HK1163083A1 - 中間體和應用所述中間體製備恩替卡韋的方法 - Google Patents

中間體和應用所述中間體製備恩替卡韋的方法

Info

Publication number
HK1163083A1
HK1163083A1 HK12103691.2A HK12103691A HK1163083A1 HK 1163083 A1 HK1163083 A1 HK 1163083A1 HK 12103691 A HK12103691 A HK 12103691A HK 1163083 A1 HK1163083 A1 HK 1163083A1
Authority
HK
Hong Kong
Prior art keywords
same
preparing entecavir
entecavir
preparing
Prior art date
Application number
HK12103691.2A
Other languages
English (en)
Inventor
李在憲
朴柯勝
金進喜
李智垠
朴哲玄
崔泰鎮
朴珢珠
金哲慶
林恩廷
張永佶
李寬淳
Original Assignee
韓美科學株式會社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 韓美科學株式會社 filed Critical 韓美科學株式會社
Publication of HK1163083A1 publication Critical patent/HK1163083A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
HK12103691.2A 2008-12-26 2012-04-16 中間體和應用所述中間體製備恩替卡韋的方法 HK1163083A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020080134756A KR101150254B1 (ko) 2008-12-26 2008-12-26 신규 중간체 및 이를 활용한 엔테카비르 제조방법
PCT/KR2009/007786 WO2010074534A2 (en) 2008-12-26 2009-12-24 Novel intermediate and process for preparing entecavir using same

Publications (1)

Publication Number Publication Date
HK1163083A1 true HK1163083A1 (zh) 2012-09-07

Family

ID=42288324

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12103691.2A HK1163083A1 (zh) 2008-12-26 2012-04-16 中間體和應用所述中間體製備恩替卡韋的方法

Country Status (13)

Country Link
US (1) US8569490B2 (zh)
EP (1) EP2382217B1 (zh)
JP (1) JP5425933B2 (zh)
KR (1) KR101150254B1 (zh)
CN (1) CN102264739B (zh)
AR (1) AR074821A1 (zh)
CA (1) CA2747777C (zh)
HK (1) HK1163083A1 (zh)
MY (1) MY158838A (zh)
SA (1) SA109310017B1 (zh)
SG (1) SG171963A1 (zh)
TW (1) TWI383983B (zh)
WO (1) WO2010074534A2 (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011046303A2 (en) * 2009-10-12 2011-04-21 Hanmi Holdings Co., Ltd. Novel method for preparing entecavir and intermediate used therein
US8481728B2 (en) 2010-02-16 2013-07-09 Scinopharm Taiwan, Ltd. Process for preparing entecavir and its intermediates
CA2705953C (en) * 2010-05-31 2018-05-01 Alphora Research Inc. Carbanucleoside synthesis and intermediate compounds useful therein
CN106928227B (zh) * 2010-07-15 2020-06-30 浙江奥翔药业股份有限公司 恩替卡韦的合成方法及其中间体化合物
EP2474548A1 (en) 2010-12-23 2012-07-11 Esteve Química, S.A. Preparation process of an antiviral drug and intermediates thereof
EP2597096A1 (en) 2011-11-24 2013-05-29 Esteve Química, S.A. Process for preparing entecavir and intermediates thereof
WO2014175974A2 (en) 2013-03-13 2014-10-30 Elitech Holding B.V. Artificial nucleic acids
KR20200108903A (ko) * 2013-06-25 2020-09-21 더 월터 앤드 엘리자 홀 인스티튜트 오브 메디컬 리서치 세포내 감염의 치료 방법
WO2015051903A1 (en) * 2013-10-08 2015-04-16 Pharmathen S.A. A novel process for the preparation of chiral cyclopentanone intermediates
WO2015051900A1 (en) 2013-10-08 2015-04-16 Pharmathen S.A. Process for the preparation of entecavir through novel intermediates
CN103675185B (zh) * 2013-12-10 2015-10-07 上海景峰制药股份有限公司 一种用高效液相色谱法测定恩替卡韦片中全反式异构体的方法
KR101647061B1 (ko) 2014-04-02 2016-08-10 서강대학교산학협력단 무인자율주행 차량의 주행경로 생성방법 및 장치
CN105037363B (zh) * 2015-07-13 2016-08-24 山东罗欣药业集团股份有限公司 一种恩替卡韦化合物的新合成方法
CN106554365B (zh) * 2016-11-12 2019-01-08 嘉兴敏实机械有限公司 一种恩替卡韦中间体的制备工艺及其应用
CN109232637B (zh) * 2018-10-29 2020-11-24 常州博海威医药科技股份有限公司 一种恩替卡韦中间体的制备方法
CA3122410A1 (en) * 2018-12-12 2020-06-18 Janssen Biopharma, Inc. Cyclopentyl nucleoside analogs as anti-virals

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206244A (en) 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
US5340816A (en) 1990-10-18 1994-08-23 E. R. Squibb & Sons, Inc. Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
WO1998009964A1 (en) 1996-09-03 1998-03-12 Bristol-Myers Squibb Company IMPROVED PROCESS FOR PREPARING THE ANTIVIRAL AGENT [1S-(1α, 3α, 4β)]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENECYCLOPENTYL]-6H-PURIN-6-ONE
ES2397104T3 (es) 2002-12-11 2013-03-04 Bristol-Myers Squibb Company Procedimiento y productos intermedios para la síntesis de entecavir
MXPA05011297A (es) 2003-04-25 2006-05-25 Gilead Sciences Inc Analogos antivirales de fosfonato.
US7511139B2 (en) 2004-06-04 2009-03-31 Bristol-Myers Squibb Company Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
US20070060599A1 (en) 2005-09-09 2007-03-15 Dimarco John D Crystalline forms of [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
CN101210015B (zh) 2006-12-26 2010-09-22 上海国创医药有限公司 一种乙肝治疗药物恩替卡韦的制备方法
CN101245068A (zh) 2007-02-14 2008-08-20 浙江医药股份有限公司新昌制药厂 结晶型态的恩替卡韦及其制备方法和其药物组合物及用途
CN101245067B (zh) 2007-02-14 2011-09-28 浙江金立源药业有限公司 一种恩替卡韦的制备方法及其中间体
CN101235034A (zh) 2008-02-28 2008-08-06 陆锦康 恩替卡韦的合成方法

Also Published As

Publication number Publication date
WO2010074534A3 (en) 2010-11-11
SG171963A1 (en) 2011-07-28
JP5425933B2 (ja) 2014-02-26
CA2747777A1 (en) 2010-07-01
EP2382217A2 (en) 2011-11-02
EP2382217B1 (en) 2013-10-23
MY158838A (en) 2016-11-15
CA2747777C (en) 2013-11-12
SA109310017B1 (ar) 2013-12-15
CN102264739A (zh) 2011-11-30
TW201028417A (en) 2010-08-01
US20110251387A1 (en) 2011-10-13
EP2382217A4 (en) 2012-08-15
JP2012513988A (ja) 2012-06-21
KR20100076640A (ko) 2010-07-06
CN102264739B (zh) 2014-12-10
TWI383983B (zh) 2013-02-01
AR074821A1 (es) 2011-02-16
KR101150254B1 (ko) 2012-06-12
WO2010074534A2 (en) 2010-07-01
US8569490B2 (en) 2013-10-29

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20181228