HK1166331A1 - 抗- 抗體用於治療腦病的應用 - Google Patents

抗- 抗體用於治療腦病的應用

Info

Publication number: HK1166331A1
Authority: HK; Hong Kong
Prior art keywords: tau; antibody; treatment; brain diseases; brain
Prior art date: 2009-06-10

Application number

HK12107020.5A

Other languages

English (en)

Inventor

貝恩德．博爾曼

烏爾裡希．格普費特

菲奧娜．格呂寧格爾

瓦爾特．胡貝爾

漢斯-威利．克雷爾

瓦萊裡婭．利夫可

奧拉夫．蒙迪戈爾

索尼亞．奧夫納

勞倫斯．奧茲曼

邁克爾．施雷爾姆

Original Assignee

霍夫曼-拉羅奇有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-06-10

Filing date

2012-07-18

Publication date

2012-10-26

2012-07-18 Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司

2012-10-26 Publication of HK1166331A1 publication Critical patent/HK1166331A1/zh

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Immunology (AREA)
Neurology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Cell Biology (AREA)
Toxicology (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Psychiatry (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Mycology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)

HK12107020.5A 2009-06-10 2012-07-18 抗- 抗體用於治療腦病的應用 HK1166331A1 (zh)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP09007656		2009-06-10
EP09008487		2009-06-30
PCT/EP2010/003437 WO2010142423A2 (en)	2009-06-10	2010-06-08	Use of an anti-tau ps422 antibody for the treatment of brain diseases

Publications (1)

Publication Number	Publication Date
HK1166331A1 true HK1166331A1 (zh)	2012-10-26

Family

ID=42753372

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK12107020.5A HK1166331A1 (zh)	2009-06-10	2012-07-18	抗- 抗體用於治療腦病的應用

Country Status (23)

