HK1200449A1 - 在治療過度增殖性疾病中用作 激酶抑制劑的取代的苄基吲唑 - Google Patents

在治療過度增殖性疾病中用作 激酶抑制劑的取代的苄基吲唑

Info

Publication number
HK1200449A1
HK1200449A1 HK15100857.5A HK15100857A HK1200449A1 HK 1200449 A1 HK1200449 A1 HK 1200449A1 HK 15100857 A HK15100857 A HK 15100857A HK 1200449 A1 HK1200449 A1 HK 1200449A1
Authority
HK
Hong Kong
Prior art keywords
bub1
treatment
kinase inhibitors
hyperproliferative diseases
benzylindazoles
Prior art date
Application number
HK15100857.5A
Other languages
English (en)
Inventor
．希契科克
．門格爾
．皮特
．西邁斯特
．溫內爾
．布里姆
．艾斯
．舒爾策
．費爾南德斯-蒙塔爾萬
．佩克特
．霍爾頓
．方黑內爾
．利瑙
．普羅伊塞
．格諾特
Original Assignee
Bayer Pharma AG
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG, Bayer Ip Gmbh filed Critical Bayer Pharma AG
Publication of HK1200449A1 publication Critical patent/HK1200449A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • A01H6/36—Ericaceae, e.g. azalea, cranberry or blueberry
    • A01H6/368—Vaccinium, e.g. cranberry, blueberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Physiology (AREA)
  • Botany (AREA)
  • Environmental Sciences (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK15100857.5A 2011-10-06 2015-01-26 在治療過度增殖性疾病中用作 激酶抑制劑的取代的苄基吲唑 HK1200449A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11184061 2011-10-06
PCT/EP2012/069562 WO2013050438A1 (en) 2011-10-06 2012-10-04 Substituted benzylindazoles for use as bub1 kinase inhibitors in the treatment of hyperproliferative diseases.

Publications (1)

Publication Number Publication Date
HK1200449A1 true HK1200449A1 (zh) 2015-08-07

Family

ID=46968229

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15100857.5A HK1200449A1 (zh) 2011-10-06 2015-01-26 在治療過度增殖性疾病中用作 激酶抑制劑的取代的苄基吲唑

Country Status (38)

Country Link
US (3) US20140249133A1 (zh)
EP (1) EP2763982B1 (zh)
JP (1) JP6140170B2 (zh)
KR (1) KR102007056B1 (zh)
CN (1) CN103974948B (zh)
AP (1) AP3847A (zh)
AR (1) AR088449A1 (zh)
AU (1) AU2012320582B2 (zh)
BR (1) BR112014008045A2 (zh)
CA (1) CA2851037A1 (zh)
CO (1) CO6930363A2 (zh)
CR (1) CR20140161A (zh)
CU (1) CU20140043A7 (zh)
CY (1) CY1120318T1 (zh)
DK (1) DK2763982T3 (zh)
DO (1) DOP2014000062A (zh)
EA (1) EA201400412A1 (zh)
EC (1) ECSP14013284A (zh)
ES (1) ES2665036T3 (zh)
GT (1) GT201400063A (zh)
HK (1) HK1200449A1 (zh)
HR (1) HRP20180546T1 (zh)
HU (1) HUE037154T2 (zh)
IL (1) IL231591A (zh)
LT (1) LT2763982T (zh)
MX (1) MX361279B (zh)
NO (1) NO2763982T3 (zh)
PE (1) PE20141203A1 (zh)
PL (1) PL2763982T3 (zh)
PT (1) PT2763982T (zh)
RS (1) RS57099B1 (zh)
SG (1) SG11201400616YA (zh)
SI (1) SI2763982T1 (zh)
TN (1) TN2014000138A1 (zh)
TW (1) TWI588141B (zh)
UA (1) UA111754C2 (zh)
UY (1) UY34374A (zh)
WO (1) WO2013050438A1 (zh)

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WO2018215282A1 (en) 2017-05-26 2018-11-29 Bayer Pharma Aktiengesellschaft Combination of bub1 and pi3k inhibitors

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CN103974948B (zh) 2017-07-28
CY1120318T1 (el) 2019-07-10
KR102007056B1 (ko) 2019-08-02
US20140249133A1 (en) 2014-09-04
RS57099B1 (sr) 2018-06-29
US20190284206A1 (en) 2019-09-19
US10266548B2 (en) 2019-04-23
SG11201400616YA (en) 2014-09-26
TWI588141B (zh) 2017-06-21
JP6140170B2 (ja) 2017-05-31
LT2763982T (lt) 2018-04-25
AU2012320582B2 (en) 2017-06-15
KR20140075775A (ko) 2014-06-19
CA2851037A1 (en) 2013-04-11
CN103974948A (zh) 2014-08-06
IL231591A (en) 2016-09-29
WO2013050438A1 (en) 2013-04-11
IL231591A0 (en) 2014-05-28
SI2763982T1 (en) 2018-06-29
AP3847A (en) 2016-09-30
CO6930363A2 (es) 2014-04-28
CR20140161A (es) 2014-06-03
MX361279B (es) 2018-12-03
UY34374A (es) 2013-05-31
BR112014008045A2 (pt) 2017-04-11
AU2012320582A1 (en) 2014-04-17
ECSP14013284A (es) 2014-05-31
HUE037154T2 (hu) 2018-08-28
CU20140043A7 (es) 2014-08-28
TN2014000138A1 (en) 2015-09-30
MX2014004122A (es) 2014-06-04
DOP2014000062A (es) 2014-07-15
AR088449A1 (es) 2014-06-11
HRP20180546T1 (hr) 2018-05-04
EA201400412A1 (ru) 2014-08-29
AP2014007533A0 (en) 2014-03-31
JP2014531465A (ja) 2014-11-27
PT2763982T (pt) 2018-04-16
US10604532B2 (en) 2020-03-31
NZ623098A (en) 2016-09-30
TW201321370A (zh) 2013-06-01
GT201400063A (es) 2015-12-07
PE20141203A1 (es) 2014-10-01
UA111754C2 (uk) 2016-06-10
PL2763982T3 (pl) 2018-07-31
EP2763982A1 (en) 2014-08-13
EP2763982B1 (en) 2018-01-10
ES2665036T3 (es) 2018-04-24
US20170260198A1 (en) 2017-09-14
DK2763982T3 (en) 2018-04-23
NO2763982T3 (zh) 2018-06-09

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