HK1181316A1 - 結合劑及其使用方法 - Google Patents

結合劑及其使用方法

Info

Publication number
HK1181316A1
HK1181316A1 HK13108710.7A HK13108710A HK1181316A1 HK 1181316 A1 HK1181316 A1 HK 1181316A1 HK 13108710 A HK13108710 A HK 13108710A HK 1181316 A1 HK1181316 A1 HK 1181316A1
Authority
HK
Hong Kong
Prior art keywords
notch1
methods
binding agents
notch1 binding
agents
Prior art date
Application number
HK13108710.7A
Other languages
English (en)
Inventor
愛德華．特恩．圖恩．范德霍斯特
Original Assignee
昂考梅德藥品有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 昂考梅德藥品有限公司 filed Critical 昂考梅德藥品有限公司
Publication of HK1181316A1 publication Critical patent/HK1181316A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK13108710.7A 2010-01-13 2013-07-25 結合劑及其使用方法 HK1181316A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29476210P 2010-01-13 2010-01-13
US41065110P 2010-11-05 2010-11-05
PCT/US2011/021135 WO2011088215A2 (en) 2010-01-13 2011-01-13 Notch1 binding agents and methods of use thereof

Publications (1)

Publication Number Publication Date
HK1181316A1 true HK1181316A1 (zh) 2013-11-08

Family

ID=44304970

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13108710.7A HK1181316A1 (zh) 2010-01-13 2013-07-25 結合劑及其使用方法

Country Status (8)

Country Link
US (1) US8834875B2 (zh)
EP (1) EP2523682B1 (zh)
CN (1) CN102958534B (zh)
AU (1) AU2011205316B2 (zh)
ES (1) ES2561102T3 (zh)
HK (1) HK1181316A1 (zh)
MX (1) MX2012008085A (zh)
WO (1) WO2011088215A2 (zh)

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US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
PL2307459T3 (pl) 2008-07-08 2015-05-29 Oncomed Pharm Inc Czynniki wiążące receptor Notch1 i sposoby ich stosowania
US9090690B2 (en) 2009-06-18 2015-07-28 Pfizer Inc. Anti Notch-1 antibodies
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WO2013119923A1 (en) 2012-02-09 2013-08-15 The Regents Of The University Of Michigan Different states of cancer stem cells
AU2013317886A1 (en) * 2012-09-21 2015-04-09 Oncomed Pharmaceuticals, Inc. Methods of treating hematological malignancies with NOTCH1 antibodies
JP2016506411A (ja) * 2012-12-21 2016-03-03 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｂ細胞ホジキンリンパ腫の治療のための抗体標的療法についての候補であるｔｓｐａｎ３３
WO2014172653A2 (en) * 2013-04-19 2014-10-23 Aveo Pharmaceuticals, Inc. Anti-notch1 antibodies
CN103820498B (zh) * 2014-01-29 2016-08-17 中国人民解放军第四军医大学 一种基于Notch信号胞内域NICD1构建的慢病毒表达载体及其应用
CN106488775A (zh) 2014-07-11 2017-03-08 基因泰克公司 Notch途径抑制
JP6827415B2 (ja) * 2014-10-31 2021-02-10 メレオ バイオファーマ ５ インコーポレイテッド 疾患の処置のための併用療法
CN105585636B (zh) * 2015-11-24 2020-03-03 南方医科大学 一种人NOTCH1 NICD蛋白Ser2162位点磷酸化抗体及其制备方法和应用
CN106591229A (zh) * 2017-01-20 2017-04-26 南京千年健干细胞基因工程有限公司 miR‑34a及靶基因NOTCH1在制备基于间充质干细胞的胶质瘤靶向载体中的应用
WO2019099852A1 (en) * 2017-11-17 2019-05-23 University Of Massachusetts Humanized 2c7 monoclonal antibody directed against a neisseria gonorrhoeae lipooligosaccharide (los) epitope, for human use
US12016885B2 (en) * 2018-11-06 2024-06-25 Alsatech, Inc. Method of solubilizing TDP-43 protein aggregates in amyotrophic lateral sclerosis using a microvascular endothelial cell expressing an anti-TDP-43 Fab

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Also Published As

Publication number Publication date
CN102958534B (zh) 2014-11-05
EP2523682A2 (en) 2012-11-21
WO2011088215A3 (en) 2011-09-29
WO2011088215A2 (en) 2011-07-21
CN102958534A (zh) 2013-03-06
US20120213786A1 (en) 2012-08-23
ES2561102T3 (es) 2016-02-24
EP2523682A4 (en) 2013-05-29
EP2523682B1 (en) 2015-12-16
MX2012008085A (es) 2012-09-12
AU2011205316B2 (en) 2015-05-28
US8834875B2 (en) 2014-09-16
AU2011205316A1 (en) 2012-08-02

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