Country	Link
US (2)	US8609097B2 (zh)
EP (1)	EP2440578B1 (zh)
JP (2)	JP2012529275A (zh)
KR (1)	KR101429367B1 (zh)
CN (1)	CN102459333B (zh)
AR (1)	AR077016A1 (zh)
AU (1)	AU2010257799B2 (zh)
BR (1)	BRPI1012993A2 (zh)
CA (1)	CA2762594C (zh)
CL (1)	CL2011003122A1 (zh)
CO (1)	CO6450613A2 (zh)
CR (1)	CR20110606A (zh)
EC (1)	ECSP11011514A (zh)
HK (1)	HK1166331A1 (zh)
IL (1)	IL216509A0 (zh)
MA (1)	MA33339B1 (zh)
MX (1)	MX2011012837A (zh)
NZ (1)	NZ596187A (zh)
PE (1)	PE20120543A1 (zh)
RU (1)	RU2536247C2 (zh)
SG (1)	SG176754A1 (zh)
TW (1)	TW201103560A (zh)
WO (1)	WO2010142423A2 (zh)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP4001409A1 (en)	2006-03-31	2022-05-25	Chugai Seiyaku Kabushiki Kaisha	Methods for controlling blood pharmacokinetics of antibodies
DK2202245T3 (en)	2007-09-26	2016-11-21	Chugai Pharmaceutical Co Ltd	A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR
EP3521311A1 (en)	2008-04-11	2019-08-07	Chugai Seiyaku Kabushiki Kaisha	Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
MA33418B1 (fr)	2009-06-10	2012-07-03	Chugai Pharmaceutical Co Ltd	Composé tétracyclique
KR101362589B1 (ko)	2010-08-20	2014-02-12	추가이 세이야쿠 가부시키가이샤	4환성 화합물을 포함하는 조성물
ES2686550T3 (es)	2010-10-11	2018-10-18	Biogen International Neuroscience Gmbh	Anticuerpos anti-tau humanos
CA2819356C (en)	2010-11-30	2023-01-24	Chugai Seiyaku Kabushiki Kaisha	Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
GB201112056D0 (en)	2011-07-14	2011-08-31	Univ Leuven Kath	Antibodies
HUE036177T2 (hu)	2011-09-19	2018-06-28	Axon Neuroscience Se	TAU-mediált patológia protein alapú terápiája és diagnózisa Alzheimer-betegségben
CA2859665C (en)	2011-12-20	2024-05-21	Janssen Biotech, Inc.	Anti-phf-tau antibodies and their uses
EP2794652B1 (en) *	2011-12-21	2017-11-15	F. Hoffmann-La Roche AG	Rapid method for cloning and expression of cognate antibody variable region gene segments
HUE046919T2 (hu)	2012-05-31	2020-04-28	Univ Osaka City	Terápiás szer vagy profilaktikus szer demenciára
KR102076384B1 (ko)	2012-08-16	2020-02-11	아이피어리언 인코포레이티드	타우병증을 치료하는 방법
KR20230110836A (ko)	2012-08-24	2023-07-25	추가이 세이야쿠 가부시키가이샤	ＦｃγＲＩＩｂ 특이적 Ｆｃ영역 개변체
US11236168B2 (en)	2012-08-24	2022-02-01	Chugai Seiyaku Kabushiki Kaisha	Mouse FcγammaRII-specific Fc antibody
LT2902029T (lt)	2012-09-25	2018-10-25	Chugai Seiyaku Kabushiki Kaisha	Ret inhibitorius
LT2935326T (lt) *	2012-12-21	2020-12-10	Biogen Ma Inc.	Žmogaus antikūnai prieš tau baltymą
WO2014096321A1 (en) *	2012-12-21	2014-06-26	INSERM (Institut National de la Santé et de la Recherche Médicale)	Antibodies specific to tau phosphorylated at serine 422 and uses for the treatment and diagnosis of tauopathies
US8980270B2 (en)	2013-01-18	2015-03-17	Ipierian, Inc.	Methods of treating a tauopathy
EP2982689B1 (en)	2013-04-02	2020-08-26	Chugai Seiyaku Kabushiki Kaisha	Fc region variant
CR20160270A (es)	2013-12-20	2016-09-05	Hoffmann La Roche	ANTICUERPOS ANTI-TAU (pS422) HUMANIZADOS Y MÉTODOS DE UTILIZACIÓN
EP2899208A1 (en)	2014-01-28	2015-07-29	F.Hoffmann-La Roche Ag	Camelid single-domain antibody directed against phosphorylated tau proteins and methods for producing conjugates thereof
EP3104870A4 (en)	2014-02-14	2017-09-13	Ipierian, Inc.	Tau peptides, anti-tau antibodies, and methods of use thereof
KR20160142383A (ko)	2014-04-25	2016-12-12	추가이 세이야쿠 가부시키가이샤	4환성 화합물의 신규 결정
SG10202009484WA (en)	2014-04-25	2020-11-27	Chugai Pharmaceutical Co Ltd	Preparation containing tetracyclic compound at high dose
AR100978A1 (es) *	2014-06-26	2016-11-16	Hoffmann La Roche	LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
TW202136296A (zh) *	2014-06-27	2021-10-01	美商Ｃ２Ｎ醫療診斷有限責任公司	人類化抗-tau抗體
TWI718102B (zh)	2014-08-08	2021-02-11	日商中外製藥股份有限公司	４環性化合物的非晶質體
WO2016061389A2 (en) *	2014-10-16	2016-04-21	Genentech, Inc.	Anti-alpha-synuclein antibodies and methods of use
HUE053239T2 (hu) *	2014-11-19	2021-06-28	Axon Neuroscience Se	Humanizált tau-ellenanyagok Alzheimer-kór kezelésére
NZ730607A (en)	2014-12-19	2022-07-01	Chugai Pharmaceutical Co Ltd	Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
JP6741596B2 (ja)	2015-01-16	2020-08-19	中外製薬株式会社	併用医薬
EA201791754A1 (ru)	2015-02-05	2019-01-31	Чугаи Сейяку Кабусики Кайся	АНТИТЕЛА, СОДЕРЖАЩИЕ ЗАВИСЯЩИЙ ОТ КОНЦЕНТРАЦИИ ИОНОВ АНТИГЕНСВЯЗЫВАЮЩИЙ ДОМЕН, ВАРИАНТЫ Fc-ОБЛАСТИ, IL-8-СВЯЗЫВАЮЩИЕ АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ
JO3576B1 (ar)	2015-02-26	2020-07-05	Lilly Co Eli	أجسام مضادة لـ tau واستخداماتها
JP6752222B2 (ja) *	2015-04-16	2020-09-09	アルダー・バイオファーマシューティカルズ・インコーポレーテッド	羞明を処置、予防、または阻害するための抗ｐａｃａｐ抗体及びそれらの抗原結合性断片の使用
UA126272C2 (uk)	2015-06-05	2022-09-14	Дженентек, Інк.	Антитіло проти тау-білка та спосіб його застосування
CN113929779A (zh)	2015-06-24	2022-01-14	豪夫迈·罗氏有限公司	人源化的抗-Tau(pS422)抗体和使用方法
JP6630426B2 (ja)	2015-07-06	2020-01-15	ユーシービーバイオファルマエスピーアールエル	Ｔａｕ結合抗体
TN2017000543A1 (en) *	2015-07-06	2019-04-12	Ucb Biopharma Sprl	Tau-binding antibodies
JO3711B1 (ar)	2015-07-13	2021-01-31	H Lundbeck As	أجسام مضادة محددة لبروتين تاو وطرق استعمالها
FI3334761T3 (fi) *	2015-08-13	2023-08-14	Univ New York	Vasta-ainepohjaisia molekyylejä, jotka ovat selektiivisiä Taun {p}Ser404-epitoopille, ja niiden käyttöjä tauopatian diagnosoinnissa ja hoidossa
JP7141336B2 (ja)	2015-12-25	2022-09-22	中外製薬株式会社	抗ミオスタチン抗体および使用方法
WO2017181031A2 (en)	2016-04-15	2017-10-19	Alder Biopharmaceuticals, Inc.	Anti-pacap antibodies and uses thereof
JOP20180117B1 (ar)	2016-07-12	2022-03-14	H Lundbeck As	أجسام مضادة انتقائية لـ tau فائق المعالجة بفوسفوريلات وطرق لاستخدامها
CN109689099B (zh)	2016-08-05	2023-02-28	中外制药株式会社	用于预防或治疗il-8相关疾病的组合物
WO2018031361A2 (en)	2016-08-09	2018-02-15	Eli Lilly And Company	Combination therapy
EP3551655A2 (en)	2016-12-07	2019-10-16	Genentech, Inc.	Anti-tau antibodies and methods of their use
WO2018106781A1 (en)	2016-12-07	2018-06-14	Genentech, Inc	Anti-tau antibodies and methods of use
GB201700487D0 (en)	2017-01-11	2017-02-22	Hermon-Taylor John	Diagnostic
MX2019009817A (es)	2017-02-17	2019-11-21	Denali Therapeutics Inc	Anticuerpos anti-tau y metodos de uso de los mismos.
JP2018139530A (ja)	2017-02-27	2018-09-13	帝人ファーマ株式会社	認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤
JOP20180021A1 (ar)	2017-03-16	2019-01-30	Janssen Biotech Inc	الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها
CA3077247A1 (en)	2017-10-16	2019-04-25	Eisai R & D Management Co., Ltd.	Anti-tau antibodies and uses thereof
GB201720975D0 (en) *	2017-12-15	2018-01-31	Ucb Biopharma Sprl	Anti-alpha synuclein antibodies
KR20200116105A (ko) *	2018-02-01	2020-10-08	얀센 백신스 앤드 프리벤션 비.브이.	타우에 특이적으로 결합하는 결합 분자
KR20230143199A (ko)	2018-07-03	2023-10-11	에프. 호프만-라 로슈 아게	타우 발현을 조절하기 위한 올리고뉴클레오티드
JP2021530552A (ja)	2018-07-31	2021-11-11	イーライリリーアンドカンパニー	併用療法
MX2021002311A (es)	2018-09-04	2021-04-28	Chugai Pharmaceutical Co Ltd	Metodo para producir un compuesto tetraciclico.
CA3183835A1 (en)	2020-06-25	2021-12-30	Jeanne E. Baker	High affinity antibodies targeting tau phosphorylated at serine 413
WO2023092004A1 (en)	2021-11-17	2023-05-25	Voyager Therapeutics, Inc.	Compositions and methods for the treatment of tau-related disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8928874D0 (en) *	1989-12-21	1990-02-28	Celltech Ltd	Humanised antibodies
DK0618968T3 (da)	1991-12-06	2000-04-10	Max Planck Gesellschaft	Midler til diagnostisering og behandling af Alzheimer's sygdom
US20020086009A1 (en)	1996-03-13	2002-07-04	Koichi Ishiguro	Anti-phosphorylated tau protein antibodies and methods for detecting alzheimer`s disease with the use of the same
AU5508798A (en)	1996-11-19	1998-06-10	Trustees Of The University Of Pennsylvania, The	Diagnostic and therapeutic reagents for alzheimer's disease
IT1312107B1 (it) *	1999-05-14	2002-04-04	Umberto Cornelli	Glicosaminoglicani aventi peso molecolare medio di 2400 d atti altrattamento della demenza senile
AT500379B8 (de)	2001-02-02	2009-08-15	Axon Neuroscience	Tau-proteine
US8012936B2 (en)	2006-03-29	2011-09-06	New York University	Tau fragments for immunotherapy
US20070280935A1 (en) *	2006-04-07	2007-12-06	Bernd Bohrmann	Antibody that recognizes phosphorylated peptides
EP1876185A1 (en)	2006-07-04	2008-01-09	F. Hoffmann-La Roche Ag	An antibody which recognizes phosphorylated polypeptides

