HK1201533A1 - 雜化化合物及其應用方法 - Google Patents
雜化化合物及其應用方法Info
- Publication number
- HK1201533A1 HK1201533A1 HK15102125.7A HK15102125A HK1201533A1 HK 1201533 A1 HK1201533 A1 HK 1201533A1 HK 15102125 A HK15102125 A HK 15102125A HK 1201533 A1 HK1201533 A1 HK 1201533A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- methods
- heterocyclic compounds
- heterocyclic
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2012900286A AU2012900286A0 (en) | 2012-01-25 | "Methods of treatment or prophylaxis" | |
| PCT/AU2013/000061 WO2013110134A1 (en) | 2012-01-25 | 2013-01-25 | Heterocyclic compounds and methods for their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1201533A1 true HK1201533A1 (zh) | 2015-09-04 |
Family
ID=48872832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15102125.7A HK1201533A1 (zh) | 2012-01-25 | 2015-03-03 | 雜化化合物及其應用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20150011565A1 (zh) |
| EP (1) | EP2807153B1 (zh) |
| JP (2) | JP6258867B2 (zh) |
| CN (1) | CN104470903B (zh) |
| AU (1) | AU2013202973C9 (zh) |
| CA (1) | CA2861231C (zh) |
| ES (1) | ES2798289T3 (zh) |
| HK (1) | HK1201533A1 (zh) |
| NZ (1) | NZ627560A (zh) |
| PL (1) | PL2807153T3 (zh) |
| PT (1) | PT2807153T (zh) |
| WO (1) | WO2013110134A1 (zh) |
| ZA (1) | ZA201405255B (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2723732B1 (en) | 2011-06-22 | 2017-01-18 | Purdue Pharma LP | Trpv1 antagonists including dihydroxy substituent and uses thereof |
| WO2013102242A1 (en) | 2012-01-06 | 2013-07-11 | Spinifex Pharmaceuticals Pty Ltd | Heterocyclic compounds and methods for their use |
| NZ627560A (en) * | 2012-01-25 | 2016-08-26 | Novartis Ag | Heterocyclic piperazine compounds and methods for their use |
| CN105358532B (zh) | 2013-07-08 | 2019-07-23 | 诺华股份有限公司 | 杂环化合物和它们的使用方法 |
| ES2671323T3 (es) | 2013-07-22 | 2018-06-06 | Idorsia Pharmaceuticals Ltd | Derivados 1¿(piperazin¿1¿il)¿2¿([1,2,4]triazol¿1¿il)¿etanona |
| WO2015063709A1 (en) * | 2013-10-31 | 2015-05-07 | Ranbaxy Laboratories Limited | Process for the preparation of 1-(3-methyl-1-phenyl-1h-pyrazol-5-yl)piperazine |
| JP6667551B2 (ja) * | 2015-01-13 | 2020-03-18 | ノバルティス アーゲー | アンジオテンシンｉｉ２型拮抗薬としてのピロリジン誘導体 |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| AR103414A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de hidroxialquil-piperazina como moduladores del receptor cxcr3 |
| ES2898635T3 (es) | 2015-03-12 | 2022-03-08 | Novartis Ag | Compuestos heterocíclicos y métodos para su uso |
| CN105503787A (zh) * | 2015-12-31 | 2016-04-20 | 阜阳欣奕华材料科技有限公司 | 一种索非布韦中间体的纯化方法 |
| WO2019040105A2 (en) * | 2017-08-21 | 2019-02-28 | Acadia Pharmaceuticals Inc. | COMPOUNDS, SALTS THEREOF AND METHODS FOR THE TREATMENT OF DISEASES |
| RU2020123261A (ru) | 2017-12-15 | 2022-01-17 | Интера Байосайенс Аг | Производные оксопиперазина |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4400511A (en) * | 1982-05-07 | 1983-08-23 | American Home Products Corporation | 2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids |
| PT94070A (pt) * | 1989-05-18 | 1991-01-08 | Glaxo Group Ltd | Processo para a preparacao de derivados de piperazina |
| US5292726A (en) * | 1991-05-22 | 1994-03-08 | Merck & Co., Inc. | N,N-diacylpiperazines |
| US5344830A (en) * | 1992-12-10 | 1994-09-06 | Merck & Co., Inc. | N,N-diacylpiperazine tachykinin antagonists |
| US5348955A (en) * | 1993-06-22 | 1994-09-20 | Merck & Co., Inc. | N,N-diacylpiperazines |
| US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| WO1998007702A1 (fr) * | 1996-08-23 | 1998-02-26 | Kowa Co., Ltd. | Composes a base de diamide et medicaments les contenant |
| DE69825589T2 (de) * | 1997-06-17 | 2005-09-08 | Schering Corp. | Benzpyrido cycloheptan derivate mit farnesyl protein transferase inhibierender wirkung |
| US5968938A (en) * | 1997-06-18 | 1999-10-19 | Merck & Co., Inc. | Piperazine oxytocin receptor antagonists |
| US20060084660A1 (en) * | 1998-06-30 | 2006-04-20 | Neuromed Technologies Inc. | Calcium channel blockers comprising two benzhydril moieties |
| US6951862B2 (en) * | 1998-06-30 | 2005-10-04 | Neuromed Technologies, Inc. | Calcium channel blockers comprising two benzhydril moieties |
