical Research | Tissue-Nonspecific Alkaline Phosphatase (TNAP): a Therapeutic Target for Arterial Calcification |
SE0402735D0 (sv) * | 2004-11-09 | 2004-11-09 | Astrazeneca Ab | Novel compounds |
GB0425026D0 (en) * | 2004-11-12 | 2004-12-15 | Biofocus Discovery Ltd | Compounds which bind to the active site of protein kinase enzymes |
JP2008519814A (ja) * | 2004-11-12 | 2008-06-12 | ガラパゴス・ナムローゼ・フェンノートシャップ | プロテインキナーゼ酵素の活性部位と結合する窒素複素環式芳香族化合物 |
US20080161187A1 (en) * | 2005-03-16 | 2008-07-03 | Basf Aktiengesellschaft | Biphenyl-N-(4-Pyridyl) Methylsulfonamides |
WO2007014008A2 (en) * | 2005-07-22 | 2007-02-01 | Glaxo Group Limted | Benzenesulfonamide inhibitor of ccr2 chemokine receptor |
JP2009526775A (ja) * | 2006-02-14 | 2009-07-23 | ビーエーエスエフ ソシエタス・ヨーロピア | ピリジン−4−イルメチルアミド |
WO2007129052A1 (en) * | 2006-05-03 | 2007-11-15 | Astrazeneca Ab | Pyrazole derivatives and their use as pi3k inhibitors |
EP2016075A1 (en) * | 2006-05-03 | 2009-01-21 | AstraZeneca AB | Thiazole derivatives and their use as anti-tumour agents |
EP2081888A1 (en) * | 2006-09-08 | 2009-07-29 | Novartis AG | N-biaryl (hetero) arylsulphonamide derivatives useful in the treatment of diseases mediated by lymphocytes interactions |
WO2008042867A2 (en) * | 2006-09-29 | 2008-04-10 | Emiliem Inc. | Modulators of multiple kinases |
JP5671336B2 (ja) * | 2007-05-08 | 2015-02-18 | バーナム インスティテュート フォー メディカル リサーチ | 組織非特異的アルカリホスファターゼ阻害因子および血管石灰化を処置するためのそれらの使用 |
EP2190466A4 (en) * | 2007-08-10 | 2011-12-21 | Burnham Inst Medical Research | Tissue-specific alkaline phosphatase (TNAP) activators and their use |
US8039493B2 (en) * | 2007-09-27 | 2011-10-18 | Hoffmann-La Roche Inc. | Biaryl sulfonamide derivatives |
US20100311736A1 (en) * | 2007-10-22 | 2010-12-09 | Glaxosmithkline Llc | Pyridosulfonamide derivatives as p13 kinase inhibitors |
US8268834B2 (en) * | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
EP2291372A4 (en) * | 2008-05-19 | 2012-04-25 | Burnham Inst Medical Research | MODULATORS OF ALKALINE PHOSPHATASE FROM DARM AND APPLICATIONS THEREOF |
UA104147C2 (uk) * | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
UY32158A (es) * | 2008-10-03 | 2010-04-30 | Astrazeneca Ab | Derivados heterociclicos y metodos de uso de los mismos |
WO2010130638A1 (en) * | 2009-05-14 | 2010-11-18 | Evotec Ag | Sulfonamide compounds, pharmaceutical compositions and uses thereof |
AU2010247414B2 (en) * | 2009-05-15 | 2013-08-01 | Novartis Ag | Aryl pyridine as aldosterone synthase inhibitors |
IN2012DN00471A (pt) * | 2009-06-29 | 2015-06-05 | Agios Pharmaceuticals Inc | |
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CA2865071C (en) | 2012-02-22 | 2020-06-23 | Sanford-Burnham Medical Research Institute | Sulfonamide compounds and uses as tnap inhibitors |
WO2016054056A1 (en) * | 2014-10-01 | 2016-04-07 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Methods of treating pxe with tnap inhibitors |
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2013
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- 2013-02-21 CN CN201380021207.0A patent/CN104334527B/zh active Active
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- 2013-02-21 US US14/379,475 patent/US9458147B2/en active Active
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- 2013-02-21 RU RU2014137402A patent/RU2627701C2/ru active
- 2013-02-21 WO PCT/US2013/027191 patent/WO2013126608A1/en active Application Filing
- 2013-02-21 JP JP2014558836A patent/JP6302846B2/ja active Active
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2015
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2016
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2018
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- 2018-02-05 US US15/888,736 patent/US10370333B2/en active Active
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US20160355479A1 (en) | 2016-12-08 |
RU2627701C2 (ru) | 2017-08-10 |
KR20140129191A (ko) | 2014-11-06 |
JP2018104434A (ja) | 2018-07-05 |
BR112014020773A2 (pt) | 2020-10-27 |
CA2865071A1 (en) | 2013-08-29 |
US10370333B2 (en) | 2019-08-06 |
EP2817292A1 (en) | 2014-12-31 |
JP6544545B2 (ja) | 2019-07-17 |
RU2014137402A (ru) | 2016-04-10 |
CN104334527B (zh) | 2017-05-24 |
EP2817292B1 (en) | 2019-12-18 |
AU2013222345A1 (en) | 2014-09-11 |
CA2865071C (en) | 2020-06-23 |
US20190010126A1 (en) | 2019-01-10 |
US9884826B2 (en) | 2018-02-06 |
JP2015508102A (ja) | 2015-03-16 |
US9458147B2 (en) | 2016-10-04 |
JP6302846B2 (ja) | 2018-03-28 |
AU2013222345B2 (en) | 2017-09-07 |
EP2817292A4 (en) | 2015-08-26 |
WO2013126608A1 (en) | 2013-08-29 |
CN104334527A (zh) | 2015-02-04 |
US20150011551A1 (en) | 2015-01-08 |
KR102083041B1 (ko) | 2020-05-27 |
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