2010
- 2010-06-03 US US12/792,810 patent/US8609097B2/en active Active
- 2010-06-07 TW TW099118463A patent/TW201103560A/zh unknown
- 2010-06-08 BR BRPI1012993A patent/BRPI1012993A2/pt not_active Application Discontinuation
- 2010-06-08 RU RU2011152816/10A patent/RU2536247C2/ru active
- 2010-06-08 EP EP10722962.7A patent/EP2440578B1/en active Active
- 2010-06-08 KR KR1020127000595A patent/KR101429367B1/ko active IP Right Grant
- 2010-06-08 CA CA2762594A patent/CA2762594C/en not_active Expired - Fee Related
- 2010-06-08 AU AU2010257799A patent/AU2010257799B2/en not_active Ceased
- 2010-06-08 PE PE2011002053A patent/PE20120543A1/es not_active Application Discontinuation
- 2010-06-08 SG SG2011091139A patent/SG176754A1/en unknown
- 2010-06-08 CN CN201080025548.1A patent/CN102459333B/zh active Active
- 2010-06-08 JP JP2012514380A patent/JP2012529275A/ja active Pending
- 2010-06-08 MX MX2011012837A patent/MX2011012837A/es active IP Right Grant
- 2010-06-08 NZ NZ596187A patent/NZ596187A/xx not_active IP Right Cessation
- 2010-06-08 MA MA34419A patent/MA33339B1/fr unknown
- 2010-06-08 WO PCT/EP2010/003437 patent/WO2010142423A2/en active Application Filing
- 2010-06-08 AR ARP100102006A patent/AR077016A1/es not_active Application Discontinuation
2011
- 2011-10-31 CO CO11147439A patent/CO6450613A2/es not_active Application Discontinuation
- 2011-11-16 CR CR20110606A patent/CR20110606A/es unknown
- 2011-11-21 IL IL216509A patent/IL216509A0/en unknown
- 2011-12-09 CL CL2011003122A patent/CL2011003122A1/es unknown
- 2011-12-09 EC EC2011011514A patent/ECSP11011514A/es unknown
2012
- 2012-07-18 HK HK12107020.5A patent/HK1166331A1/zh unknown
2013
- 2013-06-06 US US13/911,991 patent/US9290567B2/en not_active Expired - Fee Related
2016
- 2016-09-16 JP JP2016181500A patent/JP6513617B2/ja active Active

