HK1190306A1 - 含有心源性因子的組合物和相關方法、細胞，以及所述組合物、方法和細胞的應用 - Google Patents

含有心源性因子的組合物和相關方法、細胞，以及所述組合物、方法和細胞的應用

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Publication number
HK1190306A1
HK1190306A1 HK14103374.4A HK14103374A HK1190306A1 HK 1190306 A1 HK1190306 A1 HK 1190306A1 HK 14103374 A HK14103374 A HK 14103374A HK 1190306 A1 HK1190306 A1 HK 1190306A1
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Hong Kong
Prior art keywords
cells
compositions containing
related method
cardiogenic factors
factors
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HK14103374.4A
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English (en)
Inventor
安德烈．泰爾齊奇
阿塔．貝法爾
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梅奧醫學教育和研究基金會
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Publication of HK1190306A1 publication Critical patent/HK1190306A1/zh

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
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    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Epidemiology (AREA)
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  • Biotechnology (AREA)
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  • Cardiology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
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HK14103374.4A 2008-05-27 2014-04-08 含有心源性因子的組合物和相關方法、細胞，以及所述組合物、方法和細胞的應用 HK1190306A1 (zh)

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Application Number Priority Date Filing Date Title
PCT/US2008/064895 WO2009145761A1 (en) 2008-05-27 2008-05-27 Methods and materials for using cells to treat heart tissue

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HK1190306A1 true HK1190306A1 (zh) 2014-07-04

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HK11104901.7A HK1152225A1 (en) 2008-05-27 2011-05-18 Compositions and methods for using cells to treat heart tissue
HK14103374.4A HK1190306A1 (zh) 2008-05-27 2014-04-08 含有心源性因子的組合物和相關方法、細胞，以及所述組合物、方法和細胞的應用

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US (2) US8835384B2 (zh)
EP (2) EP2303310B1 (zh)
JP (1) JP6093500B2 (zh)
KR (2) KR101721958B1 (zh)
CN (2) CN103340902B (zh)
AU (1) AU2009257801C1 (zh)
BR (1) BRPI0912292A2 (zh)
CA (1) CA2724694A1 (zh)
ES (1) ES2556631T3 (zh)
HK (2) HK1152225A1 (zh)
IL (3) IL209555A (zh)
MX (1) MX2010012998A (zh)
NZ (2) NZ589415A (zh)
RU (1) RU2519762C2 (zh)
SG (2) SG10201506904TA (zh)
WO (2) WO2009145761A1 (zh)
ZA (2) ZA201008046B (zh)

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US8173118B2 (en) 2004-07-30 2012-05-08 Mayo Foundation For Medical Education And Research Compositions consisting essentially of TGF-β, BMP-2 FGF-4, leukemia inhibitory factor, IGF-1, IL-6 and H-α-thrombin
US9765298B2 (en) 2006-07-24 2017-09-19 Mayo Foundation For Medical Education And Research Methods and materials for providing cardiac cells
WO2009145761A1 (en) 2008-05-27 2009-12-03 Mayo Foundation For Medical Education And Research Methods and materials for using cells to treat heart tissue
EP2433125B1 (en) * 2009-05-20 2018-11-28 Mayo Foundation For Medical Education And Research Method for determining the cardio-generative potential of mammalian cells
CN102438636A (zh) 2009-05-20 2012-05-02 卡迪欧参生物科技有限公司 用于治疗心脏疾病的药物组合物
EP2506867B1 (en) * 2009-12-02 2014-10-08 Cardio3 Biosciences S.A. Pharmaceutical compositions for the stimulation of stem cells.
DK2590661T3 (da) 2010-07-06 2020-01-27 Nanologica Ab Forbedret fremgangsmåde til stamcelledifferentiering in vivo ved afgivelse af morfogener med mesoporøst siliciumdioxid og tilsvarende farmaceutisk aktive bestanddele
US9017661B2 (en) 2011-02-22 2015-04-28 The Board Of Regents Of The University Of Texas System Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes
JP5911399B2 (ja) * 2011-08-19 2016-04-27 日本特殊陶業株式会社 燃焼圧検知センサ付きグロープラグ
EP3329779B1 (en) * 2012-11-02 2019-06-05 Cornell University Angiogenic conditioning to enhance cardiac cellular reprogramming of fibroblasts of the infarcted myocardium
US10596123B2 (en) 2015-03-11 2020-03-24 Mayo Foundation For Medical Education And Research Exosome delivery technology
CN105985985B (zh) * 2016-05-06 2019-12-31 苏州大学 Crispr技术编辑并用igf优化的异体间充质干细胞的制备方法及在治疗心梗中应用
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