| US7589199B2 (en) * | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| EP1656368A4 (en) * | 2002-07-09 | 2009-08-26 | Bristol Myers Squibb Co | SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AGENTS AND ANTIABESITY AND THEIR MANUFACTURING PROCESS |
| DE10309005A1 (de) * | 2003-03-01 | 2004-09-09 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen, die Dipetidyl Peptidase (DPPIV) und Neurale Endopeptidase (NEP) inhibieren |
| EP1745042A4 (en) * | 2004-04-09 | 2010-07-14 | Neuromed Pharmaceuticals Ltd | DIARYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS |
| DK1830869T3 (da) * | 2004-12-24 | 2013-08-26 | Spinifex Pharm Pty Ltd | Fremgangsmåde til behandling eller profylakse |
| WO2006086609A2 (en) * | 2005-02-10 | 2006-08-17 | Axys Pharmaceuticals, Inc. | Inhibitors of tryptase |
| US20070049578A1 (en) * | 2005-08-24 | 2007-03-01 | Astrazeneca Ab | Cinnamamide compounds as metabotropic glutamate receptor antagonists |
| WO2007063934A1 (ja) * | 2005-12-02 | 2007-06-07 | Mitsubishi Tanabe Pharma Corporation | 脂環式複素環化合物 |
| US8551950B2 (en) | 2006-03-20 | 2013-10-08 | Spinifex Pharmaceuticals Pty Ltd | Method of treatment or prophylaxis of inflammatory pain |
| US8362021B2 (en) * | 2006-05-11 | 2013-01-29 | Zalicus Pharmaceuticals Ltd. | Method for increasing the bioavailability of benzhydryl piperazine containing compounds |
| JP2008031064A (ja) * | 2006-07-27 | 2008-02-14 | Astellas Pharma Inc | ジアシルピペラジン誘導体 |
| JP2009007341A (ja) * | 2007-06-01 | 2009-01-15 | Mitsubishi Tanabe Pharma Corp | 医薬組成物 |
| EP2303876B1 (en) | 2008-06-25 | 2014-03-19 | Bristol-Myers Squibb Company | Diketo azolopiperidines and azolopiperazines as anti-hiv agents |
| EP2525795B1 (en) | 2010-01-19 | 2015-10-21 | Spinifex Pharmaceuticals Pty Ltd | Methods and compositions for improved nerve conduction velocity |
| WO2013102242A1 (en) | 2012-01-06 | 2013-07-11 | Spinifex Pharmaceuticals Pty Ltd | Heterocyclic compounds and methods for their use |
| NZ627560A (en) * | 2012-01-25 | 2016-08-26 | Novartis Ag | Heterocyclic piperazine compounds and methods for their use |
| NZ627558A (en) | 2012-01-25 | 2016-07-29 | Novartis Ag | Heterocyclic piperidine compounds and methods of their use |
-
2013
- 2013-01-25 NZ NZ627560A patent/NZ627560A/en unknown
- 2013-01-25 WO PCT/AU2013/000061 patent/WO2013110134A1/en active Application Filing
- 2013-01-25 US US14/373,355 patent/US20150011565A1/en not_active Abandoned
- 2013-01-25 CN CN201380016259.9A patent/CN104470903B/zh active Active
- 2013-01-25 PT PT137414462T patent/PT2807153T/pt unknown
- 2013-01-25 PL PL13741446T patent/PL2807153T3/pl unknown
- 2013-01-25 JP JP2014553581A patent/JP6258867B2/ja active Active
- 2013-01-25 AU AU2013202973A patent/AU2013202973C9/en active Active
- 2013-01-25 EP EP13741446.2A patent/EP2807153B1/en active Active
- 2013-01-25 CA CA2861231A patent/CA2861231C/en active Active
- 2013-01-25 ES ES13741446T patent/ES2798289T3/es active Active
-
2014
- 2014-07-17 ZA ZA2014/05255A patent/ZA201405255B/en unknown
-
2015
- 2015-03-03 HK HK15102125.7A patent/HK1201533A1/zh unknown
-
2016
- 2016-05-09 US US15/149,641 patent/US9708275B2/en active Active
-
2017
- 2017-10-25 JP JP2017205744A patent/JP2018076297A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP2807153B1 (en) | 2020-03-25 |
| AU2013202973B2 (en) | 2016-06-02 |
| PL2807153T3 (pl) | 2020-09-07 |
| ES2798289T3 (es) | 2020-12-10 |
| AU2013202973B9 (en) | 2016-11-24 |
| WO2013110134A1 (en) | 2013-08-01 |
| US20150011565A1 (en) | 2015-01-08 |
| EP2807153A4 (en) | 2015-06-10 |
| JP2018076297A (ja) | 2018-05-17 |
| JP2015504900A (ja) | 2015-02-16 |
| US20160257656A1 (en) | 2016-09-08 |
| CA2861231C (en) | 2021-04-13 |
| PT2807153T (pt) | 2020-06-18 |
| AU2013202973C9 (en) | 2016-12-22 |
| EP2807153A1 (en) | 2014-12-03 |
| AU2013202973C1 (en) | 2016-11-24 |
| CA2861231A1 (en) | 2013-08-01 |
| US9708275B2 (en) | 2017-07-18 |
| CN104470903B (zh) | 2017-02-22 |
| ZA201405255B (en) | 2019-04-24 |
| CN104470903A (zh) | 2015-03-25 |
| JP6258867B2 (ja) | 2018-01-10 |
| NZ627560A (en) | 2016-08-26 |
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