Also Published As

Publication number	Publication date
ECSP11011514A (es)	2012-01-31
US9290567B2 (en)	2016-03-22
CL2011003122A1 (es)	2012-07-20
RU2536247C2 (ru)	2014-12-20
EP2440578B1 (en)	2017-03-08
US20110059093A1 (en)	2011-03-10
CA2762594A1 (en)	2010-12-16
IL216509A0 (en)	2012-02-29
KR20120024952A (ko)	2012-03-14
AU2010257799A1 (en)	2011-12-01
US8609097B2 (en)	2013-12-17
KR101429367B1 (ko)	2014-08-11
CA2762594C (en)	2017-02-28
NZ596187A (en)	2013-11-29
WO2010142423A3 (en)	2011-05-26
JP2017031176A (ja)	2017-02-09
MX2011012837A (es)	2011-12-16
CO6450613A2 (es)	2012-05-31
TW201103560A (en)	2011-02-01
CR20110606A (es)	2012-01-12
WO2010142423A2 (en)	2010-12-16
AU2010257799B2 (en)	2013-10-17
US20130310541A1 (en)	2013-11-21
PE20120543A1 (es)	2012-05-23
AR077016A1 (es)	2011-07-27
SG176754A1 (en)	2012-01-30
MA33339B1 (fr)	2012-06-01
CN102459333A (zh)	2012-05-16
EP2440578A2 (en)	2012-04-18
JP6513617B2 (ja)	2019-05-15
CN102459333B (zh)	2015-07-15
BRPI1012993A2 (pt)	2018-01-16
JP2012529275A (ja)	2012-11-22
RU2011152816A (ru)	2013-07-20

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